ONTOLOGY REPORT - ANNOTATIONS
Term: metaphase/anaphase transition of mitotic cell cycle
Accession: GO:0007091
browse the term
Definition: The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
Synonyms: exact_synonym: metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic metaphase/anaphase transition
xref: Reactome:R-HSA-68881 "Mitotic Metaphase/Anaphase Transition"
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Anapc1
anaphase promoting complex subunit 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273
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Anapc2
anaphase promoting complex subunit 2
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178
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Apc
APC regulator of WNT signaling pathway
acts_upstream_of_or_within
ISO
MGI:1333889|MGI:1856318|MGI:3589207 (PMID:15767571), (PMID:16025118)
RGD
PMID:15767571 PMID:16025118
NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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Bub1b
BUB1 mitotic checkpoint serine/threonine kinase B
acts_upstream_of_or_within
ISO IEA
MGI:88039 (PMID:15767571) GO_REF:0000107
RGD Ensembl
PMID:15767571
GO_REF:0000107
NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547
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Cdc27
cell division cycle 27
acts_upstream_of_or_within involved_in
ISO IBA
(PMID:7736578) GO_REF:0000033
RGD GO_Central
PMID:7736578
GO_REF:0000033
NCBI chr10:89,400,720...89,449,816
Ensembl chr10:89,400,940...89,449,736
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Cit
citron rho-interacting serine/threonine kinase
acts_upstream_of_or_within
ISO
MGI:2447844 (PMID:12764032)
RGD
PMID:12764032
NCBI chr12:40,603,073...40,764,846
Ensembl chr12:40,605,563...40,763,860
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Tacc3
transforming, acidic coiled-coil containing protein 3
involved_in
ISO
(PMID:23532825)
RGD
PMID:23532825
NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219
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Mad1l1
mitotic arrest deficient 1 like 1
involved_in
ISO
(PMID:19010891)
RGD
PMID:19010891
NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
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Mad2l1bp
MAD2L1 binding protein
involved_in
ISO IEA
(PMID:18022368) GO_REF:0000107
RGD Ensembl
PMID:18022368
GO_REF:0000107
NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447
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Prap1
proline-rich acidic protein 1
involved_in
ISS ISO IEA
GO_REF:0000024 (PMID:24374861) GO_REF:0000107
UniProt RGD Ensembl
PMID:24374861
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872
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Apc
APC regulator of WNT signaling pathway
acts_upstream_of_or_within
ISO
(PMID:17227893)
RGD
PMID:17227893
NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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Atm
ATM serine/threonine kinase
involved_in
ISO
(PMID:11943150)
RGD
PMID:11943150
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Birc5
baculoviral IAP repeat-containing 5
involved_in
ISO ISS
(PMID:12805209) GO_REF:0000024
RGD UniProt
PMID:12805209
GO_REF:0000024
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
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Bub1
BUB1 mitotic checkpoint serine/threonine kinase
involved_in
ISO IEA IBA
(PMID:18995837) GO_REF:0000107 GO_REF:0000002 GO_REF:0000033
RGD Ensembl InterPro GO_Central
PMID:18995837
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
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Bub1b
BUB1 mitotic checkpoint serine/threonine kinase B
involved_in
ISO IEA IBA
(PMID:10477750), (PMID:20220147) GO_REF:0000107 GO_REF:0000002 GO_REF:0000033
RGD Ensembl InterPro GO_Central
PMID:10477750 PMID:20220147
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547
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Cenpe
centromere protein E
involved_in
ISO
(PMID:12925705)
RGD
PMID:12925705
NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
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Haspin
histone H3 associated protein kinase
involved_in
ISO IEA
(PMID:23071153) GO_REF:0000107
RGD Ensembl
PMID:23071153
GO_REF:0000107
NCBI chr10:57,747,731...57,750,518
Ensembl chr10:57,747,573...57,750,512
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Ik
IK cytokine
involved_in
ISS ISO
GO_REF:0000024 (PMID:22351768)
UniProt RGD
PMID:22351768
GO_REF:0000024
NCBI chr18:28,358,004...28,372,809
Ensembl chr18:28,357,977...28,378,832
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Khdc3
KH domain containing 3, subcortical maternal complex member
acts_upstream_of_or_within
ISO
MGI:3844604 (PMID:19376971)
RGD
