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ONTOLOGY REPORT - ANNOTATIONS

Term:mitotic spindle assembly checkpoint signaling
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Accession:GO:0007094 term browser browse the term
Definition:A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC).
Synonyms:exact_synonym: mitotic cell cycle spindle assembly checkpoint;   mitotic checkpoint;   mitotic spindle assembly checkpoint;   mitotic spindle assembly checkpoint signalling;   signal transduction involved in mitotic cell cycle spindle assembly checkpoint;   signal transduction involved in mitotic spindle assembly checkpoint
 narrow_synonym: Dma1-dependent checkpoint;   Mad2-dependent checkpoint;   SAC-independent checkpoint;   signal transduction involved in Dma1-dependent checkpoint;   signal transduction involved in SAC-independent checkpoint;   signaling cascade involved in Dma1-dependent checkpoint;   signaling cascade involved in SAC-independent checkpoint;   signalling cascade involved in Dma1-dependent checkpoint;   signalling cascade involved in SAC-independent checkpoint
 related_synonym: signaling pathway involved in Dma1-dependent checkpoint;   signaling pathway involved in SAC-independent checkpoint;   signalling pathway involved in Dma1-dependent checkpoint;   signalling pathway involved in SAC-independent checkpoint
 alt_id: GO:0044810;   GO:0072480;   GO:1902420
 xref: Reactome:R-HSA-69618 "Mitotic Spindle Checkpoint"


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mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:252,052...380,506
Ensembl chr 3:253,081...322,993 		JBrowse link
G ATM ATM serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 involved_in ISS UniProt GO_REF:0000024 NCBI chr 9:2,930,308...2,959,307 JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase involved_in IEA
IBA 		InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr17:35,208,989...35,252,296
Ensembl chr17:35,208,991...35,252,975 		JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B involved_in IEA
IBA 		InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr30:7,361,982...7,410,162
Ensembl chr30:7,322,912...7,438,052 		JBrowse link
G BUB3 BUB3 mitotic checkpoint protein involved_in IBA GO_Central GO_REF:0000033 NCBI chr28:32,693,104...32,703,293
Ensembl chr28:32,679,421...32,703,023 		JBrowse link
G CENPE centromere protein E involved_in ISO (PMID:12925705) UniProt PMID:12925705 NCBI chr32:24,447,373...24,530,407
Ensembl chr32:24,447,358...24,530,382 		JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 4:41,779,950...42,177,957
Ensembl chr 4:41,780,436...42,235,177 		JBrowse link
G HASPIN histone H3 associated protein kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:47,540,417...47,542,953
Ensembl chr 9:47,540,446...47,542,791 		JBrowse link
G IK IK cytokine involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:35,805,631...35,818,205
Ensembl chr 2:35,805,689...35,818,050 		JBrowse link
G KHDC3L KH domain containing 3 like, subcortical maternal complex member acts_upstream_of_or_within ISO (PMID:19376971) MGI PMID:19376971 NCBI chr12:35,434,123...35,435,679
Ensembl chr12:35,434,123...35,468,943 		JBrowse link
G KLHL22 kelch like family member 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:30,248,253...30,281,989
Ensembl chr26:30,248,240...30,281,843 		JBrowse link
G KNTC1 kinetochore associated 1 involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr26:6,777,667...6,867,798
Ensembl chr26:6,777,383...6,865,016 		JBrowse link
G LOC100684931 inactive serine/threonine-protein kinase TEX14-like involved_in IEA
IBA 		InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:116,849,031...116,851,289 JBrowse link
G LOC100687713 BUB3-interacting and GLEBS motif-containing protein ZNF207 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:1,027,387...1,029,505 JBrowse link
G LOC119876650 inactive serine/threonine-protein kinase TEX14-like involved_in IEA
IBA 		Ensembl
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
G LOC476070 mitotic arrest deficient 2 like 1 acts_upstream_of_or_within
involved_in 		ISO (PMID:11201745)
(PMID:18981471) 		MGI
UniProt		 PMID:11201745 PMID:18981471 NCBI chr18:55,653,677...55,661,017 JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 involved_in IEA
IBA 		InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:14,889,126...15,236,194
Ensembl chr 6:14,882,875...15,236,192 		JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 involved_in IBA GO_Central GO_REF:0000033
G PLK1 polo like kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:22,165,338...22,176,847
Ensembl chr 6:22,165,338...22,176,441 		JBrowse link
G PSMG2 proteasome assembly chaperone 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:78,092,877...78,112,831
Ensembl chr 7:78,092,876...78,112,702 		JBrowse link
G SPDL1 spindle apparatus coiled-coil protein 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 4:42,214,997...42,235,282
Ensembl chr 4:41,780,436...42,235,177 		JBrowse link
G TEX14 testis expressed 14, intercellular bridge forming factor involved_in IEA
IBA 		InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:33,174,813...33,289,202
Ensembl chr 9:33,174,814...33,262,870 		JBrowse link
G TPR translocated promoter region, nuclear basket protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:19,376,951...19,442,368
Ensembl chr 7:19,376,975...19,442,303 		JBrowse link
G TRIP13 thyroid hormone receptor interactor 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:11,522,940...11,539,885
Ensembl chr34:11,522,940...11,539,885 		JBrowse link
G TTK TTK protein kinase involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr12:40,915,733...40,959,423
