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ONTOLOGY REPORT - ANNOTATIONS


Term:reciprocal meiotic recombination
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Accession:GO:0007131 term browser browse the term
Definition:The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.
Synonyms:exact_synonym: gene conversion with reciprocal crossover
 narrow_synonym: female meiotic recombination
 alt_id: GO:0000021;   GO:0007145


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reciprocal meiotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC119332.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:219,864,113...219,898,243 JBrowse link
G Ccnb1ip1 cyclin B1 interacting protein 1 involved_in IBA
ISO
PMID:21873635
(MGI:5545848|PMID:24390283)
RGD PMID:24390283, PMID:21873635 MGI:5545848, RGD:13792537 NCBI chr15:27,720,220...27,736,528
Ensembl chr15:27,720,223...27,733,785
JBrowse link
G Cep63 centrosomal protein 63 acts_upstream_of_or_within ISO MGI:4377328 (MGI:5662131|PMID:26158450) RGD PMID:26158450 MGI:5662131 NCBI chr 8:111,063,988...111,116,014
Ensembl chr 8:111,064,049...111,116,014
JBrowse link
G Chtf18 chromosome transmission fidelity factor 18 acts_upstream_of_or_within ISO MGI:2177588 (MGI:5470363|PMID:23133398) RGD PMID:23133398 MGI:5470363 NCBI chr10:15,090,762...15,098,825
Ensembl chr10:15,090,316...15,098,791
JBrowse link
G Cntd1 cyclin N-terminal domain containing 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:4363686 (MGI:5606256|PMID:24891606)
RGD PMID:24891606, PMID:21873635 MGI:5606256, RGD:13792537 NCBI chr10:89,199,988...89,210,369
Ensembl chr10:89,199,880...89,209,393
JBrowse link
G Dmc1 DNA meiotic recombinase 1 involved_in IBA
ISO
PMID:21873635
(PMID:21307306)
RGD PMID:21307306, PMID:21873635 RGD:13792537 NCBI chr 7:120,796,217...120,840,524
Ensembl chr 7:120,796,217...120,839,577
JBrowse link
G LOC689986 hypothetical protein LOC689986 involved_in ISO (MGI:6478065|PMID:30746471) RGD PMID:30746471 MGI:6478065 NCBI chr14:3,247,640...3,288,017
Ensembl chr14:3,248,080...3,288,017
JBrowse link
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO MGI:1857946 (MGI:1340178|PMID:10385520), (MGI:3612347|PMID:16307920), (MGI:81751|PMID:8673133) RGD PMID:8673133 PMID:10385520 PMID:16307920 MGI:1340178 MGI:3612347 MGI:81751 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Mnd1 meiotic nuclear divisions 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:183,073,029...183,140,768
Ensembl chr 2:183,073,187...183,128,932
JBrowse link
G Msh3 mutS homolog 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:21,790,048...21,931,791
Ensembl chr 2:21,790,044...21,931,720
JBrowse link
G Msh5 mutS homolog 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:5,020,690...5,037,125
Ensembl chr20:5,020,667...5,037,088
JBrowse link
G Psmc3ip PSMC3 interacting protein involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:89,002,109...89,006,075
Ensembl chr10:89,002,116...89,005,213
JBrowse link
G Rad50 RAD50 double strand break repair protein TAS RGD PMID:10908350 RGD:68816 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Rad51 RAD51 recombinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rad51c RAD51 paralog C involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3707422|MGI:3707425 (MGI:3703317|PMID:17312021)
RGD PMID:17312021, PMID:21873635 MGI:3703317, RGD:13792537 NCBI chr10:74,697,713...74,724,004
Ensembl chr10:74,697,716...74,724,472
JBrowse link
G Rad51d RAD51 paralog D involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:70,222,703...70,241,352
