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ONTOLOGY REPORT - ANNOTATIONS


Term:ER-nucleus signaling pathway
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Accession:GO:0006984 term browser browse the term
Definition:Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.
Synonyms:exact_synonym: ER to nucleus signaling pathway;   ER to nucleus signalling pathway;   ER-nuclear signaling pathway;   ER-nuclear signalling pathway;   endoplasmic reticulum to nucleus signaling pathway;   endoplasmic reticulum-nuclear signaling pathway


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ER-nucleus signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 39,553,903 39,603,326 RGD:1624291
ER overload response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg10 autophagy related 10 JBrowse link 2 19,853,546 20,152,918 RGD:1624291
G Ccdc47 coiled-coil domain containing 47 JBrowse link 10 94,388,425 94,406,949 RGD:1624291
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:70575
RGD:13792537
RGD:1600115
RGD:1624291
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1600115
RGD:1624291
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
RGD:1600115
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1624291
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1624291
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B JBrowse link 13 49,933,155 49,940,961 RGD:1624291
G Selenos selenoprotein S JBrowse link 1 126,979,579 126,989,344 RGD:1600115
RGD:1624291
G Tmco1 transmembrane and coiled-coil domains 1 JBrowse link 13 85,465,015 85,559,113 RGD:1624291
RGD:1600115
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf6b activating transcription factor 6 beta JBrowse link 20 4,414,283 4,422,283 RGD:1624291
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link 14 78,640,707 78,665,224 RGD:1624291
RGD:10047363
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:1624291
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:1624291
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
PERK-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:1600115
RGD:1624291
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:1624291
G Tmed2 transmembrane p24 trafficking protein 2 JBrowse link 12 37,471,259 37,480,344 RGD:1624291
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf6 activating transcription factor 6 JBrowse link 13 89,053,457 89,242,531 RGD:1624291
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:13782257
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:13782257
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:13782257
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agr2 anterior gradient 2, protein disulphide isomerase family member JBrowse link 6 55,465,782 55,487,087 RGD:1624291
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
RGD:1600115
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
G Tmem33 transmembrane protein 33 JBrowse link 14 42,537,352 42,559,580 RGD:1600115
RGD:1624291
positive regulation of SREBP signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Spring1 SREBF pathway regulator in golgi 1 JBrowse link 12 43,920,564 43,940,798 RGD:1624291
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:1624291
positive regulation of sterol regulatory element binding protein cleavage term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lpcat3 lysophosphatidylcholine acyltransferase 3 JBrowse link 4 157,181,722 157,222,997 RGD:1600115
RGD:1624291
regulation of SREBP signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:1624291
G Tmed2 transmembrane p24 trafficking protein 2 JBrowse link 12 37,471,259 37,480,344 RGD:1624291
SREBP signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07060293.1 RGD:13792537
G Arhgef10l Rho guanine nucleotide exchange factor 10 like JBrowse link 5 159,018,373 159,089,383 RGD:1624291
RGD:13792537
G Eif2a eukaryotic translation initiation factor 2A JBrowse link 2 148,722,343 148,755,781 RGD:1624291
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
G Erlin1 ER lipid raft associated 1 JBrowse link 1 263,810,439 263,845,762 RGD:1624291
RGD:13792537
G Erlin2 ER lipid raft associated 2 JBrowse link 16 69,179,005 69,195,452 RGD:1624291
RGD:13792537
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:13792537
RGD:1624291
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:13792537
RGD:1600115
RGD:1624291
G Scap SREBF chaperone JBrowse link 8 118,551,869 118,628,650 RGD:1624291
RGD:1600115
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:1624291
RGD:1600115
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:1600115
RGD:1624291
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07060293.1 RGD:13792537
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:13792537
RGD:1624291
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:13792537
RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    signaling 7553
      signal transduction 6968
        ER-nucleus signaling pathway 41
          ATF6-mediated unfolded protein response + 3
          ER overload response + 13
          PERK-mediated unfolded protein response + 11
          SREBP signaling pathway + 16
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            ER-nucleus signaling pathway 41
              ATF6-mediated unfolded protein response + 3
              ER overload response + 13
              PERK-mediated unfolded protein response + 11
              SREBP signaling pathway + 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.