Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:epidermal growth factor catabolic process
go back to main search page
Accession:GO:0007174 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor.
Comment:This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'.
Synonyms:exact_synonym: EGF breakdown;   EGF catabolism;   epidermal growth factor breakdown;   epidermal growth factor catabolism
 related_synonym: EGF receptor ligand processing;   epidermal growth factor ligand processing;   intracellular EGF processing;   receptor-mediated EGF processing


show annotations for term's descendants           Sort by:
 
epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:18272684)
(PMID:16282324)
RGD PMID:16282324 PMID:18272684 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889
JBrowse link
G Snx5 sorting nexin 5 IDA RGD PMID:16487940 RGD:13508623 NCBI chr 3:131,621,709...131,641,205
Ensembl chr 3:131,621,880...131,641,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      signal transduction 6882
        negative regulation of signal transduction 1264
          negative regulation of ERBB signaling pathway 30
            negative regulation of epidermal growth factor receptor signaling pathway 28
              epidermal growth factor catabolic process 2
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        regulation of cellular process 12232
          signal transduction 6882
            cell surface receptor signaling pathway 2779
              enzyme linked receptor protein signaling pathway 978
                transmembrane receptor protein tyrosine kinase signaling pathway 613
                  ERBB signaling pathway 115
                    regulation of ERBB signaling pathway 77
                      negative regulation of ERBB signaling pathway 30
                        negative regulation of epidermal growth factor receptor signaling pathway 28
                          epidermal growth factor catabolic process 2
paths to the root