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ONTOLOGY REPORT - ANNOTATIONS

Term:microtubule nucleation
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Accession:GO:0007020 term browser browse the term
Definition:The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).
Synonyms:xref: Wikipedia:Microtubule_nucleation

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microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap9 A-kinase anchoring protein 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936621:2,247,082...2,374,407
Ensembl chrNW_004936621:2,246,179...2,374,454 		JBrowse link
G Ccdc57 coiled-coil domain containing 57 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936594:5,648,250...5,687,880
Ensembl chrNW_004936594:5,613,684...5,687,878 		JBrowse link
G Clasp1 cytoplasmic linker associated protein 1 involved_in ISO (PMID:17543864) UniProt PMID:17543864 NCBI chrNW_004936469:49,067,357...49,335,212
Ensembl chrNW_004936469:49,067,012...49,335,219 		JBrowse link
G Clasp2 cytoplasmic linker associated protein 2 involved_in ISO (PMID:17543864) UniProt PMID:17543864 NCBI chrNW_004936473:23,756,291...23,940,966
Ensembl chrNW_004936473:23,755,627...23,900,014 		JBrowse link
G Csnk1d casein kinase 1 delta involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24648492) Ensembl
SYSCILIA_CCNET		 PMID:24648492 GO_REF:0000107 NCBI chrNW_004936594:5,720,887...5,743,206
Ensembl chrNW_004936594:5,724,406...5,743,180 		JBrowse link
G Golga2 golgin A2 involved_in ISO (PMID:19242490)
(PMID:26165940)		 UniProt PMID:19242490 PMID:26165940 NCBI chrNW_004936487:15,798,623...15,814,360 JBrowse link
G Haus2 HAUS augmin like complex subunit 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936471:5,826,889...5,840,872
Ensembl chrNW_004936471:5,826,950...5,840,346 		JBrowse link
G LOC101969275 tubulin gamma-1 chain involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936490:17,357,782...17,363,006
Ensembl chrNW_004936490:17,357,608...17,398,008 		JBrowse link
G LOC101974646 nuclear distribution protein nudE-like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936496:7,323,455...7,325,655 JBrowse link
G Nde1 nudE neurodevelopment protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11163258) Ensembl
MGI
TreeGrafter		 PMID:11163258 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936501:3,193,962...3,234,640
Ensembl chrNW_004936501:3,193,916...3,221,700 		JBrowse link
G Ndel1 nudE neurodevelopment protein 1 like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936595:1,656,956...1,692,775
Ensembl chrNW_004936595:1,656,956...1,689,322 		JBrowse link
G Slain1 SLAIN motif family member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936511:3,615,251...3,671,429
Ensembl chrNW_004936511:3,614,303...3,671,847 		JBrowse link
G Slain2 SLAIN motif family member 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936482:14,396,635...14,455,204
Ensembl chrNW_004936482:14,396,630...14,455,636 		JBrowse link
G Ssna1 SS nuclear autoantigen 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936669:795,929...797,422
Ensembl chrNW_004936669:795,950...797,422 		JBrowse link
G Tpx2 TPX2 microtubule nucleation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:18,718,801...18,773,315
Ensembl chrNW_004936485:18,718,795...18,767,951 		JBrowse link
G Tubg2 tubulin gamma 2 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936490:17,392,613...17,398,000
Ensembl chrNW_004936490:17,357,608...17,398,008 		JBrowse link
G Tubgcp2 tubulin gamma complex component 2 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936486:19,404,651...19,423,601
Ensembl chrNW_004936486:19,402,526...19,421,976 		JBrowse link
G Tubgcp3 tubulin gamma complex component 3 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936472:896,513...965,410
Ensembl chrNW_004936472:896,488...965,915 		JBrowse link
G Tubgcp4 tubulin gamma complex component 4 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936471:6,542,295...6,588,484
Ensembl chrNW_004936471:6,541,713...6,591,692 		JBrowse link
G Tubgcp5 tubulin gamma complex component 5 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936471:38,180,670...38,215,972
Ensembl chrNW_004936471:38,181,252...38,216,306 		JBrowse link
G Tubgcp6 tubulin gamma complex component 6 involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936629:568,014...587,726
Ensembl chrNW_004936629:568,067...587,554 		JBrowse link
astral microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpj centromere protein J acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11003675) MGI
