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ONTOLOGY REPORT - ANNOTATIONS

Term:phagocytosis, engulfment
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Accession:GO:0006911 term browser browse the term
Definition:The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
Synonyms:related_synonym: phagosome biosynthesis;   phagosome formation

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phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 acts_upstream_of_or_within ISO (PMID:10878804) MGI PMID:10878804 NCBI chr12:34,587,123...34,734,936
Ensembl chr12:34,587,118...34,731,642 		JBrowse link
G AIF1 allograft inflammatory factor 1 involved_in ISO (MGI:5315376|PMID:10934045) UniProt PMID:10934045 MGI:5315376
G ARHGAP12 Rho GTPase activating protein 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:31,124,281...31,249,546
Ensembl chr 9:31,123,727...31,249,524 		JBrowse link
G ARHGAP25 Rho GTPase activating protein 25 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr14:38,297,738...38,389,692
Ensembl chr14:38,297,213...38,389,777 		JBrowse link
G BIN2 bridging integrator 2 involved_in ISO (PMID:23285027) UniProt PMID:23285027 NCBI chr11:47,480,322...47,521,970 JBrowse link
G CDC42 cell division cycle 42 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:110,568,004...110,608,318
Ensembl chr20:110,569,352...110,582,562 		JBrowse link
G CLCN2 chloride voltage-gated channel 2 involved_in ISO (PMID:36964785) UniProt PMID:36964785 NCBI chr15:5,057,687...5,073,596
Ensembl chr15:5,057,900...5,073,184 		JBrowse link
G CLCN3 chloride voltage-gated channel 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16522634) Ensembl
MGI		 PMID:16522634 GO_REF:0000107 NCBI chr 7:115,826,756...115,926,842
Ensembl chr 7:115,826,778...115,928,609 		JBrowse link
G CLEC7A C-type lectin domain containing 7A acts_upstream_of_or_within ISO (PMID:14707091) MGI PMID:14707091 NCBI chr11:9,989,520...10,007,442
Ensembl chr11:9,995,203...10,006,746 		JBrowse link
G ELMO1 engulfment and cell motility 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:21,066,910...21,639,149
Ensembl chr21:21,066,924...21,640,705 		JBrowse link
G FCER1G Fc fragment of IgE receptor Ig acts_upstream_of_or_within ISO (PMID:11237803), (PMID:11911823)
(PMID:11901193)		 MGI PMID:11237803 PMID:11901193 PMID:11911823 NCBI chr20:2,763,412...2,767,774
Ensembl chr20:2,763,417...2,767,248 		JBrowse link
G FCGR1A Fc fragment of IgG receptor Ia acts_upstream_of_or_within ISO (PMID:11911824)
(PMID:11911823), (PMID:9551950)		 MGI PMID:9551950 PMID:11911823 PMID:11911824
G GSN gelsolin involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:18,253,079...18,317,285
Ensembl chr12:18,253,324...18,285,938 		JBrowse link
G GULP1 GULP PTB domain containing engulfment adaptor 1 acts_upstream_of_or_within ISO (PMID:11729193) MGI PMID:11729193 NCBI chr10:73,809,773...74,111,624
Ensembl chr10:73,812,072...74,111,730 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:18414680 GO_REF:0000118 RGD:2316597 NCBI chr23:59,422,769...59,454,183
Ensembl chr23:59,423,334...59,453,531 		JBrowse link
G ITGAM integrin subunit alpha M involved_in ISO (MGI:5319446|PMID:22438044), (MGI:5905548|PMID:20199584), (MGI:6189359|PMID:22632727) ARUK-UCL PMID:20199584 PMID:22438044 PMID:22632727 MGI:5319446 MGI:5905548 MGI:6189359 NCBI chr 5:27,957,162...28,042,697
Ensembl chr 5:27,957,324...28,042,691 		JBrowse link
G ITGB2 integrin subunit beta 2 involved_in ISO (MGI:5905548|PMID:20199584) ARUK-UCL PMID:20199584 MGI:5905548 NCBI chr 2:88,597,554...88,644,890
Ensembl chr 2:88,597,556...88,624,025 		JBrowse link
G LOC103222345 trem-like transcript 4 protein acts_upstream_of_or_within ISO (PMID:19155473) MGI PMID:19155473 NCBI chr17:30,907,797...30,923,226
Ensembl chr17:30,915,052...30,923,486 		JBrowse link
G LOC103223283 pyridoxal phosphate phosphatase involved_in ISO (PMID:26465210) UniProt PMID:26465210 NCBI chr19:20,340,535...20,357,426
Ensembl chr19:20,360,108...20,368,247
Ensembl chr19:20,360,108...20,368,247 		JBrowse link
G LOC103223672 low affinity immunoglobulin gamma Fc region receptor II-b acts_upstream_of_or_within ISO (PMID:8769481) MGI PMID:8769481 NCBI chr20:2,398,425...2,413,328 JBrowse link
G LOC103237529 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:136,704,318...136,784,581
Ensembl chr 8:136,704,341...136,783,991 		JBrowse link
G LOC103246325 cell division control protein 42 homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:34,420,934...34,422,472 JBrowse link
