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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular iron ion homeostasis
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Accession:GO:0006879 term browser browse the term
Definition:A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.
Synonyms:exact_synonym: cellular iron ion homeostasis
 broad_synonym: iron homeostasis
 xref: Reactome:R-HSA-917937 "Iron uptake and transport"


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intracellular iron ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP-binding cassette, sub-family B member 7 acts_upstream_of_or_within
involved_in		 IMP
IBA
ISO
ISS		 (PMID:16424901)
(PMID:30765471)		 MGI
GO_Central
UniProt		 PMID:16424901 PMID:30765471 GO_REF:0000024 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 NCBI chr  X:103,324,171...103,457,452
Ensembl chr  X:103,324,263...103,457,462 		JBrowse link
G Aco1 aconitase 1 involved_in
acts_upstream_of_or_within		 ISO
IBA
IMP
IGI		 (PMID:14726953) RGD
GO_Central
MGI		 PMID:14726953 PMID:15086359 GO_REF:0000033 GO_REF:0000096 RGD:1642737 NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338 		JBrowse link
G Acvr2b activin receptor IIB involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061 		JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid acts_upstream_of_or_within IMP (PMID:10562540) MGI PMID:10562540 NCBI chr  X:149,330,443...149,353,614
Ensembl chr  X:149,330,371...149,353,634 		JBrowse link
G Atp13a2 ATPase type 13A2 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 4:140,711,812...140,734,641
Ensembl chr 4:140,714,184...140,734,641 		JBrowse link
G Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr  X:73,340,753...73,348,297
Ensembl chr  X:73,340,703...73,348,327 		JBrowse link
G Atp6v0a2 ATPase, H+ transporting, lysosomal V0 subunit A2 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 5:124,767,117...124,801,519
Ensembl chr 5:124,766,641...124,801,519 		JBrowse link
G Atp6v0d1 ATPase, H+ transporting, lysosomal V0 subunit D1 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 8:106,251,093...106,292,696
Ensembl chr 8:106,251,097...106,292,679 		JBrowse link
G Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr16:43,905,765...43,960,055
Ensembl chr16:43,905,765...43,960,068 		JBrowse link
G Atp6v1g1 ATPase, H+ transporting, lysosomal V1 subunit G1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 4:63,463,002...63,468,938
Ensembl chr 4:63,463,009...63,468,987 		JBrowse link
G B2m beta-2 microglobulin involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:121,978,168...121,983,563
Ensembl chr 2:121,978,167...121,983,564 		JBrowse link
G Bmp6 bone morphogenetic protein 6 acts_upstream_of_or_within
involved_in		 IMP (PMID:21703414)
(PMID:19252488)		 MGI
BHF-UCL		 PMID:19252488 PMID:21703414 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278 		JBrowse link
G Bmyc brain expressed myelocytomatosis oncogene involved_in ISO GO_Central GO_REF:0000119 NCBI chr 2:25,596,891...25,597,733
Ensembl chr 2:25,596,751...25,597,733 		JBrowse link
G Bola2 bolA family member 2 involved_in IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 7:126,295,172...126,295,865
Ensembl chr 7:126,294,573...126,298,970 		JBrowse link
G Ccdc115 coiled-coil domain containing 115 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 1:34,475,751...34,478,753
Ensembl chr 1:34,475,751...34,478,753 		JBrowse link
G Cisd1 CDGSH iron sulfur domain 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:71,166,324...71,180,679
Ensembl chr10:71,166,310...71,180,784 		JBrowse link
G Cp ceruloplasmin involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309 		JBrowse link
G Cyb561 cytochrome b-561 involved_in IDA (PMID:14499595) ARUK-UCL PMID:14499595 NCBI chr11:105,824,528...105,844,157
Ensembl chr11:105,824,528...105,844,162 		JBrowse link
G Cyb561a3 cytochrome b561 family, member A3 involved_in IDA (PMID:16911521) UniProt PMID:16911521 NCBI chr19:10,554,521...10,574,196
Ensembl chr19:10,554,536...10,573,325 		JBrowse link
G Cybrd1 cytochrome b reductase 1 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:70,948,398...70,973,270
Ensembl chr 2:70,948,267...70,973,270 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 involved_in IMP (PMID:26818499) ParkinsonsUK-UCL PMID:26818499 NCBI chr 8:125,635,325...125,676,063
Ensembl chr 8:125,635,326...125,676,063 		JBrowse link
G Erfe erythroferrone involved_in IMP (PMID:24880340) UniProt PMID:24880340 NCBI chr 1:91,293,033...91,301,939
Ensembl chr 1:91,294,152...91,301,939 		JBrowse link
G Fbxl5 F-box and leucine-rich repeat protein 5 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 5:43,901,958...43,939,529
