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ONTOLOGY REPORT - ANNOTATIONS

Term:ER-nucleus signaling pathway
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Accession:GO:0006984 term browser browse the term
Definition:The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.
Synonyms:exact_synonym: ER to nucleus signaling pathway;   ER to nucleus signalling pathway;   ER-nuclear signaling pathway;   ER-nuclear signalling pathway;   endoplasmic reticulum to nucleus signaling pathway;   endoplasmic reticulum-nuclear signaling pathway


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ER-nucleus signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:14561754)		 Ensembl
RGD		 PMID:14561754 GO_REF:0000107 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Manf mesencephalic astrocyte-derived neurotrophic factor involved_in IEA
ISO		 GO_REF:0000107
(PMID:27984733)		 Ensembl
RGD		 PMID:27984733 GO_REF:0000107 NCBI chr 8:116,427,053...116,430,259
Ensembl chr 8:107,548,352...107,551,438 		JBrowse link
ER overload response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg10 autophagy related 10 involved_in ISO (PMID:17256008) RGD PMID:17256008 NCBI chr 2:23,843,695...24,133,459
Ensembl chr 2:22,108,426...22,398,233 		JBrowse link
G Ccdc47 coiled-coil domain containing 47 acts_upstream_of_or_within ISO (PMID:17204322) RGD PMID:17204322 NCBI chr10:91,630,101...91,648,626
Ensembl chr10:91,130,303...91,148,881 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA		 MGI:2179046 (PMID:11854325)
GO_REF:0000033		 RGD
GO_Central		 PMID:11854325 PMID:11158311 GO_REF:0000033, RGD:70575 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO
ISS		 (PMID:10677345), (PMID:11907036)
GO_REF:0000024		 RGD
UniProt		 PMID:10677345 PMID:11907036 GO_REF:0000024 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14744935)
GO_REF:0000107		 RGD
Ensembl		 PMID:14744935 GO_REF:0000107 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:11854325)		 Ensembl
RGD		 PMID:11854325 GO_REF:0000107 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ins2 insulin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857572 (PMID:11854325)		 Ensembl
RGD		 PMID:11854325 GO_REF:0000107 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B acts_upstream_of_or_within ISO (PMID:14638860) RGD PMID:14638860 NCBI chr13:47,130,000...47,137,805
Ensembl chr13:44,577,932...44,585,737 		JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA		 (PMID:16574427), (PMID:17210132)
GO_REF:0000107		 RGD
Ensembl		 PMID:16574427 PMID:17210132 GO_REF:0000107 NCBI chr 1:129,070,240...129,080,007
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 involved_in ISO
IEA
ISS		 (PMID:27212239)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:27212239 GO_REF:0000024 GO_REF:0000107 NCBI chr13:81,993,172...82,016,496
Ensembl chr13:79,460,135...79,483,555 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14744935)
GO_REF:0000107		 RGD
Ensembl		 PMID:14744935 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IEA
ISO		 GO_REF:0000107
(PMID:16989814)		 Ensembl
RGD		 PMID:16989814 GO_REF:0000107 NCBI chr14:78,035,205...78,059,718
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO (PMID:9837962) RGD PMID:9837962 NCBI chr20:4,095,534...4,103,534
Ensembl chr20:4,090,921...4,098,894 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IGI
ISO		 PMID:20160352
(PMID:20160352)		 RGD PMID:20160352 PMID:20160352 RGD:10047363 NCBI chr14:78,035,205...78,059,718
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:27030769) RGD PMID:27030769 NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:21954288)		 Ensembl
RGD		 PMID:21954288 GO_REF:0000107 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:21954288)		 Ensembl
RGD		 PMID:21954288 GO_REF:0000107 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:21954288)		 Ensembl
RGD		 PMID:21954288 GO_REF:0000107 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Atad3a ATPase family, AAA domain containing 3A involved_in ISO
