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ONTOLOGY REPORT - ANNOTATIONS


Term:response to sterol depletion
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Accession:GO:0006991 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
Synonyms:exact_synonym: sterol depletion response



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response to sterol depletion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insig1 insulin induced gene 1 acts_upstream_of_or_within ISO (MGI:2388133|PMID:12242332) RGD PMID:12242332 MGI:2388133 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insig2 insulin induced gene 2 acts_upstream_of_or_within ISO (MGI:2388215|PMID:12354157) RGD PMID:12354157 MGI:2388215 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IEP RGD PMID:10330413 RGD:2303706 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:25035345), (PMID:29146937)
UniProt
RGD
PMID:25035345 PMID:29146937 GO_REF:0000024 NCBI chr15:24,146,854...24,150,739
Ensembl chr15:24,146,856...24,150,702
JBrowse link
cellular response to sterol depletion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 involved_in ISO (PMID:19325169) RGD PMID:19325169 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
JBrowse link
positive regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spring1 SREBF pathway regulator in golgi 1 involved_in ISO (PMID:32111832)
(MGI:6401656|PMID:32111832)
RGD PMID:32111832 MGI:6401656 NCBI chr12:38,308,731...38,329,175
Ensembl chr12:38,297,837...38,329,138
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:6120228|PMID:29420538) RGD PMID:29420538 MGI:6120228 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
JBrowse link
positive regulation of sterol regulatory element binding protein cleavage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5927299|PMID:28846071)
UniProt
RGD
PMID:28846071 GO_REF:0000024 MGI:5927299 NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880
JBrowse link
regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO (MGI:6276494|PMID:22863805) RGD PMID:22863805 MGI:6276494 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO MGI:4456438 (MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:5914333 NCBI chr12:32,052,542...32,061,596
Ensembl chr12:32,052,543...32,071,903
JBrowse link
SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef10l Rho guanine nucleotide exchange factor 10 like involved_in ISO
IBA
(PMID:16112081)
PMID:21873635
RGD PMID:16112081 PMID:21873635 RGD:13792537 NCBI chr 5:152,792,247...152,935,255
Ensembl chr 5:152,792,252...152,919,538
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A acts_upstream_of_or_within ISO (MGI:3815371|PMID:18852460) RGD PMID:18852460 MGI:3815371 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (MGI:3815371|PMID:18852460) RGD PMID:18852460 MGI:3815371 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO
IBA
(PMID:24217618)
PMID:21873635
RGD PMID:24217618 PMID:21873635 RGD:13792537 NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394
JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in IBA
ISO
PMID:21873635
(PMID:24217618)
RGD PMID:24217618 PMID:21873635 RGD:13792537 NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671
JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO
IBA
(PMID:12242332), (PMID:32322062)
PMID:21873635
RGD PMID:12242332 PMID:32322062 PMID:21873635 RGD:13792537 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insig2 insulin induced gene 2 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:12242332), (PMID:17428920), (PMID:32322062)
UniProt
RGD
PMID:12242332 PMID:17428920 PMID:32322062 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link
G LOC120102490 insulin-induced gene 1 protein-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:67,330,399...67,331,371
Ensembl chr 4:67,330,588...67,331,346
JBrowse link
G Scap SREBF chaperone involved_in ISO
ISS
(PMID:11726962), (PMID:32322062)
GO_REF:0000024
RGD
UniProt
PMID:11726962 PMID:32322062 GO_REF:0000024 NCBI chr 8:110,306,031...110,360,677
Ensembl chr 8:110,306,031...110,360,666
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in ISO
ISS
(PMID:32322062)
GO_REF:0000024
(PMID:27614840)
RGD
UniProt
PMID:27614840 PMID:32322062 GO_REF:0000024 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:27614840)
(PMID:32322062)
Ensembl
UniProt
RGD
PMID:27614840 PMID:32322062 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insig1 insulin induced gene 1 involved_in IBA
ISO
PMID:21873635
(PMID:12202038), (PMID:32322062)
RGD PMID:12202038 PMID:32322062 PMID:21873635 RGD:13792537 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insig2 insulin induced gene 2 involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:32322062)
UniProt
RGD
PMID:32322062 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link
G LOC120102490 insulin-induced gene 1 protein-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:67,330,399...67,331,371
Ensembl chr 4:67,330,588...67,331,346
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 20091
    response to stimulus 10574
      response to stress 4267
        response to sterol depletion 19
          cellular response to sterol depletion + 17
paths to the root