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ONTOLOGY REPORT - ANNOTATIONS


Term:ER-nucleus signaling pathway
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Accession:GO:0006984 term browser browse the term
Definition:Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.
Synonyms:exact_synonym: ER to nucleus signaling pathway;   ER to nucleus signalling pathway;   ER-nuclear signaling pathway;   ER-nuclear signalling pathway;   endoplasmic reticulum to nucleus signaling pathway;   endoplasmic reticulum-nuclear signaling pathway


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ER-nucleus signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within ISO (MGI:2684521|PMID:14561754) MGI PMID:14561754 MGI:2684521 NCBI chrNW_004955482:7,233,336...7,295,754
Ensembl chrNW_004955482:7,233,336...7,295,754
JBrowse link
ER overload response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg10 autophagy related 10 involved_in ISO (PMID:17256008) BHF-UCL PMID:17256008 NCBI chrNW_004955418:28,118,843...28,368,358
Ensembl chrNW_004955418:28,119,912...28,363,714
JBrowse link
G Ccdc47 coiled-coil domain containing 47 acts_upstream_of_or_within ISO (MGI:3721716|PMID:17204322) MGI PMID:17204322 MGI:3721716 NCBI chrNW_004955478:8,053,057...8,074,530
Ensembl chrNW_004955478:8,053,057...8,074,820
JBrowse link
G Ddit3 DNA damage inducible transcript 3 acts_upstream_of_or_within ISO (MGI:2158984|PMID:11854325) RGD
MGI
PMID:11158311 PMID:11854325 MGI:2158984 RGD:70575 NCBI chrNW_004955458:5,232,979...5,238,513
Ensembl chrNW_004955458:5,232,979...5,238,513
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (PMID:10677345), (PMID:11907036) UniProt PMID:10677345 PMID:11907036 NCBI chrNW_004955424:210,867...279,267
Ensembl chrNW_004955424:226,038...280,593
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta acts_upstream_of_or_within ISO (MGI:3032464|PMID:14744935)
(PMID:14744935)
MGI PMID:14744935 MGI:3032464 NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 acts_upstream_of_or_within ISO (MGI:2158984|PMID:11854325) MGI PMID:11854325 MGI:2158984 NCBI chrNW_004955419:3,055,420...3,060,208
Ensembl chrNW_004955419:3,055,420...3,062,131
JBrowse link
G Ins insulin acts_upstream_of_or_within ISO (MGI:2158984|PMID:11854325) MGI PMID:11854325 MGI:2158984 NCBI chrNW_004955422:13,909,408...13,910,419
Ensembl chrNW_004955422:13,909,407...13,910,419
JBrowse link
G Ppp1r15b protein phosphatase 1 regulatory subunit 15B acts_upstream_of_or_within ISO (MGI:2681361|PMID:14638860) MGI PMID:14638860 MGI:2681361 NCBI chrNW_004955406:40,232,516...40,238,711
Ensembl chrNW_004955406:40,232,607...40,238,901
JBrowse link
G Selenos selenoprotein S involved_in ISO (PMID:16574427)
(PMID:17210132)
BHF-UCL PMID:16574427 PMID:17210132 NCBI chrNW_004955416:28,152,984...28,162,173
Ensembl chrNW_004955416:28,153,460...28,162,095
JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 involved_in ISO (PMID:27212239) UniProt PMID:27212239 NCBI chrNW_004955462:10,925,383...10,973,814
Ensembl chrNW_004955462:10,925,383...10,973,814
JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO (PMID:14744935) MGI PMID:14744935 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928
JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chrNW_004955437:582,083...592,026
Ensembl chrNW_004955437:582,431...591,810
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (PMID:20160352) ParkinsonsUK-UCL PMID:20160352 RGD:10047363 NCBI chrNW_004955514:3,902,508...3,924,281
Ensembl chrNW_004955514:3,902,454...3,924,610
JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) ARUK-UCL PMID:27030769 MGI:5774886 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772
JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:14676213)
(MGI:5613478|PMID:14676213)
