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ONTOLOGY REPORT - ANNOTATIONS

Term:phagocytosis, engulfment
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Accession:GO:0006911 term browser browse the term
Definition:The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
Synonyms:related_synonym: phagosome biosynthesis;   phagosome formation


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phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10878804) Ensembl
MGI		 PMID:10878804 GO_REF:0000107 NCBI chr11:60,761,669...60,869,753
Ensembl chr11:60,761,655...60,890,496 		JBrowse link
G ADGRB1 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:36,627,791...36,649,013
Ensembl chr13:36,614,498...36,690,936 		JBrowse link
G AIF1 allograft inflammatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,104,350...1,106,179
Ensembl chr12:1,104,394...1,106,177 		JBrowse link
G ARHGAP12 Rho GTPase activating protein 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:14,959,556...15,114,710
Ensembl chr 2:14,976,416...15,115,194 		JBrowse link
G ARHGAP25 Rho GTPase activating protein 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:67,597,527...67,687,721 JBrowse link
G BIN2 bridging integrator 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:3,563,431...3,597,363
Ensembl chr27:3,563,475...3,596,817 		JBrowse link
G CDC42 cell division cycle 42 involved_in ISS UniProt GO_REF:0000024
G CLCN2 chloride voltage-gated channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:17,224,136...17,238,755
Ensembl chr34:17,223,215...17,239,621 		JBrowse link
G CLCN3 chloride voltage-gated channel 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16522634) Ensembl
MGI		 PMID:16522634 GO_REF:0000107 NCBI chr25:20,528,708...20,616,687
Ensembl chr25:20,528,699...20,615,070 		JBrowse link
G CLEC7A C-type lectin domain containing 7A acts_upstream_of_or_within ISO (PMID:14707091) MGI PMID:14707091 NCBI chr27:35,852,685...35,885,673
Ensembl chr27:35,853,099...36,007,157 		JBrowse link
G ELMO1 engulfment and cell motility 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:48,163,218...48,610,626
Ensembl chr14:48,164,049...48,730,248 		JBrowse link
G FCER1G Fc epsilon receptor Ig acts_upstream_of_or_within ISO (PMID:11237803), (PMID:11911823)
(PMID:11901193)		 MGI PMID:11237803 PMID:11901193 PMID:11911823 NCBI chr38:21,267,841...21,271,036
Ensembl chr38:21,268,001...21,270,940 		JBrowse link
G FCGR1A Fc fragment of IgG receptor Ia acts_upstream_of_or_within ISO (PMID:11911824)
(PMID:11911823), (PMID:9551950)		 MGI PMID:9551950 PMID:11911823 PMID:11911824 NCBI chr17:59,073,139...59,102,023
Ensembl chr17:59,092,933...59,102,015 		JBrowse link
G FCGR2B Fc fragment of IgG receptor IIb acts_upstream_of_or_within ISO (PMID:8769481) MGI PMID:8769481 NCBI chr38:20,980,777...20,994,403 JBrowse link
G GSN gelsolin involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:74,248,227...74,268,129
Ensembl chr11:74,233,457...74,268,129 		JBrowse link
G GULP1 GULP PTB domain containing engulfment adaptor 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11729193) MGI
Ensembl		 PMID:11729193 GO_REF:0000107 NCBI chr36:30,108,886...30,248,805
Ensembl chr36:30,108,947...30,265,896 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO RGD PMID:18414680 RGD:2316597 NCBI chr 4:53,012,223...53,066,611
Ensembl chr 4:53,046,970...53,128,952
Ensembl chr 4:53,046,970...53,128,952 		JBrowse link
G ITGAM integrin subunit alpha M involved_in ISO (MGI:5319446|PMID:22438044), (MGI:5905548|PMID:20199584), (MGI:6189359|PMID:22632727) ARUK-UCL PMID:20199584 PMID:22438044 PMID:22632727 MGI:5319446 MGI:5905548 MGI:6189359 NCBI chr 6:16,944,062...16,996,525
Ensembl chr 6:16,808,971...16,996,286 		JBrowse link
