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ONTOLOGY REPORT - ANNOTATIONS

Term:phagocytosis, engulfment
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Accession:GO:0006911 term browser browse the term
Definition:The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
Synonyms:related_synonym: phagosome biosynthesis;   phagosome formation


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phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10878804) Ensembl
MGI		 PMID:10878804 GO_REF:0000107 NCBI chr 9:75,948,831...76,096,136
Ensembl chr 9:104,076,516...104,224,188 		JBrowse link
G ADGRB1 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:139,154,065...139,251,115
Ensembl chr 8:142,220,827...142,301,070 		JBrowse link
G AIF1 allograft inflammatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:31,276,215...31,278,051
Ensembl chr 6:32,166,301...32,168,125 		JBrowse link
G ARHGAP12 Rho GTPase activating protein 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:31,932,294...32,061,450
Ensembl chr10:32,527,838...32,628,690 		JBrowse link
G ARHGAP25 Rho GTPase activating protein 25 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr2A:68,775,637...68,867,870
Ensembl chr2A:69,897,974...69,989,955 		JBrowse link
G BIN2 bridging integrator 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:37,430,061...37,473,182
Ensembl chr12:38,314,126...38,357,264 		JBrowse link
G CDC42 cell division cycle 42 involved_in ISO (PMID:26465210) UniProt PMID:26465210 NCBI chr 1:21,245,970...21,286,210 JBrowse link
G CLCN2 chloride voltage-gated channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:181,383,608...181,399,200
Ensembl chr 3:189,862,489...189,881,049 		JBrowse link
G CLCN3 chloride voltage-gated channel 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16522634) Ensembl
MGI		 PMID:16522634 GO_REF:0000107 NCBI chr 4:161,838,061...161,943,072
Ensembl chr 4:173,925,474...174,011,681 		JBrowse link
G CLEC7A C-type lectin domain containing 7A acts_upstream_of_or_within ISO (PMID:14707091) MGI PMID:14707091 NCBI chr12:10,161,780...10,174,943
Ensembl chr12:10,410,384...10,425,452 		JBrowse link
G ELMO1 engulfment and cell motility 1 involved_in ISO (PMID:11595183) UniProt PMID:11595183 NCBI chr 7:37,493,854...38,085,555 JBrowse link
G FCER1G Fc epsilon receptor Ig acts_upstream_of_or_within ISO (PMID:11901193)
(PMID:11237803), (PMID:11911823)		 MGI PMID:11237803 PMID:11901193 PMID:11911823 NCBI chr 1:136,627,672...136,631,696
Ensembl chr 1:140,539,555...140,544,810 		JBrowse link
G FCGR1A Fc gamma receptor Ia acts_upstream_of_or_within ISO (PMID:11911823), (PMID:9551950)
(PMID:11911824)		 MGI PMID:9551950 PMID:11911823 PMID:11911824 NCBI chr 1:125,127,073...125,136,911
Ensembl chr 1:128,805,484...128,814,220 		JBrowse link
G FCGR2B Fc gamma receptor IIb acts_upstream_of_or_within ISO (PMID:8769481) MGI PMID:8769481 NCBI chr 1:137,074,342...137,090,962
Ensembl chr 1:140,882,043...140,890,637 		JBrowse link
G GSN gelsolin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831 		JBrowse link
G GULP1 GULP PTB domain containing engulfment adaptor 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11729193) MGI
Ensembl		 PMID:11729193 GO_REF:0000107 NCBI chr2B:75,588,843...75,896,253
Ensembl chr2B:193,695,139...193,815,861 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:18414680 GO_REF:0000118 RGD:2316597 NCBI chr 5:152,429,337...152,459,800
Ensembl chr 5:158,413,073...158,442,481 		JBrowse link
G ITGAM integrin subunit alpha M involved_in ISO (MGI:5319446|PMID:22438044), (MGI:5905548|PMID:20199584), (MGI:6189359|PMID:22632727) ARUK-UCL PMID:20199584 PMID:22438044 PMID:22632727 MGI:5319446 MGI:5905548 MGI:6189359 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406 		JBrowse link
G ITGB2 integrin subunit beta 2 involved_in ISO (MGI:5905548|PMID:20199584) ARUK-UCL PMID:20199584 MGI:5905548 NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963 		JBrowse link
G LOC100968722 chronophin involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:18,552,737...18,585,014
Ensembl chr22:36,391,200...36,407,938 		JBrowse link
G MARCO macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chr2B:5,896,433...5,940,284
Ensembl chr2B:119,475,677...119,520,385 		JBrowse link
G MSR1 macrophage scavenger receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:15,335,795...15,421,472
