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ONTOLOGY REPORT - ANNOTATIONS


Term:phagocytosis, engulfment
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Accession:GO:0006911 term browser browse the term
Definition:The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
Synonyms:related_synonym: phagosome biosynthesis;   phagosome formation


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phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 acts_upstream_of_or_within ISO (PMID:10878804) MGI PMID:10878804 NCBI chrNW_004955419:21,553,863...21,681,626
Ensembl chrNW_004955419:21,553,835...21,681,619
JBrowse link
G Adgrb1 adhesion G protein-coupled receptor B1 involved_in ISO (PMID:26838550) UniProt PMID:26838550 NCBI chrNW_004955454:1,250,261...1,313,547
Ensembl chrNW_004955454:1,237,363...1,314,127
JBrowse link
G Aif1 allograft inflammatory factor 1 involved_in ISO (PMID:10934045) UniProt PMID:10934045 NCBI chrNW_004955437:157,509...158,919
Ensembl chrNW_004955437:157,509...158,919
JBrowse link
G Arhgap12 Rho GTPase activating protein 12 involved_in ISO (PMID:26465210) UniProt PMID:26465210 NCBI chrNW_004955429:23,452,880...23,560,948
Ensembl chrNW_004955429:23,450,268...23,560,948
JBrowse link
G Arhgap25 Rho GTPase activating protein 25 involved_in ISO (PMID:26465210) UniProt PMID:26465210 NCBI chrNW_004955424:16,166,285...16,241,481
Ensembl chrNW_004955424:16,164,324...16,241,481
JBrowse link
G Bin2 bridging integrator 2 involved_in ISO (PMID:23285027) UniProt PMID:23285027 NCBI chrNW_004955547:1,774,330...1,798,031 JBrowse link
G Cdc42 cell division cycle 42 involved_in ISO (PMID:26465210) UniProt PMID:26465210 NCBI chrNW_004955452:2,255,940...2,299,042
Ensembl chrNW_004955452:2,255,117...2,299,042
JBrowse link
G Clcn2 chloride voltage-gated channel 2 involved_in ISO (PMID:36964785) UniProt PMID:36964785 NCBI chrNW_004955420:23,138,558...23,152,462
Ensembl chrNW_004955420:23,138,605...23,152,311
JBrowse link
G Clcn3 chloride voltage-gated channel 3 acts_upstream_of_or_within ISO (PMID:16522634) MGI PMID:16522634 NCBI chrNW_004955403:36,625,871...36,710,201
Ensembl chrNW_004955403:36,625,770...36,710,201
JBrowse link
G Elmo1 engulfment and cell motility 1 involved_in ISO (PMID:11595183) UniProt PMID:11595183 NCBI chrNW_004955460:6,044,827...6,580,770
Ensembl chrNW_004955460:6,044,725...6,581,269
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig acts_upstream_of_or_within ISO (PMID:11901193)
(PMID:11237803), (PMID:11911823)
MGI PMID:11237803 PMID:11901193 PMID:11911823 NCBI chrNW_004955468:12,971,931...12,975,206
Ensembl chrNW_004955468:12,971,931...12,975,206
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb acts_upstream_of_or_within ISO (PMID:8769481) MGI PMID:8769481 NCBI chrNW_004955462:14,639,396...14,653,801 JBrowse link
G Gsn gelsolin involved_in ISO (PMID:23325791) UniProt PMID:23325791 NCBI chrNW_004955419:6,682,202...6,733,361
Ensembl chrNW_004955419:6,682,058...6,733,361
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 acts_upstream_of_or_within ISO (PMID:11729193) MGI PMID:11729193 NCBI chrNW_004955403:10,079,781...10,328,168
Ensembl chrNW_004955403:10,078,355...10,326,904
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO RGD PMID:18414680 RGD:2316597 NCBI chrNW_004955408:11,047,679...11,070,492 JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (PMID:20199584), (PMID:22438044), (PMID:22632727) ARUK-UCL PMID:20199584 PMID:22438044 PMID:22632727 NCBI chrNW_004955493:8,116,886...8,160,806
Ensembl chrNW_004955493:8,116,834...8,260,759
JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (PMID:20199584) ARUK-UCL PMID:20199584 NCBI chrNW_004955407:41,779,849...41,805,637
Ensembl chrNW_004955407:41,777,777...41,800,201
JBrowse link
