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ONTOLOGY REPORT - ANNOTATIONS

Term:ER overload response
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Accession:GO:0006983 term browser browse the term
Definition:The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.
Synonyms:exact_synonym: EOR;   endoplasmic reticulum overload response
 narrow_synonym: EOR-mediated NF-kappaB activation;   EOR-mediated activation of NF-kappaB;   positive regulation of NF-kappaB transcription factor activity by EOR;   positive regulation of NF-kappaB transcription factor activity by ER overload response
 alt_id: GO:0006985


show annotations for term's descendants           Sort by:
ER overload response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg10 autophagy related 10 involved_in ISO GO_Central GO_REF:0000119 NCBI chr13:91,083,467...91,372,189
Ensembl chr13:91,083,475...91,372,087 		JBrowse link
G Ccdc47 coiled-coil domain containing 47 acts_upstream_of_or_within IMP (PMID:17204322) MGI PMID:17204322 NCBI chr11:106,090,086...106,107,349
Ensembl chr11:106,088,234...106,107,170 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in
acts_upstream_of_or_within 		ISO
IBA
IMP 		(PMID:11854325) RGD
GO_Central
MGI		 PMID:11158311 PMID:11854325 GO_REF:0000033 GO_REF:0000096 RGD:70575 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO
ISS 		GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta acts_upstream_of_or_within IDA
ISO 		(PMID:14744935) MGI PMID:14744935 GO_REF:0000008 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Hspa5 heat shock protein 5 acts_upstream_of_or_within IDA (PMID:11854325) MGI PMID:11854325 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Ins2 insulin II acts_upstream_of_or_within IMP (PMID:11854325) MGI PMID:11854325 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B acts_upstream_of_or_within IDA
IMP 		(PMID:14638860) MGI PMID:14638860 NCBI chr 1:133,058,904...133,067,538
Ensembl chr 1:133,058,881...133,067,521 		JBrowse link
G Selenos selenoprotein S involved_in IEA
ISO 		Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 7:65,729,397...65,739,153
Ensembl chr 7:65,729,397...65,739,153 		JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 involved_in ISS
ISO 		UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 1:167,136,239...167,161,547
Ensembl chr 1:167,135,947...167,161,547 		JBrowse link
G Trp53 transformation related protein 53 acts_upstream_of_or_within ISO MGI GO_REF:0000008 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:37,123,448...37,146,326
Ensembl chr 5:37,123,448...37,146,549 		JBrowse link
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 BCL2 like 11 involved_in ISO RGD
GO_Central		 PMID:25772147 GO_REF:0000096 RGD:13782257 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in ISO RGD
GO_Central		 PMID:25772147 GO_REF:0000096 RGD:13782257 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in ISO RGD
GO_Central		 PMID:25772147 GO_REF:0000096 RGD:13782257 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28626
    cellular process 18393
      cellular response to stimulus 8751
        cellular response to biotic stimulus 443
          ER overload response 14
            detection of endoplasmic reticulum overloading 0
            positive regulation of autophagy in response to ER overload 3
Path 2
Term Annotations click to browse term
  biological_process 28626
    biological regulation 13468
      regulation of biological process 13028
        signaling 7549
          signal transduction 6967
            intracellular signal transduction 3254
              ER-nucleus signaling pathway 52
                ER overload response 14
                  detection of endoplasmic reticulum overloading 0
                  positive regulation of autophagy in response to ER overload 3
paths to the root