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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, alternative pathway
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Accession:GO:0006957 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Synonyms:exact_synonym: complement cascade, alternative pathway


show annotations for term's descendants           Sort by:
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G C5 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195 		JBrowse link
G C7 complement C7 involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:40,909,497...40,984,643
Ensembl chr 5:40,909,492...41,020,216 		JBrowse link
G C8A complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:56,854,797...56,918,223
Ensembl chr 1:56,854,768...56,918,223 		JBrowse link
G C8B complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:56,929,207...56,966,015
Ensembl chr 1:56,929,207...56,974,383 		JBrowse link
G C8G complement C8 gamma chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:136,945,243...136,946,975
Ensembl chr 9:136,945,185...136,946,975 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:39,284,140...39,364,495
Ensembl chr 5:39,284,140...39,371,324 		JBrowse link
G CFB complement factor B involved_in
acts_upstream_of_or_within		 TAS
ISO
NAS
IEA		 (PMID:9238044)
(PMID:27564415)
(PMID:8225386)		 Reactome
MGI
UniProt		 PMID:8225386 PMID:9238044 PMID:27564415 GO_REF:0000043 Reactome:R-HSA-173736 NCBI chr 6:31,946,095...31,952,084
Ensembl chr 6:31,945,650...31,952,086 		JBrowse link
G CFD complement factor D involved_in
acts_upstream_of_or_within		 TAS
ISO
IEA		 (PMID:27564415) Reactome
MGI
Ensembl
UniProt		 PMID:27564415 GO_REF:0000043 GO_REF:0000107 Reactome:R-HSA-173736 NCBI chr19:859,664...863,641
Ensembl chr19:859,453...867,884 		JBrowse link
G CFH complement factor H involved_in
acts_upstream_of_or_within_negative_effect		 IEA
ISO		 (PMID:19828624)
(PMID:27564415)		 UniProt
MGI		 PMID:19828624 PMID:27564415 GO_REF:0000043 NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476 		JBrowse link
G CFHR5 complement factor H related 5 involved_in NAS (PMID:11058592) UniProt PMID:11058592 NCBI chr 1:196,975,034...197,009,678
Ensembl chr 1:196,975,010...197,009,678 		JBrowse link
G CFP complement factor properdin involved_in IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr  X:47,623,282...47,630,305
Ensembl chr  X:47,623,172...47,630,305 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IMP (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765 		JBrowse link
G CR2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect		 IMP
ISO		 (PMID:11981823)
(PMID:19828624)		 ARUK-UCL
MGI		 PMID:11981823 PMID:19828624 NCBI chr 1:207,454,328...207,489,892
Ensembl chr 1:207,453,024...207,489,895 		JBrowse link
G VSIG4 V-set and immunoglobulin domain containing 4 involved_in IEA UniProt GO_REF:0000043 NCBI chr  X:66,021,738...66,040,080
Ensembl chr  X:66,021,738...66,040,125 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chr 1:207,752,038...207,795,516
Ensembl chr 1:207,752,037...207,795,513 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IDA (PMID:10531307) UniProt PMID:10531307 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765 		JBrowse link
G SUSD4 sushi domain containing 4 involved_in IDA
IEA
IBA		 (PMID:23482636) UniProt
TreeGrafter
GO_Central		 PMID:23482636 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:223,220,831...223,365,235
Ensembl chr 1:223,220,819...223,364,233 		JBrowse link
G VSIG4 V-set and immunoglobulin domain containing 4 involved_in IPI
IBA		 (PMID:17051150) UniProt
GO_Central		 PMID:17051150 GO_REF:0000033 NCBI chr  X:66,021,738...66,040,080
Ensembl chr  X:66,021,738...66,040,125 		JBrowse link
positive regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR520B microRNA 520b involved_in IDA (PMID:20574151) ARUK-UCL PMID:20574151 NCBI chr19:53,701,227...53,701,287
Ensembl chr19:53,701,227...53,701,287 		JBrowse link
G MIR520E microRNA 520e involved_in IDA (PMID:20574151) ARUK-UCL PMID:20574151 NCBI chr19:53,675,711...53,675,797
Ensembl chr19:53,675,711...53,675,797 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H involved_in IDA (PMID:20378178), (PMID:28671664) ComplexPortal PMID:20378178 PMID:28671664 NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    immune system process 3226
      immune response 2289
        innate immune response 1084
          complement activation, alternative pathway 19
            negative regulation of complement activation, alternative pathway 4
            positive regulation of complement activation, alternative pathway 2
            regulation of complement activation, alternative pathway + 7
Path 2
Term Annotations click to browse term
  biological_process 19669
    biological regulation 13397
      regulation of biological process 13016
        positive regulation of biological process 7043
          positive regulation of response to stimulus 2635
            positive regulation of immune response 837
              activation of immune response 626
                complement activation 75
                  complement activation, alternative pathway 19
                    negative regulation of complement activation, alternative pathway 4
                    positive regulation of complement activation, alternative pathway 2
                    regulation of complement activation, alternative pathway + 7
paths to the root