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ONTOLOGY REPORT - ANNOTATIONS


Term:microtubule nucleation
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Accession:GO:0007020 term browser browse the term
Definition:The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).
Synonyms:xref: Wikipedia:Microtubule_nucleation



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microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap9 A-kinase anchoring protein 9 involved_in ISO (PMID:19242490) RGD PMID:19242490 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
JBrowse link
G Ccdc57 coiled-coil domain containing 57 involved_in ISO (PMID:32402286) RGD PMID:32402286 NCBI chr10:106,092,784...106,196,405
Ensembl chr10:106,092,947...106,196,077
JBrowse link
G Clasp1 cytoplasmic linker associated protein 1 involved_in ISO (PMID:17543864) RGD PMID:17543864 NCBI chr13:29,493,554...29,715,151
Ensembl chr13:29,493,596...29,715,146
JBrowse link
G Clasp2 cytoplasmic linker associated protein 2 involved_in ISO
ISS
(PMID:17543864)
GO_REF:0000024
RGD
UniProt
PMID:17543864 GO_REF:0000024 NCBI chr 8:113,677,345...113,859,957
Ensembl chr 8:113,677,284...113,858,731
JBrowse link
G Csnk1d casein kinase 1, delta involved_in ISO (PMID:24648492) RGD PMID:24648492 NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614
JBrowse link
G Golga2 golgin A2 involved_in ISS
ISO
GO_REF:0000024
(PMID:19242490), (PMID:26165940)
UniProt
RGD
PMID:19242490 PMID:26165940 GO_REF:0000024 NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279
JBrowse link
G Haus2 HAUS augmin like complex subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:107,553,094...107,565,982
Ensembl chr 3:107,553,161...107,565,157
JBrowse link
G Nde1 nudE neurodevelopment protein 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:1928549|PMID:11163258)
RGD PMID:11163258 PMID:21873635 MGI:1928549, RGD:13792537 NCBI chr10:839,788...883,946
Ensembl chr10:839,788...883,869
JBrowse link
G Ndel1 nudE neurodevelopment protein 1-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:53,505,628...53,582,025
Ensembl chr10:53,516,491...53,570,907
JBrowse link
G Slain1 SLAIN motif family, member 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:80,482,818...80,542,461
Ensembl chr15:80,482,367...80,542,350
JBrowse link
G Slain2 SLAIN motif family, member 2 involved_in ISO
IBA
(PMID:21646404)
PMID:21873635
RGD PMID:21646404 PMID:21873635 RGD:13792537 NCBI chr14:35,236,034...35,314,186
Ensembl chr14:35,236,041...35,304,678
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor involved_in ISO (PMID:26414402) RGD PMID:26414402 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
JBrowse link
G Tubg1 tubulin, gamma 1 involved_in TAS
IBA
PMID:21873635 RGD
GO_Central
PMID:10470852 PMID:21873635 RGD:634415, RGD:13792537 NCBI chr10:86,052,845...86,059,436
Ensembl chr10:86,052,743...86,059,433
JBrowse link
G Tubg2 tubulin, gamma 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:86,091,205...86,108,053
Ensembl chr10:86,091,188...86,097,580
JBrowse link
G Tubgcp2 tubulin, gamma complex associated protein 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:194,791,113...194,817,807
Ensembl chr 1:194,792,142...194,817,619
JBrowse link
G Tubgcp3 tubulin, gamma complex associated protein 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:76,851,859...76,912,499
Ensembl chr16:76,851,810...76,912,499
JBrowse link
G Tubgcp4 tubulin, gamma complex associated protein 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:108,141,081...108,172,207
Ensembl chr 3:108,141,625...108,169,437
JBrowse link
G Tubgcp5 tubulin, gamma complex associated protein 5 involved_in ISO
IBA
(PMID:11694571)
PMID:21873635
RGD PMID:11694571 PMID:21873635 RGD:13792537 NCBI chr 1:106,636,526...106,672,175
Ensembl chr 1:106,636,526...106,672,175
JBrowse link
G Tubgcp6 tubulin, gamma complex associated protein 6 involved_in ISO
IBA
(PMID:11694571)
PMID:21873635
RGD PMID:11694571 PMID:21873635 RGD:13792537 NCBI chr 7:120,177,686...120,198,986
Ensembl chr 7:120,177,686...120,199,011
JBrowse link
astral microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpj centromere protein J acts_upstream_of_or_within ISO (PMID:11003675) RGD PMID:11003675 NCBI chr15:30,626,946...30,690,384
Ensembl chr15:30,627,224...30,686,791
JBrowse link
centrosome-templated microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cep192 centrosomal protein 192 involved_in ISO
IBA
(PMID:17980596)
PMID:21873635
RGD PMID:17980596 PMID:21873635 RGD:13792537 NCBI chr18:61,346,957...61,458,405
Ensembl chr18:61,332,158...61,458,379
JBrowse link
