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ONTOLOGY REPORT - ANNOTATIONS

Term:phagocytosis, engulfment
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Accession:GO:0006911 term browser browse the term
Definition:The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
Synonyms:related_synonym: phagosome biosynthesis;   phagosome formation


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phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10878804) Ensembl
MGI		 PMID:10878804 GO_REF:0000107 NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492 		JBrowse link
G ADGRB1 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:1,582,321...1,658,639
Ensembl chr 4:1,582,330...1,647,573 		JBrowse link
G AIF1 allograft inflammatory factor 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:23,711,752...23,731,191
Ensembl chr 7:23,726,787...23,731,671 		JBrowse link
G ARHGAP12 Rho GTPase activating protein 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:42,458,115...42,577,351
Ensembl chr10:42,454,646...42,577,345 		JBrowse link
G ARHGAP25 Rho GTPase activating protein 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:73,556,561...73,649,997
Ensembl chr 3:73,556,565...73,649,849 		JBrowse link
G BIN2 bridging integrator 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107
G CDC42 cell division cycle 42 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:80,035,034...80,089,243
Ensembl chr 6:80,035,123...80,089,233 		JBrowse link
G CLCN2 chloride voltage-gated channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:122,234,731...122,249,889
Ensembl chr13:122,234,736...122,249,867 		JBrowse link
G CLCN3 chloride voltage-gated channel 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16522634) Ensembl
MGI		 PMID:16522634 GO_REF:0000107 NCBI chr14:20,037,628...20,127,160
Ensembl chr14:20,026,685...20,127,155 		JBrowse link
G CLEC7A C-type lectin domain containing 7A acts_upstream_of_or_within ISO (PMID:14707091) MGI PMID:14707091 NCBI chr 5:61,832,910...61,846,441
Ensembl chr 5:61,832,954...61,846,434 		JBrowse link
G ELMO1 engulfment and cell motility 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:36,755,026...37,336,095
Ensembl chr18:36,786,378...37,347,283 		JBrowse link
G FCER1G Fc epsilon receptor Ig acts_upstream_of_or_within ISO (PMID:11901193)
(PMID:11237803), (PMID:11911823)		 MGI PMID:11237803 PMID:11901193 PMID:11911823 NCBI chr 4:89,242,467...89,246,344
Ensembl chr 4:89,242,472...89,246,450 		JBrowse link
G FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11911824)
(PMID:11911823), (PMID:9551950)		 Ensembl
MGI		 PMID:9551950 PMID:11911823 PMID:11911824 GO_REF:0000107 NCBI chr 4:99,233,632...99,242,531
Ensembl chr 4:99,233,611...99,242,586 		JBrowse link
G FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) acts_upstream_of_or_within ISO (PMID:8769481) MGI PMID:8769481 NCBI chr 4:88,873,762...88,892,964 JBrowse link
G GSN gelsolin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:261,295,711...261,372,848
Ensembl chr 1:261,307,008...261,372,848 		JBrowse link
G GULP1 GULP PTB domain containing engulfment adaptor 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11729193) MGI
Ensembl		 PMID:11729193 GO_REF:0000107 NCBI chr15:92,988,094...93,252,188
Ensembl chr15:92,911,054...93,252,180 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 involved_in ISO
IBA		 RGD
GO_Central		 PMID:18414680 GO_REF:0000033 RGD:2316597 NCBI chr16:66,162,318...66,208,868 JBrowse link
G ITGB2 integrin subunit beta 2 involved_in ISO (MGI:5905548|PMID:20199584) ARUK-UCL PMID:20199584 MGI:5905548 NCBI chr13:207,514,281...207,544,108
Ensembl chr13:207,512,950...207,544,107 		JBrowse link
G LOC100515209 sialic acid-binding Ig-like lectin 13 acts_upstream_of ISO (PMID:24227736) MGI PMID:24227736 NCBI chr 6:58,440,468...58,448,682 JBrowse link
G MARCO macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chr15:24,502,935...24,541,286
Ensembl chr15:24,503,108...24,541,283 		JBrowse link
G MSR1 macrophage scavenger receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:3,859,903...3,939,612
Ensembl chr17:3,859,692...3,939,726 		JBrowse link
G MYH9 myosin heavy chain 9 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:11,365,603...11,456,475
Ensembl chr 5:11,360,660...11,456,472 		JBrowse link
G RAC1 Rac family small GTPase 1 involved_in ISO (MGI:5315376|PMID:10934045) UniProt PMID:10934045 MGI:5315376 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543 		JBrowse link
G SH3BP1 SH3 domain binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,172,303...10,187,883
Ensembl chr 5:10,172,667...10,187,906 		JBrowse link
G SIRPA signal regulatory protein alpha acts_upstream_of_or_within ISO (PMID:14634079) MGI PMID:14634079 NCBI chr17:33,566,270...33,611,375 JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in
acts_upstream_of_or_within		 ISO (MGI:5606096|PMID:24990881)
(PMID:19155473)		 UniProt
MGI		 PMID:19155473 PMID:24990881 MGI:5606096 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
G VAMP7 vesicle associated membrane protein 7 involved_in ISO PMID:15133481 UniProt PMID:15133481 RGD:4892614 NCBI chr  X:125,863,266...125,917,232
Ensembl chr  X:125,863,292...125,917,225 		JBrowse link
engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRB1 adhesion G protein-coupled receptor B1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:1,582,321...1,658,639
Ensembl chr 4:1,582,330...1,647,573 		JBrowse link
G BECN1 beclin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373 		JBrowse link
G MEGF10 multiple EGF like domains 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27170117) Ensembl
MGI		 PMID:27170117 GO_REF:0000107 NCBI chr 2:130,226,222...130,403,960
Ensembl chr 2:130,189,556...130,401,077 		JBrowse link