G MARCO macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chr10:11,329,036...11,389,428
Ensembl chr10:11,329,026...11,388,999 		JBrowse link
G MSR1 macrophage scavenger receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:14,221,389...14,305,059
Ensembl chr 8:14,220,529...14,304,946 		JBrowse link
G MYH9 myosin heavy chain 9 involved_in ISO (MGI:5619440|PMID:23325791) UniProt PMID:23325791 MGI:5619440 NCBI chr19:18,985,709...19,093,304
Ensembl chr19:18,986,598...19,052,671 		JBrowse link
G RAC1 Rac family small GTPase 1 involved_in ISO (MGI:5315376|PMID:10934045) UniProt PMID:10934045 MGI:5315376 NCBI chr28:15,583,609...15,610,753
Ensembl chr28:15,583,516...15,610,328 		JBrowse link
G SIGLEC9 sialic acid binding Ig like lectin 9 acts_upstream_of ISO (PMID:24227736) MGI PMID:24227736 NCBI chr 6:44,132,958...44,139,941
Ensembl chr 6:44,134,688...44,139,733 		JBrowse link
G SIRPA signal regulatory protein alpha acts_upstream_of_or_within ISO (PMID:14634079) MGI PMID:14634079 NCBI chr 2:54,590,151...54,636,381 JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in
acts_upstream_of_or_within		 ISO (MGI:5606096|PMID:24990881)
(PMID:19155473)		 UniProt
MGI		 PMID:19155473 PMID:24990881 MGI:5606096 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
G VAMP7 vesicle associated membrane protein 7 involved_in ISO PMID:15133481 UniProt PMID:15133481 RGD:4892614 NCBI chr  X:129,937,026...129,984,071
Ensembl chr  X:129,937,046...129,984,119 		JBrowse link
cytoskeletal rearrangement involved in phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TIMD4 T cell immunoglobulin and mucin domain containing 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr23:59,320,120...59,381,965
Ensembl chr23:59,319,749...59,355,100 		JBrowse link
engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN1 beclin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:63,469,187...63,482,627
Ensembl chr16:63,469,192...63,485,322 		JBrowse link
G LOC103237529 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:136,704,318...136,784,581
Ensembl chr 8:136,704,341...136,783,991 		JBrowse link
G MEGF10 multiple EGF like domains 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27170117) Ensembl
MGI		 PMID:27170117 GO_REF:0000107 NCBI chr23:30,028,154...30,405,033
Ensembl chr23:30,234,489...30,404,996 		JBrowse link
G RAC1 Rac family small GTPase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr28:15,583,609...15,610,753
Ensembl chr28:15,583,516...15,610,328 		JBrowse link
G RAC2 Rac family small GTPase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:19,930,799...19,949,381
Ensembl chr19:19,929,892...19,949,376 		JBrowse link
G RAC3 Rac family small GTPase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:73,919,086...73,921,647
Ensembl chr16:73,919,128...73,925,277 		JBrowse link
G RHOBTB1 Rho related BTB domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:70,266,735...70,398,839
Ensembl chr 9:70,356,290...70,396,791 		JBrowse link
G RHOBTB2 Rho related BTB domain containing 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:21,069,255...21,098,000
Ensembl chr 8:21,079,411...21,097,026 		JBrowse link
G RHOG ras homolog family member G involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:62,881,857...62,896,073
Ensembl chr 1:62,881,941...62,895,529 		JBrowse link
G RHOH ras homolog family member H involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr27:10,061,316...10,109,124
Ensembl chr27:10,062,014...10,062,589 		JBrowse link
G THBS1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:43,410,693...43,427,816
Ensembl chr26:43,410,580...43,427,812 		JBrowse link
G XKR5 XK related 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:6,589,913...6,616,045
Ensembl chr 8:6,590,302...6,615,308 		JBrowse link
G XKR6 XK related 6 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr 8:8,172,082...8,204,775 JBrowse link
G XKR7 XK related 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:36,357,516...36,387,284
Ensembl chr 2:36,358,337...36,385,140 		JBrowse link
G XKR8 XK related 8 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:104,830,967...104,851,913
Ensembl chr20:104,842,157...104,851,280 		JBrowse link
G XKR9 XK related 9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:66,406,484...66,463,500
Ensembl chr 8:66,441,550...66,463,496 		JBrowse link
negative regulation of phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD300A CD300a molecule involved_in ISO (PMID:22302738) UniProt PMID:22302738
G SIGLEC9 sialic acid binding Ig like lectin 9 acts_upstream_of_or_within ISO (PMID:24227736) MGI PMID:24227736 NCBI chr 6:44,132,958...44,139,941