ParkinsonsUK-UCL PMID:14676213 MGI:5613478 NCBI chrNW_004955501:1,867,956...1,963,091 JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO (MGI:5613478|PMID:14676213) ParkinsonsUK-UCL PMID:14676213 MGI:5613478 NCBI chrNW_004955470:10,487,962...10,593,046
Ensembl chrNW_004955470:10,487,481...10,593,046
JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 involved_in ISO (PMID:21216966)
(MGI:5619464|PMID:21216966)
ParkinsonsUK-UCL PMID:21216966 MGI:5619464 NCBI chrNW_004955445:7,754,313...7,819,229
Ensembl chrNW_004955445:7,754,319...7,819,275
JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISO (MGI:3798818|PMID:12667446)
(MGI:3722921|PMID:14729979)
UniProt
ParkinsonsUK-UCL
PMID:12667446 PMID:14729979 MGI:3722921 MGI:3798818 NCBI chrNW_004955413:25,406,589...25,408,727
Ensembl chrNW_004955413:25,406,589...25,412,218
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) UniProt PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chrNW_004955424:210,867...279,267
Ensembl chrNW_004955424:226,038...280,593
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chrNW_004955466:2,838,785...2,855,443
Ensembl chrNW_004955466:2,838,785...2,855,172
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:2677605|PMID:14517290) ParkinsonsUK-UCL PMID:14517290 MGI:2677605 NCBI chrNW_004955403:19,510,122...19,536,428
Ensembl chrNW_004955403:19,532,103...19,535,944
JBrowse link
G Qrich1 glutamine rich 1 involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chrNW_004955532:1,052,174...1,092,211
Ensembl chrNW_004955532:1,052,174...1,091,449
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO (MGI:5914333|PMID:28797121) MGI PMID:28797121 MGI:5914333 NCBI chrNW_004955482:5,404,739...5,415,243
Ensembl chrNW_004955482:5,404,739...5,415,243
JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chrNW_004955462:14,352,956...14,553,299
Ensembl chrNW_004955462:14,357,945...14,548,543
JBrowse link
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 BCL2 like 11 ISO RGD PMID:25772147 RGD:13782257 NCBI chrNW_004955470:2,740,682...2,780,225 JBrowse link
G Bid BH3 interacting domain death agonist ISO RGD PMID:25772147 RGD:13782257 NCBI chrNW_004955454:5,776,656...5,785,500
Ensembl chrNW_004955454:5,777,667...5,783,118
JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO RGD PMID:25772147 RGD:13782257 NCBI chrNW_004955458:5,232,979...5,238,513
Ensembl chrNW_004955458:5,232,979...5,238,513
JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) UniProt PMID:23220234 NCBI chrNW_004955410:19,984,768...19,995,446
Ensembl chrNW_004955410:19,984,768...19,995,733
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5648772|PMID:26015568) UniProt PMID:26015568 MGI:5648772 NCBI chrNW_004955542:224,471...232,401
Ensembl chrNW_004955542:224,471...232,428
JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (MGI:5619464|PMID:21216966) ParkinsonsUK-UCL PMID:21216966 MGI:5619464 NCBI chrNW_004955402:771,410...846,671 JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO (PMID:26268696) UniProt PMID:26268696 NCBI chrNW_004955443:5,747,681...5,773,759
Ensembl chrNW_004955443:5,747,699...5,773,773
JBrowse link
positive regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spring1 SREBF pathway regulator in golgi 1 involved_in ISO (PMID:32111832)
(MGI:6401656|PMID:32111832)
UniProt PMID:32111832 MGI:6401656 NCBI chrNW_004955455:14,331,512...14,349,252
Ensembl chrNW_004955455:14,331,399...14,349,475
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:6120228|PMID:29420538) UniProt PMID:29420538 MGI:6120228 NCBI chrNW_004955545:1,504,656...1,519,954
Ensembl chrNW_004955545:1,503,514...1,521,003
JBrowse link
positive regulation of sterol regulatory element binding protein cleavage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in ISO (MGI:5927299|PMID:28846071) UniProt PMID:28846071 MGI:5927299 NCBI chrNW_004955413:4,571,028...4,605,097