G RAC1 Rac family small GTPase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543 		JBrowse link
G RAC3 Rac family small GTPase 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:981,072...984,222
Ensembl chr12:981,074...984,227 		JBrowse link
G THBS1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,784...131,746,115 		JBrowse link
G XKR4 XK related 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:76,056,895...76,382,976
Ensembl chr 4:76,062,430...76,382,818 		JBrowse link
G XKR5 XK related 5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:37,880,406...37,898,737
Ensembl chr15:37,880,116...37,898,687 		JBrowse link
G XKR6 XK related 6 involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:14,087,419...14,381,402
Ensembl chr14:14,086,418...14,381,402 		JBrowse link
G XKR7 XK related 7 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:35,632,287...35,662,600
Ensembl chr17:35,632,088...35,659,306 		JBrowse link
G XKR8 XK related 8 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:85,084,641...85,093,167
Ensembl chr 6:85,085,066...85,160,234 		JBrowse link
G XKR9 XK related 9 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:64,678,734...64,727,495
Ensembl chr 4:64,679,170...64,707,710 		JBrowse link
negative regulation of phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD300A CD300a molecule involved_in ISO (PMID:22302738) UniProt PMID:22302738 NCBI chr12:6,665,578...6,681,329 JBrowse link
G LOC100515209 sialic acid-binding Ig-like lectin 13 acts_upstream_of_or_within ISO (PMID:24227736) MGI PMID:24227736 NCBI chr 6:58,440,468...58,448,682 JBrowse link
positive regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:3662940|PMID:16908670) Alzheimers_University_of_Toronto PMID:16908670 MGI:3662940 NCBI chr 2:77,357,161...77,375,349
Ensembl chr 2:77,357,218...77,375,180 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
positive regulation of phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:23238794 RGD:8696010 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162 		JBrowse link
G ANO6 anoctamin 6 involved_in ISO (MGI:5634870|PMID:25651887) UniProt PMID:25651887 MGI:5634870 NCBI chr 5:76,112,428...76,337,073
Ensembl chr 5:76,113,236...76,337,069 		JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:6271154|PMID:25568335) UniProt PMID:25568335 MGI:6271154 NCBI chr 5:79,356,046...79,412,235
Ensembl chr 5:79,356,067...79,412,235 		JBrowse link
G C3 complement C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G CD36 CD36 molecule acts_upstream_of_or_within ISO (PMID:16061696) MGI PMID:16061696 NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858 		JBrowse link
G FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) ISO RGD PMID:19657115 RGD:9685698 NCBI chr 4:99,233,632...99,242,531
Ensembl chr 4:99,233,611...99,242,586 		JBrowse link
G GATA2 GATA binding protein 2 ISO RGD PMID:12933836 RGD:632788 NCBI chr13:71,981,139...71,997,626
Ensembl chr13:71,984,067...71,997,619 		JBrowse link
G ITGA2 integrin subunit alpha 2 ISO RGD PMID:9284952 RGD:2307413 NCBI chr16:32,336,240...32,440,311
Ensembl chr16:32,336,292...32,437,103 		JBrowse link
G LBP lipopolysaccharide binding protein ISO RGD PMID:11104656 RGD:9685187 NCBI chr17:41,398,935...41,429,467
Ensembl chr17:41,393,818...41,429,551 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:19,677,613...19,720,550
Ensembl chr 5:19,677,875...19,723,132 		JBrowse link
G PLCG2 phospholipase C gamma 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
Ensembl		 PMID:32514138 GO_REF:0000107 NCBI chr 6:6,433,146...6,603,092
Ensembl chr 6:6,433,153...6,603,060 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO RGD PMID:15940641 RGD:8553017 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944 		JBrowse link
G RAB31 RAB31, member RAS oncogene family involved_in ISO (MGI:6271154|PMID:25568335) UniProt PMID:25568335 MGI:6271154 NCBI chr 6:98,278,644...98,385,857
Ensembl chr 6:98,278,647...98,385,795 		JBrowse link
G STAP1 signal transducing adaptor family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:65,318,861...65,372,838
Ensembl chr 8:65,332,522...65,392,965 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
Ensembl		 PMID:32514138 GO_REF:0000107 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12 arachidonate 12-lipoxygenase, 12S type involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,401,810...52,414,903 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,287,160...52,295,871 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17634
    cellular process 16614
      vesicle-mediated transport 1537
        endocytosis 684
          phagocytosis 214
            phagocytosis, engulfment 55
              cytoskeletal rearrangement involved in phagocytosis, engulfment 0
              engulfment of apoptotic cell + 16
              membrane reorganization involved in phagocytosis, engulfment 0
              negative regulation of phagocytosis, engulfment + 2
              positive regulation of phagocytosis, engulfment + 17
              regulation of phagocytosis, engulfment + 21
Path 2
Term Annotations click to browse term
  biological_process 17634
    localization 5331
      establishment of localization 4641
        transport 4353
          vesicle-mediated transport 1537
            endocytosis 684
              phagocytosis 214
                phagocytosis, engulfment 55
                  cytoskeletal rearrangement involved in phagocytosis, engulfment 0
                  engulfment of apoptotic cell + 16
                  membrane reorganization involved in phagocytosis, engulfment 0
                  negative regulation of phagocytosis, engulfment + 2
                  positive regulation of phagocytosis, engulfment + 17
                  regulation of phagocytosis, engulfment + 21
paths to the root