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ONTOLOGY REPORT - ANNOTATIONS

Term:phagocytosis, engulfment
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Accession:GO:0006911 term browser browse the term
Definition:The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
Synonyms:related_synonym: phagosome biosynthesis;   phagosome formation

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phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10878804) Ensembl
MGI		 PMID:10878804 GO_REF:0000107 NCBI chrNW_004936559:7,177,887...7,312,660
Ensembl chrNW_004936559:7,177,904...7,312,741 		JBrowse link
G Aif1 allograft inflammatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,907,493...1,909,350
Ensembl chrNW_004936727:1,907,505...1,909,338 		JBrowse link
G Arhgap12 Rho GTPase activating protein 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936574:407,639...514,268
Ensembl chrNW_004936574:407,639...506,950 		JBrowse link
G Arhgap25 Rho GTPase activating protein 25 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936491:13,055,790...13,138,370
Ensembl chrNW_004936491:13,055,790...13,138,227 		JBrowse link
G Bin2 bridging integrator 2 involved_in ISO (PMID:23285027) UniProt PMID:23285027 NCBI chrNW_004936512:8,869,131...8,901,171 JBrowse link
G Cdc42 cell division cycle 42 involved_in ISO (PMID:26465210) UniProt PMID:26465210 NCBI chrNW_004936474:7,556,765...7,598,687 JBrowse link
G Clcn2 chloride voltage-gated channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936578:5,525,461...5,539,351
Ensembl chrNW_004936578:5,525,601...5,539,472 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16522634) Ensembl
MGI		 PMID:16522634 GO_REF:0000107 NCBI chrNW_004936516:1,678,610...1,760,099
Ensembl chrNW_004936516:1,678,653...1,760,294 		JBrowse link
G Clec7a C-type lectin domain containing 7A acts_upstream_of_or_within ISO (PMID:14707091) MGI PMID:14707091 NCBI chrNW_004936902:436,224...446,435 JBrowse link
G Elmo1 engulfment and cell motility 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:12,308,255...12,754,957
Ensembl chrNW_004936478:12,306,450...12,754,963 		JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig acts_upstream_of_or_within ISO (PMID:11237803), (PMID:11911823)
(PMID:11901193)		 MGI PMID:11237803 PMID:11901193 PMID:11911823 NCBI chrNW_004936903:514,278...517,975
Ensembl chrNW_004936903:514,761...517,948 		JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11911824)
(PMID:11911823), (PMID:9551950)		 Ensembl
MGI		 PMID:9551950 PMID:11911823 PMID:11911824 GO_REF:0000107 NCBI chrNW_004936580:115,552...144,970
Ensembl chrNW_004936580:115,450...145,785 		JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb acts_upstream_of_or_within ISO (PMID:8769481) MGI PMID:8769481 NCBI chrNW_004937131:80,014...96,114 JBrowse link
G Gsn gelsolin involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chrNW_004936487:9,749,755...9,802,787
Ensembl chrNW_004936487:9,764,944...9,802,841 		JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11729193) MGI
Ensembl		 PMID:11729193 GO_REF:0000107 NCBI chrNW_004936506:9,233,590...9,501,139
Ensembl chrNW_004936506:9,234,691...9,332,911 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:18414680 GO_REF:0000118 RGD:2316597 NCBI chrNW_004936515:6,030,402...6,051,161 JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (MGI:5319446|PMID:22438044), (MGI:5905548|PMID:20199584), (MGI:6189359|PMID:22632727) ARUK-UCL PMID:20199584 PMID:22438044 PMID:22632727 MGI:5319446 MGI:5905548 MGI:6189359 NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524 		JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (MGI:5905548|PMID:20199584) ARUK-UCL PMID:20199584 MGI:5905548 NCBI chrNW_004936778:1,286,475...1,311,184
Ensembl chrNW_004936778:1,286,341...1,311,194 		JBrowse link
G LOC101964702 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:9,247,749...9,313,230
Ensembl chrNW_004936470:9,248,319...9,313,230 		JBrowse link
G Marco macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chrNW_004936469:51,323,746...51,366,551 JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936573:5,345,282...5,391,946
Ensembl chrNW_004936573:5,328,526...5,388,901 		JBrowse link
