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ONTOLOGY REPORT - ANNOTATIONS

Term:activation-induced cell death of T cells
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Accession:GO:0006924 term browser browse the term
Definition:A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors.
Synonyms:exact_synonym: activation-induced cell death of T lymphocytes
 broad_synonym: AICD;   activated T cell apoptosis;   antigen-driven apoptosis


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activation-induced cell death of T cells term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 acts_upstream_of_or_within ISO (PMID:14749367) MGI PMID:14749367 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 acts_upstream_of_or_within IMP (PMID:15879105) MGI PMID:15879105 NCBI chr16:4,501,934...4,525,559
Ensembl chr16:4,457,853...4,525,559 		JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within
involved_in		 IMP
IDA
IBA		 (PMID:8640868)
(PMID:7602121)
(PMID:12702495)		 MGI
GO_Central		 PMID:7602121 PMID:8640868 PMID:12702495 GO_REF:0000033 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial acts_upstream_of IMP (PMID:18971390) MGI PMID:18971390 NCBI chr19:55,056,067...55,115,666
Ensembl chr19:55,055,700...55,115,670 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain acts_upstream_of_or_within IMP (PMID:7584142) MGI PMID:7584142 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Rps6 ribosomal protein S6 acts_upstream_of_or_within IMP (PMID:16357222) MGI PMID:16357222 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649 		JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:112,611,262...112,615,586
Ensembl chr12:112,611,113...112,615,583 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 acts_upstream_of IDA (PMID:8206089) MGI PMID:8206089 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Tnfrsf23 tumor necrosis factor receptor superfamily, member 23 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:143,219,544...143,239,836
Ensembl chr 7:143,219,546...143,239,609 		JBrowse link
negative regulation of activation-induced cell death of T cells term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain involved_in IMP (MGI:5291865|PMID:21876153) UniProt PMID:21876153 MGI:5291865 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial acts_upstream_of_or_within IMP (PMID:18971390) MGI PMID:18971390 NCBI chr19:55,056,067...55,115,666
Ensembl chr19:55,055,700...55,115,670 		JBrowse link
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 involved_in IMP (MGI:2150820|PMID:11567634) BHF-UCL PMID:11567634 MGI:2150820 NCBI chr 4:156,098,049...156,101,070
Ensembl chr 4:156,098,300...156,101,069 		JBrowse link
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 involved_in IC (MGI:2150820|PMID:11567634) BHF-UCL PMID:11567634 MGI:2150820 NCBI chr 1:161,223,009...161,245,777
Ensembl chr 1:161,222,980...161,245,981 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 involved_in
acts_upstream_of_or_within		 IBA
IDA		 (PMID:9430225) GO_Central
MGI		 PMID:9430225 GO_REF:0000033 NCBI chr  X:139,440,277...139,501,257
Ensembl chr  X:139,440,277...139,501,408 		JBrowse link
positive regulation of activation-induced cell death of T cells term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb2 transforming growth factor, beta 2 acts_upstream_of_or_within IDA (PMID:8206089) MGI PMID:8206089 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
regulation of activation-induced cell death of T cells term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in IGI (MGI:5291865|PMID:21876153) UniProt PMID:21876153 MGI:5291865 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    immune system process 3142
      leukocyte homeostasis 144
        lymphocyte homeostasis 98
          T cell homeostasis 56
            activation-induced cell death of T cells 14
              negative regulation of activation-induced cell death of T cells 5
              positive regulation of activation-induced cell death of T cells 1
              regulation of activation-induced cell death of T cells + 7
Path 2
Term Annotations click to browse term
  biological_process 28573
    cellular process 17545
      cell death 2253
        programmed cell death 2253
          apoptotic process 2166
            leukocyte apoptotic process 165
              lymphocyte apoptotic process 115
                T cell apoptotic process 71
                  activation-induced cell death of T cells 14
                    negative regulation of activation-induced cell death of T cells 5
                    positive regulation of activation-induced cell death of T cells 1
                    regulation of activation-induced cell death of T cells + 7
paths to the root