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ONTOLOGY REPORT - ANNOTATIONS

Term:mitotic centrosome separation
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Accession:GO:0007100 term browser browse the term
Definition:Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.


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mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AURKA aurora kinase A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19075002)
(PMID:17060449)		 InterPro
MGI		 PMID:17060449 PMID:19075002 GO_REF:0000002 NCBI chr24:41,585,483...41,604,875
Ensembl chr24:41,585,518...41,604,791 		JBrowse link
G KIF11 kinesin family member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12840069) Ensembl
MGI		 PMID:12840069 GO_REF:0000107 NCBI chr28:6,982,296...7,034,380
Ensembl chr28:6,982,146...7,033,104 		JBrowse link
G NDE1 nudE neurodevelopment protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:28,143,244...28,186,069
Ensembl chr 6:28,143,244...28,186,051 		JBrowse link
G NDEL1 nudE neurodevelopment protein 1 like 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17060449) Ensembl
MGI
TreeGrafter		 PMID:17060449 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:33,187,614...33,244,483
Ensembl chr 5:33,204,452...33,266,052 		JBrowse link
G NUP62 nucleoporin 62 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:106,636,282...106,661,250 JBrowse link
negative regulation of mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KIF25 kinesin family member 25 involved_in ISO (PMID:28263957) UniProt PMID:28263957 NCBI chr 1:55,537,884...55,588,346
Ensembl chr 1:55,537,879...55,588,226 		JBrowse link
positive regulation of mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NSFL1C NSFL1 cofactor involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:19,575,543...19,599,002
Ensembl chr24:19,575,580...19,597,653 		JBrowse link
G RANBP1 RAN binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12840069) TreeGrafter
MGI		 PMID:12840069 GO_REF:0000118 NCBI chr26:29,211,559...29,219,247
Ensembl chr26:29,211,863...29,220,451 		JBrowse link
G UBXN2B UBX domain protein 2B involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:9,229,070...9,258,269
Ensembl chr29:9,228,985...9,259,372 		JBrowse link
regulation of mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEP85 centrosomal protein 85 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:73,740,112...73,774,525
Ensembl chr 2:73,741,648...73,767,968 		JBrowse link
G CHEK1 checkpoint kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:8,878,511...8,910,626
Ensembl chr 5:8,879,147...8,907,669 		JBrowse link
G KIF11 kinesin family member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:6,982,296...7,034,380
Ensembl chr28:6,982,146...7,033,104 		JBrowse link
G MAP9 microtubule associated protein 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,895,062...52,930,275
Ensembl chr15:52,897,302...52,928,565 		JBrowse link
G NEK2 NIMA related kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:10,039,617...10,052,511
Ensembl chr 7:10,040,187...10,052,512 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    cellular process 16926
      cell cycle process 1347
        centrosome separation 14
          mitotic centrosome separation 13
            negative regulation of mitotic centrosome separation 1
            positive regulation of mitotic centrosome separation 3
            regulation of mitotic centrosome separation + 9
Path 2
Term Annotations click to browse term
  biological_process 17917
    cellular process 16926
      cellular component organization or biogenesis 6943
        cellular component organization 6705
          organelle organization 3760
            cytoskeleton organization 1590
              microtubule cytoskeleton organization 719
                microtubule organizing center organization 153
                  centrosome cycle 140
                    centrosome separation 14
                      mitotic centrosome separation 13
                        negative regulation of mitotic centrosome separation 1
                        positive regulation of mitotic centrosome separation 3
                        regulation of mitotic centrosome separation + 9
paths to the root