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ONTOLOGY REPORT - ANNOTATIONS


Term:telomere maintenance via telomerase
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Accession:GO:0007004 term browser browse the term
Definition:The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.
Synonyms:exact_synonym: telomerase-dependent telomere maintenance


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telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD, shelterin complex subunit and telomerase recruitment factor involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr19:33,586,739...33,589,481
Ensembl chr19:33,586,745...33,589,461
JBrowse link
G Dkc1 dyskerin pseudouridine synthase 1 involved_in ISO
ISS
GO:0090669 (PMID:23685356), (PMID:26950371), (PMID:29695869)
GO_REF:0000024
RGD
UniProt
PMID:23685356 PMID:26950371 PMID:29695869 GO_REF:0000024
G Gar1 GAR1 ribonucleoprotein involved_in ISS
ISO
GO_REF:0000024
(PMID:29695869)
UniProt
RGD
PMID:29695869 GO_REF:0000024 NCBI chr 2:218,375,231...218,382,509
Ensembl chr 2:218,375,353...218,382,524
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 involved_in ISO (PMID:10197982) RGD PMID:10197982 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 involved_in ISO (PMID:10197982) RGD PMID:10197982 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Nhp2 NHP2 ribonucleoprotein involved_in ISO (PMID:29695869) RGD PMID:29695869 NCBI chr10:35,877,015...35,880,409
Ensembl chr10:35,877,054...35,882,545
JBrowse link
G Nop10 NOP10 ribonucleoprotein involved_in ISO (PMID:29695869) RGD PMID:29695869 NCBI chr 3:99,066,857...99,067,942
Ensembl chr 3:99,066,857...99,067,942
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 NOT|acts_upstream_of_or_within ISO MGI:109573 (MGI:3045914|PMID:15169895) RGD PMID:15169895 MGI:3045914 NCBI chr15:30,690,503...30,792,868 JBrowse link
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 acts_upstream_of_or_within ISO (PMID:11701125) RGD PMID:11701125 NCBI chr15:38,098,027...38,157,143
Ensembl chr15:38,097,886...38,157,140
JBrowse link
G Pot1 protection of telomeres 1 involved_in ISO (PMID:12768206) RGD PMID:12768206 NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042
JBrowse link
G Ptges3 prostaglandin E synthase 3 involved_in ISO
IBA
(PMID:10197982), (PMID:19740745)
(MGI:5819359|PMID:10197982)
PMID:21873635
RGD PMID:10197982 PMID:19740745 PMID:21873635 MGI:5819359, RGD:13792537 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
JBrowse link
G Ptges3l1 prostaglandin E synthase 3-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:42,215,200...42,224,472
Ensembl chr  X:42,214,756...42,225,047
JBrowse link
G Rad50 RAD50 double strand break repair protein involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:9705271)
UniProt
RGD
PMID:9705271 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
JBrowse link
G Rpa1 replication protein A1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G Telo2 telomere maintenance 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:14,120,491...14,135,729
Ensembl chr10:14,120,818...14,135,698
JBrowse link
G Tep1 telomerase associated protein 1 NOT|acts_upstream_of_or_within ISO MGI:2685589 (MGI:3045914|PMID:15169895) RGD PMID:15169895 MGI:3045914 NCBI chr15:24,045,876...24,093,526
Ensembl chr15:24,045,878...24,093,526
JBrowse link
G Terc telomerase RNA component acts_upstream_of_or_within TAS
ISO
MGI:1857930 (MGI:1097832|PMID:9335332) RGD PMID:9335332 PMID:10423530 MGI:1097832, RGD:1299555 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Terf1 telomeric repeat binding factor 1 involved_in ISO
IBA
(PMID:9034193)
PMID:21873635
(PMID:23685356)
RGD PMID:9034193 PMID:23685356 PMID:21873635 RGD:13792537 NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340
JBrowse link
G Tert telomerase reverse transcriptase involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:16043710), (PMID:17940095), (PMID:19701182), (PMID:21531765), (PMID:29695869), (PMID:9443919), (PMID:9454332)
UniProt
RGD
PMID:9443919 PMID:9454332 PMID:16043710 PMID:17940095 PMID:19701182 More... GO_REF:0000024, RGD:13792537 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Wrap53 WD repeat containing, antisense to TP53 involved_in ISS
ISO
GO_REF:0000024
(PMID:23685356), (PMID:29695869), (PMID:29804836)
UniProt
RGD
PMID:23685356 PMID:29695869 PMID:29804836 GO_REF:0000024 NCBI chr10:54,282,092...54,299,908
Ensembl chr10:54,282,105...54,298,929
JBrowse link
negative regulation of telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD, shelterin complex subunit and telomerase recruitment factor involved_in ISO
IBA
UniProtKB:Q9NUX5 (PMID:15181449), (PMID:15380063)
PMID:21873635
RGD PMID:15181449 PMID:15380063 PMID:21873635 RGD:13792537 NCBI chr19:33,586,739...33,589,481
Ensembl chr19:33,586,745...33,589,461
JBrowse link
G Ctc1 CST telomere replication complex component 1 involved_in ISO (PMID:22763445) RGD PMID:22763445 NCBI chr10:53,714,614...53,735,298