G Marco macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chrNW_004955459:10,700,645...10,739,222
Ensembl chrNW_004955459:10,698,294...10,739,131
JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in ISO (PMID:22438044) ARUK-UCL PMID:22438044 NCBI chrNW_004955463:1,197,086...1,263,943
Ensembl chrNW_004955463:1,197,022...1,264,765
JBrowse link
G Myh9 myosin heavy chain 9 involved_in ISO (PMID:23325791) UniProt PMID:23325791 NCBI chrNW_004955413:22,881,759...22,972,182
Ensembl chrNW_004955413:22,881,045...22,972,450
JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (PMID:10934045) UniProt PMID:10934045 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351
JBrowse link
G Sh3bp1 SH3 domain binding protein 1 involved_in ISO (PMID:26465210) UniProt PMID:26465210 NCBI chrNW_004955413:24,042,875...24,054,826
Ensembl chrNW_004955413:24,042,875...24,055,041
JBrowse link
G Sirpa signal regulatory protein alpha acts_upstream_of_or_within ISO (PMID:14634079) MGI PMID:14634079 NCBI chrNW_004955415:13,030,752...13,072,735 JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in
acts_upstream_of_or_within
ISO (PMID:24990881)
(PMID:19155473)
UniProt
MGI
PMID:19155473 PMID:24990881 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697
JBrowse link
G Treml4 triggering receptor expressed on myeloid cells like 4 acts_upstream_of_or_within ISO (PMID:19155473) MGI PMID:19155473 NCBI chrNW_004955437:7,827,329...7,846,406 JBrowse link
G Vamp7 vesicle associated membrane protein 7 involved_in ISO PMID:15133481 UniProt PMID:15133481 RGD:4892614 NCBI chrNW_004955594:20,496...72,648
Ensembl chrNW_004955594:18,727...72,654
JBrowse link
engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrb1 adhesion G protein-coupled receptor B1 involved_in ISO (PMID:24509909)
(PMID:17960134)
UniProt PMID:17960134 PMID:24509909 NCBI chrNW_004955454:1,250,261...1,313,547
Ensembl chrNW_004955454:1,237,363...1,314,127
JBrowse link
G Becn1 beclin 1 involved_in ISO (PMID:22393062) CACAO PMID:22393062 NCBI chrNW_004955451:16,616,595...16,625,731
Ensembl chrNW_004955451:16,616,595...16,625,730
JBrowse link
G Megf10 multiple EGF like domains 10 acts_upstream_of_or_within ISO (PMID:27170117) MGI PMID:27170117 NCBI chrNW_004955415:393,642...513,157
Ensembl chrNW_004955415:335,012...513,891
JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (PMID:20691665) BHF-UCL PMID:20691665 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351
JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:16882710) BHF-UCL PMID:16882710 NCBI chrNW_004955416:6,490,034...6,506,419
Ensembl chrNW_004955416:6,489,451...6,506,419
JBrowse link
G Xkr8 XK related 8 involved_in ISO (PMID:29440417), (PMID:31712393)
(PMID:23845944)
UniProt PMID:23845944 PMID:29440417 PMID:31712393 NCBI chrNW_004955452:7,141,088...7,148,571
Ensembl chrNW_004955452:7,141,201...7,146,443
JBrowse link
negative regulation of phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a CD300a molecule involved_in ISO (PMID:22302738) UniProt PMID:22302738 NCBI chrNW_004955553:1,335,854...1,356,001
Ensembl chrNW_004955553:1,336,227...1,460,376
JBrowse link
positive regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:16908670) Alzheimers_University_of_Toronto PMID:16908670 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:24990881) UniProt PMID:24990881 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697
JBrowse link
positive regulation of phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor ISO RGD PMID:23238794 RGD:8696010 NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479
JBrowse link
G Ano6 anoctamin 6 involved_in ISO (PMID:25651887) UniProt PMID:25651887 NCBI chrNW_004955500:4,462,314...4,652,634
Ensembl chrNW_004955500:4,462,524...4,652,782
JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (PMID:25568335) UniProt PMID:25568335 NCBI chrNW_004955405:39,503,020...39,540,069
Ensembl chrNW_004955405:39,503,020...39,540,335
JBrowse link
G C3 complement C3 involved_in ISO (PMID:22438044), (PMID:22632727)
(PMID:20199584)
ARUK-UCL PMID:20199584 PMID:22438044 PMID:22632727 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
JBrowse link
G Cd36 CD36 molecule (CD36 blood group) acts_upstream_of_or_within ISO (PMID:16061696) MGI PMID:16061696 NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:21501162) UniProt PMID:21501162 NCBI chrNW_004955425:24,050,901...24,054,039 JBrowse link
G Gata2 GATA binding protein 2 ISO RGD PMID:12933836 RGD:632788 NCBI chrNW_004955429:15,326,551...15,334,774
Ensembl chrNW_004955429:15,327,113...15,336,460
JBrowse link
G Itga2 integrin subunit alpha 2 ISO RGD PMID:9284952 RGD:2307413 NCBI chrNW_004955446:14,309,516...14,421,991
Ensembl chrNW_004955446:14,309,349...14,422,170
JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISO (PMID:19015308) UniProt PMID:19015308 NCBI chrNW_004955458:1,733,799...1,785,591
Ensembl chrNW_004955458:1,733,883...1,784,182
JBrowse link
G Plcg2 phospholipase C gamma 2 acts_upstream_of_or_within ISO (PMID:32514138) ARUK-UCL PMID:32514138 NCBI chrNW_004955522:4,352,890...4,480,735
Ensembl chrNW_004955522:4,358,233...4,468,986
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO RGD PMID:15940641 RGD:8553017 NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387
JBrowse link
G Rab31 RAB31, member RAS oncogene family involved_in ISO (PMID:25568335) UniProt PMID:25568335 NCBI chrNW_004955402:2,354,399...2,446,537
Ensembl chrNW_004955402:2,354,646...2,446,453
JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO (PMID:19100238) BHF-UCL PMID:19100238 NCBI chrNW_004955447:5,292,708...5,345,214
Ensembl chrNW_004955447:5,293,227...5,330,187
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in
acts_upstream_of
ISO (PMID:28855300), (PMID:33097708)
(PMID:25631124), (PMID:29752066)
(PMID:32514138)
UniProt
ARUK-UCL
PMID:25631124 PMID:28855300 PMID:29752066 PMID:32514138 PMID:33097708 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697
JBrowse link
regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase involved_in ISO (PMID:11278875), (PMID:22503541) UniProt PMID:11278875 PMID:22503541 NCBI chrNW_004955467:10,032,792...10,039,789 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12600
    cellular process 12034
      vesicle-mediated transport 1245
        endocytosis 585
          phagocytosis 191
            phagocytosis, engulfment 46
              cytoskeletal rearrangement involved in phagocytosis, engulfment 0
              engulfment of apoptotic cell + 9
              membrane reorganization involved in phagocytosis, engulfment 0
              negative regulation of phagocytosis, engulfment + 1
              positive regulation of phagocytosis, engulfment + 15
              regulation of phagocytosis, engulfment + 17
Path 2
Term Annotations click to browse term
  biological_process 12600
    localization 4342
      establishment of localization 3713
        transport 3445
          vesicle-mediated transport 1245
            endocytosis 585
              phagocytosis 191
                phagocytosis, engulfment 46
                  cytoskeletal rearrangement involved in phagocytosis, engulfment 0
                  engulfment of apoptotic cell + 9
                  membrane reorganization involved in phagocytosis, engulfment 0
                  negative regulation of phagocytosis, engulfment + 1
                  positive regulation of phagocytosis, engulfment + 15
                  regulation of phagocytosis, engulfment + 17
paths to the root