Ensembl chr10:70,227,163...70,241,254
JBrowse link
G Rad54b RAD54 homolog B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:25,140,531...25,214,469
Ensembl chr 5:25,146,949...25,214,376
JBrowse link
G RGD1563323 similar to hypothetical protein FLJ22531 involved_in ISO (MGI:5752405|PMID:26917764) RGD PMID:26917764 MGI:5752405 NCBI chr 1:219,864,108...219,952,143 JBrowse link
G Rnf212 ring finger protein 212 involved_in ISO (MGI:5487470|PMID:23396135), (MGI:5545848|PMID:24390283) RGD PMID:23396135 PMID:24390283 MGI:5487470 MGI:5545848 NCBI chr14:1,959,148...1,998,077
Ensembl chr14:1,959,610...1,998,102
JBrowse link
G Shoc1 shortage in chiasmata 1 involved_in ISO (MGI:6272683|PMID:30272023) RGD PMID:30272023 MGI:6272683 NCBI chr 5:76,190,486...76,298,723 JBrowse link
G Spo11 SPO11, initiator of meiotic double stranded breaks involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2178805 (MGI:3612347|PMID:16307920)
RGD PMID:16307920, PMID:21873635 MGI:3612347, RGD:13792537 NCBI chr 3:170,991,573...171,008,226
Ensembl chr 3:170,994,038...171,013,185
JBrowse link
G Syce3 synaptonemal complex central element protein 3 involved_in IBA
ISO
PMID:21873635
(MGI:5008660|PMID:21637789)
RGD PMID:21637789, PMID:21873635 MGI:5008660, RGD:13792537 NCBI chr 7:130,360,511...130,386,673
Ensembl chr 7:130,360,517...130,368,819
JBrowse link
G Sycp1 synaptonemal complex protein 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3579731|PMID:15937223)
UniProt
RGD
PMID:15937223 GO_REF:0000024 MGI:3579731 NCBI chr 2:205,274,766...205,426,869
Ensembl chr 2:205,274,769...205,426,869
JBrowse link
G Tex11 testis expressed 11 involved_in IBA
ISO
PMID:21873635
(MGI:3797180|PMID:18369460)
RGD PMID:18369460, PMID:21873635 MGI:3797180, RGD:13792537 NCBI chr  X:70,670,212...70,946,621
Ensembl chr  X:70,670,322...70,946,565
JBrowse link
G Tex19.1 testis expressed 19.1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:110,346,453...110,348,655
Ensembl chr10:110,346,453...110,348,652
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 involved_in
acts_upstream_of_or_within
IBA
ISO
ISS
PMID:21873635
(MGI:4821667|PMID:20711356)
MGI:3719273 (MGI:3719060|PMID:17696610)
GO_REF:0000024
RGD
UniProt
PMID:17696610 PMID:20711356, PMID:21873635 GO_REF:0000024 MGI:3719060 MGI:4821667, RGD:13792537 NCBI chr 1:31,967,980...32,012,923
Ensembl chr 1:31,967,978...32,012,919
JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 involved_in ISO (MGI:5908463|PMID:28708824) RGD PMID:28708824 MGI:5908463 NCBI chr 9:16,003,058...16,080,152
Ensembl chr 9:16,003,058...16,080,152
JBrowse link
chiasma assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brip1 BRCA1 interacting helicase 1 acts_upstream_of_or_within ISO MGI:4129733 (MGI:5700253|PMID:26490168) RGD PMID:26490168 MGI:5700253 NCBI chr10:73,507,009...73,632,742
Ensembl chr10:73,507,100...73,629,581
JBrowse link
G Ccnb1ip1 cyclin B1 interacting protein 1 acts_upstream_of_or_within
involved_in
ISO MGI:3050548 (MGI:3757893|PMID:17784788)
(MGI:5545848|PMID:24390283)
RGD PMID:17784788 PMID:24390283 MGI:3757893 MGI:5545848 NCBI chr15:27,720,220...27,736,528
Ensembl chr15:27,720,223...27,733,785
JBrowse link
G Rnf212 ring finger protein 212 involved_in ISO (MGI:5545848|PMID:24390283) RGD PMID:24390283 MGI:5545848 NCBI chr14:1,959,148...1,998,077
Ensembl chr14:1,959,610...1,998,102
JBrowse link
G Sycp1 synaptonemal complex protein 1 involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
MGI:109542 (MGI:5315075|PMID:22164254)
