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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular iron ion homeostasis
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Accession:GO:0006879 term browser browse the term
Definition:A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.
Synonyms:exact_synonym: cellular iron ion homeostasis
 broad_synonym: iron homeostasis
 xref: Reactome:R-HSA-917937 "Iron uptake and transport"

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intracellular iron ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936683:1,224,703...1,326,761
Ensembl chrNW_004936683:1,222,450...1,326,765 		JBrowse link
G Aco1 aconitase 1 acts_upstream_of_or_within ISO
IEA		 RGD
Ensembl		 PMID:15086359 GO_REF:0000107 RGD:1642737 NCBI chrNW_004936524:1,081,672...1,134,971
Ensembl chrNW_004936524:1,081,696...1,134,971 		JBrowse link
G Acvr2b activin A receptor type 2B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:27,816,366...27,822,555
Ensembl chrNW_004936473:27,815,399...27,822,476 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936751:1,818,255...1,841,028
Ensembl chrNW_004936751:1,814,446...1,841,531 		JBrowse link
G Atp13a2 ATPase cation transporting 13A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:3,968,216...3,980,821
Ensembl chrNW_004936474:3,968,506...3,980,815 		JBrowse link
G Atp6ap1 ATPase H+ transporting accessory protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936809:1,179,507...1,188,172
Ensembl chrNW_004936809:1,179,464...1,188,283 		JBrowse link
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936558:1,104,627...1,138,487
Ensembl chrNW_004936558:1,103,135...1,134,573 		JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit d1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:17,888,788...17,927,513
Ensembl chrNW_004936475:17,886,371...17,927,557 		JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936536:1,257,801...1,314,770
Ensembl chrNW_004936536:1,257,990...1,312,530 		JBrowse link
G Atp6v1g1 ATPase H+ transporting V1 subunit G1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:3,801,745...3,809,997
Ensembl chrNW_004936487:3,801,665...3,811,293 		JBrowse link
G B2m beta-2-microglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:7,646,504...7,655,656
Ensembl chrNW_004936471:7,646,373...7,655,778 		JBrowse link
G Bmp6 bone morphogenetic protein 6 acts_upstream_of_or_within
involved_in		 IEA
ISO		 (PMID:19252488) Ensembl
BHF-UCL		 PMID:19252488 GO_REF:0000107 NCBI chrNW_004936534:4,707,658...4,871,865
Ensembl chrNW_004936534:4,709,064...4,871,023 		JBrowse link
G Bola2b bolA family member 2B involved_in IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936501:12,335,330...12,335,941 JBrowse link
G Cp ceruloplasmin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936519:6,431,156...6,473,183
Ensembl chrNW_004936519:6,431,144...6,481,858 		JBrowse link
G Egln1 egl-9 family hypoxia inducible factor 1 involved_in ISO (PMID:26818499) ParkinsonsUK-UCL PMID:26818499 NCBI chrNW_004936484:19,343,770...19,386,087 JBrowse link
G Erfe erythroferrone involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936525:324,814...330,067
Ensembl chrNW_004936525:323,090...329,664 		JBrowse link
G Fbxl5 F-box and leucine rich repeat protein 5 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936477:12,279,521...12,312,927
Ensembl chrNW_004936477:12,279,541...12,313,007 		JBrowse link
G Frrs1 ferric chelate reductase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936537:89,844...116,512
Ensembl chrNW_004936537:89,830...116,048 		JBrowse link
G Fth1 ferritin heavy chain 1 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004936581:1,118,905...1,120,592 JBrowse link
G Ftl ferritin light chain involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004936664:2,976,325...2,977,878
Ensembl chrNW_004936664:2,976,314...2,977,877 		JBrowse link
G Ftmt ferritin mitochondrial involved_in IEA InterPro
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 NCBI chrNW_004936575:2,077,732...2,078,445
Ensembl chrNW_004936575:2,077,732...2,078,445 		JBrowse link
G Fxn frataxin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9405681) MGI
TreeGrafter		 PMID:9405681 GO_REF:0000118 NCBI chrNW_004936503:5,323,206...5,343,228 JBrowse link
G Glrx3 glutaredoxin 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936486:17,201,838...17,233,171
Ensembl chrNW_004936486:17,207,309...17,233,171 		JBrowse link
G Hamp hepcidin antimicrobial peptide involved_in ISO
IEA		 RGD
Ensembl
TreeGrafter
InterPro		 PMID:14592944 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1304454 NCBI chrNW_004936570:1,009,344...1,010,654
Ensembl chrNW_004936570:1,009,312...1,010,686 		JBrowse link
G Hephl1 hephaestin like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936674:778,160...846,119
Ensembl chrNW_004936674:778,160...846,119 		JBrowse link
