ONTOLOGY REPORT - ANNOTATIONS
Term: phagocytosis, engulfment
Accession: GO:0006911
browse the term
Definition: The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
Synonyms: related_synonym: phagosome biosynthesis; phagosome formation
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Abca1
ATP binding cassette subfamily A member 1
acts_upstream_of_or_within
ISO
(PMID:10878804)
MGI
PMID:10878804
NCBI chrNW_004955419:21,553,863...21,681,626
Ensembl chrNW_004955419:21,553,835...21,681,619
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Adgrb1
adhesion G protein-coupled receptor B1
involved_in
ISO
(PMID:26838550)
UniProt
PMID:26838550
NCBI chrNW_004955454:1,250,261...1,313,547
Ensembl chrNW_004955454:1,237,363...1,314,127
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Aif1
allograft inflammatory factor 1
involved_in
ISO
(PMID:10934045)
UniProt
PMID:10934045
NCBI chrNW_004955437:157,509...158,919
Ensembl chrNW_004955437:157,509...158,919
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Arhgap12
Rho GTPase activating protein 12
involved_in
ISO
(PMID:26465210)
UniProt
PMID:26465210
NCBI chrNW_004955429:23,452,880...23,560,948
Ensembl chrNW_004955429:23,450,268...23,560,948
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Arhgap25
Rho GTPase activating protein 25
involved_in
ISO
(PMID:26465210)
UniProt
PMID:26465210
NCBI chrNW_004955424:16,166,285...16,241,481
Ensembl chrNW_004955424:16,164,324...16,241,481
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Bin2
bridging integrator 2
involved_in
ISO
(PMID:23285027)
UniProt
PMID:23285027
NCBI chrNW_004955547:1,774,330...1,798,031
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Cdc42
cell division cycle 42
involved_in
ISO
(PMID:26465210)
UniProt
PMID:26465210
NCBI chrNW_004955452:2,255,940...2,299,042
Ensembl chrNW_004955452:2,255,117...2,299,042
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Clcn2
chloride voltage-gated channel 2
involved_in
ISO
(PMID:36964785)
UniProt
PMID:36964785
NCBI chrNW_004955420:23,138,558...23,152,462
Ensembl chrNW_004955420:23,138,605...23,152,311
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Clcn3
chloride voltage-gated channel 3
acts_upstream_of_or_within
ISO
(PMID:16522634)
MGI
PMID:16522634
NCBI chrNW_004955403:36,625,871...36,710,201
Ensembl chrNW_004955403:36,625,770...36,710,201
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Elmo1
engulfment and cell motility 1
involved_in
ISO
(PMID:11595183)
UniProt
PMID:11595183
NCBI chrNW_004955460:6,044,827...6,580,770
Ensembl chrNW_004955460:6,044,725...6,581,269
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Fcer1g
Fc fragment of IgE receptor Ig
acts_upstream_of_or_within
ISO
(PMID:11901193) (PMID:11237803), (PMID:11911823)
MGI
PMID:11237803 PMID:11901193 PMID:11911823
NCBI chrNW_004955468:12,971,931...12,975,206
Ensembl chrNW_004955468:12,971,931...12,975,206
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Fcgr2b
Fc fragment of IgG receptor IIb
acts_upstream_of_or_within
ISO
(PMID:8769481)
MGI
PMID:8769481
NCBI chrNW_004955462:14,639,396...14,653,801
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Gsn
gelsolin
involved_in
ISO
(PMID:23325791)
UniProt
PMID:23325791
NCBI chrNW_004955419:6,682,202...6,733,361
Ensembl chrNW_004955419:6,682,058...6,733,361
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Gulp1
GULP PTB domain containing engulfment adaptor 1
acts_upstream_of_or_within
ISO
(PMID:11729193)
MGI
PMID:11729193
NCBI chrNW_004955403:10,079,781...10,328,168
Ensembl chrNW_004955403:10,078,355...10,326,904
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Havcr1
hepatitis A virus cellular receptor 1
ISO
RGD
PMID:18414680
RGD:2316597
NCBI chrNW_004955408:11,047,679...11,070,492
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Itgam
integrin subunit alpha M
involved_in
ISO
(PMID:20199584), (PMID:22438044), (PMID:22632727)
ARUK-UCL
PMID:20199584 PMID:22438044 PMID:22632727
NCBI chrNW_004955493:8,116,886...8,160,806
Ensembl chrNW_004955493:8,116,834...8,260,759
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Itgb2
integrin subunit beta 2
involved_in
ISO
(PMID:20199584)
ARUK-UCL
PMID:20199584
NCBI chrNW_004955407:41,779,849...41,805,637
Ensembl chrNW_004955407:41,777,777...41,800,201
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Marco
