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ONTOLOGY REPORT - ANNOTATIONS


Term:mitotic spindle assembly checkpoint signaling
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Accession:GO:0007094 term browser browse the term
Definition:A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC).
Synonyms:exact_synonym: mitotic cell cycle spindle assembly checkpoint;   mitotic checkpoint;   mitotic spindle assembly checkpoint;   mitotic spindle assembly checkpoint signalling;   signal transduction involved in mitotic cell cycle spindle assembly checkpoint;   signal transduction involved in mitotic spindle assembly checkpoint
 narrow_synonym: Dma1-dependent checkpoint;   Mad2-dependent checkpoint;   SAC-independent checkpoint;   signal transduction involved in Dma1-dependent checkpoint;   signal transduction involved in SAC-independent checkpoint;   signaling cascade involved in Dma1-dependent checkpoint;   signaling cascade involved in SAC-independent checkpoint;   signalling cascade involved in Dma1-dependent checkpoint;   signalling cascade involved in SAC-independent checkpoint
 related_synonym: signaling pathway involved in Dma1-dependent checkpoint;   signaling pathway involved in SAC-independent checkpoint;   signalling pathway involved in Dma1-dependent checkpoint;   signalling pathway involved in SAC-independent checkpoint
 alt_id: GO:0044810;   GO:0072480;   GO:1902420



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mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17227893)
GO_REF:0000107
RGD
Ensembl
PMID:17227893 GO_REF:0000107 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (PMID:11943150) RGD PMID:11943150 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 involved_in ISO
ISS
(PMID:12805209)
GO_REF:0000024
RGD
UniProt
PMID:12805209 GO_REF:0000024 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase involved_in ISO
IBA
(PMID:18995837)
GO_REF:0000033
RGD
GO_Central
PMID:18995837 GO_REF:0000033 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B involved_in ISO
IBA
(PMID:10477750), (PMID:20220147)
GO_REF:0000033
RGD
GO_Central
PMID:10477750 PMID:20220147 GO_REF:0000033 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036
JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) RGD PMID:12925705 MGI:2673075 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Haspin histone H3 associated protein kinase involved_in ISO (PMID:23071153) RGD PMID:23071153 NCBI chr10:57,747,731...57,750,518
Ensembl chr10:57,747,573...57,750,512
JBrowse link
G Ik IK cytokine involved_in ISS
ISO
GO_REF:0000024
(PMID:22351768)
UniProt
RGD
PMID:22351768 GO_REF:0000024 NCBI chr18:28,358,004...28,372,809
Ensembl chr18:28,357,977...28,378,832
JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member acts_upstream_of_or_within ISO MGI:3844604 (PMID:19376971) RGD PMID:19376971 NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248
JBrowse link
G Klhl22 kelch-like family member 22 involved_in ISS
ISO
GO_REF:0000024
(PMID:23455478)
UniProt
RGD
PMID:23455478 GO_REF:0000024 NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770
JBrowse link
G Kntc1 kinetochore associated 1 involved_in ISO
IBA
(PMID:11146660)
GO_REF:0000033
RGD
GO_Central
PMID:11146660 GO_REF:0000033 NCBI chr12:32,769,020...32,839,617
Ensembl chr12:32,769,020...32,839,561
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO
IBA
(PMID:18981471), (PMID:36322655), (PMID:9546394)
GO_REF:0000033
RGD
GO_Central
PMID:9546394 PMID:18981471 PMID:36322655 GO_REF:0000033 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:18981471)
MGI:2178781 (PMID:11201745)
GO_REF:0000033
RGD
GO_Central
PMID:11201745 PMID:18981471 GO_REF:0000033 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Plk1 polo-like kinase 1 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:23455478)
Ensembl
UniProt
RGD
PMID:23455478 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Psmg2 proteasome assembly chaperone 2 acts_upstream_of_or_within ISO (PMID:12147697) RGD PMID:12147697 NCBI chr18:61,208,669...61,227,671
Ensembl chr18:61,208,678...61,259,816
JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:19,269,125...19,294,213
Ensembl chr10:19,269,127...19,294,127
JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor involved_in IEA
IBA
ISO
ISS
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118
GO_REF:0000002
(MGI:5318128|PMID:22405274)
GO_REF:0000024
Ensembl
GO_Central
TreeGrafter
InterPro
RGD
UniProt
PMID:22405274 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:5318128 NCBI chr10:72,231,766...72,356,938
Ensembl chr10:72,231,801...72,355,805
JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISO
IEA
ISS
(PMID:20133940)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20133940 GO_REF:0000024 GO_REF:0000107 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 involved_in ISO
ISS
(PMID:28553959)
GO_REF:0000024
RGD
UniProt
PMID:28553959 GO_REF:0000024 NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
JBrowse link
G Ttk Ttk protein kinase involved_in IBA
ISO
GO_REF:0000033
MGI:5056148 (PMID:25197064)
GO_Central
RGD
PMID:25197064 GO_REF:0000033 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
JBrowse link
