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ONTOLOGY REPORT - ANNOTATIONS

Term:ER overload response
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Accession:GO:0006983 term browser browse the term
Definition:The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.
Synonyms:exact_synonym: EOR;   endoplasmic reticulum overload response
 narrow_synonym: EOR-mediated NF-kappaB activation;   EOR-mediated activation of NF-kappaB;   positive regulation of NF-kappaB transcription factor activity by EOR;   positive regulation of NF-kappaB transcription factor activity by ER overload response
 alt_id: GO:0006985


show annotations for term's descendants           Sort by:
ER overload response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG10 autophagy related 10 involved_in IMP (PMID:17256008) BHF-UCL PMID:17256008 NCBI chr 5:81,972,023...82,256,133
Ensembl chr 5:81,972,023...82,276,857 		JBrowse link
G CCDC47 coiled-coil domain containing 47 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:63,745,255...63,773,597
Ensembl chr17:63,745,255...63,776,351 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		RGD
Ensembl
GO_Central		 PMID:11158311 GO_REF:0000033 GO_REF:0000107 RGD:70575 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in IDA (PMID:10677345), (PMID:11907036) UniProt PMID:10677345 PMID:11907036 NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta acts_upstream_of_or_within IDA (PMID:14744935) MGI PMID:14744935 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G INS insulin acts_upstream_of_or_within ISO (PMID:11854325) MGI PMID:11854325 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
G LOC128125814 uncharacterized LOC128125814 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:57,517,712...57,520,480 JBrowse link
G PPP1R15B protein phosphatase 1 regulatory subunit 15B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:204,395,826...204,411,817
Ensembl chr 1:204,396,492...204,411,887 		JBrowse link
G SELENOS selenoprotein S involved_in IDA
IMP 		(PMID:16574427)
(PMID:17210132) 		BHF-UCL PMID:16574427 PMID:17210132 NCBI chr15:101,270,809...101,277,485
Ensembl chr15:101,270,531...101,277,500 		JBrowse link
G TMCO1 transmembrane and coiled-coil domains 1 involved_in IDA (PMID:27212239) UniProt PMID:27212239 NCBI chr 1:165,724,291...165,768,922
Ensembl chr 1:165,724,293...165,827,755 		JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within IDA (PMID:14744935) MGI PMID:14744935 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in TAS
IDA 		(PMID:17947299)
(PMID:16989814) 		BHF-UCL PMID:16989814 PMID:17947299 NCBI chr 4:6,269,850...6,303,265
Ensembl chr 4:6,269,849...6,303,265 		JBrowse link
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2L11 BCL2 like 11 ISO RGD PMID:25772147 RGD:13782257 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444 		JBrowse link
G BID BH3 interacting domain death agonist ISO RGD PMID:25772147 RGD:13782257 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 ISO RGD PMID:25772147 RGD:13782257 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27205
    cellular process 19782
      cellular response to stimulus 8326
        cellular response to biotic stimulus 414
          ER overload response 15
            detection of endoplasmic reticulum overloading 0
            positive regulation of autophagy in response to ER overload 3
Path 2
Term Annotations click to browse term
  biological_process 27205
    biological regulation 13700
      regulation of biological process 13241
        signaling 7270
          signal transduction 6672
            intracellular signal transduction 3371
              ER-nucleus signaling pathway 58
                ER overload response 15
                  detection of endoplasmic reticulum overloading 0
                  positive regulation of autophagy in response to ER overload 3
paths to the root