Ensembl chrNW_004955413:4,571,028...4,605,097
JBrowse link
regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO (MGI:6276494|PMID:22863805) UniProt PMID:22863805 MGI:6276494 NCBI chrNW_004955433:14,172,871...14,205,484
Ensembl chrNW_004955433:14,172,808...14,212,110
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO (MGI:5914333|PMID:28797121) MGI PMID:28797121 MGI:5914333 NCBI chrNW_004955482:5,404,739...5,415,243
Ensembl chrNW_004955482:5,404,739...5,415,243
JBrowse link
SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef10l Rho guanine nucleotide exchange factor 10 like involved_in ISO (PMID:16112081) HGNC-UCL PMID:16112081 NCBI chrNW_004955527:1,315,509...1,448,306
Ensembl chrNW_004955527:1,314,077...1,448,366
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A acts_upstream_of_or_within ISO (MGI:3815371|PMID:18852460) MGI PMID:18852460 MGI:3815371 NCBI chrNW_004955448:1,743,060...1,781,401
Ensembl chrNW_004955448:1,743,060...1,781,466
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (MGI:3815371|PMID:18852460) MGI PMID:18852460 MGI:3815371 NCBI chrNW_004955424:210,867...279,267
Ensembl chrNW_004955424:226,038...280,593
JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chrNW_004955507:6,029,247...6,062,946
Ensembl chrNW_004955507:6,028,324...6,063,689
JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chrNW_004955463:13,445,468...13,460,370
Ensembl chrNW_004955463:13,444,722...13,463,132
JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO (PMID:12242332), (PMID:32322062) UniProt PMID:12242332 PMID:32322062 NCBI chrNW_004955491:8,333,624...8,344,658
Ensembl chrNW_004955491:8,335,359...8,344,658
JBrowse link
G Insig2 insulin induced gene 2 involved_in ISO (PMID:12242332), (PMID:17428920), (PMID:32322062) UniProt PMID:12242332 PMID:17428920 PMID:32322062 NCBI chrNW_004955459:11,571,582...11,596,069
Ensembl chrNW_004955459:11,571,145...11,592,146
JBrowse link
G Scap SREBF chaperone involved_in ISO (PMID:11726962)
(PMID:32322062)
UniProt PMID:11726962 PMID:32322062 NCBI chrNW_004955420:24,813,683...24,869,602
Ensembl chrNW_004955420:24,813,534...24,869,480
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in ISO (PMID:27614840)
(PMID:27614840), (PMID:32322062)
CACAO PMID:27614840 PMID:32322062 NCBI chrNW_004955577:171,425...183,669
Ensembl chrNW_004955577:171,425...186,046
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in ISO (PMID:27614840)
(PMID:27614840), (PMID:32322062)
CACAO PMID:27614840 PMID:32322062 NCBI chrNW_004955413:27,271,717...27,326,655
Ensembl chrNW_004955413:27,271,953...27,326,759
JBrowse link
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insig1 insulin induced gene 1 involved_in ISO (PMID:12202038), (PMID:32322062) UniProt PMID:12202038 PMID:32322062 NCBI chrNW_004955491:8,333,624...8,344,658
Ensembl chrNW_004955491:8,335,359...8,344,658
JBrowse link
G Insig2 insulin induced gene 2 involved_in ISO (PMID:32322062) UniProt PMID:32322062 NCBI chrNW_004955459:11,571,582...11,596,069
Ensembl chrNW_004955459:11,571,145...11,592,146
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12096
    signaling 4316
      signal transduction 3836
        ER-nucleus signaling pathway 43
          ATF6-mediated unfolded protein response + 3
          ER overload response + 13
          PERK-mediated unfolded protein response + 14
          SREBP signaling pathway + 15
Path 2
Term Annotations click to browse term
  biological_process 12096
    biological regulation 8911
      regulation of biological process 8452
        regulation of cellular process 8025
          signal transduction 3836
            ER-nucleus signaling pathway 43
              ATF6-mediated unfolded protein response + 3
              ER overload response + 13
              PERK-mediated unfolded protein response + 14
              SREBP signaling pathway + 15
paths to the root