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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:ER-nucleus signaling pathway
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Accession:GO:0006984 term browser browse the term
Definition:The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.
Synonyms:exact_synonym: ER to nucleus signaling pathway;   ER to nucleus signalling pathway;   ER-nuclear signaling pathway;   ER-nuclear signalling pathway;   endoplasmic reticulum to nucleus signaling pathway;   endoplasmic reticulum-nuclear signaling pathway


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ER-nucleus signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14561754) Ensembl
MGI		 PMID:14561754 GO_REF:0000107 NCBI chr14:31,674,659...31,744,981
Ensembl chr14:31,674,757...31,744,969 		JBrowse link
ER overload response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG10 autophagy related 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:90,436,795...90,665,383
Ensembl chr 2:90,437,027...90,666,196 		JBrowse link
G CCDC47 coiled-coil domain containing 47 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17204322) Ensembl
MGI		 PMID:17204322 GO_REF:0000107 NCBI chr12:15,165,268...15,186,141
Ensembl chr12:15,165,405...15,192,356 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:11854325) RGD
MGI
TreeGrafter
GO_Central
Ensembl		 PMID:11158311 PMID:11854325 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:70575 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14744935) MGI
Ensembl		 PMID:14744935 GO_REF:0000107 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,569 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11854325) Ensembl
MGI		 PMID:11854325 GO_REF:0000107 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G INS insulin acts_upstream_of_or_within ISO (PMID:11854325) MGI PMID:11854325 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841 		JBrowse link
G PPP1R15B protein phosphatase 1 regulatory subunit 15B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14638860) Ensembl
MGI		 PMID:14638860 GO_REF:0000107 NCBI chr 9:65,056,495...65,069,083
Ensembl chr 9:65,056,398...65,066,775 		JBrowse link
G SELENOS selenoprotein S involved_in ISO (PMID:16574427)
(PMID:17210132)		 BHF-UCL PMID:16574427 PMID:17210132 NCBI chr 1:139,829,002...139,836,923
Ensembl chr 1:139,828,791...139,836,914 		JBrowse link
G TMCO1 transmembrane and coiled-coil domains 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:84,961,912...85,011,139
Ensembl chr 4:84,961,819...85,017,820 		JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14744935) MGI
Ensembl		 PMID:14744935 GO_REF:0000107 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6B activating transcription factor 6 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:24,153,551...24,171,743
Ensembl chr 7:24,161,061...24,171,709 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:4,362,678...4,405,185
Ensembl chr 8:4,362,680...4,385,273 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) ARUK-UCL PMID:27030769 MGI:5774886 NCBI chr 2:77,357,161...77,375,349
Ensembl chr 2:77,357,218...77,375,180 		JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:77,863,655...77,940,944
Ensembl chr13:77,863,701...77,945,468 		JBrowse link
G NCK2 NCK adaptor protein 2 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:49,063,813...49,222,274
Ensembl chr 3:49,063,991...49,198,664 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,130...52,086,736 		JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) UniProt PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G QRICH1 glutamine rich 1 involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chr13:31,663,812...31,714,523
Ensembl chr13:31,658,642...31,714,455 		JBrowse link
G RPAP2 RNA polymerase II associated protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:124,691,655...124,773,914
Ensembl chr 4:124,690,317...124,773,887 		JBrowse link
G TMED2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO (PMID:28797121) MGI PMID:28797121 NCBI chr14:29,390,903...29,400,454
Ensembl chr14:29,390,335...29,400,440 		JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304 		JBrowse link
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2L11 BCL2 like 11 ISO RGD PMID:25772147 RGD:13782257 NCBI chr 3:45,156,791...45,202,996
Ensembl chr 3:45,160,155...45,201,186 		JBrowse link
G BID BH3 interacting domain death agonist ISO RGD PMID:25772147 RGD:13782257 NCBI chr 5:69,849,007...69,874,647
Ensembl chr 5:69,849,002...69,875,853 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 ISO RGD PMID:25772147 RGD:13782257 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:86,042,070...86,053,893
Ensembl chr 9:86,041,369...86,053,857 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:140,171,134...140,184,126
Ensembl chr15:140,171,143...140,184,121 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,253...96,847,125 		JBrowse link
G TMEM33 transmembrane protein 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:33,012,540...33,036,448
Ensembl chr 8:33,012,390...33,036,993 		JBrowse link
positive regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR96 microRNA mir-96 involved_in ISO (PMID:30460077) BHF-UCL PMID:30460077 NCBI chr18:18,982,506...18,982,590
Ensembl chr18:18,982,506...18,982,590 		JBrowse link
G SPRING1 SREBF pathway regulator in golgi 1 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr14:35,705,901...36,061,831
Ensembl chr14:35,705,943...35,742,739 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,408...94,796,657 		JBrowse link
regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMFR autocrine motility factor receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:29,366,812...29,417,800
Ensembl chr 6:29,366,936...29,413,697 		JBrowse link
G TMED2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO (PMID:28797121) MGI PMID:28797121 NCBI chr14:29,390,903...29,400,454
Ensembl chr14:29,390,335...29,400,440 		JBrowse link
SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARHGEF10L Rho guanine nucleotide exchange factor 10 like involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:76,064,212...76,229,310
Ensembl chr 6:76,083,725...76,229,307 		JBrowse link
G EIF2A eukaryotic translation initiation factor 2A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18852460) Ensembl
MGI		 PMID:18852460 GO_REF:0000107 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (PMID:18852460) MGI PMID:18852460 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245 		JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in IEA TreeGrafter GO_REF:0000118
G ERLIN2 ER lipid raft associated 2 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr15:48,643,722...48,662,648
Ensembl chr15:48,643,724...48,662,536 		JBrowse link
G INSIG1 insulin induced gene 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr18:2,885,494...2,898,758
Ensembl chr18:2,885,612...2,898,767 		JBrowse link
G INSIG2 insulin induced gene 2 involved_in ISS
IBA
IEA		 UniProt
GO_Central
TreeGrafter
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr15:23,676,684...23,699,591
Ensembl chr15:23,676,683...23,699,582 		JBrowse link
G SCAP SREBF chaperone involved_in IEA
ISS		 Ensembl
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr13:30,253,262...30,320,625
Ensembl chr13:30,253,268...30,320,526 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,267 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:6,719,484...6,784,724
Ensembl chr 5:6,719,490...6,784,671 		JBrowse link
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INSIG1 insulin induced gene 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr18:2,885,494...2,898,758
Ensembl chr18:2,885,612...2,898,767 		JBrowse link
G INSIG2 insulin induced gene 2 involved_in ISS
IBA
IEA		 UniProt
GO_Central
TreeGrafter
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr15:23,676,684...23,699,591
Ensembl chr15:23,676,683...23,699,582 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17813
    cellular process 16883
      signal transduction 6956
        ER-nucleus signaling pathway 44
          ATF6-mediated unfolded protein response + 3
          ER overload response + 13
          PERK-mediated unfolded protein response + 15
          SREBP signaling pathway + 15
Path 2
Term Annotations click to browse term
  biological_process 17813
    biological regulation 12832
      regulation of biological process 12482
        signaling 7500
          signal transduction 6956
            ER-nucleus signaling pathway 44
              ATF6-mediated unfolded protein response + 3
              ER overload response + 13
              PERK-mediated unfolded protein response + 15
              SREBP signaling pathway + 15
paths to the root