Ensembl		 PMID:11003675 GO_REF:0000107 NCBI chrNW_004936720:2,149,296...2,201,599
Ensembl chrNW_004936720:2,149,302...2,204,139 		JBrowse link
centrosome-templated microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cep192 centrosomal protein 192 involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936626:2,565,302...2,659,863
Ensembl chrNW_004936626:2,565,281...2,658,295 		JBrowse link
G Nin ninein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15784680) Ensembl
MGI
TreeGrafter		 PMID:15784680 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936495:14,791,246...14,897,454
Ensembl chrNW_004936495:14,791,216...14,897,449 		JBrowse link
microtubule nucleation by interphase microtubule organizing center term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mzt1 mitotic spindle organizing protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936511:8,134,607...8,149,923 JBrowse link
microtubule nucleation by microtubule organizing center term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tppp tubulin polymerization promoting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936815:842,279...882,985
Ensembl chrNW_004936815:842,087...883,368 		JBrowse link
negative regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef7 Rho guanine nucleotide exchange factor 7 involved_in ISO (PMID:27012601) UniProt PMID:27012601 NCBI chrNW_004936472:1,784,215...1,857,296
Ensembl chrNW_004936472:1,784,195...1,874,774 		JBrowse link
positive regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckap5 cytoskeleton associated protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936562:2,269,341...2,369,098
Ensembl chrNW_004936562:2,269,332...2,371,224 		JBrowse link
G Dctn1 dynactin subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936556:601,550...632,321
Ensembl chrNW_004936556:601,548...621,609 		JBrowse link
G Git1 GIT ArfGAP 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:5,684,660...5,694,779
Ensembl chrNW_004936538:5,684,644...5,695,043 		JBrowse link
G LOC101955831 heat shock 70 kDa protein 1 involved_in ISO (PMID:27137183) UniProt PMID:27137183 NCBI chrNW_004936727:1,718,952...1,721,691 JBrowse link
G LOC101956126 heat shock 70 kDa protein 1 involved_in ISO (PMID:27137183) UniProt PMID:27137183 NCBI chrNW_004936727:1,732,323...1,735,128 JBrowse link
G Mecp2 methyl-CpG binding protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936809:902,938...967,771
Ensembl chrNW_004936809:911,764...966,839 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:6,001,126...6,135,663
Ensembl chrNW_004936498:6,001,014...6,086,614 		JBrowse link
regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eml2 EMAP like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:2,018,951...2,044,695
Ensembl chrNW_004936706:2,018,934...2,044,739 		JBrowse link
G Nme7 NME/NM23 family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:17,280,661...17,438,496
Ensembl chrNW_004936481:17,280,464...17,438,084 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15871
    cellular process 15001
      microtubule-based process 954
        microtubule cytoskeleton organization 656
          microtubule nucleation 36
            chromatin-templated microtubule nucleation 0
            microtubule nucleation by microtubule organizing center + 5
            mitotic spindle-templated microtubule nucleation 0
            negative regulation of microtubule nucleation 1
            positive regulation of microtubule nucleation + 7
            regulation of microtubule nucleation + 10
Path 2
Term Annotations click to browse term
  biological_process 15871
    cellular process 15001
      cellular component organization or biogenesis 6443
        cellular component organization 6231
          organelle organization 3482
            cytoskeleton organization 1461
              microtubule cytoskeleton organization 656
                microtubule polymerization or depolymerization 139
                  microtubule polymerization 91
                    microtubule nucleation 36
                      chromatin-templated microtubule nucleation 0
                      microtubule nucleation by microtubule organizing center + 5
                      mitotic spindle-templated microtubule nucleation 0
                      negative regulation of microtubule nucleation 1
                      positive regulation of microtubule nucleation + 7
                      regulation of microtubule nucleation + 10
paths to the root