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ONTOLOGY REPORT - ANNOTATIONS


Term:sister chromatid cohesion
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Accession:GO:0007062 term browser browse the term
Definition:The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
Synonyms:exact_synonym: cohesion-mediated DNA tethering
 xref: Reactome:R-HSA-2468052 "Establishment of Sister Chromatid Cohesion"



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sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx11 DEAD/H-box helicase 11 involved_in ISO (PMID:17105772) RGD PMID:17105772 NCBI chr 9:105,833,234...105,862,844 JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 involved_in ISO (PMID:15917200) RGD PMID:15917200 NCBI chr 2:170,149,706...170,311,536 JBrowse link
G Kif22 kinesin family member 22 involved_in ISO
IEA
ISS
(PMID:15843429)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15843429 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:181,635,347...181,650,351 JBrowse link
G Mcmbp minichromosome maintenance complex binding protein involved_in ISO
IEA
ISS
(PMID:20090939)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20090939 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:192,702,383...192,747,381 JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in ISO
IEA
(PMID:15917200)
GO_REF:0000107
RGD
Ensembl
PMID:15917200 GO_REF:0000107 NCBI chr 8:19,900,211...19,961,906 JBrowse link
G Phb2 prohibitin 2 involved_in ISO
IEA
(PMID:23548868)
GO_REF:0000107
RGD
Ensembl
PMID:23548868 GO_REF:0000107 NCBI chr 4:157,517,662...157,522,268 JBrowse link
G Rad21 RAD21 cohesin complex component involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:85,177,715...85,204,657 JBrowse link
G Rad21l1 RAD21 cohesin complex component like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:140,160,128...140,188,324 JBrowse link
G Recql4 RecQ like helicase 4 acts_upstream_of ISO MGI:3045113 (PMID:15703196) RGD PMID:15703196 NCBI chr 7:110,304,092...110,311,426 JBrowse link
G Smc1a structural maintenance of chromosomes 1A involved_in ISO
IBA
IEA
(PMID:15917200)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:15917200 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:24,582,732...24,627,462 JBrowse link
G Smc1b structural maintenance of chromosomes 1B involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:11564881)
GO_Central
RGD
PMID:11564881 GO_REF:0000033 NCBI chr 7:116,180,987...116,242,778 JBrowse link
G Smc3 structural maintenance of chromosomes 3 involved_in ISO
IEA
(PMID:15917200)
GO_REF:0000107
RGD
Ensembl
PMID:15917200 GO_REF:0000107 NCBI chr 1:252,601,422...252,644,522 JBrowse link
G Stag1 STAG1 cohesin complex component involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:110,057,981...110,443,666 JBrowse link
G Stag2 STAG2 cohesin complex component involved_in ISO
IBA
(PMID:15917200), (PMID:28296084), (PMID:29263825)
GO_REF:0000033
RGD
GO_Central
PMID:15917200 PMID:28296084 PMID:29263825 GO_REF:0000033 NCBI chr  X:120,974,687...121,105,677 JBrowse link
G Stag3 STAG3 cohesin complex component involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:17,284,677...17,314,936 JBrowse link
establishment of meiotic sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stag3 STAG3 cohesin complex component involved_in ISO
IBA
ISS
(PMID:31682730)
GO_REF:0000033
GO_REF:0000024
RGD
GO_Central
UniProt
PMID:31682730 GO_REF:0000024 GO_REF:0000033 NCBI chr12:17,284,677...17,314,936 JBrowse link
establishment of mitotic sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit involved_in ISO (PMID:27422821) RGD PMID:27422821 NCBI chr11:70,044,281...70,066,754 JBrowse link
G Nipbl NIPBL, cohesin loading factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:57,399,443...57,586,770 JBrowse link
establishment of sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx11 DEAD/H-box helicase 11 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:105,833,234...105,862,844 JBrowse link