ISS		 (PMID:39116259)
GO_REF:0000024		 RGD
UniProt		 PMID:39116259 GO_REF:0000024 NCBI chr 5:171,632,545...171,652,725
Ensembl chr 5:166,350,304...166,370,482 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:30842412) RGD PMID:30842412 NCBI chr 3:138,315,006...138,336,691
Ensembl chr 3:117,861,653...117,882,680 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISO
IEA		 (PMID:11907036)
GO_REF:0000107		 RGD
Ensembl		 PMID:11907036 GO_REF:0000107 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IBA		 (PMID:14676213)
GO_REF:0000033
UniProtKB:O55033 (PMID:14676213)		 RGD
GO_Central		 PMID:14676213 GO_REF:0000033 NCBI chr 8:109,897,723...109,958,247
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IBA		 UniProtKB:Q99M51 (PMID:14676213)
GO_REF:0000033		 RGD
GO_Central		 PMID:14676213 GO_REF:0000033 NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
IBA		 (PMID:21216966)
GO_REF:0000033		 RGD
GO_Central		 PMID:21216966 GO_REF:0000033 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS
ISO		 GO_REF:0000024
(PMID:31023583)
(PMID:12667446), (PMID:14729979)		 UniProt
RGD		 PMID:12667446 PMID:14729979 PMID:31023583 GO_REF:0000024 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (PMID:10026192), (PMID:25925385), (PMID:31023583), (PMID:39116259)
(PMID:10882126), (PMID:14729979), (PMID:16418533), (PMID:17707796), (PMID:21954288), (PMID:29386355)		 RGD PMID:10026192 PMID:10882126 PMID:14729979 PMID:16418533 PMID:17707796 More... NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISS
ISO		 GO_REF:0000024
(PMID:31023583), (PMID:33384352)		 UniProt
RGD		 PMID:31023583 PMID:33384352 GO_REF:0000024 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (PMID:14517290) RGD PMID:14517290 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:118,095,435...118,135,001
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
G Rpap2 RNA polymerase II associated protein 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:30118681)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:30118681 GO_REF:0000024 GO_REF:0000107 NCBI chr14:2,253,966...2,332,251
Ensembl chr14:2,109,053...2,187,350 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:4456438 (PMID:28797121)		 Ensembl
RGD		 PMID:28797121 GO_REF:0000107 NCBI chr12:37,713,522...37,722,606
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO
IEA		 (PMID:9837962)
GO_REF:0000107		 RGD
Ensembl		 PMID:9837962 GO_REF:0000107 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 Bcl2-like 11 IMP RGD PMID:25772147 RGD:13782257 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bid BH3 interacting domain death agonist IMP RGD PMID:25772147 RGD:13782257 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IMP RGD PMID:25772147 RGD:13782257 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:58,435,908...58,456,678
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO		 GO_REF:0000024
(PMID:26015568)		 UniProt
RGD		 PMID:26015568 GO_REF:0000024 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:21216966)		 Ensembl
RGD		 PMID:21216966 GO_REF:0000107 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
ISS		 (PMID:26268696)
GO_REF:0000024		 RGD
UniProt		 PMID:26268696 GO_REF:0000024 NCBI chr14:41,242,358...41,264,586
Ensembl chr14:40,885,712...40,910,715 		JBrowse link
positive regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir96 microRNA 96 involved_in ISO (PMID:30460077) RGD PMID:30460077 NCBI chr 4:59,755,841...59,755,946
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Paqr3 progestin and adipoQ receptor family member 3 involved_in ISO (PMID:26311497) RGD PMID:26311497 NCBI chr14:12,766,539...12,796,461
Ensembl chr14:12,462,563...12,479,994 		JBrowse link
G Spring1 SREBF pathway regulator in golgi 1 involved_in ISO (PMID:32111832) RGD PMID:32111832 NCBI chr12:43,967,146...43,990,083
Ensembl chr12:38,297,837...38,329,138 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (PMID:29420538) RGD PMID:29420538 NCBI chr 2:177,093,569...177,111,894