G Zfp207 zinc finger protein 207 involved_in ISO (PMID:24462186), (PMID:24462187) RGD PMID:24462186 PMID:24462187 NCBI chr10:65,385,807...65,398,086
Ensembl chr10:65,385,740...65,397,386
JBrowse link
G Zw10 zw10 kinetochore protein involved_in ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:11146660), (PMID:15824131)
HGNC-UCL
GO_Central
RGD
PMID:11146660 PMID:15824131 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:49,396,541...49,424,743
Ensembl chr 8:49,396,545...49,421,805
JBrowse link
G Zwilch zwilch kinetochore protein involved_in ISO
IBA
(PMID:15824131)
GO_REF:0000033
RGD
GO_Central
PMID:15824131 GO_REF:0000033 NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916
JBrowse link
G Zwint ZW10 interacting kinetochore protein involved_in ISO
IBA
(PMID:15485811)
GO_REF:0000033
RGD
GO_Central
PMID:15485811 GO_REF:0000033 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) RGD PMID:19010891 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Mad2l1bp MAD2L1 binding protein involved_in ISO (PMID:18022368) RGD PMID:18022368 NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447
JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:24374861)
UniProt
RGD
PMID:24374861 GO_REF:0000024 NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19229290)
UniProt
Ensembl
RGD
PMID:19229290 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:22898774), (PMID:36322655) RGD PMID:22898774 PMID:36322655 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in ISO (MGI:4839685|PMID:20870947)
(PMID:20870947), (PMID:22898774), (PMID:8824189)
RGD PMID:8824189 PMID:20870947 PMID:22898774 MGI:4839685 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:25743205) RGD PMID:25743205 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Pcid2 PCI domain containing 2 involved_in ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
RGD PMID:20870947 MGI:4839685 NCBI chr16:76,423,245...76,448,712
Ensembl chr16:76,423,245...76,448,712
JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:18981471), (PMID:19273613)
UniProt
Ensembl
RGD
PMID:18981471 PMID:19273613 GO_REF:0000024 GO_REF:0000107 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 involved_in ISO
IEA
IBA
ISS
(PMID:21926987)
GO_REF:0000118
GO_REF:0000033
GO_REF:0000002
GO_REF:0000024
RGD
TreeGrafter
GO_Central
InterPro
UniProt
PMID:21926987 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145
JBrowse link
G Ccnb1 cyclin B1 involved_in ISO
IEA
(PMID:18195732)
GO_REF:0000107
RGD
Ensembl
PMID:18195732 GO_REF:0000107 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 involved_in ISS
IBA
IEA
ISO
GO_REF:0000024
GO_REF:0000033
GO_REF:0000118
(PMID:19282672)
GO_REF:0000107
UniProt
GO_Central
TreeGrafter
RGD
Ensembl
PMID:19282672 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782
JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Knl1 kinetochore scaffold 1 involved_in ISO (PMID:19893618) RGD PMID:19893618 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17724024)
GO_REF:0000107
RGD
Ensembl
PMID:17724024 GO_REF:0000107 NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112
JBrowse link
G Prpf4b pre-mRNA processing factor 4B involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:17998396)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17998396 GO_REF:0000024 GO_REF:0000107 NCBI chr17:29,985,343...30,020,285
Ensembl chr17:29,985,343...30,019,625
JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO (MGI:5448515|PMID:21853124) RGD PMID:21853124 MGI:5448515 NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      cell cycle process 1350
        negative regulation of cell cycle process 319
          negative regulation of mitotic nuclear division 51
            negative regulation of mitotic metaphase/anaphase transition 42
              mitotic spindle assembly checkpoint signaling 40
                negative regulation of mitotic spindle assembly checkpoint signaling + 3
                positive regulation of mitotic cell cycle spindle assembly checkpoint + 8
                regulation of mitotic cell cycle spindle assembly checkpoint + 18
Path 2
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      cellular component organization or biogenesis 7290
        cellular component organization 6980
          organelle organization 3887
            organelle fission 540
              nuclear division 480
                mitotic nuclear division 278
                  mitotic sister chromatid segregation 186
                    regulation of mitotic sister chromatid segregation 50
                      negative regulation of mitotic sister chromatid segregation 42
                        negative regulation of mitotic sister chromatid separation 42
                          negative regulation of mitotic metaphase/anaphase transition 42
                            mitotic spindle assembly checkpoint signaling 40
                              negative regulation of mitotic spindle assembly checkpoint signaling + 3
                              positive regulation of mitotic cell cycle spindle assembly checkpoint + 8
                              regulation of mitotic cell cycle spindle assembly checkpoint + 18
paths to the root