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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase C-activating G protein-coupled receptor signaling pathway
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Accession:GO:0007200 term browser browse the term
Definition:A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
Comment:This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) activity.
Synonyms:exact_synonym: G protein signaling, coupled to IP3 second messenger (phospholipase C activating);   G protein signalling, coupled to IP3 second messenger (phospholipase C activating);   G-protein coupled receptor signaling pathway coupled to IP3 second messenger;   PLC-activating GPCR signaling pathway
 related_synonym: activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger;   phospholipase C-activating dopamine receptor signaling pathway



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phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:1203366|PMID:9590558)
RGD PMID:9590558 PMID:21873635 MGI:1203366, RGD:13792537 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra1d adrenoceptor alpha 1D involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
JBrowse link
G Agtr1a angiotensin II receptor, type 1a IDA RGD PMID:11906170 RGD:70819 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Ano1 anoctamin 1 involved_in ISO (MGI:5461590|PMID:22634729) RGD PMID:22634729 MGI:5461590 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
JBrowse link
G C3ar1 complement C3a receptor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
JBrowse link
G C5ar1 complement C5a receptor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G C5ar2 complement C5a receptor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:76,930,381...76,945,432
Ensembl chr 1:76,930,383...76,959,517
JBrowse link
G Casr calcium-sensing receptor IDA RGD PMID:22192592 RGD:7207059 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Cckbr cholecystokinin B receptor involved_in ISO
IBA
IEA
(PMID:7681836)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:7681836 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
JBrowse link
G Cmklr1 chemerin chemokine-like receptor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:42,974,462...43,027,321
Ensembl chr12:42,974,410...43,028,129
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IDA in transfected HEK cells RGD PMID:15932935 RGD:1626241 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 involved_in ISO (MGI:6162594|PMID:10187784) RGD PMID:10187784 MGI:6162594 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 involved_in ISO (PMID:10438939) RGD PMID:10438939 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Ednrb endothelin receptor type B IMP RGD PMID:15245872 RGD:1581866 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Esr1 estrogen receptor 1 involved_in IDA PMID:15705806 UniProt PMID:15705806 RGD:8553914 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G F2r coagulation factor II (thrombin) receptor involved_in ISO
IEA
(PMID:20164183)
GO_REF:0000107
RGD
Ensembl
PMID:20164183 GO_REF:0000107 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G Ffar4 free fatty acid receptor 4 involved_in ISO
ISS
(PMID:27852822)
(MGI:6203732|PMID:27852822)
GO_REF:0000024
RGD
UniProt
PMID:27852822 GO_REF:0000024 MGI:6203732 NCBI chr 1:235,873,576...235,891,597
Ensembl chr 1:235,873,576...235,891,597
JBrowse link
G Fpr1 formyl peptide receptor 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:22859307)
(MGI:5467169|PMID:22859307)
RGD PMID:22859307 PMID:21873635 MGI:5467169, RGD:13792537 NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559
JBrowse link
G Fpr2 formyl peptide receptor 2 acts_upstream_of_or_within ISO (MGI:5467169|PMID:22859307) RGD PMID:22859307 MGI:5467169 NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019
JBrowse link
G Fpr2l1 formyl peptide receptor 2 like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:59,686,519...59,687,550
Ensembl chr 1:59,686,103...59,716,622
JBrowse link
G Fpr2l2 formyl peptide receptor 2 like 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:58,997,091...58,998,062
Ensembl chr 1:58,968,268...58,999,984
JBrowse link
G Fpr3 formyl peptide receptor 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:58,884,400...58,893,475
Ensembl chr 1:58,845,118...58,893,467
JBrowse link
