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ONTOLOGY REPORT - ANNOTATIONS


Term:mitotic G2 DNA damage checkpoint signaling
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Accession:GO:0007095 term browser browse the term
Definition:A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.
Synonyms:exact_synonym: G2/M transition DNA damage checkpoint;   mitotic G2 DNA damage checkpoint;   mitotic cell cycle G2/M transition DNA damage checkpoint;   signal transduction involved in G2 DNA damage checkpoint;   signal transduction involved in G2/M transition DNA damage checkpoint;   signal transduction involved in mitotic G2 DNA damage checkpoint;   signal transduction involved in mitotic G2/M transition DNA damage checkpoint
 narrow_synonym: down regulation of signal transduction involved in mitotic G2 DNA damage checkpoint;   down regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint;   inhibition of signal transduction involved in mitotic G2 DNA damage checkpoint;   negative regulation of signal transduction involved in mitotic G2 DNA damage checkpoint;   negative regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint;   positive regulation of signal transduction involved in mitotic G2 DNA damage checkpoint;   positive regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint;   regulation of signal transduction involved in mitotic G2 DNA damage checkpoint;   regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint
 related_synonym: G2 DNA damage checkpoint
 alt_id: GO:0031572;   GO:0072425;   GO:0072434;   GO:1902504;   GO:1902505;   GO:1902506



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mitotic G2 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049960.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Abraxas1 abraxas 1, BRCA1 A complex subunit involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:17525340), (PMID:17643121), (PMID:19261748)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:17525340 PMID:17643121 PMID:19261748 GO_REF:0000024 GO_REF:0000107 NCBI chr14:8,796,281...8,810,625
Ensembl chr14:8,796,266...8,810,622
JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (PMID:15149599) RGD PMID:15149599 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Babam1 BRISC and BRCA1 A complex member 1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:19261746), (PMID:19261748), (PMID:19261749)
UniProt
RGD
PMID:19261746 PMID:19261748 PMID:19261749 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr16:18,068,830...18,074,938
Ensembl chr16:18,068,884...18,074,923
JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:19261748)
UniProt
RGD
PMID:19261748 GO_REF:0000024 NCBI chr 6:24,369,021...24,833,335
Ensembl chr 6:24,369,022...24,833,951
JBrowse link
G Blm BLM RecQ like helicase involved_in ISO (PMID:11309417) RGD PMID:11309417 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
JBrowse link
G Brca1 BRCA1, DNA repair associated involved_in ISO
IEA
(PMID:17525340), (PMID:17643121), (PMID:19261748)
GO_REF:0000107
RGD
Ensembl
PMID:17525340 PMID:17643121 PMID:19261748 GO_REF:0000107 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:17525341), (PMID:19261746), (PMID:19261748)
UniProt
RGD
PMID:17525341 PMID:19261746 PMID:19261748 GO_REF:0000024 NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
JBrowse link
G Brsk1 BR serine/threonine kinase 1 involved_in ISO (PMID:15150265) RGD PMID:15150265 NCBI chr 1:69,134,166...69,159,947
Ensembl chr 1:69,134,565...69,160,365
JBrowse link
G Brsk2 BR serine/threonine kinase 2 involved_in ISS PMID:15150265 UniProt PMID:15150265 RGD:8554801 NCBI chr 1:197,035,522...197,088,624
Ensembl chr 1:197,035,633...197,088,092
JBrowse link
G Ccng1 cyclin G1 IMP RGD PMID:9464250 RGD:2316029 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cdc14b cell division cycle 14B involved_in ISO (PMID:18662541) RGD PMID:18662541 NCBI chr17:844,731...934,787
Ensembl chr17:844,685...933,235
JBrowse link
G Cdk1 cyclin-dependent kinase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2679752|PMID:12937170)
RGD PMID:12937170 PMID:21873635 MGI:2679752, RGD:13792537 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO
IEA
ISS
(PMID:15790566)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15790566 GO_REF:0000024 GO_REF:0000107 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in ISO (PMID:23213251) RGD PMID:23213251 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chek1 checkpoint kinase 1 involved_in ISO (PMID:20932473) RGD PMID:20932473 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Clspn claspin involved_in ISO
IBA
(PMID:18662541)
PMID:21873635
RGD PMID:18662541 PMID:21873635 RGD:13792537 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
JBrowse link
G Donson DNA replication fork stabilization factor DONSON involved_in ISO (PMID:28191891) RGD PMID:28191891 NCBI chr11:30,911,616...30,933,150
Ensembl chr11:30,923,239...30,932,889
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog involved_in ISO
IBA
(PMID:17085480)
PMID:21873635
