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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
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Accession:GO:0006978 term browser browse the term
Definition:A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.


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DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated IEA
ISO
GO_REF:0000107
MGI:1930616 (MGI:84760|PMID:8738145)
Ensembl
RGD
PMID:8738145 GO_REF:0000107, MGI:84760 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO (MGI:1354114|PMID:10710310) RGD PMID:10710310 MGI:1354114 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek2 checkpoint kinase 2 ISO MGI:2386905 (MGI:1354114|PMID:10710310) RGD PMID:10710310 MGI:1354114 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Foxm1 forkhead box M1 IEA
ISO
IBA
GO_REF:0000107
(MGI:3698692|PMID:17101782)
PMID:21873635
(PMID:17101782)
Ensembl
RGD
PMID:17101782, PMID:21873635 GO_REF:0000107, MGI:3698692, RGD:13792537 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 ISO (PMID:14647468) RGD PMID:14647468 NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912
JBrowse link
G Ing4 inhibitor of growth family, member 4 ISO (PMID:16387653) RGD PMID:16387653 NCBI chr 4:157,554,729...157,563,353
Ensembl chr 4:157,554,794...157,563,352
JBrowse link
G Kat5 lysine acetyltransferase 5 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:14966270)
Ensembl
UniProt
RGD
PMID:14966270 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:220,967,795...220,974,596
Ensembl chr 1:220,967,796...220,974,597
JBrowse link
G Muc1 mucin 1, cell surface associated ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Rbm38 RNA binding motif protein 38 ISO (PMID:17050675) RGD PMID:17050675 NCBI chr 3:171,037,891...171,050,500
Ensembl chr 3:171,037,957...171,050,475
JBrowse link
G Rps27l ribosomal protein S27-like ISO (PMID:18056458) RGD PMID:18056458 NCBI chr 8:72,741,155...72,746,090
Ensembl chr 8:72,741,155...72,746,090
JBrowse link
G Rps6ka6 ribosomal protein S6 kinase A6 ISO (PMID:15042092) RGD PMID:15042092 NCBI chr  X:82,641,679...82,743,771
Ensembl chr  X:82,641,687...82,743,753
JBrowse link
G Sp100 SP100 nuclear antigen ISO (PMID:14647468) RGD PMID:14647468 NCBI chr 9:92,675,103...92,718,489
Ensembl chr 9:92,681,078...92,717,929
JBrowse link
G Tfap4 transcription factor AP-4 ISO (PMID:18818310) RGD PMID:18818310 NCBI chr10:11,204,616...11,222,975
Ensembl chr10:11,206,226...11,223,370
JBrowse link
G Tp53 tumor protein p53 ISO (PMID:16213212), (PMID:16479015), (PMID:7958916)
(MGI:1354114|PMID:10710310)
RGD PMID:7958916, PMID:10710310, PMID:16213212, PMID:16479015 MGI:1354114 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcbp4 poly(rC) binding protein 4 ISO (MGI:5050389|PMID:20817677) RGD PMID:20817677 MGI:5050389 NCBI chr 8:115,154,848...115,165,706
Ensembl chr 8:115,155,470...115,165,706
JBrowse link
positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl26 ribosomal protein L26 ISO (PMID:16213212) RGD PMID:16213212 NCBI chr10:55,492,417...55,495,547
Ensembl chr10:55,492,404...55,496,012
JBrowse link
G Zfp385a zinc finger protein 385A ISO (PMID:17719541) RGD PMID:17719541 NCBI chr 7:144,939,616...144,966,364
Ensembl chr 7:144,939,619...144,966,370
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      signal transduction 7010
        intracellular signal transduction 2593
          signal transduction in response to DNA damage 95
            DNA damage response, signal transduction resulting in transcription 18
              DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 17
                negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 1
                positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 2
                regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + 3
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          signal transduction 7010
            intracellular signal transduction 2593
              signal transduction in response to DNA damage 95
                DNA damage response, signal transduction by p53 class mediator 68
                  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 17
                    negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 1
                    positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 2
                    regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.