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ONTOLOGY REPORT - ANNOTATIONS


Term:ER-nucleus signaling pathway
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Accession:GO:0006984 term browser browse the term
Definition:Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.
Synonyms:exact_synonym: ER to nucleus signaling pathway;   ER to nucleus signalling pathway;   ER-nuclear signaling pathway;   ER-nuclear signalling pathway;   endoplasmic reticulum to nucleus signaling pathway;   endoplasmic reticulum-nuclear signaling pathway



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ER-nucleus signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within ISO (MGI:2684521|PMID:14561754) MGI PMID:14561754 MGI:2684521 NCBI chr12:107,857,009...107,924,938
Ensembl chr12:111,246,508...111,311,923
JBrowse link
ER overload response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG10 autophagy related 10 involved_in ISO (PMID:17256008) BHF-UCL PMID:17256008 NCBI chr 5:33,029,074...33,315,496
Ensembl chr 5:33,348,306...33,615,883
JBrowse link
G CCDC47 coiled-coil domain containing 47 acts_upstream_of_or_within ISO (MGI:3721716|PMID:17204322) MGI PMID:17204322 MGI:3721716 NCBI chr17:57,825,328...57,853,626
Ensembl chr17:62,970,109...62,998,465
JBrowse link
G DDIT3 DNA damage inducible transcript 3 acts_upstream_of_or_within ISO (MGI:2158984|PMID:11854325) RGD
MGI
PMID:11158311 PMID:11854325 MGI:2158984 RGD:70575 NCBI chr12:31,406,332...31,410,293
Ensembl chr12:31,664,743...31,668,701
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (PMID:10677345), (PMID:11907036) UniProt PMID:10677345 PMID:11907036 NCBI chr2A:87,688,732...87,759,580
Ensembl chr2A:89,596,833...89,667,468
JBrowse link
G GSK3B glycogen synthase kinase 3 beta acts_upstream_of_or_within ISO (MGI:3032464|PMID:14744935)
(PMID:14744935)
MGI PMID:14744935 MGI:3032464 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 acts_upstream_of_or_within ISO (MGI:2158984|PMID:11854325) MGI PMID:11854325 MGI:2158984 NCBI chr 9:96,351,645...96,356,761
Ensembl chr 9:124,865,211...124,870,458
JBrowse link
G INS insulin acts_upstream_of_or_within ISO (MGI:2158984|PMID:11854325) MGI PMID:11854325 MGI:2158984 NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666
JBrowse link
G PPP1R15B protein phosphatase 1 regulatory subunit 15B acts_upstream_of_or_within ISO (MGI:2681361|PMID:14638860) MGI PMID:14638860 MGI:2681361 NCBI chr 1:180,002,895...180,014,956
Ensembl chr 1:184,293,640...184,302,316
JBrowse link
G SELENOS selenoprotein S involved_in ISO (PMID:16574427)
(PMID:17210132)
BHF-UCL PMID:16574427 PMID:17210132 NCBI chr15:79,995,678...80,002,159
Ensembl chr15:99,279,203...99,285,682
JBrowse link
G TMCO1 transmembrane and coiled-coil domains 1 involved_in ISO (PMID:27212239) UniProt PMID:27212239 NCBI chr 1:141,159,657...141,201,018
Ensembl chr 1:144,944,105...144,989,794
JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within ISO (PMID:14744935) MGI PMID:14744935 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6B activating transcription factor 6 beta involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chr 6:31,762,161...31,775,136
Ensembl chr 6:32,643,124...32,655,617
JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in ISO PMID:20160352
(PMID:20160352)
ParkinsonsUK-UCL PMID:20160352 RGD:10047363 Ensembl chr 4:6,345,864...6,379,287 JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) ARUK-UCL PMID:27030769 MGI:5774886 NCBI chr19:62,811...77,897
Ensembl chr19:1,018,095...1,042,104
JBrowse link
G NCK1 NCK adaptor protein 1 involved_in ISO (PMID:14676213)
(MGI:5613478|PMID:14676213)
ParkinsonsUK-UCL PMID:14676213 MGI:5613478 NCBI chr 3:133,902,463...133,990,414