PMID:19376971
NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248
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Klhl22
kelch-like family member 22
involved_in
ISS ISO
GO_REF:0000024 (PMID:23455478)
UniProt RGD
PMID:23455478
GO_REF:0000024
NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770
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Kntc1
kinetochore associated 1
involved_in
ISO IEA IBA
(PMID:11146660) GO_REF:0000107 GO_REF:0000033
RGD Ensembl GO_Central
PMID:11146660
GO_REF:0000033 GO_REF:0000107
NCBI chr12:32,769,020...32,839,617
Ensembl chr12:32,769,020...32,839,561
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Mad1l1
mitotic arrest deficient 1 like 1
involved_in
ISO IEA IBA
(PMID:18981471), (PMID:36322655), (PMID:9546394) GO_REF:0000002 GO_REF:0000107 GO_REF:0000033
RGD InterPro Ensembl GO_Central
PMID:9546394 PMID:18981471 PMID:36322655
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
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Mad2l1
mitotic arrest deficient 2 like 1
involved_in acts_upstream_of_or_within
ISO IEA IBA
(PMID:18981471) GO_REF:0000107 MGI:2178781 (PMID:11201745) GO_REF:0000033
RGD Ensembl GO_Central
PMID:11201745 PMID:18981471
GO_REF:0000033 GO_REF:0000107
NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
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Plk1
polo-like kinase 1
involved_in
IEA ISS ISO
GO_REF:0000107 GO_REF:0000024 (PMID:23455478)
Ensembl UniProt RGD
PMID:23455478
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:176,716,420...176,726,400
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Psmg2
proteasome assembly chaperone 2
acts_upstream_of_or_within
ISO
(PMID:12147697)
RGD
PMID:12147697
NCBI chr18:61,208,669...61,227,671
Ensembl chr18:61,208,678...61,259,816
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Spdl1
spindle apparatus coiled-coil protein 1
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr10:19,269,125...19,294,213
Ensembl chr10:19,269,127...19,294,127
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Tex14
testis expressed 14, intercellular bridge forming factor
involved_in
IEA ISO IBA ISS
GO_REF:0000107 (PMID:22405274) GO_REF:0000033 GO_REF:0000002 GO_REF:0000024
Ensembl RGD GO_Central InterPro UniProt
PMID:22405274
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr10:72,231,766...72,356,938
Ensembl chr10:72,231,801...72,355,805
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Tpr
translocated promoter region, nuclear basket protein
involved_in
ISO IEA ISS
(PMID:20133940) GO_REF:0000107 GO_REF:0000024
RGD Ensembl UniProt
PMID:20133940
GO_REF:0000024 GO_REF:0000107
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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Trip13
thyroid hormone receptor interactor 13
involved_in
ISO IEA ISS
(PMID:28553959) GO_REF:0000107 GO_REF:0000024
RGD Ensembl UniProt
PMID:28553959
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
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Ttk
Ttk protein kinase
involved_in
ISO IEA IBA
MGI:5056148 (PMID:25197064) GO_REF:0000107 GO_REF:0000033 (PMID:18243099)
RGD Ensembl GO_Central
PMID:18243099 PMID:25197064
GO_REF:0000033 GO_REF:0000107
NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:84,754,315...84,792,651
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Zfp207
zinc finger protein 207
involved_in
ISO
(PMID:24462186), (PMID:24462187)
RGD
PMID:24462186 PMID:24462187
NCBI chr10:65,385,807...65,398,086
Ensembl chr10:65,385,740...65,397,386
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Zw10
zw10 kinetochore protein
involved_in
ISS IEA IBA ISO
GO_REF:0000024 GO_REF:0000107 GO_REF:0000033 (PMID:11146660), (PMID:15824131)
HGNC-UCL Ensembl GO_Central RGD
PMID:11146660 PMID:15824131
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr 8:49,396,541...49,424,743
Ensembl chr 8:49,396,545...49,421,805
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Zwilch
zwilch kinetochore protein
involved_in
ISO IEA IBA
(PMID:15824131) GO_REF:0000107 GO_REF:0000104 GO_REF:0000033
RGD Ensembl UniProt GO_Central
PMID:15824131
GO_REF:0000033 GO_REF:0000104 GO_REF:0000107
NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916
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Zwint
ZW10 interacting kinetochore protein
involved_in
ISO IBA
(PMID:15485811) GO_REF:0000033
RGD GO_Central
PMID:15485811
GO_REF:0000033
NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
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Fbxo5
F-box protein 5
involved_in
ISO IEA
(PMID:11988738), (PMID:16921029) GO_REF:0000107
RGD Ensembl
PMID:11988738 PMID:16921029
GO_REF:0000107
NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
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Rad21
