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Term:G protein-coupled receptor signaling pathway
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Accession:GO:0007186 term browser browse the term
Definition:A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
Synonyms:exact_synonym: G protein coupled receptor protein signaling pathway;   G protein coupled receptor protein signalling pathway;   G-protein coupled receptor protein signal transduction;   G-protein coupled receptor signalling pathway;   GPCR signaling pathway;   GPCR signalling pathway
 narrow_synonym: G-protein coupled receptor signaling pathway via GPCR dimer;   dimeric G-protein coupled receptor signaling pathway;   dimeric G-protein coupled receptor signalling pathway
 alt_id: GO:0038042


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Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        G protein-coupled receptor signaling pathway 2509
          G protein-coupled acetylcholine receptor signaling pathway + 14
          G protein-coupled glutamate receptor signaling pathway + 20
          G protein-coupled purinergic receptor signaling pathway + 14
          G protein-coupled receptor signaling in absence of ligand 0
          G protein-coupled receptor signaling pathway involved in dauer larval development 0
          G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium 0
          G protein-coupled receptor signaling pathway involved in heart process + 12
          G protein-coupled receptor signaling pathway involved in social behavior 0
          G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger + 258
          G protein-coupled serotonin receptor signaling pathway + 42
          adrenergic receptor signaling pathway + 29
          angiotensin-activated signaling pathway + 17
          apelin receptor signaling pathway 3
          bombesin receptor signaling pathway 3
          calcitonin family receptor signaling pathway + 8
          cannabinoid signaling pathway + 9
          cholecystokinin signaling pathway + 2
          complement component C5a signaling pathway 2
          endothelin receptor signaling pathway + 8
          follicle-stimulating hormone signaling pathway 9
          gamma-aminobutyric acid signaling pathway 29
          gastric inhibitory peptide signaling pathway 1
          ion channel modulating, G protein-coupled receptor signaling pathway + 0
          leukotriene signaling pathway 5
          luteinizing hormone signaling pathway + 3
          negative regulation of G protein-coupled receptor signaling pathway + 61
          neuropeptide signaling pathway + 106
          octopamine or tyramine signaling pathway + 0
          opioid receptor signaling pathway + 11
          phospholipase C-activating G protein-coupled receptor signaling pathway + 100
          phospholipase C-inhibiting G protein-coupled receptor signaling pathway 1
          phospholipase D-activating G protein-coupled receptor signaling pathway 2
          positive regulation of G protein-coupled receptor signaling pathway + 32
          protein kinase C-activating G protein-coupled receptor signaling pathway 28
          regulation of G protein-coupled receptor signaling pathway + 132
          rhodopsin mediated signaling pathway + 8
          somatostatin receptor signaling pathway + 5
          sphingosine-1-phosphate receptor signaling pathway 14
          tachykinin receptor signaling pathway + 9
          thrombin-activated receptor signaling pathway + 11
          thromboxane A2 signaling pathway 1
          thyroid-stimulating hormone signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            G protein-coupled receptor signaling pathway 2509
              G protein-coupled acetylcholine receptor signaling pathway + 14
              G protein-coupled glutamate receptor signaling pathway + 20
              G protein-coupled purinergic receptor signaling pathway + 14
              G protein-coupled receptor signaling in absence of ligand 0
              G protein-coupled receptor signaling pathway involved in dauer larval development 0
              G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium 0
              G protein-coupled receptor signaling pathway involved in heart process + 12
              G protein-coupled receptor signaling pathway involved in social behavior 0
              G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger + 258
              G protein-coupled serotonin receptor signaling pathway + 42
              adrenergic receptor signaling pathway + 29
              angiotensin-activated signaling pathway + 17
              apelin receptor signaling pathway 3
              bombesin receptor signaling pathway 3
              calcitonin family receptor signaling pathway + 8
              cannabinoid signaling pathway + 9
              cholecystokinin signaling pathway + 2
              complement component C5a signaling pathway 2
              endothelin receptor signaling pathway + 8
              follicle-stimulating hormone signaling pathway 9
              gamma-aminobutyric acid signaling pathway 29
              gastric inhibitory peptide signaling pathway 1
              ion channel modulating, G protein-coupled receptor signaling pathway + 0
              leukotriene signaling pathway 5
              luteinizing hormone signaling pathway + 3
              negative regulation of G protein-coupled receptor signaling pathway + 61
              neuropeptide signaling pathway + 106
              octopamine or tyramine signaling pathway + 0
              opioid receptor signaling pathway + 11
              phospholipase C-activating G protein-coupled receptor signaling pathway + 100
              phospholipase C-inhibiting G protein-coupled receptor signaling pathway 1
              phospholipase D-activating G protein-coupled receptor signaling pathway 2
              positive regulation of G protein-coupled receptor signaling pathway + 32
              protein kinase C-activating G protein-coupled receptor signaling pathway 28
              regulation of G protein-coupled receptor signaling pathway + 132
              rhodopsin mediated signaling pathway + 8
              somatostatin receptor signaling pathway + 5
              sphingosine-1-phosphate receptor signaling pathway 14
              tachykinin receptor signaling pathway + 9
              thrombin-activated receptor signaling pathway + 11
              thromboxane A2 signaling pathway 1
              thyroid-stimulating hormone signaling pathway 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.