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ONTOLOGY REPORT - ANNOTATIONS


Term:microtubule nucleation
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Accession:GO:0007020 term browser browse the term
Definition:The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).
Synonyms:xref: Wikipedia:Microtubule_nucleation



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microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC125920.1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr19:54,975,097...54,975,705 JBrowse link
G Akap9 A-kinase anchoring protein 9 involved_in ISO (PMID:19242490) RGD PMID:19242490 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
JBrowse link
G Ccdc57 coiled-coil domain containing 57 involved_in ISO
IBA
(PMID:32402286)
GO_REF:0000033
RGD
GO_Central
PMID:32402286 GO_REF:0000033 NCBI chr10:106,092,784...106,196,405
Ensembl chr10:106,092,947...106,196,077
JBrowse link
G Clasp1 cytoplasmic linker associated protein 1 involved_in ISO (PMID:17543864) RGD PMID:17543864 NCBI chr13:29,493,554...29,715,151
Ensembl chr13:29,493,596...29,715,146
JBrowse link
G Clasp2 cytoplasmic linker associated protein 2 involved_in ISO
ISS
(PMID:17543864)
GO_REF:0000024
RGD
UniProt
PMID:17543864 GO_REF:0000024 NCBI chr 8:113,677,345...113,859,957
Ensembl chr 8:113,677,284...113,858,731
JBrowse link
G Csnk1d casein kinase 1, delta acts_upstream_of_or_within ISO (PMID:24648492) RGD PMID:24648492 NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614
JBrowse link
G Golga2 golgin A2 involved_in ISS
ISO
GO_REF:0000024
(PMID:19242490), (PMID:26165940)
UniProt
RGD
PMID:19242490 PMID:26165940 GO_REF:0000024 NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279
JBrowse link
G Haus2 HAUS augmin like complex subunit 2 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 3:107,553,146...107,565,982
Ensembl chr 3:107,553,161...107,565,157
JBrowse link
G Haus2-ps1 HAUS augmin like complex subunit 2, pseudogene 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr19:54,975,001...54,975,705
Ensembl chr19:54,975,097...54,975,705
JBrowse link
G Nde1 nudE neurodevelopment protein 1 acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
(MGI:1928549|PMID:11163258)
GO_REF:0000118
GO_REF:0000033
GO_REF:0000107
RGD
TreeGrafter
GO_Central
Ensembl
PMID:11163258 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:1928549 NCBI chr10:839,788...883,946
Ensembl chr10:839,788...883,869
JBrowse link
G Ndel1 nudE neurodevelopment protein 1-like 1 involved_in IEA
IBA
GO_REF:0000118
GO_REF:0000033
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr10:53,505,628...53,582,025
Ensembl chr10:53,516,491...53,570,907
JBrowse link
G Nedd1 NEDD1 gamma-tubulin ring complex targeting factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:27,233,050...27,274,486
Ensembl chr 7:27,233,316...27,274,486
JBrowse link
G Slain1 SLAIN motif family, member 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr15:80,482,818...80,542,461
Ensembl chr15:80,482,367...80,542,350
JBrowse link
G Slain2 SLAIN motif family, member 2 involved_in ISO
IBA
(PMID:21646404)
GO_REF:0000033
RGD
GO_Central
PMID:21646404 GO_REF:0000033 NCBI chr14:35,236,034...35,314,186
Ensembl chr14:35,236,041...35,304,678
JBrowse link
G Ssna1 SS nuclear autoantigen 1 involved_in ISO (PMID:34970964) RGD PMID:34970964 NCBI chr 3:8,084,949...8,086,417
Ensembl chr 3:8,084,974...8,086,356
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor involved_in ISO (PMID:26414402) RGD PMID:26414402 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
JBrowse link
G Tubg1 tubulin, gamma 1 involved_in TAS
IBA
GO_REF:0000033 GO_Central
RGD
PMID:10470852 GO_REF:0000033, RGD:634415 NCBI chr10:86,052,845...86,059,436
Ensembl chr10:86,052,743...86,059,433
JBrowse link
G Tubg2 tubulin, gamma 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:86,091,205...86,108,053
Ensembl chr10:86,091,188...86,097,580
JBrowse link
G Tubgcp2 tubulin gamma complex component 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:194,791,113...194,817,807
Ensembl chr 1:194,792,142...194,817,619
JBrowse link
G Tubgcp3 tubulin gamma complex component 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:76,851,859...76,912,499
Ensembl chr16:76,851,810...76,912,499
JBrowse link
G Tubgcp4 tubulin gamma complex component 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:108,141,081...108,172,207
Ensembl chr 3:108,141,625...108,169,437
JBrowse link
G Tubgcp5 tubulin gamma complex component 5 involved_in ISO
IBA
(PMID:11694571)
GO_REF:0000033
RGD
GO_Central
PMID:11694571 GO_REF:0000033 NCBI chr 1:106,636,526...106,672,175
Ensembl chr 1:106,636,526...106,672,175
JBrowse link
G Tubgcp6 tubulin gamma complex component 6 involved_in ISO
IBA
(PMID:11694571)
GO_REF:0000033
RGD
GO_Central
PMID:11694571 GO_REF:0000033 NCBI chr 7:120,177,686...120,198,986
Ensembl chr 7:120,177,686...120,199,011
JBrowse link
astral microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpj centromere protein J acts_upstream_of_or_within ISO (PMID:11003675) RGD PMID:11003675 NCBI chr15:30,627,206...30,690,384