GO_REF:0000107
RGD
Ensembl
PMID:22164254, PMID:21873635 GO_REF:0000107 MGI:5315075, RGD:13792537 NCBI chr 2:205,274,766...205,426,869
Ensembl chr 2:205,274,769...205,426,869
JBrowse link
G Sycp3 synaptonemal complex protein 3 involved_in
acts_upstream_of_or_within
ISO (MGI:2179610|PMID:12004129)
MGI:105931 (MGI:5315075|PMID:22164254)
RGD PMID:12004129 PMID:22164254 MGI:2179610 MGI:5315075 NCBI chr 7:29,029,887...29,044,344
Ensembl chr 7:29,029,263...29,044,251
JBrowse link
G Tex11 testis expressed 11 acts_upstream_of_or_within ISO MGI:3526163 (MGI:3774244|PMID:18316482) RGD PMID:18316482 MGI:3774244 NCBI chr  X:70,670,212...70,946,621
Ensembl chr  X:70,670,322...70,946,565
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B acts_upstream_of_or_within ISO MGI:2183933 (MGI:2450033|PMID:12556476) RGD PMID:12556476 MGI:2450033 NCBI chr10:37,439,947...37,454,867
Ensembl chr10:37,441,284...37,455,022
JBrowse link
double-strand break repair involved in meiotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brip1 BRCA1 interacting helicase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:4129733 (MGI:5700253|PMID:26490168)
RGD PMID:26490168, PMID:21873635 MGI:5700253, RGD:13792537 NCBI chr10:73,507,009...73,632,742
Ensembl chr10:73,507,100...73,629,581
JBrowse link
G Brme1 break repair meiotic recombinase recruitment factor 1 involved_in ISO (MGI:6443349|PMID:32463460), (MGI:6447091|PMID:32345962), (MGI:6448646|PMID:32460033) RGD PMID:32345962 PMID:32460033 PMID:32463460 MGI:6443349 MGI:6447091 MGI:6448646 NCBI chr19:25,262,064...25,283,786
Ensembl chr19:25,262,076...25,283,972
JBrowse link
G Fancd2 FA complementation group D2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Hsf2bp heat shock transcription factor 2 binding protein involved_in ISO (MGI:6283956|PMID:30760716), (MGI:6443349|PMID:32463460), (MGI:6447091|PMID:32345962), (MGI:6456264|PMID:31242413) RGD PMID:30760716 PMID:31242413 PMID:32345962 PMID:32463460 MGI:6283956 MGI:6443349 MGI:6447091 MGI:6456264 NCBI chr20:10,757,172...10,844,177
Ensembl chr20:10,757,854...10,844,178
JBrowse link
G Mcmdc2 minichromosome maintenance domain containing 2 acts_upstream_of_or_within ISO MGI:1349669|MGI:2178050|MGI:5511194 (MGI:5805564|PMID:27760146) RGD PMID:27760146 MGI:5805564 NCBI chr 5:8,973,861...9,039,616
Ensembl chr 5:8,978,010...9,038,594
JBrowse link
G Morc2b microrchidia 2B involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 7:15,479,754...15,483,834
Ensembl chr 7:15,479,762...15,483,834
JBrowse link
G Prdm9 PR/SET domain 9 involved_in ISS
ISO
GO_REF:0000024
(MGI:6102131|PMID:25894966), (MGI:6114980|PMID:29478809)
UniProt
RGD
PMID:25894966 PMID:29478809 GO_REF:0000024 MGI:6102131 MGI:6114980 NCBI chr 1:57,533,602...57,555,155
Ensembl chr 1:57,533,577...57,555,048
JBrowse link
G Spo11 SPO11, initiator of meiotic double stranded breaks acts_upstream_of_or_within ISO MGI:3045334 (MGI:5805564|PMID:27760146) RGD PMID:27760146 MGI:5805564 NCBI chr 3:170,991,573...171,008,226
Ensembl chr 3:170,994,038...171,013,185
JBrowse link
meiotic DNA double-strand break formation involved in reciprocal meiotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd31 ankyrin repeat domain 31 involved_in ISO (MGI:6316415|PMID:31003867), (MGI:6316551|PMID:31000436) RGD PMID:31000436 PMID:31003867 MGI:6316415 MGI:6316551 NCBI chr 2:27,571,129...27,743,668 JBrowse link
meiotic DNA double-strand break processing involved in reciprocal meiotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brip1 BRCA1 interacting helicase 1 acts_upstream_of_or_within ISO MGI:4129733 (MGI:5700253|PMID:26490168) RGD PMID:26490168 MGI:5700253 NCBI chr10:73,507,009...73,632,742
