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ONTOLOGY REPORT - ANNOTATIONS


Term:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
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Accession:GO:0007197 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
Synonyms:exact_synonym: muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway;   muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway
 related_synonym: inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway;   inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway;   inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway


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adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(MGI:61071|PMID:7916637)
Ensembl
RGD
PMID:7916637, PMID:21873635 GO_REF:0000107 MGI:61071, RGD:13792537 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Hrh3 histamine receptor H3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395
JBrowse link
G Hrh4 histamine receptor H4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:4,365,429...4,382,599
Ensembl chr18:4,365,429...4,382,599
JBrowse link
G Oprm1 opioid receptor, mu 1 IDA PMID:8051154 GO_Central PMID:8051154 RGD:8656009 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20030
    signaling 7581
      signal transduction 7012
        G protein-coupled receptor signaling pathway 2509
          G protein-coupled acetylcholine receptor signaling pathway 14
            adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway 8
              adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate 0
Path 2
Term Annotations click to browse term
  biological_process 20030
    biological regulation 13774
      regulation of biological process 13076
        regulation of cellular process 12564
          signal transduction 7012
            G protein-coupled receptor signaling pathway 2509
              G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 258
                adenylate cyclase-modulating G protein-coupled receptor signaling pathway 229
                  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 77
                    adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway 8
                      adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate 0
paths to the root