Ensembl chr15:30,627,224...30,686,791
JBrowse link
centrosome-templated microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cep192 centrosomal protein 192 involved_in ISO (PMID:17980596) RGD PMID:17980596 NCBI chr18:61,373,937...61,458,405
Ensembl chr18:61,332,158...61,458,379
JBrowse link
G Nin ninein acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:3575622|PMID:15784680)
GO_REF:0000033
RGD
GO_Central
PMID:15784680 GO_REF:0000033 MGI:3575622 NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639
JBrowse link
microtubule nucleation by interphase microtubule organizing center term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mzt1 mitotic spindle organizing protein 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:75,787,281...75,797,589
Ensembl chr15:75,786,994...75,797,589
JBrowse link
microtubule nucleation by microtubule organizing center term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tppp tubulin polymerization promoting protein involved_in ISO
IEA
ISS
(PMID:31522887)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:31522887 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:29,257,111...29,281,134
Ensembl chr 1:29,261,255...29,281,134
JBrowse link
negative regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef7 Rho guanine nucleotide exchange factor 7 involved_in ISS
ISO
GO_REF:0000024
(PMID:27012601)
UniProt
RGD
PMID:27012601 GO_REF:0000024 NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697
JBrowse link
positive regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckap5 cytoskeleton associated protein 5 involved_in ISO (PMID:26414402) RGD PMID:26414402 NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264
JBrowse link
G Dctn1 dynactin subunit 1 involved_in ISO
ISS
IEA
(PMID:23874158)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:23874158 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:115,671,024...115,703,824
Ensembl chr 4:115,661,638...115,703,815
JBrowse link
G Git1 GIT ArfGAP 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:27012601)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:27012601 GO_REF:0000024 GO_REF:0000107 NCBI chr10:62,342,082...62,356,379
Ensembl chr10:62,342,299...62,356,373
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO
ISS
(PMID:27137183)
GO_REF:0000024
RGD
UniProt
PMID:27137183 GO_REF:0000024 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISS
ISO
GO_REF:0000024
(PMID:27137183)
UniProt
RGD
PMID:27137183 GO_REF:0000024 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Mecp2 methyl CpG binding protein 2 involved_in ISO (PMID:25527496) RGD PMID:25527496 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 involved_in ISO
ISS
(PMID:27012601)
GO_REF:0000024
RGD
UniProt
PMID:27012601 GO_REF:0000024 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein involved_in ISO
IBA
IEA
(PMID:29162697)
GO_REF:0000033
GO_REF:0000118
RGD
GO_Central
TreeGrafter
PMID:29162697 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379
JBrowse link
regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eml2 EMAP like 2 involved_in ISO
IEA
ISS
(PMID:11694528)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:11694528 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341
JBrowse link
G Nme7 NME/NM23 family member 7 involved_in IEA
ISO
GO_REF:0000107
(PMID:24807905)
Ensembl
RGD
PMID:24807905 GO_REF:0000107 NCBI chr13:76,657,303...76,786,768
Ensembl chr13:76,657,367...76,786,765
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20325
    cellular process 18797
      microtubule-based process 1059
        microtubule cytoskeleton organization 738
          microtubule nucleation 39
            chromatin-templated microtubule nucleation 0
            microtubule nucleation by microtubule organizing center + 5
            mitotic spindle-templated microtubule nucleation 0
            negative regulation of microtubule nucleation 1
            positive regulation of microtubule nucleation + 8
            regulation of microtubule nucleation + 11
Path 2
Term Annotations click to browse term
  biological_process 20325
    cellular process 18797
      cellular component organization or biogenesis 7201
        cellular component organization 6891
          organelle organization 3829
            cytoskeleton organization 1632
              microtubule cytoskeleton organization 738
                microtubule polymerization or depolymerization 148
                  microtubule polymerization 95
                    microtubule nucleation 39
                      chromatin-templated microtubule nucleation 0
                      microtubule nucleation by microtubule organizing center + 5
                      mitotic spindle-templated microtubule nucleation 0
                      negative regulation of microtubule nucleation 1
                      positive regulation of microtubule nucleation + 8
                      regulation of microtubule nucleation + 11
paths to the root