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ONTOLOGY REPORT - ANNOTATIONS


Term:response to sterol depletion
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Accession:GO:0006991 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
Synonyms:exact_synonym: sterol depletion response


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response to sterol depletion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insig1 insulin induced gene 1 ISO (MGI:MGI:2388133|PMID:12242332) RGD PMID:12242332 MGI:MGI:2388133 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insig2 insulin induced gene 2 ISO (MGI:MGI:2388215|PMID:12354157) RGD PMID:12354157 MGI:MGI:2388215 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IEP RGD PMID:10330413 RGD:2303706 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 ISO
ISS
(PMID:25035345), (PMID:29146937)
GO_REF:0000024
RGD
UniProt
PMID:25035345, PMID:29146937 GO_REF:0000024 NCBI chr15:27,852,152...27,855,999
Ensembl chr15:27,852,154...27,855,999
JBrowse link
cellular response to sterol depletion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 ISO (PMID:19325169) RGD PMID:19325169 NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694
JBrowse link
positive regulation of SREBP signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spring1 SREBF pathway regulator in golgi 1 ISO (PMID:32111832)
(MGI:MGI:6401656|PMID:32111832)
RGD PMID:32111832 MGI:MGI:6401656 NCBI chr12:43,920,564...43,940,798
Ensembl chr12:43,920,564...43,940,798
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B ISO (MGI:MGI:6120228|PMID:29420538) RGD PMID:29420538 MGI:MGI:6120228 NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704
JBrowse link
positive regulation of sterol regulatory element binding protein cleavage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat3 lysophosphatidylcholine acyltransferase 3 ISS
ISO
GO_REF:0000024
(MGI:MGI:5927299|PMID:28846071)
UniProt
RGD
PMID:28846071 GO_REF:0000024, MGI:MGI:5927299 NCBI chr 4:157,181,722...157,222,997
Ensembl chr 4:157,181,795...157,222,996
JBrowse link
regulation of SREBP signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor ISO (MGI:MGI:6276494|PMID:22863805) RGD PMID:22863805 MGI:MGI:6276494 NCBI chr19:11,473,538...11,509,500
Ensembl chr19:11,473,541...11,508,102
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 ISO MGI:MGI:4456438 (MGI:MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:MGI:5914333 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297
JBrowse link
SREBP signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07060293.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 4:66,336,143...66,336,901 JBrowse link
G Arhgef10l Rho guanine nucleotide exchange factor 10 like ISO
IBA
(PMID:16112081)
PMID:21873635
RGD PMID:16112081, PMID:21873635 RGD:13792537 NCBI chr 5:159,018,373...159,089,383
Ensembl chr 5:159,018,893...159,119,171
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO (MGI:MGI:3815371|PMID:18852460) RGD PMID:18852460 MGI:MGI:3815371 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:3815371|PMID:18852460) RGD PMID:18852460 MGI:MGI:3815371 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Erlin1 ER lipid raft associated 1 ISO
IBA
(PMID:24217618)
PMID:21873635
RGD PMID:24217618, PMID:21873635 RGD:13792537 NCBI chr 1:263,810,439...263,845,762
Ensembl chr 1:263,810,439...263,845,762
JBrowse link
G Erlin2 ER lipid raft associated 2 ISO
IBA
(PMID:24217618)
PMID:21873635
RGD PMID:24217618, PMID:21873635 RGD:13792537 NCBI chr16:69,179,005...69,195,452
Ensembl chr16:69,179,588...69,195,097
JBrowse link
G Insig1 insulin induced gene 1 IBA
ISO
PMID:21873635
(PMID:12242332), (PMID:32322062)
RGD PMID:12242332, PMID:32322062, PMID:21873635 RGD:13792537 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insig2 insulin induced gene 2 IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:12242332), (PMID:17428920), (PMID:32322062)
UniProt
RGD
PMID:12242332, PMID:17428920, PMID:32322062, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link
G Scap SREBF chaperone ISO
ISS
(PMID:11726962), (PMID:32322062)
GO_REF:0000024
RGD
UniProt
PMID:11726962, PMID:32322062 GO_REF:0000024 NCBI chr 8:118,551,869...118,628,650
Ensembl chr 8:118,570,503...118,628,651
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO
ISS
(PMID:27614840), (PMID:32322062)
GO_REF:0000024
RGD
UniProt
PMID:27614840, PMID:32322062 GO_REF:0000024 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:27614840), (PMID:32322062)
Ensembl
UniProt
RGD
PMID:27614840, PMID:32322062 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07060293.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 4:66,336,143...66,336,901 JBrowse link
G Insig1 insulin induced gene 1 IBA
ISO
PMID:21873635
(PMID:12202038), (PMID:32322062)
RGD PMID:12202038, PMID:32322062, PMID:21873635 RGD:13792537 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insig2 insulin induced gene 2 IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:32322062)
UniProt
RGD
PMID:32322062, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to stress 4061
        response to sterol depletion 19
          cellular response to sterol depletion + 17
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.