G Hfe homeostatic iron regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936671:1,940,079...1,947,574
Ensembl chrNW_004936671:1,940,101...1,947,580 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157 		JBrowse link
G Hjv hemojuvelin BMP co-receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936867:742,539...747,035
Ensembl chrNW_004936867:742,501...746,930 		JBrowse link
G Hmox1 heme oxygenase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311 		JBrowse link
G Hpx hemopexin involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936842:485,515...495,684
Ensembl chrNW_004936842:485,517...494,742 		JBrowse link
G Ireb2 iron responsive element binding protein 2 acts_upstream_of_or_within
involved_in		 IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:36,547,552...36,601,327
Ensembl chrNW_004936471:36,547,500...36,600,636 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936769:492,024...498,587
Ensembl chrNW_004936769:491,530...498,692 		JBrowse link
G LOC101958683 ferritin heavy chain involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004936553:7,117,118...7,117,669 JBrowse link
G LOC101964946 ferritin heavy chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004936502:1,857,103...1,857,678 JBrowse link
G LOC101966789 V-type proton ATPase catalytic subunit A-like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936488:17,223,190...17,224,731
Ensembl chrNW_004936536:1,257,990...1,312,530 		JBrowse link
G LOC101968635 cytochrome b561 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936541:4,123,187...4,130,819
Ensembl chrNW_004936541:4,123,202...4,132,835 		JBrowse link
G LOC101968723 ferritin heavy chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004936502:4,362,737...4,363,288 JBrowse link
G LOC101970831 serotransferrin involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936529:6,917,762...6,947,512
Ensembl chrNW_004936529:6,855,958...6,947,394 		JBrowse link
G LOC101972941 ferritin heavy chain involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004937483:12,972...13,859 JBrowse link
G LOC101974307 protein SCO1 homolog, mitochondrial acts_upstream_of_or_within ISO (PMID:36301669) MGI PMID:36301669 NCBI chrNW_004936595:3,523,789...3,537,933
Ensembl chrNW_004936595:3,523,779...3,538,150 		JBrowse link
G LOC101974571 cytochrome b ascorbate-dependent protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:1,685,876...1,696,159
Ensembl chrNW_004936581:1,685,876...1,696,173 		JBrowse link
G LOC101976046 cytochrome b reductase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:1,770,931...1,797,442
Ensembl chrNW_004936509:1,770,477...1,800,619 		JBrowse link
G LOC120884499 ferritin, heavy subunit-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043
G LOC120886140 ferritin light chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043
G LOC120890581 frataxin, mitochondrial-like involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000118
G Mecr mitochondrial trans-2-enoyl-CoA reductase acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:13,146,572...13,183,707
Ensembl chrNW_004936474:13,147,938...13,183,770 		JBrowse link
G Meltf melanotransferrin NOT|acts_upstream_of_or_within ISO (PMID:16291590) MGI PMID:16291590 NCBI chrNW_004936833:853,925...875,069
Ensembl chrNW_004936833:853,007...875,547 		JBrowse link
G Mon1a MON1 homolog A, secretory trafficking associated acts_upstream_of_or_within ISO (PMID:17632513) MGI PMID:17632513 NCBI chrNW_004936529:1,513,796...1,527,121
Ensembl chrNW_004936529:1,513,753...1,527,506 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:20,480,844...20,485,955
Ensembl chrNW_004936470:20,480,829...20,485,965 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 involved_in
acts_upstream_of_or_within		 IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936728:376,915...402,539
Ensembl chrNW_004936728:376,852...402,539 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in ISO (PMID:18776082) UniProt PMID:18776082 NCBI chrNW_004936504:12,053,470...12,103,346 JBrowse link
G Neo1 neogenin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:32,345,578...32,517,245
Ensembl chrNW_004936471:32,292,745...32,516,624 		JBrowse link
G Nubp1 NUBP iron-sulfur cluster assembly factor 1, cytosolic involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936530:8,970,963...8,985,925
Ensembl chrNW_004936530:8,971,380...8,986,033 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167 		JBrowse link
G Scara5 scavenger receptor class A member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936675:763,467...868,021
Ensembl chrNW_004936675:765,378...863,843 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within		 IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:888,309...895,991
Ensembl chrNW_004936569:887,742...895,977 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936506:8,396,593...8,415,069