RAD21 cohesin complex component
involved_in
ISO IEA
(PMID:10375619) GO_REF:0000107
RGD Ensembl
PMID:10375619
GO_REF:0000107
NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
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Usp44
ubiquitin specific peptidase 44
involved_in
ISO IEA
(PMID:17443180) GO_REF:0000107
RGD Ensembl
PMID:17443180
GO_REF:0000107
NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053
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Ska1
spindle and kinetochore associated complex subunit 1
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:26981768)
UniProt Ensembl RGD
PMID:26981768
GO_REF:0000024 GO_REF:0000107
NCBI chr18:67,794,722...67,805,037
Ensembl chr18:67,794,725...67,805,037
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Ska3
spindle and kinetochore associated complex subunit 3
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:19646878)
UniProt Ensembl RGD
PMID:19646878
GO_REF:0000024 GO_REF:0000107
NCBI chr15:31,951,812...31,971,010
Ensembl chr15:31,951,825...31,971,010
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Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:19229290)
UniProt Ensembl RGD
PMID:19229290
GO_REF:0000024 GO_REF:0000107
NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934
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Gen1
GEN1 Holliday junction 5' flap endonuclease
involved_in
ISO
(PMID:23108668)
RGD
PMID:23108668
NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401
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Mad1l1
mitotic arrest deficient 1 like 1
involved_in
ISO IEA
(PMID:22898774), (PMID:36322655) GO_REF:0000107
RGD Ensembl
PMID:22898774 PMID:36322655
GO_REF:0000107
NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
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Mad2l1
mitotic arrest deficient 2 like 1
involved_in
ISO
(PMID:22898774), (PMID:8824189)
RGD
PMID:8824189 PMID:22898774
NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
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Ndc80
NDC80 kinetochore complex component
involved_in
ISO IEA
(PMID:25743205) GO_REF:0000107
RGD Ensembl
PMID:25743205
GO_REF:0000107
NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
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Tpr
translocated promoter region, nuclear basket protein
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:18981471), (PMID:19273613)
UniProt Ensembl RGD
PMID:18981471 PMID:19273613
GO_REF:0000024 GO_REF:0000107
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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Xrcc3
X-ray repair cross complementing 3
involved_in
ISO IEA
(PMID:23108668) GO_REF:0000107
RGD Ensembl
PMID:23108668
GO_REF:0000107
NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
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Anapc11
anaphase promoting complex subunit 11
involved_in
ISO IEA
(PMID:11739784) GO_REF:0000107
RGD Ensembl
PMID:11739784
GO_REF:0000107
NCBI chr10:106,373,610...106,384,633
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Anapc5
anaphase-promoting complex subunit 5
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr12:33,748,709...33,781,709
Ensembl chr12:33,748,735...33,781,781
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Anapc7
anaphase promoting complex subunit 7
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr12:34,131,214...34,160,819
Ensembl chr12:34,133,429...34,160,005
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Cdc16
cell division cycle 16
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550
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Cdc20
cell division cycle 20
involved_in
ISO IEA
(PMID:9637688) GO_REF:0000107
RGD Ensembl
PMID:9637688
GO_REF:0000107
NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512
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Cdc23
cell division cycle 23
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163
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Cenpe
centromere protein E
involved_in
ISO
(PMID:12925705)
RGD
PMID:12925705
NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
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Cul3
cullin 3
involved_in
ISO IEA
(PMID:17543862) GO_REF:0000107
RGD Ensembl
PMID:17543862
GO_REF:0000107
NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:81,592,641...81,670,462
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Npb
neuropeptide B
involved_in
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr10:106,382,307...106,385,566
Ensembl chr10:105,874,708...105,887,254
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Nsmce2
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
involved_in
ISO IEA ISS
