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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
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Accession:GO:0006978 term browser browse the term
Definition:A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.

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DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2 DNA repair associated acts_upstream_of_or_within ISO (PMID:8738145) MGI PMID:8738145 NCBI chrNW_004936472:26,945,659...27,017,693 JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10710310) Ensembl
MGI		 PMID:10710310 GO_REF:0000107 NCBI chrNW_004936476:22,717,308...22,725,127
Ensembl chrNW_004936476:22,717,260...22,725,182 		JBrowse link
G Chek2 checkpoint kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10710310) Ensembl
MGI		 PMID:10710310 GO_REF:0000107 NCBI chrNW_004936657:2,805,947...2,848,180
Ensembl chrNW_004936657:2,805,959...2,848,180 		JBrowse link
G Foxm1 forkhead box M1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936606:3,185,289...3,198,427
Ensembl chrNW_004936606:3,185,982...3,198,378 		JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:3,767,526...3,775,416
Ensembl chrNW_004936599:3,766,242...3,776,128 		JBrowse link
G Rbm38 RNA binding motif protein 38 involved_in ISO (PMID:17050675) UniProt PMID:17050675 NCBI chrNW_004936530:227,266...249,285 JBrowse link
G Rps27l ribosomal protein S27 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:23,738,896...23,742,355
Ensembl chrNW_004936471:23,738,823...23,745,382 		JBrowse link
G Rps6ka6 ribosomal protein S6 kinase A6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936547:4,846,012...4,952,773
Ensembl chrNW_004936547:4,857,685...4,975,222 		JBrowse link
G Tfap4 transcription factor AP-4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936694:210,863...222,531
Ensembl chrNW_004936694:210,672...222,619 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10710310) Ensembl
MGI		 PMID:10710310 GO_REF:0000107 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcbp4 poly(rC) binding protein 4 acts_upstream_of_or_within ISO (PMID:20817677) MGI PMID:20817677 NCBI chrNW_004936529:3,304,171...3,308,422
Ensembl chrNW_004936529:3,300,712...3,308,288 		JBrowse link
positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ing4 inhibitor of growth family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936709:1,140,485...1,147,982
Ensembl chrNW_004936709:1,140,345...1,149,843 		JBrowse link
G Rpl26 ribosomal protein L26 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:1,603,913...1,609,125
Ensembl chrNW_004936595:1,603,413...1,609,132 		JBrowse link
G Znf385a zinc finger protein 385A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:11,562,635...11,585,026
Ensembl chrNW_004936512:11,561,435...11,585,402 		JBrowse link
G Znhit1 zinc finger HIT-type containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936543:1,098,095...1,104,731
Ensembl chrNW_004936543:1,097,588...1,105,162 		JBrowse link
regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops3 COP9 signalosome subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936741:905,593...931,148
Ensembl chrNW_004936741:905,252...931,408 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15871
    cellular process 15001
      signal transduction 5667
        intracellular signal transduction 2532
          signal transduction by p53 class mediator 150
            DNA damage response, signal transduction by p53 class mediator 67
              DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 16
                negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 1
                positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 4
                regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + 6
Path 2
Term Annotations click to browse term
  biological_process 15871
    biological regulation 11036
      regulation of biological process 10703
        regulation of cellular process 10266
          signal transduction 5667
            intracellular signal transduction 2532
              signal transduction by p53 class mediator 150
                DNA damage response, signal transduction by p53 class mediator 67
                  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 16
                    negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 1
                    positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 4
                    regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + 6
paths to the root