Ensembl chr10:73,507,100...73,629,581
JBrowse link
G Six6os1 Six6 opposite strand transcript 1 involved_in IBA
ISO
PMID:21873635
(MGI:5822939|PMID:27796301)
RGD PMID:27796301, PMID:21873635 MGI:5822939, RGD:13792537 NCBI chr 6:95,761,718...95,797,314
Ensembl chr 6:95,762,332...95,796,502
JBrowse link
positive regulation of reciprocal meiotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prdm9 PR/SET domain 9 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:21750151)
(MGI:4452589|PMID:20044538), (MGI:5306625|PMID:22028627)
RGD PMID:20044538 PMID:21750151 PMID:22028627, PMID:21873635 MGI:4452589 MGI:5306625, RGD:13792537 NCBI chr 1:57,533,602...57,555,155
Ensembl chr 1:57,533,577...57,555,048
JBrowse link
G Rad51ap1 RAD51 associated protein 1 involved_in ISO (PMID:17996711) RGD PMID:17996711 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B acts_upstream_of_or_within ISO MGI:2183933 (MGI:2450033|PMID:12556476) RGD PMID:12556476 MGI:2450033 NCBI chr10:37,439,947...37,454,867
Ensembl chr10:37,441,284...37,455,022
JBrowse link
resolution of meiotic recombination intermediates term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07030926.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr10:109,891,383...109,891,879 JBrowse link
G AABR07048387.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 5:76,240,167...76,261,198 JBrowse link
G AC117889.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr10:975,697...1,003,352 JBrowse link
G Cenps centromere protein S involved_in ISO (PMID:20347428) RGD PMID:20347428 NCBI chr 5:165,946,106...165,955,723 JBrowse link
G Cenpx centromere protein X involved_in ISO (PMID:20347428) RGD PMID:20347428 NCBI chr10:109,890,904...109,893,804 JBrowse link
G Eme1 essential meiotic structure-specific endonuclease 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:82,366,820...82,375,510
Ensembl chr10:82,367,084...82,374,171
JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:14,253,552...14,257,017
Ensembl chr10:14,254,252...14,256,930
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:2,010,140...2,037,953
Ensembl chr10:2,010,648...2,037,891
JBrowse link
G Fancm FA complementation group M involved_in ISO (PMID:20347428) RGD PMID:20347428 NCBI chr 6:86,823,195...86,877,067
Ensembl chr 6:86,823,684...86,876,633
JBrowse link
G Hfm1 helicase for meiosis 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5477835|PMID:23555294)
RGD PMID:23555294, PMID:21873635 MGI:5477835, RGD:13792537 NCBI chr14:3,879,172...3,961,139
Ensembl chr14:3,882,398...3,960,909
JBrowse link
G Meiob meiosis specific with OB-fold involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:5527015|PMID:24068956), (MGI:5538413|PMID:24240703)
PMID:21873635
UniProt
RGD
PMID:24068956 PMID:24240703, PMID:21873635 GO_REF:0000024 MGI:5527015 MGI:5538413, RGD:13792537 NCBI chr10:14,174,645...14,206,026
Ensembl chr10:14,174,732...14,206,025
JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857946 (MGI:1340178|PMID:10385520), (MGI:2386157|PMID:12217320)
Ensembl
RGD
PMID:10385520 PMID:12217320 GO_REF:0000107 MGI:1340178 MGI:2386157 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Msh4 mutS homolog 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:260,057,708...260,108,897
Ensembl chr 2:260,057,855...260,108,897
JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:220,862,474...220,867,973
Ensembl chr 1:220,862,386...220,867,815