G Fshr follicle stimulating hormone receptor acts_upstream_of_or_within ISO (MGI:1337390|PMID:10330114) RGD PMID:10330114 MGI:1337390 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Galr2 galanin receptor 2 involved_in ISO (PMID:9832121) RGD PMID:9832121 NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176
JBrowse link
G Gna15 G protein subunit alpha 15 acts_upstream_of_or_within IMP
ISO
MGI:2152420 (MGI:1352374|PMID:10629036) RGD PMID:10629036 PMID:9685675 MGI:1352374, RGD:728647 NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508
JBrowse link
G Gnaq G protein subunit alpha q IMP RGD PMID:9677408 RGD:1598490 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Gnb1 G protein subunit beta 1 acts_upstream_of_or_within ISO (MGI:1932393|PMID:10570481) RGD PMID:10570481 MGI:1932393 NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124
JBrowse link
G Gng13 G protein subunit gamma 13 acts_upstream_of_or_within ISO (MGI:1932393|PMID:10570481) RGD PMID:10570481 MGI:1932393 NCBI chr10:14,741,179...14,743,083
Ensembl chr10:14,741,239...14,743,083
JBrowse link
G Gpr139 G protein-coupled receptor 139 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:3619839|PMID:16378626)
PMID:21873635
RGD PMID:16378626 PMID:21873635 MGI:3619839, RGD:13792537 NCBI chr 1:173,481,583...173,522,451
Ensembl chr 1:173,481,583...173,522,451
JBrowse link
G Gpr33 G protein-coupled receptor 33 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:69,474,435...69,475,440
Ensembl chr 6:69,474,435...69,475,440
JBrowse link
G Gpr4 G protein-coupled receptor 4 involved_in ISO (PMID:20211729) RGD PMID:20211729 NCBI chr 1:78,865,376...78,877,126
Ensembl chr 1:78,865,409...78,876,599
JBrowse link
G Gpr83 G protein-coupled receptor 83 involved_in ISO (MGI:6141494|PMID:27117253) RGD PMID:27117253 MGI:6141494 NCBI chr 8:11,693,540...11,704,028
Ensembl chr 8:11,693,540...11,704,028
JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Grpr gastrin releasing peptide receptor involved_in ISS
ISO
GO_REF:0000024
(MGI:5704231|PMID:26658875)
UniProt
RGD
PMID:26658875 GO_REF:0000024 MGI:5704231 NCBI chr  X:30,998,425...31,038,442
Ensembl chr  X:30,998,416...31,038,442
JBrowse link
G Hcrt hypocretin neuropeptide precursor IMP RGD PMID:16247802 RGD:1600968 NCBI chr10:85,689,992...85,691,206
Ensembl chr10:85,689,465...85,691,210
JBrowse link
G Hcrtr2 hypocretin receptor 2 acts_upstream_of_or_within ISO (MGI:3487185|PMID:15256537) RGD PMID:15256537 MGI:3487185 NCBI chr 8:76,989,834...77,105,893
Ensembl chr 8:76,989,834...77,105,893
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor involved_in IDA
ISO
IEA
IBA
(MGI:5318037|PMID:10493819)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:10493819 PMID:3026357 PMID:21873635 GO_REF:0000107 MGI:5318037, RGD:2292621, RGD:13792537 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Mlnr motilin receptor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:50,413,570...50,422,842
Ensembl chr19:50,413,580...50,418,770
JBrowse link
G Nmur1 neuromedin U receptor 1 involved_in ISO (PMID:10899166) RGD PMID:10899166 NCBI chr 9:87,033,231...87,038,070
Ensembl chr 9:87,033,279...87,036,684
JBrowse link
G Nmur2 neuromedin U receptor 2 involved_in ISO (PMID:10899166) RGD PMID:10899166 NCBI chr10:40,166,223...40,182,078
Ensembl chr10:40,166,226...40,182,078
JBrowse link
G Npr3 natriuretic peptide receptor 3 IMP RGD PMID:15044621 RGD:1581459 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
JBrowse link
G Ntsr2 neurotensin receptor 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:82706|PMID:8795617)
Ensembl
RGD
PMID:8795617 GO_REF:0000107 MGI:82706 NCBI chr 6:39,424,297...39,431,015
Ensembl chr 6:39,424,324...39,431,014
JBrowse link
G Oprd1 opioid receptor, delta 1 involved_in IDA PMID:9572309 UniProt PMID:9572309 RGD:8553369 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 involved_in IDA PMID:9572309 UniProt PMID:9572309 RGD:8553369 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 involved_in IDA PMID:9572309 UniProt PMID:9572309 RGD:8553369 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G P2ry1 purinergic receptor P2Y1 involved_in ISO
IBA
ISS
(PMID:9442040)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:9442040 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457
JBrowse link
G P2ry12 purinergic receptor P2Y12 involved_in IMP PMID:18183622 ARUK-UCL PMID:18183622 RGD:13673786 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
JBrowse link
G P2ry2 purinergic receptor P2Y2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
JBrowse link
G Plcb2 phospholipase C, beta 2 involved_in IDA PMID:9860142 UniProt PMID:9860142 RGD:729588 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302