Ensembl chr 5:43,901,957...43,978,980 		JBrowse link
G Frrs1 ferric-chelate reductase 1 involved_in IBA
IDA		 (PMID:14499595) GO_Central
ARUK-UCL		 PMID:14499595 GO_REF:0000033 NCBI chr 3:116,653,212...116,701,363
Ensembl chr 3:116,653,113...116,701,826 		JBrowse link
G Fth1 ferritin heavy polypeptide 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462 		JBrowse link
G Fthl17e ferritin, heavy polypeptide-like 17, member E involved_in IEA UniProt GO_REF:0000043 NCBI chr  X:8,899,725...8,900,572
Ensembl chr  X:8,899,732...8,900,572 		JBrowse link
G Ftl1 ferritin light polypeptide 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308 		JBrowse link
G Ftmt ferritin mitochondrial acts_upstream_of_or_within
involved_in		 TAS
ISS
ISO		 (PMID:11323407) MGI
UniProt
GO_Central		 PMID:11323407 GO_REF:0000024 GO_REF:0000119 NCBI chr18:52,464,608...52,466,068
Ensembl chr18:52,464,621...52,466,068 		JBrowse link
G Fxn frataxin acts_upstream_of_or_within
involved_in		 IMP
ISO		 (PMID:9405681) MGI
GO_Central		 PMID:9405681 GO_REF:0000119 NCBI chr19:24,236,909...24,257,954
Ensembl chr19:24,238,817...24,257,969 		JBrowse link
G Gdf2 growth differentiation factor 2 involved_in TAS (PMID:20406889) DFLAT PMID:20406889 NCBI chr14:33,662,996...33,669,155
Ensembl chr14:33,662,996...33,669,155 		JBrowse link
G Glrx3 glutaredoxin 3 involved_in ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr 7:137,039,302...137,071,360
Ensembl chr 7:137,039,343...137,070,323 		JBrowse link
G Hamp hepcidin antimicrobial peptide involved_in ISO
IBA
IDA		 (PMID:11447267) RGD
GO_Central
UniProt		 PMID:11447267 PMID:14592944 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:1304454 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457 		JBrowse link
G Hamp2 hepcidin antimicrobial peptide 2 involved_in IEA
IBA
ISO		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 NCBI chr 7:30,621,797...30,623,606
Ensembl chr 7:30,621,797...30,624,106 		JBrowse link
G Hephl1 hephaestin-like 1 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 9:14,963,137...15,023,466
Ensembl chr 9:14,963,137...15,023,404 		JBrowse link
G Hfe homeostatic iron regulator involved_in ISO GO_Central GO_REF:0000119 NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit acts_upstream_of_or_within IMP (PMID:16787915) MGI PMID:16787915 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hjv hemojuvelin BMP co-receptor involved_in IMP (PMID:25860887) BHF-UCL PMID:25860887 NCBI chr 3:96,432,479...96,436,532
Ensembl chr 3:96,432,488...96,436,526 		JBrowse link
G Hmox1 heme oxygenase 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hpx hemopexin involved_in IEA InterPro GO_REF:0000002 NCBI chr 7:105,240,818...105,249,323
Ensembl chr 7:105,240,820...105,249,344 		JBrowse link
G Ireb2 iron responsive element binding protein 2 acts_upstream_of_or_within
involved_in		 IMP
IBA
ISO
IGI
IDA		 (PMID:14726953), (PMID:15831703)
(PMID:11175792)		 MGI
GO_Central		 PMID:11175792 PMID:14726953 PMID:15831703 GO_REF:0000033 GO_REF:0000119 NCBI chr 9:54,769,942...54,819,812
Ensembl chr 9:54,771,073...54,819,814 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in IBA
ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 5:113,910,479...113,916,349
Ensembl chr 5:113,910,809...113,916,349 		JBrowse link
G Mecr mitochondrial trans-2-enoyl-CoA reductase acts_upstream_of ISS UniProt GO_REF:0000024 NCBI chr 4:131,570,755...131,595,097
Ensembl chr 4:131,570,781...131,595,097 		JBrowse link
G Meltf melanotransferrin NOT|acts_upstream_of_or_within IMP (PMID:16291590) MGI PMID:16291590 NCBI chr16:31,697,449...31,717,838
Ensembl chr16:31,697,628...31,717,838 		JBrowse link
G Mon1a MON1 homolog A, secretory traffciking associated acts_upstream_of_or_within IMP (PMID:17632513) MGI PMID:17632513 NCBI chr 9:107,765,282...107,780,338
Ensembl chr 9:107,765,350...107,780,338 		JBrowse link
G Myc myelocytomatosis oncogene involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 acts_upstream_of_or_within IMP (PMID:25327288) MGI PMID:25327288 NCBI chr14:31,881,884...31,901,210
Ensembl chr14:31,881,822...31,901,812 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr18:38,551,960...38,598,250
Ensembl chr18:38,543,449...38,598,356 		JBrowse link
G Neo1 neogenin acts_upstream_of_or_within IMP (PMID:20065295) MGI PMID:20065295 NCBI chr 9:58,781,962...58,943,926
Ensembl chr 9:58,781,970...58,943,724 		JBrowse link
G Nubp1 nucleotide binding protein 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr16:10,229,802...10,242,317
Ensembl chr16:10,229,812...10,242,292 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 7:89,778,711...89,858,655
Ensembl chr 7:89,779,421...89,862,673 		JBrowse link