G ITGB2 integrin subunit beta 2 involved_in ISO (MGI:5905548|PMID:20199584) ARUK-UCL PMID:20199584 MGI:5905548 NCBI chr31:38,520,733...38,547,003
Ensembl chr31:38,521,103...38,547,018 		JBrowse link
G LOC102152131 sialic acid-binding Ig-like lectin 14 acts_upstream_of ISO (PMID:24227736) MGI PMID:24227736 NCBI chr 1:105,551,488...105,555,358 JBrowse link
G LOC403934 cell division cycle 42 involved_in ISS UniProt GO_REF:0000024 NCBI chr 2:77,153,276...77,169,947
Ensembl chr 2:77,153,095...77,199,211 		JBrowse link
G MARCO macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chr19:30,996,209...31,034,520
Ensembl chr19:30,996,347...31,034,487 		JBrowse link
G MSR1 macrophage scavenger receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:39,434,948...39,513,727
Ensembl chr16:39,436,753...39,527,438 		JBrowse link
G MYH9 myosin heavy chain 9 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:28,063,626...28,122,953
Ensembl chr10:28,063,624...28,122,953 		JBrowse link
G RAC1 Rac family small GTPase 1 involved_in ISO (MGI:5315376|PMID:10934045) UniProt PMID:10934045 MGI:5315376 NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216 		JBrowse link
G SH3BP1 SH3 domain binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:26,953,993...26,966,417
Ensembl chr10:26,954,137...26,966,417 		JBrowse link
G SIRPA signal regulatory protein alpha acts_upstream_of_or_within ISO (PMID:14634079) MGI PMID:14634079 NCBI chr24:19,094,930...19,136,655 JBrowse link
G VAMP7 vesicle associated membrane protein 7 involved_in ISO PMID:15133481 UniProt PMID:15133481 RGD:4892614 NCBI chr  X:123,717,524...123,783,781
Ensembl chr  X:123,717,446...123,783,014 		JBrowse link
engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRB1 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:36,627,791...36,649,013
Ensembl chr13:36,614,498...36,690,936 		JBrowse link
G BECN1 beclin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:20,204,203...20,215,081
Ensembl chr 9:20,204,220...20,214,236 		JBrowse link
G LOC119877912 beclin-1 involved_in IEA Ensembl GO_REF:0000107
G LOC119881459 ras-related C3 botulinum toxin substrate 1 involved_in IBA GO_Central GO_REF:0000033
G MEGF10 multiple EGF like domains 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27170117) Ensembl
MGI		 PMID:27170117 GO_REF:0000107 NCBI chr11:16,359,648...16,574,882
Ensembl chr11:16,378,669...16,617,335 		JBrowse link
G RAC1 Rac family small GTPase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216 		JBrowse link
G THBS1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:6,770,212...6,786,875
Ensembl chr30:6,769,470...6,784,915 		JBrowse link
G XKR8 XK related 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:72,419,950...72,426,315
Ensembl chr 2:72,418,872...72,450,737 		JBrowse link
negative regulation of phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD300A CD300a molecule involved_in ISO (PMID:22302738) UniProt PMID:22302738 NCBI chr 9:5,952,428...5,976,328 JBrowse link
G LOC102152131 sialic acid-binding Ig-like lectin 14 acts_upstream_of_or_within ISO (PMID:24227736) MGI PMID:24227736 NCBI chr 1:105,551,488...105,555,358 JBrowse link
positive regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:3662940|PMID:16908670) Alzheimers_University_of_Toronto PMID:16908670 MGI:3662940 NCBI chr20:57,668,371...57,684,111
Ensembl chr20:57,667,706...57,677,342 		JBrowse link
G TREML1 triggering receptor expressed on myeloid cells like 1 involved_in ISO (PMID:24990881) UniProt PMID:24990881 NCBI chr12:9,915,692...9,928,322
Ensembl chr12:9,915,677...9,928,174 		JBrowse link
positive regulation of phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:23238794 RGD:8696010 NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129 		JBrowse link
G ANO6 anoctamin 6 involved_in ISO (MGI:5634870|PMID:25651887) UniProt PMID:25651887 MGI:5634870 NCBI chr27:8,882,691...9,067,057