female meiosis sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad51c RAD51 paralog C acts_upstream_of_or_within ISO MGI:3707422|MGI:3707425 (PMID:17312021) RGD PMID:17312021 NCBI chr10:72,702,299...72,728,980 JBrowse link
G Sycp3 synaptonemal complex protein 3 involved_in ISO (PMID:15870106) RGD PMID:15870106 NCBI chr 7:22,874,055...22,888,512 JBrowse link
maintenance of meiotic sister chromatid cohesion, centromeric term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sgo2 shugoshin 2 acts_upstream_of ISO MGI:3809644 (PMID:18765791) RGD PMID:18765791 NCBI chr 9:59,548,605...59,573,229 JBrowse link
maintenance of mitotic sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dscc1 DNA replication and sister chromatid cohesion 1 involved_in ISO
IBA
(PMID:16682347), (PMID:19907496)
GO_REF:0000033
RGD
GO_Central
PMID:16682347 PMID:19907496 GO_REF:0000033 NCBI chr 7:88,372,349...88,390,815 JBrowse link
G Mau2 MAU2 sister chromatid cohesion factor involved_in ISO
IBA
(PMID:16682347), (PMID:16802858)
GO_REF:0000033
RGD
GO_Central
PMID:16682347 PMID:16802858 GO_REF:0000033 NCBI chr16:19,383,847...19,414,996 JBrowse link
G Nipbl NIPBL, cohesin loading factor involved_in ISO (PMID:16682347) RGD PMID:16682347 NCBI chr 2:57,399,443...57,586,770 JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in ISO
IEA
(PMID:20551165)
GO_REF:0000107
RGD
Ensembl
PMID:20551165 GO_REF:0000107 NCBI chr15:54,780,858...54,911,989 JBrowse link
meiotic sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gtf2b general transcription factor IIB involved_in IEA
ISO
GO_REF:0000107
(PMID:24244602)
Ensembl
RGD
PMID:24244602 GO_REF:0000107 NCBI chr 2:231,767,317...231,785,626 JBrowse link
G Hormad1 HORMA domain containing 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:21079677), (PMID:21478856)
UniProt
RGD
PMID:21079677 PMID:21478856 GO_REF:0000024 NCBI chr 2:183,115,815...183,152,383 JBrowse link
G Hormad2 HORMA domain containing 2 involved_in ISO (PMID:22549958), (PMID:23039116) RGD PMID:22549958 PMID:23039116 NCBI chr14:79,215,013...79,300,447 JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:129,461,689...129,598,344 JBrowse link
G Ppp2r5d protein phosphatase 2, regulatory subunit B', delta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:14,270,364...14,300,396 JBrowse link
G Rec8 REC8 meiotic recombination protein involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:29,109,862...29,117,327 JBrowse link
G Sgo2 shugoshin 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:59,548,605...59,573,229 JBrowse link
meiotic sister chromatid cohesion involved in meiosis I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Meikin meiotic kinetochore factor acts_upstream_of_or_within
involved_in
ISO
IBA
(PMID:25533956)
GO_REF:0000033
RGD
GO_Central
PMID:25533956 GO_REF:0000033 NCBI chr10:38,508,156...38,556,732 JBrowse link
G Sgo2 shugoshin 2 acts_upstream_of_or_within ISO (PMID:25533956) RGD PMID:25533956 NCBI chr 9:59,548,605...59,573,229 JBrowse link
meiotic sister chromatid cohesion, centromeric term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:135,473,525...135,504,921 JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:126,017,019...126,069,470 JBrowse link
G Meikin meiotic kinetochore factor acts_upstream_of_or_within
involved_in
ISO
IBA
(PMID:25533956)
GO_REF:0000033
RGD
GO_Central
PMID:25533956 GO_REF:0000033 NCBI chr10:38,508,156...38,556,732 JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:5287252 (PMID:24899574)
GO_REF:0000033
RGD
GO_Central
PMID:24899574 GO_REF:0000033 NCBI chr 1:69,213,198...69,232,441 JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:60,092,540...60,125,512 JBrowse link
G Sgo2 shugoshin 2 acts_upstream_of_or_within ISO (PMID:18084284), (PMID:25533956) RGD PMID:18084284 PMID:25533956 NCBI chr 9:59,548,605...59,573,229 JBrowse link
mitotic sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07057438.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Cdc20 cell division cycle 20 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1353578 (PMID:17325031)