Ensembl chr 8:12,088,873...12,175,927 		JBrowse link
G MYH9 myosin heavy chain 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:17,200,623...17,305,826
Ensembl chr22:35,039,101...35,121,618 		JBrowse link
G RAC1 Rac family small GTPase 1 involved_in ISO (MGI:5315376|PMID:10934045) UniProt PMID:10934045 MGI:5315376 NCBI chr 7:7,039,379...7,068,866 JBrowse link
G SIGLEC9 sialic acid binding Ig like lectin 9 acts_upstream_of ISO (PMID:24227736) MGI PMID:24227736 NCBI chr19:48,092,042...48,104,097
Ensembl chr19:56,979,583...56,985,098 		JBrowse link
G SIRPA signal regulatory protein alpha acts_upstream_of_or_within ISO (PMID:14634079) MGI PMID:14634079 NCBI chr20:2,006,994...2,052,894
Ensembl chr20:1,773,271...1,818,106 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19155473) Ensembl
MGI		 PMID:19155473 GO_REF:0000107 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578 		JBrowse link
G VAMP7 vesicle associated membrane protein 7 involved_in ISO PMID:15133481 UniProt PMID:15133481 RGD:4892614 NCBI chr  X:145,362,432...145,425,097
Ensembl chr  X:155,257,185...155,320,215 		JBrowse link
cytoskeletal rearrangement involved in phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TIMD4 T cell immunoglobulin and mucin domain containing 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:152,321,962...152,365,717
Ensembl chr 5:158,305,721...158,349,336 		JBrowse link
engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRB1 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:139,154,065...139,251,115
Ensembl chr 8:142,220,827...142,301,070 		JBrowse link
G BECN1 beclin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G LOC100989777 ras-related C3 botulinum toxin substrate 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:141,918,410...141,919,483 JBrowse link
G LRRC45 leucine rich repeat containing 45 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:76,427,929...76,435,779
Ensembl chr17:82,133,217...82,143,623 		JBrowse link
G MEGF10 multiple EGF like domains 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27170117) Ensembl
MGI		 PMID:27170117 GO_REF:0000107 NCBI chr 5:122,639,155...122,877,324
Ensembl chr 5:128,466,095...128,641,043 		JBrowse link
G RAC1 Rac family small GTPase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:7,039,379...7,068,866 JBrowse link
G RAC2 Rac family small GTPase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:18,138,517...18,159,023
Ensembl chr22:35,973,229...35,992,026 		JBrowse link
G RAC3 Rac family small GTPase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:76,436,264...76,439,492
Ensembl chr17:82,133,217...82,143,623 		JBrowse link
G RHOBTB1 Rho related BTB domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:57,410,347...57,541,038
Ensembl chr10:59,740,662...59,815,536 		JBrowse link
G RHOBTB2 Rho related BTB domain containing 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:22,246,075...22,269,443
Ensembl chr 8:19,183,931...19,209,420 		JBrowse link
G RHOG ras homolog family member G involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:3,698,179...3,712,402
Ensembl chr11:3,811,877...3,812,452 		JBrowse link
G RHOH ras homolog family member H involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:34,517,487...34,569,934
Ensembl chr 4:40,419,549...40,420,124 		JBrowse link
G THBS1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170 		JBrowse link
G XKR4 XK related 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:51,541,410...51,982,587
Ensembl chr 8:48,914,778...49,336,906 		JBrowse link
G XKR5 XK related 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:445,644...472,659
Ensembl chr 8:6,812,607...6,839,844 		JBrowse link
G XKR7 XK related 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:28,263,026...28,297,736
Ensembl chr20:29,392,600...29,420,363 		JBrowse link
G XKR8 XK related 8 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:27,219,682...27,228,381
Ensembl chr 1:28,259,993...28,266,978 		JBrowse link
G XKR9 XK related 9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:67,194,689...67,259,983
Ensembl chr 8:68,855,081...68,920,235 		JBrowse link
negative regulation of phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD300A CD300a molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:68,403,647...68,426,285
Ensembl chr17:73,965,008...73,983,928 		JBrowse link