JBrowse link
G Rmi1 RecQ mediated genome instability 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:6,658,285...6,665,618
Ensembl chr17:6,658,388...6,660,536
JBrowse link
G Shoc1 shortage in chiasmata 1 involved_in ISO (MGI:6159552|PMID:29742103) RGD PMID:29742103 MGI:6159552 NCBI chr 5:76,190,486...76,298,723 JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:11,787,756...11,808,326
Ensembl chr10:11,786,121...11,807,928
JBrowse link
G Tex11 testis expressed 11 acts_upstream_of_or_within ISO MGI:3526163 (MGI:3774244|PMID:18316482) RGD PMID:18316482 MGI:3774244 NCBI chr  X:70,670,212...70,946,621
Ensembl chr  X:70,670,322...70,946,565
JBrowse link
G Top2a DNA topoisomerase II alpha involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19599
    reproductive process 1800
      meiotic cell cycle process 229
        reciprocal meiotic recombination 55
          chiasma assembly 7
          double-strand break repair involved in meiotic recombination 8
          meiotic DNA double-strand break formation involved in reciprocal meiotic recombination + 1
          meiotic DNA double-strand break processing involved in reciprocal meiotic recombination + 2
          meiotic DNA recombinase assembly involved in reciprocal meiotic recombination 0
          meiotic DNA repair synthesis involved in reciprocal meiotic recombination 0
          meiotic joint molecule formation + 0
          meiotic mismatch repair involved in reciprocal meiotic recombination 0
          meiotic strand invasion involved in reciprocal meiotic recombination 0
          negative regulation of reciprocal meiotic recombination 0
          positive regulation of reciprocal meiotic recombination + 3
          regulation of reciprocal meiotic recombination + 3
          resolution of meiotic recombination intermediates 19
Path 2
Term Annotations click to browse term
  biological_process 19599
    metabolic process 11860
      organic substance metabolic process 11392
        organic cyclic compound metabolic process 5861
          nucleobase-containing compound metabolic process 5411
            nucleic acid metabolic process 4921
              DNA metabolic process 887
                DNA recombination 306
                  homologous recombination 56
                    reciprocal homologous recombination 55
                      reciprocal meiotic recombination 55
                        chiasma assembly 7
                        double-strand break repair involved in meiotic recombination 8
                        meiotic DNA double-strand break formation involved in reciprocal meiotic recombination + 1
                        meiotic DNA double-strand break processing involved in reciprocal meiotic recombination + 2
                        meiotic DNA recombinase assembly involved in reciprocal meiotic recombination 0
                        meiotic DNA repair synthesis involved in reciprocal meiotic recombination 0
                        meiotic joint molecule formation + 0
                        meiotic mismatch repair involved in reciprocal meiotic recombination 0
                        meiotic strand invasion involved in reciprocal meiotic recombination 0
                        negative regulation of reciprocal meiotic recombination 0
                        positive regulation of reciprocal meiotic recombination + 3
                        regulation of reciprocal meiotic recombination + 3
                        resolution of meiotic recombination intermediates 19
paths to the root