Ensembl chr10:53,714,644...53,735,298
JBrowse link
G Dcp2 decapping mRNA 2 involved_in ISO (PMID:26950371) RGD PMID:26950371 NCBI chr18:36,750,732...36,787,067
Ensembl chr18:36,750,732...36,788,557
JBrowse link
G Exosc10 exosome component 10 involved_in ISO (PMID:26950371) RGD PMID:26950371 NCBI chr 5:158,995,318...159,018,946
Ensembl chr 5:158,995,313...159,018,940
JBrowse link
G Gnl3l G protein nucleolar 3 like involved_in ISO (PMID:18082603) RGD PMID:18082603 NCBI chr  X:19,961,277...19,994,454
Ensembl chr  X:19,958,603...19,994,508
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 involved_in ISO (PMID:23935072) RGD PMID:23935072 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C involved_in ISO (PMID:18082603) RGD PMID:18082603 NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U involved_in IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:18082603)
Ensembl
RGD
PMID:18082603 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588
JBrowse link
G Nat10 N-acetyltransferase 10 involved_in ISO (PMID:18082603) RGD PMID:18082603 NCBI chr 3:90,111,643...90,151,644
Ensembl chr 3:90,111,645...90,149,927
JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase involved_in ISO (PMID:23657261) RGD PMID:23657261 NCBI chr 8:66,110,641...66,120,202
Ensembl chr 8:66,111,072...66,120,200
JBrowse link
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 involved_in ISO (PMID:11701125), (PMID:21119197) RGD PMID:11701125 PMID:21119197 NCBI chr15:38,098,027...38,157,143
Ensembl chr15:38,097,886...38,157,140
JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (PMID:19567472) RGD PMID:19567472 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Pot1 protection of telomeres 1 involved_in ISO UniProtKB:Q96AP0 (PMID:15181449) RGD PMID:15181449 NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stn1 STN1 subunit of CST complex involved_in ISO
IEA
(PMID:22763445)
GO_REF:0000107
RGD
Ensembl
PMID:22763445 GO_REF:0000107 NCBI chr 1:246,391,311...246,429,844
Ensembl chr 1:246,395,613...246,429,531
JBrowse link
G Ten1 TEN1 subunit of CST complex involved_in IBA
ISO
PMID:21873635
(PMID:22763445)
RGD PMID:22763445 PMID:21873635 RGD:13792537 NCBI chr10:101,431,328...101,455,105
Ensembl chr10:101,431,328...101,453,052
JBrowse link
G Tent4b terminal nucleotidyltransferase 4B involved_in ISO (PMID:26950371) RGD PMID:26950371 NCBI chr19:18,807,616...18,868,969
Ensembl chr19:18,807,525...18,869,537
JBrowse link
G Terf1 telomeric repeat binding factor 1 involved_in ISO UniProtKB:O14746 (PMID:11971978) RGD PMID:11971978 NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340
JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:11971978), (PMID:17055345) RGD PMID:11971978 PMID:17055345 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819
JBrowse link
G Tinf2 TERF1 interacting nuclear factor 2 involved_in ISO (PMID:10581025), (PMID:15133513) RGD PMID:10581025 PMID:15133513 NCBI chr15:29,170,663...29,178,015
Ensembl chr15:29,170,652...29,176,984
JBrowse link
positive regulation of telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD, shelterin complex subunit and telomerase recruitment factor involved_in ISO (PMID:17237768) RGD PMID:17237768 NCBI chr19:33,586,739...33,589,481
Ensembl chr19:33,586,745...33,589,461
JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (MGI:5705431|PMID:26586427) RGD PMID:26586427 MGI:5705431 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atr ATR serine/threonine kinase involved_in ISO (MGI:5705431|PMID:26586427) RGD PMID:26586427 MGI:5705431 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Aurkb aurora kinase B involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 involved_in ISO (PMID:25467444) RGD PMID:25467444 NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 involved_in ISO (PMID:25467444) RGD PMID:25467444 NCBI chr 2:173,765,792...173,790,353
Ensembl chr 2:173,765,698...173,790,757
JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 involved_in ISO (PMID:25467444) RGD PMID:25467444 NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 involved_in ISO (PMID:25467444) RGD PMID:25467444 NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A involved_in ISO (PMID:25467444) RGD PMID:25467444 NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 involved_in ISO (PMID:25467444) RGD PMID:25467444 NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 involved_in ISO (PMID:25467444) RGD PMID:25467444 NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079
JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
(MGI:5428344|PMID:22723415)
Ensembl
RGD
PMID:22723415 GO_REF:0000107 MGI:5428344 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Dkc1 dyskerin pseudouridine synthase 1 acts_upstream_of_or_within ISO MGI:3849598 (MGI:3047190|PMID:15240872) RGD PMID:15240872 MGI:3047190
G Fbxo4 F-box protein 4 involved_in ISO (PMID:16275645) RGD PMID:16275645 NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792