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO (PMID:22863805) RGD PMID:22863805 NCBI chr19:11,002,451...11,038,182
Ensembl chr19:10,996,099...11,032,247 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:4456438 (PMID:28797121)		 Ensembl
RGD		 PMID:28797121 GO_REF:0000107 NCBI chr12:37,713,522...37,722,606
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef10l Rho guanine nucleotide exchange factor 10 like involved_in ISO
IBA		 (PMID:16112081)
GO_REF:0000033		 RGD
GO_Central		 PMID:16112081 GO_REF:0000033 NCBI chr 5:158,075,370...158,218,358
Ensembl chr 5:152,792,252...152,919,538 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A acts_upstream_of_or_within ISO (PMID:18852460) RGD PMID:18852460 NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (PMID:18852460) RGD PMID:18852460 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO
IBA		 (PMID:24217618)
GO_REF:0000033		 RGD
GO_Central		 PMID:24217618 GO_REF:0000033 NCBI chr 1:252,870,356...252,905,681
Ensembl chr 1:242,921,152...242,956,394 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO
IBA		 (PMID:24217618)
GO_REF:0000033		 RGD
GO_Central		 PMID:24217618 GO_REF:0000033 NCBI chr16:71,720,486...71,736,999
Ensembl chr16:65,018,532...65,033,671 		JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO
IBA		 (PMID:12242332), (PMID:32322062)
GO_REF:0000033		 RGD
GO_Central		 PMID:12242332 PMID:32322062 GO_REF:0000033 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:12242332), (PMID:17428920), (PMID:32322062)		 UniProt
GO_Central
Ensembl
RGD		 PMID:12242332 PMID:17428920 PMID:32322062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:35,025,160...35,052,937
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G LOC120102490 insulin-induced gene 1 protein-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:68,295,478...68,300,681
Ensembl chr 4:67,330,588...67,331,346 		JBrowse link
G Scap SREBF chaperone involved_in ISO
ISS		 (PMID:11726962), (PMID:32322062)
GO_REF:0000024		 RGD
UniProt		 PMID:11726962 PMID:32322062 GO_REF:0000024 NCBI chr 8:119,184,366...119,239,086
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in ISO
ISS		 (PMID:27614840)
GO_REF:0000024
(PMID:32322062)		 RGD
UniProt		 PMID:27614840 PMID:32322062 GO_REF:0000024 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:32322062)
(PMID:27614840)		 Ensembl
UniProt
RGD		 PMID:27614840 PMID:32322062 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insig1 insulin induced gene 1 involved_in ISO
IBA		 (PMID:12202038), (PMID:15899885), (PMID:32322062)
GO_REF:0000033		 RGD
GO_Central		 PMID:12202038 PMID:15899885 PMID:32322062 GO_REF:0000033 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:15899885), (PMID:32322062)		 UniProt
GO_Central
Ensembl
RGD		 PMID:15899885 PMID:32322062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:35,025,160...35,052,937
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G LOC120102490 insulin-induced gene 1 protein-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:68,295,478...68,300,681
Ensembl chr 4:67,330,588...67,331,346 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      signal transduction 7262
        intracellular signal transduction 3154
          ER-nucleus signaling pathway 52
            ATF6-mediated unfolded protein response + 4
            ER overload response + 14
            PERK-mediated unfolded protein response + 21
            SREBP signaling pathway + 17
Path 2
Term Annotations click to browse term
  biological_process 20546
    biological regulation 13834
      regulation of biological process 13389
        signaling 7822
          signal transduction 7262
            intracellular signal transduction 3154
              ER-nucleus signaling pathway 52
                ATF6-mediated unfolded protein response + 4
                ER overload response + 14
                PERK-mediated unfolded protein response + 21
                SREBP signaling pathway + 17
paths to the root