Ensembl chr 3:141,427,870...141,451,444
JBrowse link
G NCK2 NCK adaptor protein 2 involved_in ISO (MGI:5613478|PMID:14676213) ParkinsonsUK-UCL PMID:14676213 MGI:5613478 NCBI chr2A:95,939,197...96,089,163
Ensembl chr2A:106,898,547...106,976,363
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in ISO (PMID:21216966)
(MGI:5619464|PMID:21216966)
ParkinsonsUK-UCL PMID:21216966 MGI:5619464 NCBI chr20:46,854,918...46,929,509
Ensembl chr20:47,983,098...48,057,421
JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 involved_in ISO (MGI:3722921|PMID:14729979)
(MGI:3798818|PMID:12667446)
ParkinsonsUK-UCL
UniProt
PMID:12667446 PMID:14729979 MGI:3722921 MGI:3798818 NCBI chr22:20,426,743...20,428,892
Ensembl chr22:38,248,094...38,249,249
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) UniProt PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr2A:87,688,732...87,759,580
Ensembl chr2A:89,596,833...89,667,468
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chr14:47,935,691...47,960,055
Ensembl chr14:66,813,953...66,839,866
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:2677605|PMID:14517290) ParkinsonsUK-UCL PMID:14517290 MGI:2677605 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085
JBrowse link
G QRICH1 glutamine rich 1 involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chr 3:48,954,345...49,018,745
Ensembl chr 3:50,035,676...50,097,596
JBrowse link
G TMED2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO (MGI:5914333|PMID:28797121) MGI PMID:28797121 MGI:5914333 NCBI chr12:121,169,915...121,183,524
Ensembl chr12:125,397,391...125,410,794
JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chr 1:137,178,629...137,382,256
Ensembl chr 1:140,977,750...141,176,725
JBrowse link
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2L11 BCL2 like 11 ISO RGD PMID:25772147 RGD:13782257 NCBI chr2A:90,862,070...90,909,833
Ensembl chr2A:112,337,927...112,385,079
JBrowse link
G BID BH3 interacting domain death agonist ISO RGD PMID:25772147 RGD:13782257 NCBI chr22:1,164,787...1,205,051
Ensembl chr22:16,594,186...16,632,844
JBrowse link
G DDIT3 DNA damage inducible transcript 3 ISO RGD PMID:25772147 RGD:13782257 NCBI chr12:31,406,332...31,410,293
Ensembl chr12:31,664,743...31,668,701
JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) UniProt PMID:23220234 NCBI chr 7:17,446,275...17,489,802
Ensembl chr 7:16,773,281...16,785,879
JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5648772|PMID:26015568) UniProt PMID:26015568 MGI:5648772 NCBI chr2B:128,832,458...128,847,918
Ensembl chr2B:247,626,494...247,640,238
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (MGI:5619464|PMID:21216966) ParkinsonsUK-UCL PMID:21216966 MGI:5619464 NCBI chr18:1,440,837...1,538,501
Ensembl chr18:16,562,052...16,659,570
JBrowse link
G TMEM33 transmembrane protein 33 involved_in ISO (PMID:26268696) UniProt PMID:26268696 NCBI chr 4:36,260,669...36,281,546
Ensembl chr 4:42,108,335...42,127,575
JBrowse link
positive regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPRING1 SREBF pathway regulator in golgi 1 involved_in ISO (PMID:32111832)
(MGI:6401656|PMID:32111832)
UniProt PMID:32111832 MGI:6401656 NCBI chr12:114,290,308...114,315,016
Ensembl chr12:117,666,838...117,684,137
JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in ISO (MGI:6120228|PMID:29420538) UniProt PMID:29420538 MGI:6120228 NCBI chr 1:130,350,798...130,366,690
Ensembl chr 1:133,959,847...133,975,729
JBrowse link
positive regulation of sterol regulatory element binding protein cleavage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LPCAT3 lysophosphatidylcholine acyltransferase 3 involved_in ISO (MGI:5927299|PMID:28846071) UniProt PMID:28846071 MGI:5927299 NCBI chr12:7,107,925...7,149,982