G Myh9 myosin heavy chain 9 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chrNW_004936492:4,384,215...4,466,229
Ensembl chrNW_004936492:4,384,215...4,466,262 		JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (MGI:5315376|PMID:10934045) UniProt PMID:10934045 MGI:5315376 NCBI chrNW_004936750:107,689...122,679
Ensembl chrNW_004936750:107,689...122,676 		JBrowse link
G Sh3bp1 SH3 domain binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:3,430,099...3,440,432
Ensembl chrNW_004936492:3,429,949...3,440,334 		JBrowse link
G Sirpa signal regulatory protein alpha acts_upstream_of_or_within ISO (PMID:14634079) MGI PMID:14634079 NCBI chrNW_004936485:16,608,317...16,654,552 JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19155473) Ensembl
MGI		 PMID:19155473 GO_REF:0000107 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
G Treml4 triggering receptor expressed on myeloid cells like 4 acts_upstream_of_or_within ISO (PMID:19155473) MGI PMID:19155473 NCBI chrNW_004936476:18,603,620...18,612,050 JBrowse link
G Vamp7 vesicle associated membrane protein 7 involved_in ISO PMID:15133481 UniProt PMID:15133481 RGD:4892614 NCBI chrNW_004936958:345,055...393,384 JBrowse link
engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,518,100...17,531,126
Ensembl chrNW_004936490:17,517,751...17,531,151 		JBrowse link
G LOC101964702 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936470:9,247,749...9,313,230
Ensembl chrNW_004936470:9,248,319...9,313,230 		JBrowse link
G Megf10 multiple EGF like domains 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27170117) Ensembl
MGI		 PMID:27170117 GO_REF:0000107 NCBI chrNW_004936504:634,167...753,438
Ensembl chrNW_004936504:586,190...756,255 		JBrowse link
G Rac1 Rac family small GTPase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936750:107,689...122,679
Ensembl chrNW_004936750:107,689...122,676 		JBrowse link
G Rac2 Rac family small GTPase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936492:3,726,375...3,737,961
Ensembl chrNW_004936492:3,726,313...3,736,905 		JBrowse link
G Rac3 Rac family small GTPase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936594:5,527,788...5,530,694
Ensembl chrNW_004936594:5,528,908...5,531,420 		JBrowse link
G Rhobtb1 Rho related BTB domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936614:2,101,175...2,230,441
Ensembl chrNW_004936614:2,103,101...2,230,444 		JBrowse link
G Rhobtb2 Rho related BTB domain containing 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936555:6,664,811...6,684,756
Ensembl chrNW_004936555:6,664,768...6,682,822 		JBrowse link
G Rhog ras homolog family member G involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936498:1,077,354...1,088,003
Ensembl chrNW_004936498:1,077,422...1,088,003 		JBrowse link
G Rhoh ras homolog family member H involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936482:7,721,815...7,723,395
Ensembl chrNW_004936482:7,689,371...7,723,321 		JBrowse link
G Thbs1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:3,064,466...3,081,125
Ensembl chrNW_004936471:3,064,422...3,081,949 		JBrowse link
G Xkr4 XK related 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936496:1,887,943...2,289,928
Ensembl chrNW_004936496:1,888,068...2,287,963 		JBrowse link
G Xkr5 XK related 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936615:4,734,805...4,753,194
Ensembl chrNW_004936615:4,734,805...4,753,194 		JBrowse link
G Xkr6 XK related 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936675:2,750,401...2,768,457
Ensembl chrNW_004936675:2,751,400...2,983,960 		JBrowse link
G Xkr7 XK related 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936485:18,907,218...18,935,306
Ensembl chrNW_004936485:18,907,218...18,929,904 		JBrowse link
G Xkr8 XK related 8 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:12,180,741...12,187,904
Ensembl chrNW_004936474:12,180,424...12,187,876 		JBrowse link
G Xkr9 XK related 9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936648:1,607...5,784
Ensembl chrNW_004936648:1,573...5,784 		JBrowse link
positive regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:3662940|PMID:16908670) Alzheimers_University_of_Toronto PMID:16908670 MGI:3662940 NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