Ensembl chrNW_004936506:8,396,912...8,416,374 		JBrowse link
G Smad1 SMAD family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936535:3,582,512...3,626,312
Ensembl chrNW_004936535:3,582,489...3,657,063 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:12,242,869...12,278,012
Ensembl chrNW_004936497:12,249,140...12,278,123 		JBrowse link
G Smad5 SMAD family member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936597:3,225,374...3,264,604
Ensembl chrNW_004936597:3,225,374...3,264,604 		JBrowse link
G Smad9 SMAD family member 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:30,980,850...31,050,138
Ensembl chrNW_004936472:30,980,928...31,049,618 		JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:10,345,154...10,352,873
Ensembl chrNW_004936500:10,345,154...10,352,867 		JBrowse link
G Tfr2 transferrin receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936543:667,570...681,872
Ensembl chrNW_004936543:668,157...682,174 		JBrowse link
G Tfrc transferrin receptor involved_in
acts_upstream_of_or_within		 IEA UniProt
Ensembl
TreeGrafter		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936784:696,738...728,385
Ensembl chrNW_004936784:696,713...728,543 		JBrowse link
G Tmprss6 transmembrane serine protease 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:3,819,347...3,848,372
Ensembl chrNW_004936492:3,819,309...3,848,075 		JBrowse link
G Ttc7a tetratricopeptide repeat domain 7A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:5,275,779...5,390,224
Ensembl chrNW_004936508:5,275,758...5,390,223 		JBrowse link
G Vma12 vacuolar ATPase assembly factor VMA12 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:4,512,866...4,517,404
Ensembl chrNW_004936538:4,511,941...4,517,498 		JBrowse link
G Vma22 vacuolar ATPase assembly factor VMA22 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:41,083,713...41,087,106
Ensembl chrNW_004936469:41,083,738...41,087,087 		JBrowse link
cellular response to iron ion starvation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hfe homeostatic iron regulator ISO RGD PMID:16208485 RGD:1582698 NCBI chrNW_004936671:1,940,079...1,947,574
Ensembl chrNW_004936671:1,940,101...1,947,580 		JBrowse link
endocytic iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tfr2 transferrin receptor 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936543:667,570...681,872
Ensembl chrNW_004936543:668,157...682,174 		JBrowse link
iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a2 solute carrier family 11 member 2 acts_upstream_of_or_within
involved_in		 IEA
ISO		 (PMID:17109629) Ensembl
UniProt		 PMID:17109629 GO_REF:0000107 NCBI chrNW_004936512:8,590,302...8,622,121
Ensembl chrNW_004936512:8,586,262...8,623,597 		JBrowse link
G Slc39a14 solute carrier family 39 member 14 involved_in ISO (PMID:20682781) UniProt PMID:20682781 NCBI chrNW_004939045:1...7,491 JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chrNW_004936469:51,084,250...51,121,738
Ensembl chrNW_004936469:51,054,517...51,126,664 		JBrowse link
G Steap4 STEAP4 metalloreductase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936763:645,910...671,674
Ensembl chrNW_004936763:645,858...670,863 		JBrowse link
iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc39a8 solute carrier family 39 member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936520:961,376...1,036,801
Ensembl chrNW_004936520:962,756...1,037,274 		JBrowse link
G Steap2 STEAP2 metalloreductase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936621:3,784,628...3,806,787
Ensembl chrNW_004936621:3,779,745...3,806,851 		JBrowse link
negative regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iscu iron-sulfur cluster assembly enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936769:492,024...498,587
Ensembl chrNW_004936769:491,530...498,692 		JBrowse link
positive regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:29061364) ARUK-UCL PMID:29061364 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Lcn2 lipocalin 2 ISO RGD PMID:25557118 RGD:126790477 NCBI chrNW_004936487:15,721,752...15,725,396
Ensembl chrNW_004936487:15,721,684...15,728,221 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17417
    homeostatic process 1851
      chemical homeostasis 1126
        inorganic ion homeostasis 552
          intracellular iron ion homeostasis 76
            cellular response to iron ion starvation + 1
            iron import into cell + 10
Path 2
Term Annotations click to browse term
  biological_process 17417
    homeostatic process 1851
      chemical homeostasis 1126
        monoatomic ion homeostasis 629
          intracellular monoatomic ion homeostasis 550
            intracellular monoatomic cation homeostasis 538
              intracellular iron ion homeostasis 76
                cellular response to iron ion starvation + 1
                iron import into cell + 10
paths to the root