JBrowse link
G Plce1 phospholipase C, epsilon 1 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:11022047), (PMID:11022048)
Ensembl
UniProt
RGD
PMID:11022047 PMID:11022048 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438
JBrowse link
G Ptger3 prostaglandin E receptor 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:69021|PMID:7945376)
RGD PMID:7945376 PMID:21873635 MGI:69021, RGD:13792537 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
G Pth1r parathyroid hormone 1 receptor acts_upstream_of_or_within
involved_in
IDA
ISO
IC
MGI:3628795 (MGI:3625556|PMID:12194850)
PMID:19608645
RGD PMID:12194850 PMID:9054374 PMID:19608645 MGI:3625556, RGD:7207455, RGD:8553376 NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729
JBrowse link
G Tgm2 transglutaminase 2 involved_in
acts_upstream_of_or_within
ISO
IDA
(PMID:7592956), (PMID:8943303)
PMID:7911253
RGD PMID:7592956 PMID:8943303 PMID:7911253 RGD:8553754 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Trhr thyrotropin releasing hormone receptor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
JBrowse link
G Vip vasoactive intestinal peptide involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bicd1 BICD cargo adaptor 1 involved_in IMP
ISO
PMID:20164183
(MGI:4887309|PMID:20164183)
RGD PMID:20164183 PMID:20164183 MGI:4887309, RGD:8693367 NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434
JBrowse link
phospholipase C-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A involved_in ISO (PMID:10948191) RGD PMID:10948191 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
phospholipase C-activating angiotensin-activated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn2 actinin alpha 2 involved_in ISO (PMID:25433700) RGD PMID:25433700 NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622
JBrowse link
G Agtr1a angiotensin II receptor, type 1a involved_in ISO (PMID:1378723) RGD PMID:1378723 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
phospholipase C-activating dopamine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd1 dopamine receptor D1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
UniProtKB:P14416 (PMID:17194762)
(PMID:1282671)
MGI:94924|MGI:95766|MGI:95776 (MGI:3621386|PMID:15016423), (MGI:3701153|PMID:17194762)
Ensembl
RGD
PMID:1282671 PMID:15016423 PMID:17194762 GO_REF:0000107 MGI:3621386 MGI:3701153 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
UniProtKB:P21728 (PMID:17194762)
MGI:95766|MGI:95776|MGI:99578 (MGI:3621386|PMID:15016423), (MGI:3701153|PMID:17194762)
RGD PMID:15016423 PMID:17194762 PMID:21873635 MGI:3621386 MGI:3701153, RGD:13792537 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Gna11 G protein subunit alpha 11 involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
MGI:94924|MGI:95776|MGI:99578 (MGI:3701153|PMID:17194762)
GO_REF:0000107
RGD
Ensembl
PMID:17194762 PMID:21873635 GO_REF:0000107 MGI:3701153, RGD:13792537 NCBI chr 7:8,163,752...8,177,636
Ensembl chr 7:8,162,750...8,179,812
JBrowse link
G Gna15 G protein subunit alpha 15 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508
JBrowse link
G Gnaq G protein subunit alpha q involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:94924|MGI:95766|MGI:99578 (MGI:3701153|PMID:17194762)
Ensembl
RGD
PMID:17194762 GO_REF:0000107 MGI:3701153 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 acts_upstream_of_or_within ISO MGI:2386785 (MGI:4819345|PMID:20200151) RGD PMID:20200151 MGI:4819345 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grm1 glutamate metabotropic receptor 1 involved_in TAS PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in TAS PMID:12514208 RGD
UniProt
PMID:12189203 PMID:12514208 RGD:625594, RGD:728711 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
phospholipase C-activating serotonin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr2a 5-hydroxytryptamine receptor 2A IDA RGD PMID:17010161 RGD:1624387 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in ISO
IEA
(PMID:12970106)
GO_REF:0000107
RGD
Ensembl
PMID:12970106 GO_REF:0000107 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C involved_in IDA
ISO
(MGI:5140621|PMID:21835345)
(PMID:12970106)
RGD PMID:12970106 PMID:21835345 PMID:12435801 MGI:5140621, RGD:1598460 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a involved_in ISO (PMID:1567413) RGD PMID:1567413 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G C3ar1 complement C3a receptor 1 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P30678|UniProtKB:P30679|UniProtKB:Q9TU29 (PMID:10571060)
