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ONTOLOGY REPORT - ANNOTATIONS

Term:signal transduction
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Accession:GO:0007165 term browser browse the term
Definition:The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Comment:Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
Synonyms:narrow_synonym: signaling cascade;   signalling cascade
 related_synonym: signaling pathway;   signalling pathway
 alt_id: GO:0023014;   GO:0023015;   GO:0023016;   GO:0023033;   GO:0023045
 xref: Wikipedia:Signal_transduction

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    Path 1
    Term Annotations click to browse term
      biological_process 180615
        cellular process 165485
          signal transduction 59926
            G protein-coupled receptor signaling pathway + 15775
            apoptotic signaling pathway + 6634
            bile acid signaling pathway + 30
            carbohydrate mediated signaling + 123
            cell surface receptor signaling pathway + 27022
            extracellular ATP signaling 0
            granzyme-mediated programmed cell death signaling pathway + 107
            hormone-mediated signaling pathway + 2142
            hydrogen peroxide mediated signaling pathway 0
            immune response-regulating signaling pathway + 5068
            intracellular signal transduction + 29251
            ligand-gated ion channel signaling pathway + 428
            lipoprotein particle mediated signaling + 40
            necroptotic signaling pathway 79
            negative regulation of signal transduction + 14179
            neuronal signal transduction + 61
            opioid growth factor receptor signaling pathway 0
            phototransduction + 309
            positive regulation of signal transduction + 16928
            postsynaptic signal transduction + 573
            presynaptic signal transduction + 20
            red or far-red light signaling pathway + 10
            regulation of blood pressure by chemoreceptor signaling pathway 0
            regulation of floral organ abscission by signal transduction 0
            regulation of signal transduction + 31240
            salicylic acid mediated signaling pathway + 0
            serotonin receptor signaling pathway + 129
            signal transduction in absence of ligand + 757
            signal transduction involved in cellular response to ammonium ion 0
            signal transduction involved in filamentous growth 0
            signal transduction involved in positive regulation of conjugation with cellular fusion + 0
            signal transduction involved in regulation of gene expression 271
            sphingolipid mediated signaling pathway + 173
    Path 2
    Term Annotations click to browse term
      biological_process 180615
        biological regulation 119666
          regulation of biological process 115915
            signaling 65180
              signal transduction 59926
                G protein-coupled receptor signaling pathway + 15775
                apoptotic signaling pathway + 6634
                bile acid signaling pathway + 30
                carbohydrate mediated signaling + 123
                cell surface receptor signaling pathway + 27022
                extracellular ATP signaling 0
                granzyme-mediated programmed cell death signaling pathway + 107
                hormone-mediated signaling pathway + 2142
                hydrogen peroxide mediated signaling pathway 0
                immune response-regulating signaling pathway + 5068
                intracellular signal transduction + 29251
                ligand-gated ion channel signaling pathway + 428
                lipoprotein particle mediated signaling + 40
                necroptotic signaling pathway 79
                negative regulation of signal transduction + 14179
                neuronal signal transduction + 61
                opioid growth factor receptor signaling pathway 0
                phototransduction + 309
                positive regulation of signal transduction + 16928
                postsynaptic signal transduction + 573
                presynaptic signal transduction + 20
                red or far-red light signaling pathway + 10
                regulation of blood pressure by chemoreceptor signaling pathway 0
                regulation of floral organ abscission by signal transduction 0
                regulation of signal transduction + 31240
                salicylic acid mediated signaling pathway + 0
                serotonin receptor signaling pathway + 129
                signal transduction in absence of ligand + 757
                signal transduction involved in cellular response to ammonium ion 0
                signal transduction involved in filamentous growth 0
                signal transduction involved in positive regulation of conjugation with cellular fusion + 0
                signal transduction involved in regulation of gene expression 271
                sphingolipid mediated signaling pathway + 173
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