G SIGLEC9 sialic acid binding Ig like lectin 9 acts_upstream_of_or_within ISO (PMID:24227736) MGI PMID:24227736 NCBI chr19:48,092,042...48,104,097
Ensembl chr19:56,979,583...56,985,098 		JBrowse link
positive regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:3662940|PMID:16908670) Alzheimers_University_of_Toronto PMID:16908670 MGI:3662940 NCBI chr19:62,811...77,897
Ensembl chr19:1,018,095...1,042,104 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578 		JBrowse link
positive regulation of phagocytosis, engulfment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:23238794 RGD:8696010 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G ANO6 anoctamin 6 involved_in ISO (MGI:5634870|PMID:25651887) UniProt PMID:25651887 MGI:5634870 NCBI chr12:43,295,928...43,512,073
Ensembl chr12:44,164,375...44,303,259 		JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:102,755,388...102,818,686
Ensembl chr12:106,151,969...106,206,879 		JBrowse link
G C3 complement C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16061696) Ensembl
MGI		 PMID:16061696 GO_REF:0000107 NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:39,006,331...39,024,265 JBrowse link
G FCGR1A Fc gamma receptor Ia ISO RGD PMID:19657115 RGD:9685698 NCBI chr 1:125,127,073...125,136,911
Ensembl chr 1:128,805,484...128,814,220 		JBrowse link
G GATA2 GATA binding protein 2 ISO RGD PMID:12933836 RGD:632788 NCBI chr 3:125,526,537...125,535,649
Ensembl chr 3:132,890,508...132,899,035 		JBrowse link
G ITGA2 integrin subunit alpha 2 ISO RGD PMID:9284952 RGD:2307413 NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720 		JBrowse link
G LBP lipopolysaccharide binding protein ISO RGD PMID:11104656 RGD:9685187 NCBI chr20:34,670,128...34,703,046
Ensembl chr20:35,780,768...35,813,188 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:34,200,102...34,249,873
Ensembl chr12:34,932,470...34,977,881 		JBrowse link
G PLCG2 phospholipase C gamma 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
Ensembl		 PMID:32514138 GO_REF:0000107 NCBI chr16:62,383,270...62,561,579
Ensembl chr16:81,812,565...81,984,064 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO RGD PMID:15940641 RGD:8553017 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060 		JBrowse link
G RAB31 RAB31, member RAS oncogene family involved_in ISO (MGI:6271154|PMID:25568335) UniProt PMID:25568335 MGI:6271154 NCBI chr18:4,424,677...4,578,263
Ensembl chr18:6,710,174...6,859,896 		JBrowse link
G STAP1 signal transducing adaptor family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:56,442,773...56,491,148
Ensembl chr 4:62,836,288...62,882,570 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
TreeGrafter
Ensembl		 PMID:32514138 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578 		JBrowse link
regulation of engulfment of apoptotic cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX15 arachidonate 15-lipoxygenase involved_in ISO (MGI:5436199|PMID:22503541), (MGI:5508294|PMID:11278875) UniProt PMID:11278875 PMID:22503541 MGI:5436199 MGI:5508294 NCBI chr17:4,686,339...4,696,877
Ensembl chr17:4,677,125...4,687,669 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16768
    cellular process 15761
      vesicle-mediated transport 1571
        endocytosis 697
          phagocytosis 227
            phagocytosis, engulfment 62
              cytoskeletal rearrangement involved in phagocytosis, engulfment 1
              engulfment of apoptotic cell + 21
              membrane reorganization involved in phagocytosis, engulfment 0
              negative regulation of phagocytosis, engulfment + 2
              positive regulation of phagocytosis, engulfment + 17
              regulation of phagocytosis, engulfment + 20
Path 2
Term Annotations click to browse term
  biological_process 16768
    localization 5348
      establishment of localization 4649
        transport 4351
          vesicle-mediated transport 1571
            endocytosis 697
              phagocytosis 227
                phagocytosis, engulfment 62
                  cytoskeletal rearrangement involved in phagocytosis, engulfment 1
                  engulfment of apoptotic cell + 21
                  membrane reorganization involved in phagocytosis, engulfment 0
                  negative regulation of phagocytosis, engulfment + 2
                  positive regulation of phagocytosis, engulfment + 17
                  regulation of phagocytosis, engulfment + 20
paths to the root