Ensembl
RGD
PMID:17325031 GO_REF:0000107 NCBI chr 5:137,251,596...137,255,799 JBrowse link
G Cdca5 cell division cycle associated 5 involved_in ISO
IBA
UniProtKB:Q29RF7 (PMID:17349791), (PMID:21111234)
GO_REF:0000033
UniProtKB:Q96FF9 (PMID:21111234)
RGD
GO_Central
PMID:17349791 PMID:21111234 GO_REF:0000033 NCBI chr 1:212,807,863...212,821,313 JBrowse link
G Chtf8 chromosome transmission fidelity factor 8 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr19:34,782,005...34,792,306 JBrowse link
G Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:1,630,560...1,686,803 JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:44,210,124...44,230,785 JBrowse link
G Haspin histone H3 associated protein kinase involved_in ISO (PMID:20705812) RGD PMID:20705812 NCBI chr10:58,246,244...58,249,031 JBrowse link
G Hdac8 histone deacetylase 8 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:22885700)
UniProt
Ensembl
RGD
PMID:22885700 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:67,385,288...67,593,014 JBrowse link
G Mau2 MAU2 sister chromatid cohesion factor involved_in ISO (PMID:22628566) RGD PMID:22628566 NCBI chr16:19,383,847...19,414,996 JBrowse link
G Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:70,044,281...70,066,754 JBrowse link
G Nipbl NIPBL, cohesin loading factor involved_in ISO (PMID:16100726), (PMID:22628566) RGD PMID:16100726 PMID:22628566 NCBI chr 2:57,399,443...57,586,770 JBrowse link
G Pds5a PDS5 cohesin associated factor A involved_in ISO
IBA
IEA
UniProtKB:Q96FF9 (PMID:21111234)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:21111234 GO_REF:0000033 GO_REF:0000107 NCBI chr14:42,905,734...43,004,740 JBrowse link
G Pds5b PDS5 cohesin associated factor B involved_in IEA
IBA
ISS
ISO
GO_REF:0000002
GO_REF:0000033
GO_REF:0000024
(PMID:15855230)
GO_REF:0000107
InterPro
GO_Central
UniProt
RGD
Ensembl
PMID:15855230 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr12:5,038,114...5,181,208 JBrowse link
G Pogz pogo transposable element derived with ZNF domain involved_in ISO (PMID:20562864) RGD PMID:20562864 NCBI chr 2:185,069,492...185,129,741 JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin acts_upstream_of_or_within ISO MGI:1859866 (PMID:17325031) RGD PMID:17325031 NCBI chr10:28,394,940...28,406,410 JBrowse link
G Smc3 structural maintenance of chromosomes 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:252,601,422...252,644,522 JBrowse link
mitotic sister chromatid cohesion, centromeric term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bod1 biorientation of chromosomes in cell division 1 involved_in ISO (PMID:24157919) RGD PMID:24157919 NCBI chr10:15,993,454...15,999,795 JBrowse link
G Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit involved_in ISO (PMID:17502424) RGD PMID:17502424 NCBI chr11:70,044,281...70,066,754 JBrowse link
G Sgo1 shugoshin 1 involved_in ISO (PMID:24157919) RGD PMID:24157919 NCBI chr 9:6,672,109...6,687,908 JBrowse link
negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit involved_in ISO (PMID:27422821) RGD PMID:27422821 NCBI chr  X:156,807,378...156,812,632 JBrowse link
negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrx ATRX, chromatin remodeler involved_in ISO
IEA
(PMID:26373281)
GO_REF:0000107
RGD
Ensembl
PMID:26373281 GO_REF:0000107 NCBI chr  X:70,850,981...70,997,330 JBrowse link
G Tnks tankyrase involved_in ISO (PMID:26373281) RGD PMID:26373281 NCBI chr16:63,922,969...64,073,972 JBrowse link
negative regulation of sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Recql4 RecQ like helicase 4 acts_upstream_of_or_within ISO MGI:3045113 (PMID:15703196) RGD PMID:15703196 NCBI chr 7:110,304,092...110,311,426 JBrowse link
G Wapl WAPL cohesin release factor involved_in ISO (PMID:19696148), (PMID:21111234) RGD PMID:19696148 PMID:21111234 NCBI chr16:10,005,520...10,075,270 JBrowse link
positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sgo2 shugoshin 2 acts_upstream_of_or_within ISO MGI:3809644 (PMID:18765791) RGD PMID:18765791 NCBI chr 9:59,548,605...59,573,229 JBrowse link
positive regulation of maintenance of mitotic sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Macroh2a1 macroH2A.1 histone involved_in ISO (PMID:26373281) RGD PMID:26373281 NCBI chr17:8,479,331...8,542,071 JBrowse link
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase involved_in ISO
IEA
ISS
(PMID:19502785)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19502785 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:90,936,112...91,173,435 JBrowse link
G Slf1 SMC5-SMC6 complex localization factor 1 involved_in ISO (PMID:25931565) RGD PMID:25931565 NCBI chr 2:6,767,015...6,874,428 JBrowse link
G Slf2 SMC5-SMC6 complex localization factor 2 involved_in ISO (PMID:25931565) RGD PMID:25931565 NCBI chr 1:243,782,786...243,845,418 JBrowse link
G Smc5 structural maintenance of chromosomes 5 involved_in ISO (PMID:19502785) RGD PMID:19502785 NCBI chr 1:220,769,366...220,839,138 JBrowse link
positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase involved_in ISO (PMID:25308863) RGD PMID:25308863 NCBI chr 3:135,473,525...135,504,921 JBrowse link
positive regulation of sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx11 DEAD/H-box helicase 11 involved_in ISO (PMID:18499658), (PMID:20124417), (PMID:27477908) RGD PMID:18499658 PMID:20124417 PMID:27477908 NCBI chr 9:105,833,234...105,862,844 JBrowse link
G Fen1 flap structure-specific endonuclease 1 involved_in ISO (PMID:18499658) RGD PMID:18499658 NCBI chr 1:216,270,016...216,274,873 JBrowse link
G Rad21 RAD21 cohesin complex component involved_in ISO (PMID:18499658) RGD PMID:18499658 NCBI chr 7:85,177,715...85,204,657 JBrowse link
G Sfpq splicing factor proline and glutamine rich acts_upstream_of_or_within ISO (PMID:20813759) RGD PMID:20813759 NCBI chr 5:139,338,034...139,353,476 JBrowse link
regulation of centromeric sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axin2 axin 2 involved_in IEA
ISO
IBA
GO_REF:0000107
(PMID:20300119)
GO_REF:0000033
Ensembl
RGD
GO_Central
PMID:20300119 GO_REF:0000033 GO_REF:0000107 NCBI chr10:94,393,379...94,426,579 JBrowse link
G Ctnnb1 catenin beta 1 involved_in ISO
ISS
IEA
(PMID:20300119)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:20300119 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661 JBrowse link
regulation of sister chromatid cohesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase involved_in ISO (PMID:15723797) RGD PMID:15723797 NCBI chr 3:135,473,525...135,504,921 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      cell cycle process 1310
        sister chromatid cohesion 61
          centromeric sister chromatid cohesion + 12
          establishment of sister chromatid cohesion + 4
          maintenance of sister chromatid cohesion + 14
          meiotic sister chromatid cohesion + 15
          mitotic sister chromatid cohesion + 29
          negative regulation of sister chromatid cohesion + 5
          positive regulation of sister chromatid cohesion + 11
          regulation of sister chromatid cohesion + 18
Path 2
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      cellular component organization or biogenesis 7187
        cellular component organization 6903
          organelle organization 3691
            chromosome organization 523
              sister chromatid cohesion 61
                centromeric sister chromatid cohesion + 12
                establishment of sister chromatid cohesion + 4
                maintenance of sister chromatid cohesion + 14
                meiotic sister chromatid cohesion + 15
                mitotic sister chromatid cohesion + 29
                negative regulation of sister chromatid cohesion + 5
                positive regulation of sister chromatid cohesion + 11
                regulation of sister chromatid cohesion + 18
paths to the root