Ensembl chr12:40,915,439...40,957,279 		JBrowse link
G ZNF207 zinc finger protein 207 involved_in IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107
G ZW10 zw10 kinetochore protein involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:19,496,531...19,527,205
Ensembl chr 5:19,496,611...19,527,200 		JBrowse link
G ZWILCH zwilch kinetochore protein involved_in IEA
IBA 		Ensembl
GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr30:30,772,219...30,811,055
Ensembl chr30:30,772,057...30,809,040 		JBrowse link
G ZWINT ZW10 interacting kinetochore protein involved_in IBA GO_Central GO_REF:0000033 NCBI chr26:32,432,385...32,459,377
Ensembl chr26:32,432,406...32,453,162 		JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAD1L1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) UniProt PMID:19010891 NCBI chr 6:14,889,126...15,236,194
Ensembl chr 6:14,882,875...15,236,192 		JBrowse link
G MAD2L1BP MAD2L1 binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:12,085,825...12,089,907
Ensembl chr12:12,085,915...12,090,411 		JBrowse link
G PRAP1 proline rich acidic protein 1 involved_in ISO (PMID:24374861) UniProt PMID:24374861 NCBI chr28:40,927,744...40,931,355 JBrowse link
negative regulation of mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SKA1 spindle and kinetochore associated complex subunit 1 involved_in ISO (PMID:26981768) UniProt PMID:26981768 NCBI chr 7:80,552,249...80,561,732
Ensembl chr 7:80,552,292...80,560,565 		JBrowse link
G SKA3 spindle and kinetochore associated complex subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:16,982,174...17,011,496
Ensembl chr25:16,981,931...17,001,803 		JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISO (PMID:19229290) UniProt PMID:19229290 NCBI chr23:12,235,539...12,283,851
Ensembl chr23:12,235,104...12,277,031 		JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:13,201,540...13,233,028
Ensembl chr17:13,201,777...13,232,120 		JBrowse link
G LOC476070 mitotic arrest deficient 2 like 1 involved_in ISO (PMID:22898774), (PMID:8824189) ComplexPortal PMID:8824189 PMID:22898774 NCBI chr18:55,653,677...55,661,017 JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:14,889,126...15,236,194
Ensembl chr 6:14,882,875...15,236,192 		JBrowse link
G NDC80 NDC80 kinetochore complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:69,268,218...69,317,126
Ensembl chr 7:69,268,242...69,317,072 		JBrowse link
G TPR translocated promoter region, nuclear basket protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:19,376,951...19,442,368
Ensembl chr 7:19,376,975...19,442,303 		JBrowse link
G XRCC3 X-ray repair cross complementing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:71,441,732...71,452,922
Ensembl chr 8:71,442,429...71,449,408 		JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC15 anaphase promoting complex subunit 15 involved_in IEA
IBA 		InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr21:25,971,680...25,975,556
Ensembl chr21:25,972,458...25,975,558 		JBrowse link
G CCNB1 cyclin B1 involved_in ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chr 2:54,256,957...54,264,749 JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr11:73,548,003...73,693,044
Ensembl chr11:73,548,038...73,690,199 		JBrowse link
G KNL1 kinetochore scaffold 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:7,753,515...7,825,019
Ensembl chr30:7,753,432...7,821,588 		JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 involved_in
acts_upstream_of_or_within 		IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:21,026,125...21,066,884
Ensembl chr 6:21,026,186...21,066,876 		JBrowse link
G PRP4K pre-mRNA processing factor kinase PRP4K involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:4,274,664...4,311,813
Ensembl chr35:4,271,685...4,307,750 		JBrowse link
G USP44 ubiquitin specific peptidase 44 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:35,401,486...35,454,351
Ensembl chr15:35,402,207...35,414,261 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22130
    cellular process 21660
      cell cycle process 1333
        negative regulation of cell cycle process 308
          negative regulation of mitotic nuclear division 56
            negative regulation of mitotic metaphase/anaphase transition 47
              mitotic spindle assembly checkpoint signaling 45
                negative regulation of mitotic spindle assembly checkpoint signaling + 5
                positive regulation of mitotic cell cycle spindle assembly checkpoint + 7
                regulation of mitotic cell cycle spindle assembly checkpoint + 18
Path 2
Term Annotations click to browse term
  biological_process 22130
    cellular process 21660
      cellular component organization or biogenesis 10073
        cellular component organization 9841
          organelle organization 3649
            organelle fission 527
              nuclear division 466
                mitotic nuclear division 285
                  mitotic sister chromatid segregation 198
                    regulation of mitotic sister chromatid segregation 56
                      negative regulation of mitotic sister chromatid segregation 47
                        negative regulation of mitotic sister chromatid separation 47
                          negative regulation of mitotic metaphase/anaphase transition 47
                            mitotic spindle assembly checkpoint signaling 45
                              negative regulation of mitotic spindle assembly checkpoint signaling + 5
                              positive regulation of mitotic cell cycle spindle assembly checkpoint + 7
                              regulation of mitotic cell cycle spindle assembly checkpoint + 18
paths to the root