G Nin ninein involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3575622|PMID:15784680)
RGD PMID:15784680 PMID:21873635 MGI:3575622, RGD:13792537 NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639
JBrowse link
microtubule nucleation by interphase microtubule organizing center term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mzt1 mitotic spindle organizing protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:75,786,992...75,797,631 JBrowse link
microtubule nucleation by microtubule organizing center term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tppp tubulin polymerization promoting protein involved_in ISO
ISS
(PMID:31522887)
GO_REF:0000024
RGD
UniProt
PMID:31522887 GO_REF:0000024 NCBI chr 1:29,257,111...29,281,134
Ensembl chr 1:29,261,255...29,281,134
JBrowse link
negative regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef7 Rho guanine nucleotide exchange factor 7 involved_in ISS
ISO
GO_REF:0000024
(PMID:27012601)
UniProt
RGD
PMID:27012601 GO_REF:0000024 NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697
JBrowse link
positive regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckap5 cytoskeleton associated protein 5 involved_in ISO (PMID:26414402) RGD PMID:26414402 NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264
JBrowse link
G Dctn1 dynactin subunit 1 involved_in ISO
ISS
(PMID:23874158)
GO_REF:0000024
RGD
UniProt
PMID:23874158 GO_REF:0000024 NCBI chr 4:115,671,024...115,703,824
Ensembl chr 4:115,661,638...115,703,815
JBrowse link
G Git1 GIT ArfGAP 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:27012601)
UniProt
Ensembl
RGD
PMID:27012601 GO_REF:0000024 GO_REF:0000107 NCBI chr10:62,342,082...62,356,379
Ensembl chr10:62,342,299...62,356,373
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISS
ISO
GO_REF:0000024
(PMID:27137183)
UniProt
RGD
PMID:27137183 GO_REF:0000024
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISS
ISO
GO_REF:0000024
(PMID:27137183)
UniProt
RGD
PMID:27137183 GO_REF:0000024 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G LOC108348108 heat shock 70 kDa protein 1A involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr20:3,870,765...3,873,221 JBrowse link
G Mecp2 methyl CpG binding protein 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:25527496)
Ensembl
RGD
PMID:25527496 GO_REF:0000107 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 involved_in ISO
ISS
(PMID:27012601)
GO_REF:0000024
RGD
UniProt
PMID:27012601 GO_REF:0000024 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein involved_in ISO (PMID:29162697) RGD PMID:29162697 NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379
JBrowse link
regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eml2 EMAP like 2 involved_in ISO
ISS
(PMID:11694528)
GO_REF:0000024
RGD
UniProt
PMID:11694528 GO_REF:0000024 NCBI chr 1:78,827,595...78,859,343
Ensembl chr 1:78,828,080...78,859,341
JBrowse link
regulation of microtubule nucleation by Ran protein signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rangrf RAN guanine nucleotide release factor involved_in ISO (PMID:29040603) RGD PMID:29040603 NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19541
    cellular process 18407
      microtubule-based process 955
        microtubule cytoskeleton organization 651
          microtubule nucleation 36
            chromatin-templated microtubule nucleation 0
            microtubule nucleation by microtubule organizing center + 5
            mitotic spindle-templated microtubule nucleation 0
            negative regulation of microtubule nucleation 1
            positive regulation of microtubule nucleation + 9
            regulation of microtubule nucleation + 12
Path 2
Term Annotations click to browse term
  biological_process 19541
    cellular process 18407
      cellular component organization or biogenesis 6664
        cellular component biogenesis 3394
          cellular component assembly 3103
            protein-containing complex assembly 1591
              cellular protein-containing complex assembly 1099
                protein polymerization 287
                  microtubule polymerization 88
                    microtubule nucleation 36
                      chromatin-templated microtubule nucleation 0
                      microtubule nucleation by microtubule organizing center + 5
                      mitotic spindle-templated microtubule nucleation 0
                      negative regulation of microtubule nucleation 1
                      positive regulation of microtubule nucleation + 9
                      regulation of microtubule nucleation + 12
paths to the root