JBrowse link
G Hmbox1 homeobox containing 1 involved_in ISO (PMID:23685356) RGD PMID:23685356 NCBI chr15:39,067,805...39,200,633
Ensembl chr15:39,067,804...39,200,323
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 involved_in ISO (PMID:23935072) RGD PMID:23935072 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 involved_in ISO
IEA
(PMID:21531765)
GO_REF:0000107
RGD
Ensembl
PMID:21531765 GO_REF:0000107 NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358
JBrowse link
G Mapk1 mitogen activated protein kinase 1 involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk15 mitogen-activated protein kinase 15 involved_in ISO
IEA
(PMID:21531765)
GO_REF:0000107
RGD
Ensembl
PMID:21531765 GO_REF:0000107 NCBI chr 7:107,694,907...107,714,640
Ensembl chr 7:107,694,964...107,714,645
JBrowse link
G Mapk3 mitogen activated protein kinase 3 involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052
JBrowse link
G Nek2 NIMA-related kinase 2 involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
JBrowse link
G Nek7 NIMA-related kinase 7 involved_in ISO
IEA
(PMID:21531765)
GO_REF:0000107
RGD
Ensembl
PMID:21531765 GO_REF:0000107 NCBI chr13:50,022,212...50,149,374
Ensembl chr13:50,022,218...50,149,296
JBrowse link
G Parn poly(A)-specific ribonuclease involved_in ISO (PMID:26482878), (PMID:26950371) RGD PMID:26482878 PMID:26950371 NCBI chr10:1,410,636...1,548,573
Ensembl chr10:1,410,642...1,548,560
JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta involved_in ISO
IEA
(PMID:21531765)
GO_REF:0000107
RGD
Ensembl
PMID:21531765 GO_REF:0000107 NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187
JBrowse link
G Pnkp polynucleotide kinase 3'-phosphatase involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr 1:95,341,465...95,346,921
Ensembl chr 1:95,341,620...95,346,920
JBrowse link
G Pot1 protection of telomeres 1 involved_in ISO (PMID:12768206), (PMID:12781132), (PMID:17237768) RGD PMID:12768206 PMID:12781132 PMID:17237768 NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042
JBrowse link
G Prkcq protein kinase C, theta involved_in ISO
IEA
(PMID:21531765)
GO_REF:0000107
RGD
Ensembl
PMID:21531765 GO_REF:0000107 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
JBrowse link
G Tcp1 t-complex 1 involved_in ISO (PMID:25467444) RGD PMID:25467444 NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839
JBrowse link
G Terc telomerase RNA component acts_upstream_of_or_within ISO MGI:1857930 (MGI:3774867|PMID:17982445) RGD PMID:17982445 MGI:3774867 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Tnks tankyrase involved_in ISO (PMID:11739745), (PMID:12782650), (PMID:18221737) RGD PMID:11739745 PMID:12782650 PMID:18221737 NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 involved_in ISO (PMID:19188702) RGD PMID:19188702 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
JBrowse link
regulation of telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO UniProtKB:Q9NUX5 (PMID:26586433) RGD PMID:26586433 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Pot1 protection of telomeres 1 involved_in IBA
ISO
PMID:21873635
UniProtKB:Q13315 (PMID:26586433)
RGD PMID:26586433 PMID:21873635 RGD:13792537 NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042
JBrowse link
G Pot1b protection of telomeres 1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:9,670,355...9,728,624
Ensembl chr 9:9,670,362...9,728,532
JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO
IBA
(PMID:19864690), (PMID:23685356)
PMID:21873635
RGD PMID:19864690 PMID:23685356 PMID:21873635 RGD:13792537 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      primary metabolic process 10531
        nucleobase-containing compound metabolic process 5380
          nucleobase-containing compound biosynthetic process 3736
            DNA biosynthetic process 183
              RNA-dependent DNA biosynthetic process 65
                telomere maintenance via telomerase 65
                  negative regulation of telomere maintenance via telomerase 20
                  positive regulation of telomere maintenance via telomerase 33
                  regulation of telomere maintenance via telomerase + 51
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      cellular metabolic process 10721
        heterocycle metabolic process 5522
          nucleobase-containing compound metabolic process 5380
            nucleic acid metabolic process 4890
              DNA metabolic process 883
                telomere maintenance 128
                  telomere maintenance via telomere lengthening 79
                    telomere maintenance via telomerase 65
                      negative regulation of telomere maintenance via telomerase 20
                      positive regulation of telomere maintenance via telomerase 33
                      regulation of telomere maintenance via telomerase + 51
paths to the root