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ONTOLOGY REPORT - ANNOTATIONS


Term:mitotic centrosome separation
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Accession:GO:0007100 term browser browse the term
Definition:Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.



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mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurka aurora kinase A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1932915|MGI:3836423 (MGI:3697244|PMID:17060449), (MGI:3835913|PMID:19075002)
Ensembl
RGD
PMID:17060449 PMID:19075002 GO_REF:0000107 MGI:3697244 MGI:3835913 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Kif11 kinesin family member 11 acts_upstream_of_or_within ISO (MGI:2671632|PMID:12840069) RGD PMID:12840069 MGI:2671632 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Nde1 nudE neurodevelopment protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:839,788...883,946
Ensembl chr10:839,788...883,869
JBrowse link
G Ndel1 nudE neurodevelopment protein 1-like 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:894678 (MGI:3697244|PMID:17060449)
RGD PMID:17060449 PMID:21873635 MGI:3697244, RGD:13792537 NCBI chr10:53,505,628...53,582,025
Ensembl chr10:53,516,491...53,570,907
JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (PMID:24107630) RGD PMID:24107630 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174
JBrowse link
positive regulation of mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsfl1c NSFL1 cofactor involved_in ISO UniProtKB:Q14CS0 (PMID:23649807) RGD PMID:23649807 NCBI chr 3:139,978,306...140,002,876
Ensembl chr 3:139,978,301...140,002,870
JBrowse link
G Ranbp1 RAN binding protein 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2671632|PMID:12840069)
RGD PMID:12840069 PMID:21873635 MGI:2671632, RGD:13792537 NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838
JBrowse link
G Ubxn2b UBX domain protein 2B involved_in ISO UniProtKB:Q9UNZ2 (PMID:23649807) RGD PMID:23649807 NCBI chr 5:19,303,634...19,333,181
Ensembl chr 5:19,303,682...19,326,849
JBrowse link
regulation of mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cep85 centrosomal protein 85 involved_in ISO (PMID:26220856) RGD PMID:26220856 NCBI chr 5:146,356,575...146,404,155
Ensembl chr 5:146,356,576...146,404,060
JBrowse link
G Chek1 checkpoint kinase 1 involved_in ISO
ISS
(PMID:15311285)
GO_REF:0000024
RGD
UniProt
PMID:15311285 GO_REF:0000024 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Kif11 kinesin family member 11 involved_in ISO (PMID:15843429) RGD PMID:15843429 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Map9 microtubule-associated protein 9 involved_in ISO (PMID:16049101) RGD PMID:16049101 NCBI chr 2:167,708,661...167,743,927
Ensembl chr 2:167,708,765...167,740,736
JBrowse link
G Nek2 NIMA-related kinase 2 involved_in ISO (PMID:26220856) RGD PMID:26220856 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19504
    cellular process 18357
      cell cycle process 1176
        centrosome separation 13
          mitotic centrosome separation 12
            negative regulation of mitotic centrosome separation 0
            positive regulation of mitotic centrosome separation 3
            regulation of mitotic centrosome separation + 8
Path 2
Term Annotations click to browse term
  biological_process 19504
    cellular process 18357
      cellular component organization or biogenesis 6519
        cellular component organization 6273
          organelle organization 3802
            cytoskeleton organization 1454
              microtubule cytoskeleton organization 639
                microtubule organizing center organization 150
                  centrosome cycle 137
                    centrosome separation 13
                      mitotic centrosome separation 12
                        negative regulation of mitotic centrosome separation 0
                        positive regulation of mitotic centrosome separation 3
                        regulation of mitotic centrosome separation + 8
paths to the root