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ONTOLOGY REPORT - ANNOTATIONS

Term:ER overload response
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Accession:GO:0006983 term browser browse the term
Definition:The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.
Synonyms:exact_synonym: EOR;   endoplasmic reticulum overload response
 narrow_synonym: EOR-mediated NF-kappaB activation;   EOR-mediated activation of NF-kappaB;   positive regulation of NF-kappaB transcription factor activity by EOR;   positive regulation of NF-kappaB transcription factor activity by ER overload response
 alt_id: GO:0006985

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ER overload response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg10 autophagy related 10 involved_in ISO (PMID:17256008) BHF-UCL PMID:17256008 NCBI chrNW_004624743:2,381,131...2,663,640
Ensembl chrNW_004624743:2,381,038...2,649,322 		JBrowse link
G Ccdc47 coiled-coil domain containing 47 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624849:1,237,364...1,282,588
Ensembl chrNW_004624849:1,237,370...1,282,611 		JBrowse link
G Ddit3 DNA damage inducible transcript 3 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:11854325) RGD
TreeGrafter
MGI		 PMID:11158311 PMID:11854325 GO_REF:0000118 RGD:70575 NCBI chrNW_004624802:10,437,998...10,443,278 JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (PMID:10677345), (PMID:11907036) UniProt PMID:10677345 PMID:11907036 NCBI chrNW_004624749:15,867,444...15,950,757
Ensembl chrNW_004624749:15,869,569...15,950,757 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624731:28,178,647...28,368,784
Ensembl chrNW_004624731:28,178,628...28,366,420 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 acts_upstream_of_or_within ISO (PMID:11854325) MGI PMID:11854325 NCBI chrNW_004624760:9,986,529...9,991,261
Ensembl chrNW_004624760:9,986,656...9,995,252 		JBrowse link
G Ins insulin acts_upstream_of_or_within ISO (PMID:11854325) MGI PMID:11854325 NCBI chrNW_004624767:14,999,088...15,000,035
Ensembl chrNW_004624767:14,999,088...15,000,035 		JBrowse link
G Ppp1r15b protein phosphatase 1 regulatory subunit 15B acts_upstream_of_or_within ISO (PMID:14638860) MGI PMID:14638860 NCBI chrNW_004624807:6,622,816...6,631,027
Ensembl chrNW_004624807:6,623,245...6,633,334 		JBrowse link
G Selenos selenoprotein S involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624768:3,539,369...3,550,716
Ensembl chrNW_004624768:3,539,465...3,550,211 		JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 involved_in ISO (PMID:27212239) UniProt PMID:27212239 NCBI chrNW_004624826:4,064,126...4,118,176 JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO (PMID:14744935) MGI PMID:14744935 NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (PMID:16989814) BHF-UCL PMID:16989814 NCBI chrNW_004624755:22,818,653...22,841,717
Ensembl chrNW_004624755:22,824,143...22,841,850 		JBrowse link
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 BCL2 like 11 ISO RGD PMID:25772147 RGD:13782257 NCBI chrNW_004624749:1,033,824...1,130,099
Ensembl chrNW_004624749:1,091,096...1,125,341 		JBrowse link
G Bid BH3 interacting domain death agonist ISO RGD PMID:25772147 RGD:13782257 NCBI chrNW_004624735:9,557,732...9,590,862
Ensembl chrNW_004624735:9,579,979...9,589,260 		JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO RGD PMID:25772147 RGD:13782257 NCBI chrNW_004624802:10,437,998...10,443,278 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17646
    cellular process 17217
      cellular response to stimulus 7510
        cellular response to biotic stimulus 279
          ER overload response 14
            detection of endoplasmic reticulum overloading 0
            positive regulation of autophagy in response to ER overload 3
Path 2
Term Annotations click to browse term
  biological_process 17646
    biological regulation 11836
      regulation of biological process 11481
        signaling 6627
          signal transduction 6131
            intracellular signal transduction 2872
              ER-nucleus signaling pathway 51
                ER overload response 14
                  detection of endoplasmic reticulum overloading 0
                  positive regulation of autophagy in response to ER overload 3
paths to the root