Ensembl
RGD
PMID:10571060 GO_REF:0000107 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
JBrowse link
G Calca calcitonin-related polypeptide alpha involved_in ISO (PMID:8078488)
(PMID:8078488), (PMID:9685362)
(PMID:9685362)
RGD PMID:8078488 PMID:9685362 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Drd1 dopamine receptor D1 involved_in ISO (PMID:1282671) RGD PMID:1282671 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 involved_in IBA
ISO
PMID:21873635
(PMID:1331329)
RGD PMID:1331329 PMID:21873635 RGD:13792537 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Edn1 endothelin 1 acts_upstream_of_or_within ISO (MGI:70451|PMID:2542249) RGD PMID:2542249 MGI:70451 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A IMP RGD PMID:12628492 RGD:728499 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G F2r coagulation factor II (thrombin) receptor involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:15145074 PMID:21873635 RGD:1582290, RGD:13792537 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098
JBrowse link
G F2rl3 F2R like thrombin or trypsin receptor 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:17,117,441...17,119,434
Ensembl chr16:17,117,441...17,119,472
JBrowse link
G Gna15 G protein subunit alpha 15 involved_in ISO
IEA
UniProtKB:P41146|UniProtKB:Q16581 (PMID:10571060)
UniProtKB:P41146|UniProtKB:Q16581 (MGI:1346917|PMID:10571060)
GO_REF:0000107
RGD
Ensembl
PMID:10571060 GO_REF:0000107 MGI:1346917 NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508
JBrowse link
G Gpr157 G protein-coupled receptor 157 involved_in ISS
ISO
GO_REF:0000024
(MGI:5825412|PMID:27142930)
UniProt
RGD
PMID:27142930 GO_REF:0000024 MGI:5825412 NCBI chr 5:160,550,703...160,566,432
Ensembl chr 5:160,550,713...160,566,432
JBrowse link
G Gpr17 G protein-coupled receptor 17 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:23,576,212...23,583,177
Ensembl chr18:23,577,242...23,582,966
JBrowse link
G Gpr174 G protein-coupled receptor 174 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:72,355,452...72,396,146
Ensembl chr  X:72,355,033...72,397,658
JBrowse link
G Gpr18 G protein-coupled receptor 18 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470
JBrowse link
G Gpr35 G protein-coupled receptor 35 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:93,526,691...93,539,302
Ensembl chr 9:93,527,127...93,539,299
JBrowse link
G Gpr4 G protein-coupled receptor 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:78,865,376...78,877,126
Ensembl chr 1:78,865,409...78,876,599
JBrowse link
G Gpr55 G protein-coupled receptor 55 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:86,584,906...86,640,601
Ensembl chr 9:86,590,885...86,640,613
JBrowse link
G Gpr65 G-protein coupled receptor 65 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:117,515,786...117,536,514
Ensembl chr 6:117,515,648...117,536,512
JBrowse link
G Grm1 glutamate metabotropic receptor 1 involved_in ISO
TAS
IEA
ISS
(PMID:24603153)
PMID:12514208
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:24603153 PMID:12514208 GO_REF:0000024 GO_REF:0000107, RGD:728711 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in TAS PMID:15758184 UniProt PMID:15758184 RGD:8554618 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C involved_in ISS
ISO
GO_REF:0000024
(MGI:5140621|PMID:21835345)
UniProt
RGD
PMID:21835345 GO_REF:0000024 MGI:5140621 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor IDA kisspeptin-10 peptide is 100% identical in rat, mouse and human RGD PMID:11457843 PMID:16222076 RGD:1357971, RGD:1599289 NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612
JBrowse link
G LOC100359656 rCG38062-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:71,801,075...71,802,621
Ensembl chr  X:71,801,139...71,801,777
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 involved_in IDA
IBA
ISO
PMID:21873635
(PMID:19733258)
RGD PMID:19733258 PMID:16242672 PMID:21873635 RGD:1626474, RGD:13792537 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895
JBrowse link
G Lpar3 lysophosphatidic acid receptor 3 IDA RGD PMID:16242672 RGD:1626474 NCBI chr 2:235,125,234...235,193,916
Ensembl chr 2:235,149,065...235,193,357
JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:72,033,486...72,046,978
Ensembl chr  X:72,033,486...72,046,977
JBrowse link
G Lpar6 lysophosphatidic acid receptor 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:48,416,548...48,418,357