Ensembl chr12:7,024,015...7,065,945
JBrowse link
regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMFR autocrine motility factor receptor involved_in ISO (MGI:6276494|PMID:22863805) UniProt PMID:22863805 MGI:6276494 NCBI chr16:36,647,792...36,711,782
Ensembl chr16:55,780,633...55,843,744
JBrowse link
G TMED2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO (MGI:5914333|PMID:28797121) MGI PMID:28797121 MGI:5914333 NCBI chr12:121,169,915...121,183,524
Ensembl chr12:125,397,391...125,410,794
JBrowse link
SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARHGEF10L Rho guanine nucleotide exchange factor 10 like involved_in ISO (PMID:16112081) HGNC-UCL PMID:16112081 NCBI chr 1:16,486,514...16,644,724
Ensembl chr 1:17,580,389...17,697,195
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A acts_upstream_of_or_within ISO (MGI:3815371|PMID:18852460) MGI PMID:18852460 MGI:3815371 NCBI chr 3:147,564,293...147,601,939
Ensembl chr 3:155,137,410...155,175,492
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (MGI:3815371|PMID:18852460) MGI PMID:18852460 MGI:3815371 NCBI chr2A:87,688,732...87,759,580
Ensembl chr2A:89,596,833...89,667,468
JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chr10:96,756,261...96,791,925
Ensembl chr10:100,238,320...100,273,942
JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chr 8:37,034,391...37,057,164
Ensembl chr 8:34,212,704...34,233,583
JBrowse link
G INSIG1 insulin induced gene 1 involved_in ISO (PMID:12242332), (PMID:32322062) UniProt PMID:12242332 PMID:32322062 NCBI chr 7:146,893,730...146,906,329
Ensembl chr 7:158,619,531...158,632,012
JBrowse link
G INSIG2 insulin induced gene 2 involved_in ISO (PMID:12242332), (PMID:17428920), (PMID:32322062) UniProt PMID:12242332 PMID:17428920 PMID:32322062 NCBI chr2B:5,046,971...5,068,757
Ensembl chr2B:118,632,402...118,652,647
JBrowse link
G SCAP SREBF chaperone involved_in ISO (PMID:32322062)
(PMID:11726962)
UniProt PMID:11726962 PMID:32322062 NCBI chr 3:47,314,535...47,379,455
Ensembl chr 3:48,414,012...48,479,845
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 involved_in ISO (PMID:27614840)
(PMID:27614840), (PMID:32322062)
CACAO PMID:27614840 PMID:32322062 NCBI chr17:33,458,196...33,484,643
Ensembl chr17:38,405,794...38,432,045
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 involved_in ISO (PMID:27614840), (PMID:32322062) CACAO PMID:27614840 PMID:32322062 NCBI chr22:22,725,790...22,799,749
Ensembl chr22:40,811,459...40,884,947
JBrowse link
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INSIG1 insulin induced gene 1 involved_in ISO (PMID:12202038), (PMID:32322062) UniProt PMID:12202038 PMID:32322062 NCBI chr 7:146,893,730...146,906,329
Ensembl chr 7:158,619,531...158,632,012
JBrowse link
G INSIG2 insulin induced gene 2 involved_in ISO (PMID:32322062) UniProt PMID:32322062 NCBI chr2B:5,046,971...5,068,757
Ensembl chr2B:118,632,402...118,652,647
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12786
    signaling 4469
      signal transduction 3978
        ER-nucleus signaling pathway 43
          ATF6-mediated unfolded protein response + 3
          ER overload response + 13
          PERK-mediated unfolded protein response + 14
          SREBP signaling pathway + 15
Path 2
Term Annotations click to browse term
  biological_process 12786
    biological regulation 9367
      regulation of biological process 8864
        regulation of cellular process 8384
          signal transduction 3978
            ER-nucleus signaling pathway 43
              ATF6-mediated unfolded protein response + 3
              ER overload response + 13
              PERK-mediated unfolded protein response + 14
              SREBP signaling pathway + 15
paths to the root