positive regulation of phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor ISO RGD PMID:23238794 RGD:8696010 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G Ano6 anoctamin 6 involved_in ISO (MGI:5634870|PMID:25651887) UniProt PMID:25651887 MGI:5634870 NCBI chrNW_004936512:3,649,103...3,736,274
Ensembl chrNW_004936512:3,540,129...3,732,776 		JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:9,477,483...9,526,692
Ensembl chrNW_004936492:9,477,373...9,526,692 		JBrowse link
G C3 complement C3 involved_in ISO (MGI:5905548|PMID:20199584)
(MGI:5319446|PMID:22438044), (MGI:6189359|PMID:22632727)		 ARUK-UCL PMID:20199584 PMID:22438044 PMID:22632727 MGI:5319446 MGI:5905548 MGI:6189359 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Cd36 CD36 molecule (CD36 blood group) involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16061696) Ensembl
MGI		 PMID:16061696 GO_REF:0000107 NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936549:142,281...153,575
Ensembl chrNW_004936549:141,512...153,602 		JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia ISO RGD PMID:19657115 RGD:9685698 NCBI chrNW_004936580:115,552...144,970
Ensembl chrNW_004936580:115,450...145,785 		JBrowse link
G Gata2 GATA binding protein 2 ISO RGD PMID:12933836 RGD:632788 NCBI chrNW_004936798:406,258...414,785
Ensembl chrNW_004936798:406,258...414,931 		JBrowse link
G Itga2 integrin subunit alpha 2 ISO RGD PMID:9284952 RGD:2307413 NCBI chrNW_004936480:14,320,292...14,417,828
Ensembl chrNW_004936480:14,320,692...14,417,786 		JBrowse link
G Lbp lipopolysaccharide binding protein ISO RGD PMID:11104656 RGD:9685187 NCBI chrNW_004936561:3,017,471...3,035,481
Ensembl chrNW_004936561:3,016,926...3,035,552 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:11,683,330...11,734,423
Ensembl chrNW_004936512:11,683,321...11,734,391 		JBrowse link
G Plcg2 phospholipase C gamma 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
Ensembl		 PMID:32514138 GO_REF:0000107 NCBI chrNW_004936475:29,248,533...29,377,335
Ensembl chrNW_004936475:29,248,516...29,377,206 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO RGD PMID:15940641 RGD:8553017 NCBI chrNW_004936602:1,230,907...1,368,588
Ensembl chrNW_004936602:1,230,907...1,304,743 		JBrowse link
G Rab31 RAB31, member RAS oncogene family involved_in ISO (MGI:6271154|PMID:25568335) UniProt PMID:25568335 MGI:6271154 NCBI chrNW_004936626:1,628,379...1,673,150
Ensembl chrNW_004936626:1,628,451...1,660,510 		JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936582:877,241...908,697
Ensembl chrNW_004936582:877,474...913,770 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
TreeGrafter
Ensembl		 PMID:32514138 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:3,232,183...3,241,307
Ensembl chrNW_004936677:3,232,183...3,241,253 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16121
    cellular process 15173
      vesicle-mediated transport 1536
        endocytosis 683
          phagocytosis 216
            phagocytosis, engulfment 59
              cytoskeletal rearrangement involved in phagocytosis, engulfment 0
              engulfment of apoptotic cell + 20
              membrane reorganization involved in phagocytosis, engulfment 0
              negative regulation of phagocytosis, engulfment + 0
              positive regulation of phagocytosis, engulfment + 17
              regulation of phagocytosis, engulfment + 18
Path 2
Term Annotations click to browse term
  biological_process 16121
    localization 5229
      establishment of localization 4544
        transport 4256
          vesicle-mediated transport 1536
            endocytosis 683
              phagocytosis 216
                phagocytosis, engulfment 59
                  cytoskeletal rearrangement involved in phagocytosis, engulfment 0
                  engulfment of apoptotic cell + 20
                  membrane reorganization involved in phagocytosis, engulfment 0
                  negative regulation of phagocytosis, engulfment + 0
                  positive regulation of phagocytosis, engulfment + 17
                  regulation of phagocytosis, engulfment + 18
paths to the root