Ensembl chr15:48,416,544...48,422,331
JBrowse link
G Myh9 myosin, heavy chain 9 IMP RGD PMID:20068007 RGD:6902910 NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 involved_in ISO UniProtKB:P30678|UniProtKB:P30679|UniProtKB:Q9TU29 (PMID:10571060) RGD PMID:10571060 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
JBrowse link
G P2ry1 purinergic receptor P2Y1 involved_in TAS PMID:20847060 BHF-UCL PMID:20847060 RGD:8554370 NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457
JBrowse link
G P2ry10 P2Y receptor family member 10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:72,121,558...72,207,174
Ensembl chr  X:72,111,264...72,212,265
JBrowse link
G Plcd1 phospholipase C, delta 1 IMP RGD PMID:16709602 RGD:2300424 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186
JBrowse link
G RGD1560455 similar to RIKEN cDNA A630033H20 gene involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:72,255,526...72,281,013
Ensembl chr  X:72,238,713...72,281,012
JBrowse link
G Rxfp3 relaxin family peptide receptor 3 acts_upstream_of_or_within ISO (MGI:3619839|PMID:16378626) RGD PMID:16378626 MGI:3619839 NCBI chr 2:60,003,256...60,004,686
Ensembl chr 2:60,003,256...60,004,686
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 IMP RGD PMID:9765227 RGD:1581785 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G Tgm2 transglutaminase 2 IMP RGD PMID:12054611 RGD:634393 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chga chromogranin A IDA RGD PMID:11257446 RGD:6907050 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
JBrowse link
G F2 coagulation factor II involved_in IEA
ISO
GO_REF:0000107
(PMID:20164183)
Ensembl
RGD
PMID:20164183 GO_REF:0000107 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Gpr27 G protein-coupled receptor 27 acts_upstream_of_or_within ISO (MGI:5311513|PMID:22253604) RGD PMID:22253604 MGI:5311513 NCBI chr 4:132,328,364...132,329,497
Ensembl chr 4:132,328,364...132,329,497
JBrowse link
G Grp gastrin releasing peptide involved_in ISS
ISO
GO_REF:0000024
(MGI:5704231|PMID:26658875)
UniProt
RGD
PMID:26658875 GO_REF:0000024 MGI:5704231 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    signaling 7370
      signal transduction 6808
        G protein-coupled receptor signaling pathway 2217
          phospholipase C-activating G protein-coupled receptor signaling pathway 99
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
            phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 0
            phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 2
            phospholipase C-activating adrenergic receptor signaling pathway 1
            phospholipase C-activating angiotensin-activated signaling pathway + 3
            phospholipase C-activating dopamine receptor signaling pathway + 7
            phospholipase C-activating rhodopsin mediated signaling pathway 0
            phospholipase C-activating serotonin receptor signaling pathway 3
            phospholipase C-activating tachykinin receptor signaling pathway 0
            positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 39
            positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway 4
            regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 18737
    biological regulation 13318
      regulation of biological process 12598
        regulation of cellular process 11911
          signal transduction 6808
            G protein-coupled receptor signaling pathway 2217
              phospholipase C-activating G protein-coupled receptor signaling pathway 99
                negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
                phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 0
                phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 2
                phospholipase C-activating adrenergic receptor signaling pathway 1
                phospholipase C-activating angiotensin-activated signaling pathway + 3
                phospholipase C-activating dopamine receptor signaling pathway + 7
                phospholipase C-activating rhodopsin mediated signaling pathway 0
                phospholipase C-activating serotonin receptor signaling pathway 3
                phospholipase C-activating tachykinin receptor signaling pathway 0
                positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 39
                positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway 4
                regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 5
paths to the root