RGD PMID:17085480 PMID:21873635 RGD:13792537 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
JBrowse link
G Foxn3 forkhead box N3 involved_in ISO UniProtKB:P38111 (PMID:9154802) RGD PMID:9154802 NCBI chr 6:118,462,018...118,842,442
Ensembl chr 6:118,466,025...118,842,401
JBrowse link
G Foxo4 forkhead box O4 acts_upstream_of_or_within ISO (MGI:2183145|PMID:12048180) RGD PMID:12048180 MGI:2183145 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115
JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in ISO (PMID:18662541) RGD PMID:18662541 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952
JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO
ISS
(PMID:16061642)
GO_REF:0000024
RGD
UniProt
PMID:16061642 GO_REF:0000024 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO MGI:3773690 (MGI:5432078|PMID:20467439) RGD PMID:20467439 MGI:5432078 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G LOC100302465 hypothetical LOC100302465 involved_in ISO (MGI:4455105|PMID:20154723) RGD PMID:20154723 MGI:4455105 NCBI chr 1:189,059,744...189,293,353
Ensembl chr 1:189,059,746...189,293,435
JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase acts_upstream_of_or_within ISO MGI:2684310 (MGI:2682526|PMID:14614141) RGD PMID:14614141 MGI:2682526 NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:3027036 (MGI:2683367|PMID:14690604)
PMID:21873635
Ensembl
RGD
PMID:14690604 PMID:21873635 GO_REF:0000107 MGI:2683367, RGD:13792537 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Mrnip MRN complex interacting protein involved_in ISO
IBA
(PMID:27568553)
PMID:21873635
RGD PMID:27568553 PMID:21873635 RGD:13792537 NCBI chr10:34,501,359...34,525,474
Ensembl chr10:34,501,384...34,525,469
JBrowse link
G Nbn nibrin involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
ISS
PMID:21873635
MGI:2183796 (MGI:3805397|PMID:18614044)
GO_REF:0000107
GO_REF:0000024
(PMID:11438675)
RGD
Ensembl
UniProt
PMID:11438675 PMID:18614044 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:3805397, RGD:13792537 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:21741933) RGD PMID:21741933 NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902
JBrowse link
G Plk1 polo-like kinase 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:18662541)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:18662541 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Rint1 RAD50 interactor 1 involved_in ISO (PMID:11096100) RGD PMID:11096100 NCBI chr 4:11,319,416...11,355,773
Ensembl chr 4:11,320,955...11,355,736
JBrowse link
G Syf2 SYF2 pre-mRNA-splicing factor acts_upstream_of_or_within ISO MGI:3904866 (MGI:5435138|PMID:22448250) RGD PMID:22448250 MGI:5435138 NCBI chr 5:147,156,492...147,164,416
Ensembl chr 5:147,156,480...147,164,414
JBrowse link
G Taok1 TAO kinase 1 involved_in ISO
IEA
ISS
(PMID:17396146)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr10:62,373,076...62,465,295
Ensembl chr10:62,381,404...62,465,766
JBrowse link
G Taok2 TAO kinase 2 involved_in ISO
IEA
ISS
(PMID:17396146)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613
JBrowse link
G Taok3 TAO kinase 3 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:17396146)
Ensembl
UniProt
RGD
PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr12:39,314,027...39,394,243
Ensembl chr12:39,314,027...39,461,244
JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Trim39 tripartite motif-containing 39 involved_in ISO
IEA
ISS
(PMID:23213251)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:23213251 GO_REF:0000024 GO_REF:0000107 NCBI chr20:2,003,320...2,017,175
Ensembl chr20:1,983,533...2,020,117
JBrowse link
G Uimc1 ubiquitin interaction motif containing 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:17525340), (PMID:17525341), (PMID:17525342), (PMID:17643121), (PMID:19261748)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17525340 PMID:17525341 PMID:17525342 PMID:17643121 PMID:19261748 GO_REF:0000024 GO_REF:0000107 NCBI chr17:9,523,793...9,592,810
Ensembl chr17:9,527,794...9,592,799
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19834
    cellular process 18637
      cell cycle process 1213
        mitotic cell cycle process 731
          mitotic cell cycle checkpoint signaling 133
            mitotic G2/M transition checkpoint 53
              mitotic G2 DNA damage checkpoint signaling 40
Path 2
Term Annotations click to browse term
  biological_process 19834
    biological regulation 13775
      regulation of biological process 13033
        regulation of cellular process 12501
          regulation of cell cycle 1077
            regulation of cell cycle process 704
              negative regulation of cell cycle process 290
                negative regulation of cell cycle phase transition 242
                  cell cycle checkpoint signaling 174
                    DNA integrity checkpoint signaling 125
                      DNA damage checkpoint signaling 116
                        mitotic DNA damage checkpoint signaling 82
                          mitotic G2 DNA damage checkpoint signaling 40
paths to the root