(PMID:19502785) GO_REF:0000107 GO_REF:0000024
RGD Ensembl UniProt
PMID:19502785
GO_REF:0000024 GO_REF:0000107
NCBI chr 7:92,825,568...93,071,037
Ensembl chr 7:90,936,112...91,164,899
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Rb1
RB transcriptional corepressor 1
involved_in
ISO IEA
(PMID:20551165) GO_REF:0000107
RGD Ensembl
PMID:20551165
GO_REF:0000107
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
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Ube2c
ubiquitin-conjugating enzyme E2C
involved_in
ISO
(PMID:12629039)
RGD
PMID:12629039
NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339
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Anapc15
anaphase promoting complex subunit 15
involved_in
ISO IEA IBA ISS
(PMID:21926987) GO_REF:0000107 GO_REF:0000033 GO_REF:0000002 GO_REF:0000024
RGD Ensembl GO_Central InterPro UniProt
PMID:21926987
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145
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Ccnb1
cyclin B1
involved_in
ISO IEA
(PMID:18195732) GO_REF:0000107
RGD Ensembl
PMID:18195732
GO_REF:0000107
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
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Cdk5rap2
CDK5 regulatory subunit associated protein 2
involved_in
ISS IBA ISO IEA
GO_REF:0000024 GO_REF:0000033 (PMID:19282672) GO_REF:0000107
UniProt GO_Central RGD Ensembl
PMID:19282672
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782
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Dusp1
dual specificity phosphatase 1
involved_in
ISS
GO_REF:0000024
UniProt
GO_REF:0000024
NCBI chr10:16,680,478...16,683,275
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Knl1
kinetochore scaffold 1
involved_in
ISO IEA
(PMID:19893618) GO_REF:0000107
RGD Ensembl
PMID:19893618
GO_REF:0000107
NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
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Lcmt1
leucine carboxyl methyltransferase 1
acts_upstream_of_or_within involved_in
ISO IEA IBA
(PMID:17724024) GO_REF:0000107 GO_REF:0000033
RGD Ensembl GO_Central
PMID:17724024
GO_REF:0000033 GO_REF:0000107
NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112
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Prpf4b
pre-mRNA processing factor 4B
involved_in
ISS ISO
GO_REF:0000024 (PMID:17998396)
UniProt RGD
PMID:17998396
GO_REF:0000024
NCBI chr17:29,985,343...30,020,285
Ensembl chr17:29,985,343...30,019,625
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Usp44
ubiquitin specific peptidase 44
involved_in
ISO IEA
(PMID:21853124) GO_REF:0000107
RGD Ensembl
PMID:21853124
GO_REF:0000107
NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053
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Anapc4
anaphase promoting complex subunit 4
involved_in
IEA
GO_REF:0000104 GO_REF:0000002
UniProt InterPro
GO_REF:0000002 GO_REF:0000104
NCBI chr14:58,125,995...58,159,253
Ensembl chr14:58,125,995...58,157,770
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Cdc23
cell division cycle 23
involved_in
ISO IEA
(PMID:9790767) GO_REF:0000107
RGD Ensembl
PMID:9790767
GO_REF:0000107
NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163
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Cdc6
cell division cycle 6
involved_in
ISO IEA
(PMID:21041660) GO_REF:0000107
RGD Ensembl
PMID:21041660
GO_REF:0000107
NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011
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Cenpe
centromere protein E
involved_in
ISO IEA
(PMID:2022189) GO_REF:0000107
RGD Ensembl
PMID:2022189
GO_REF:0000107
NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
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Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
involved_in
ISO IEA
(PMID:24163370) GO_REF:0000107
RGD Ensembl
PMID:24163370
GO_REF:0000107
NCBI chr 9:62,853,904...63,247,472
Ensembl chr 9:55,365,203...55,580,327
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Nek6
NIMA-related kinase 6
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:14563848)
UniProt Ensembl RGD
PMID:14563848
GO_REF:0000024 GO_REF:0000107
NCBI chr 3:22,284,269...22,356,302
Ensembl chr 3:22,284,279...22,395,990
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Plk1
polo-like kinase 1
involved_in
ISO IEA
(PMID:21041660), (PMID:23509069) GO_REF:0000107
RGD Ensembl
PMID:21041660 PMID:23509069
GO_REF:0000107
NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:176,716,420...176,726,400
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Riok2
RIO kinase 2
involved_in
ISO IEA
(PMID:21880710) GO_REF:0000107
RGD Ensembl
PMID:21880710
GO_REF:0000107
NCBI chr 1:58,103,132...58,119,397
Ensembl chr 1:58,103,084...58,120,512
G
Ube2c
ubiquitin-conjugating enzyme E2C
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all