macrophage receptor with collagenous structure
involved_in
ISO
PMID:15987691
ARUK-UCL
PMID:15987691
RGD:13432286
NCBI chrNW_004955459:10,700,645...10,739,222
Ensembl chrNW_004955459:10,698,294...10,739,131
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Msr1
macrophage scavenger receptor 1
involved_in
ISO
(PMID:22438044)
ARUK-UCL
PMID:22438044
NCBI chrNW_004955463:1,197,086...1,263,943
Ensembl chrNW_004955463:1,197,022...1,264,765
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Myh9
myosin heavy chain 9
involved_in
ISO
(PMID:23325791)
UniProt
PMID:23325791
NCBI chrNW_004955413:22,881,759...22,972,182
Ensembl chrNW_004955413:22,881,045...22,972,450
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Rac1
Rac family small GTPase 1
involved_in
ISO
(PMID:10934045)
UniProt
PMID:10934045
NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351
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Sh3bp1
SH3 domain binding protein 1
involved_in
ISO
(PMID:26465210)
UniProt
PMID:26465210
NCBI chrNW_004955413:24,042,875...24,054,826
Ensembl chrNW_004955413:24,042,875...24,055,041
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Sirpa
signal regulatory protein alpha
acts_upstream_of_or_within
ISO
(PMID:14634079)
MGI
PMID:14634079
NCBI chrNW_004955415:13,030,752...13,072,735
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Trem2
triggering receptor expressed on myeloid cells 2
involved_in acts_upstream_of_or_within
ISO
(PMID:24990881) (PMID:19155473)
UniProt MGI
PMID:19155473 PMID:24990881
NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697
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Treml4
triggering receptor expressed on myeloid cells like 4
acts_upstream_of_or_within
ISO
(PMID:19155473)
MGI
PMID:19155473
NCBI chrNW_004955437:7,827,329...7,846,406
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Vamp7
vesicle associated membrane protein 7
involved_in
ISO
PMID:15133481
UniProt
PMID:15133481
RGD:4892614
NCBI chrNW_004955594:20,496...72,648
Ensembl chrNW_004955594:18,727...72,654
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Adgrb1
adhesion G protein-coupled receptor B1
involved_in
ISO
(PMID:24509909) (PMID:17960134)
UniProt
PMID:17960134 PMID:24509909
NCBI chrNW_004955454:1,250,261...1,313,547
Ensembl chrNW_004955454:1,237,363...1,314,127
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Becn1
beclin 1
involved_in
ISO
(PMID:22393062)
CACAO
PMID:22393062
NCBI chrNW_004955451:16,616,595...16,625,731
Ensembl chrNW_004955451:16,616,595...16,625,730
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Megf10
multiple EGF like domains 10
acts_upstream_of_or_within
ISO
(PMID:27170117)
MGI
PMID:27170117
NCBI chrNW_004955415:393,642...513,157
Ensembl chrNW_004955415:335,012...513,891
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Rac1
Rac family small GTPase 1
involved_in
ISO
(PMID:20691665)
BHF-UCL
PMID:20691665
NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351
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Thbs1
thrombospondin 1
involved_in
ISO
(PMID:16882710)
BHF-UCL
PMID:16882710
NCBI chrNW_004955416:6,490,034...6,506,419
Ensembl chrNW_004955416:6,489,451...6,506,419
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Xkr8
XK related 8
involved_in
ISO
(PMID:29440417), (PMID:31712393) (PMID:23845944)
UniProt
PMID:23845944 PMID:29440417 PMID:31712393
NCBI chrNW_004955452:7,141,088...7,148,571
Ensembl chrNW_004955452:7,141,201...7,146,443
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Cd300a
CD300a molecule
involved_in
ISO
(PMID:22302738)
UniProt
PMID:22302738
NCBI chrNW_004955553:1,335,854...1,356,001
Ensembl chrNW_004955553:1,336,227...1,460,376
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Abca7
ATP binding cassette subfamily A member 7
involved_in
ISO
(PMID:16908670)
Alzheimers_University_of_Toronto
PMID:16908670
NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772
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Trem2
triggering receptor expressed on myeloid cells 2
involved_in
ISO
(PMID:24990881)
UniProt
PMID:24990881
NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697
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Ager
advanced glycosylation end-product specific receptor
ISO
RGD
PMID:23238794
RGD:8696010
NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479