Ensembl chr27:8,884,062...9,066,934 		JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:33,192,261...33,243,034
Ensembl chr10:33,191,602...33,242,669 		JBrowse link
G C3 complement C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16061696) Ensembl
MGI		 PMID:16061696 GO_REF:0000107 NCBI chr18:20,299,808...20,375,856
Ensembl chr18:20,339,050...20,372,639 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:29,801,119...29,810,006
Ensembl chr 3:29,800,211...29,810,180 		JBrowse link
G FCGR1A Fc fragment of IgG receptor Ia ISO RGD PMID:19657115 RGD:9685698 NCBI chr17:59,073,139...59,102,023
Ensembl chr17:59,092,933...59,102,015 		JBrowse link
G GATA2 GATA binding protein 2 ISO RGD PMID:12933836 RGD:632788 NCBI chr20:2,472,251...2,488,380
Ensembl chr20:2,473,912...2,480,991 		JBrowse link
G ITGA2 integrin subunit alpha 2 ISO RGD PMID:9284952 RGD:2307413 NCBI chr 4:62,170,137...62,268,962
Ensembl chr 4:62,170,452...62,268,983 		JBrowse link
G LBP lipopolysaccharide binding protein ISO RGD PMID:11104656 RGD:9685187 NCBI chr24:26,810,369...26,833,515
Ensembl chr24:26,809,843...26,833,434 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:805,274...858,901
Ensembl chr27:805,310...843,439 		JBrowse link
G PLCG2 phospholipase C gamma 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
Ensembl		 PMID:32514138 GO_REF:0000107 NCBI chr 5:70,054,683...70,233,459
Ensembl chr 5:70,059,255...70,207,049 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO RGD PMID:15940641 RGD:8553017 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981 		JBrowse link
G RAB31 RAB31, member RAS oncogene family involved_in ISO (MGI:6271154|PMID:25568335) UniProt PMID:25568335 MGI:6271154 NCBI chr 7:75,678,896...75,807,716
Ensembl chr 7:75,678,908...75,817,426 		JBrowse link
G STAP1 signal transducing adaptor family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:58,091,457...58,148,902
Ensembl chr13:58,091,477...58,133,711 		JBrowse link
G TREML1 triggering receptor expressed on myeloid cells like 1 acts_upstream_of
involved_in		 ISO (PMID:32514138)
(PMID:28855300), (PMID:33097708)		 ARUK-UCL
UniProt		 PMID:28855300 PMID:32514138 PMID:33097708 NCBI chr12:9,915,692...9,928,322
Ensembl chr12:9,915,677...9,928,174 		JBrowse link
regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX15 arachidonate 15-lipoxygenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:31,883,544...31,891,357
Ensembl chr 5:31,882,501...32,038,119 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17068
    cellular process 15926
      vesicle-mediated transport 1487
        endocytosis 656
          phagocytosis 211
            phagocytosis, engulfment 52
              cytoskeletal rearrangement involved in phagocytosis, engulfment 0
              engulfment of apoptotic cell + 11
              membrane reorganization involved in phagocytosis, engulfment 0
              negative regulation of phagocytosis, engulfment + 2
              positive regulation of phagocytosis, engulfment + 17
              regulation of phagocytosis, engulfment + 20
Path 2
Term Annotations click to browse term
  biological_process 17068
    localization 5310
      establishment of localization 4647
        transport 4361
          vesicle-mediated transport 1487
            endocytosis 656
              phagocytosis 211
                phagocytosis, engulfment 52
                  cytoskeletal rearrangement involved in phagocytosis, engulfment 0
                  engulfment of apoptotic cell + 11
                  membrane reorganization involved in phagocytosis, engulfment 0
                  negative regulation of phagocytosis, engulfment + 2
                  positive regulation of phagocytosis, engulfment + 17
                  regulation of phagocytosis, engulfment + 20
paths to the root