Ensembl chr 6:44,134,688...44,139,733 		JBrowse link
positive regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103233590 phospholipid-transporting ATPase ABCA7 involved_in ISO (MGI:3662940|PMID:16908670) Alzheimers_University_of_Toronto PMID:16908670 MGI:3662940 NCBI chr 6:792,684...821,522
Ensembl chr 6:792,783...821,375 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
positive regulation of phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:23238794 RGD:8696010 NCBI chr17:39,847,343...39,851,288
Ensembl chr17:39,847,759...39,851,127 		JBrowse link
G ANO6 anoctamin 6 involved_in ISO (MGI:5634870|PMID:25651887) UniProt PMID:25651887 MGI:5634870 NCBI chr11:41,420,206...41,633,323
Ensembl chr11:41,419,901...41,633,347 		JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:100,400,093...100,469,234
Ensembl chr11:100,400,084...100,462,507 		JBrowse link
G C3 complement C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:6,250,422...6,289,264 JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16061696) Ensembl
MGI		 PMID:16061696 GO_REF:0000107 NCBI chr21:68,214,875...68,309,336
Ensembl chr21:68,216,201...68,268,669 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005 		JBrowse link
G FCGR1A Fc fragment of IgG receptor Ia ISO RGD PMID:19657115 RGD:9685698
G GATA2 GATA binding protein 2 ISO RGD PMID:12933836 RGD:632788 NCBI chr22:52,549,112...52,562,911
Ensembl chr22:52,555,738...52,562,909 		JBrowse link
G ITGA2 integrin subunit alpha 2 ISO RGD PMID:9284952 RGD:2307413 NCBI chr 4:49,280,289...49,382,101
Ensembl chr 4:49,317,648...49,380,051 		JBrowse link
G LBP lipopolysaccharide binding protein ISO RGD PMID:11104656 RGD:9685187 NCBI chr 2:25,375,364...25,407,181
Ensembl chr 2:25,374,755...25,406,839 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in ISO (MGI:3818191|PMID:19015308) UniProt PMID:19015308 MGI:3818191 NCBI chr11:50,611,193...50,658,800 JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 Ensembl chr11:50,611,181...50,647,519 JBrowse link
G PLCG2 phospholipase C gamma 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
Ensembl		 PMID:32514138 GO_REF:0000107 NCBI chr 5:67,209,268...67,394,865
Ensembl chr 5:67,215,459...67,398,990 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO RGD PMID:15940641 RGD:8553017 NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418 		JBrowse link
G RAB31 RAB31, member RAS oncogene family involved_in ISO (MGI:6271154|PMID:25568335) UniProt PMID:25568335 MGI:6271154 NCBI chr18:68,583,178...68,736,182
Ensembl chr18:68,583,259...68,736,771 		JBrowse link
G STAP1 signal transducing adaptor family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:1,330,761...1,380,503
Ensembl chr 7:1,330,223...1,379,820 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
TreeGrafter
Ensembl		 PMID:32514138 GO_REF:0000107 GO_REF:0000118 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX15 arachidonate 15-lipoxygenase involved_in ISO (MGI:5436199|PMID:22503541), (MGI:5508294|PMID:11278875) UniProt PMID:11278875 PMID:22503541 MGI:5436199 MGI:5508294 NCBI chr16:4,112,795...4,121,764
Ensembl chr16:4,111,151...4,121,645 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17080
    cellular process 15997
      vesicle-mediated transport 1596
        endocytosis 704
          phagocytosis 232
            phagocytosis, engulfment 63
              cytoskeletal rearrangement involved in phagocytosis, engulfment 1
              engulfment of apoptotic cell + 19
              membrane reorganization involved in phagocytosis, engulfment 0
              negative regulation of phagocytosis, engulfment + 2
              positive regulation of phagocytosis, engulfment + 18
              regulation of phagocytosis, engulfment + 21
Path 2
Term Annotations click to browse term
  biological_process 17080
    localization 5434
      establishment of localization 4718
        transport 4416
          vesicle-mediated transport 1596
            endocytosis 704
              phagocytosis 232
                phagocytosis, engulfment 63
                  cytoskeletal rearrangement involved in phagocytosis, engulfment 1
                  engulfment of apoptotic cell + 19
                  membrane reorganization involved in phagocytosis, engulfment 0
                  negative regulation of phagocytosis, engulfment + 2
                  positive regulation of phagocytosis, engulfment + 18
                  regulation of phagocytosis, engulfment + 21
paths to the root