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Ano6
anoctamin 6
involved_in
ISO
(PMID:25651887)
UniProt
PMID:25651887
NCBI chrNW_004955500:4,462,314...4,652,634
Ensembl chrNW_004955500:4,462,524...4,652,782
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Appl2
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
involved_in
ISO
(PMID:25568335)
UniProt
PMID:25568335
NCBI chrNW_004955405:39,503,020...39,540,069
Ensembl chrNW_004955405:39,503,020...39,540,335
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C3
complement C3
involved_in
ISO
(PMID:22438044), (PMID:22632727) (PMID:20199584)
ARUK-UCL
PMID:20199584 PMID:22438044 PMID:22632727
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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Cd36
CD36 molecule (CD36 blood group)
acts_upstream_of_or_within
ISO
(PMID:16061696)
MGI
PMID:16061696
NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313
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F2rl1
F2R like trypsin receptor 1
involved_in
ISO
(PMID:21501162)
UniProt
PMID:21501162
NCBI chrNW_004955425:24,050,901...24,054,039
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Gata2
GATA binding protein 2
ISO
RGD
PMID:12933836
RGD:632788
NCBI chrNW_004955429:15,326,551...15,334,774
Ensembl chrNW_004955429:15,327,113...15,336,460
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Itga2
integrin subunit alpha 2
ISO
RGD
PMID:9284952
RGD:2307413
NCBI chrNW_004955446:14,309,516...14,421,991
Ensembl chrNW_004955446:14,309,349...14,422,170
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Nckap1l
NCK associated protein 1 like
involved_in
ISO
(PMID:19015308)
UniProt
PMID:19015308
NCBI chrNW_004955458:1,733,799...1,785,591
Ensembl chrNW_004955458:1,733,883...1,784,182
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Plcg2
phospholipase C gamma 2
acts_upstream_of_or_within
ISO
(PMID:32514138)
ARUK-UCL
PMID:32514138
NCBI chrNW_004955522:4,352,890...4,480,735
Ensembl chrNW_004955522:4,358,233...4,468,986
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Pparg
peroxisome proliferator activated receptor gamma
ISO
RGD
PMID:15940641
RGD:8553017
NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387
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Rab31
RAB31, member RAS oncogene family
involved_in
ISO
(PMID:25568335)
UniProt
PMID:25568335
NCBI chrNW_004955402:2,354,399...2,446,537
Ensembl chrNW_004955402:2,354,646...2,446,453
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Stap1
signal transducing adaptor family member 1
involved_in
ISO
(PMID:19100238)
BHF-UCL
PMID:19100238
NCBI chrNW_004955447:5,292,708...5,345,214
Ensembl chrNW_004955447:5,293,227...5,330,187
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Trem2
triggering receptor expressed on myeloid cells 2
involved_in acts_upstream_of
ISO
(PMID:28855300), (PMID:33097708) (PMID:25631124), (PMID:29752066) (PMID:32514138)
UniProt ARUK-UCL
PMID:25631124 PMID:28855300 PMID:29752066 PMID:32514138 PMID:33097708
NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697
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Alox15
arachidonate 15-lipoxygenase
involved_in
ISO
(PMID:11278875), (PMID:22503541)
UniProt
PMID:11278875 PMID:22503541
NCBI chrNW_004955467:10,032,792...10,039,789
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
biological_process
12600
cellular process
12034
vesicle-mediated transport
1245
endocytosis
585
phagocytosis
191
phagocytosis, engulfment
46
cytoskeletal rearrangement involved in phagocytosis, engulfment
0
engulfment of apoptotic cell +
9
membrane reorganization involved in phagocytosis, engulfment
0
negative regulation of phagocytosis, engulfment +
1
positive regulation of phagocytosis, engulfment +
15
regulation of phagocytosis, engulfment +
17
Path 2
biological_process
12600
localization
4342
establishment of localization
3713
transport
3445
vesicle-mediated transport
1245
endocytosis
585
phagocytosis
191
phagocytosis, engulfment
46
cytoskeletal rearrangement involved in phagocytosis, engulfment
0
engulfment of apoptotic cell +
9
membrane reorganization involved in phagocytosis, engulfment
0
negative regulation of phagocytosis, engulfment +
1
positive regulation of phagocytosis, engulfment +
15
regulation of phagocytosis, engulfment +
17