G Scara5 scavenger receptor class A, member 5 involved_in IDA (PMID:19154717) UniProt PMID:19154717 NCBI chr14:65,903,852...66,002,275
Ensembl chr14:65,903,852...66,002,275 		JBrowse link
G Sco1 SCO1 cytochrome c oxidase assembly protein acts_upstream_of_or_within IMP (PMID:36301669) MGI PMID:36301669 NCBI chr11:66,943,473...66,958,270
Ensembl chr11:66,943,496...66,957,896 		JBrowse link
G Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 acts_upstream_of_or_within
involved_in		 IMP
ISO		 (PMID:18456389), (PMID:19321419)
(PMID:11903051)		 MGI
GO_Central		 PMID:11903051 PMID:18456389 PMID:19321419 GO_REF:0000119 NCBI chr 1:74,414,318...74,429,974
Ensembl chr 1:74,414,354...74,425,221 		JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683 		JBrowse link
G Smad1 SMAD family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:80,065,024...80,126,057
Ensembl chr 8:80,065,024...80,126,147 		JBrowse link
G Smad4 SMAD family member 4 involved_in IMP (PMID:16330325) BHF-UCL PMID:16330325 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Smad5 SMAD family member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:56,850,804...56,890,191
Ensembl chr13:56,850,823...56,890,190 		JBrowse link
G Smad9 SMAD family member 9 involved_in ISO (PMID:31800957) UniProt PMID:31800957 NCBI chr 3:54,662,873...54,709,162
Ensembl chr 3:54,663,003...54,708,678 		JBrowse link
G Sod1 superoxide dismutase 1, soluble acts_upstream_of_or_within IMP (PMID:16377630) MGI PMID:16377630 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Tfr2 transferrin receptor 2 acts_upstream_of_or_within
involved_in		 TAS
ISO		 (PMID:10681454) MGI
GO_Central		 PMID:10681454 GO_REF:0000119 NCBI chr 5:137,568,127...137,586,344
Ensembl chr 5:137,568,102...137,585,743 		JBrowse link
G Tfrc transferrin receptor acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:10192390) MGI
GO_Central		 PMID:10192390 GO_REF:0000033 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612 		JBrowse link
G Tmem199 transmembrane protein 199 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr11:78,397,881...78,402,994
Ensembl chr11:78,397,881...78,402,998 		JBrowse link
G Tmprss6 transmembrane serine protease 6 involved_in IMP (PMID:25860887) BHF-UCL PMID:25860887 NCBI chr15:78,323,867...78,352,848
Ensembl chr15:78,323,867...78,352,834 		JBrowse link
G Trf transferrin involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Ttc7 tetratricopeptide repeat domain 7 acts_upstream_of_or_within IMP (PMID:15155459) MGI PMID:15155459 NCBI chr17:87,590,328...87,689,197
Ensembl chr17:87,590,314...87,689,197 		JBrowse link
cellular response to iron ion starvation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hfe homeostatic iron regulator involved_in ISO
IEA		 RGD
Ensembl		 PMID:16208485 GO_REF:0000107 RGD:1582698 NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837 		JBrowse link
endocytic iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tfr2 transferrin receptor 2 involved_in IBA
ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr 5:137,568,127...137,586,344
Ensembl chr 5:137,568,102...137,585,743 		JBrowse link
iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 acts_upstream_of_or_within
involved_in		 IMP
ISO		 (PMID:11739192) MGI
GO_Central		 PMID:11739192 GO_REF:0000119 NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953 		JBrowse link
G Slc39a14 solute carrier family 39 (zinc transporter), member 14 involved_in ISO
IMP		 (PMID:20682781) GO_Central
UniProt		 PMID:20682781 GO_REF:0000119 NCBI chr14:70,540,916...70,588,873
Ensembl chr14:70,540,918...70,588,874 		JBrowse link
G Steap3 STEAP family member 3 acts_upstream_of_or_within IDA (PMID:16609065) MGI PMID:16609065 NCBI chr 1:120,154,137...120,198,810
Ensembl chr 1:120,118,487...120,200,435 		JBrowse link
G Steap4 STEAP family member 4 acts_upstream_of_or_within IDA (PMID:16609065) MGI PMID:16609065 NCBI chr 5:8,010,472...8,032,213
Ensembl chr 5:8,010,457...8,032,213 		JBrowse link
iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc39a8 solute carrier family 39 (metal ion transporter), member 8 involved_in ISO
ISS
IMP
IDA		 (PMID:30015240)
(PMID:22898811)		 GO_Central
UniProt		 PMID:22898811 PMID:30015240 GO_REF:0000024 GO_REF:0000096 GO_REF:0000119 NCBI chr 3:135,522,644...135,594,333
Ensembl chr 3:135,531,040...135,594,333 		JBrowse link
G Steap2 six transmembrane epithelial antigen of prostate 2 acts_upstream_of_or_within IDA (PMID:16609065) MGI PMID:16609065 NCBI chr 5:5,714,829...5,744,649
Ensembl chr 5:5,714,829...5,744,578 		JBrowse link
negative regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO GO_Central GO_REF:0000119 NCBI chr 5:113,910,479...113,916,349
Ensembl chr 5:113,910,809...113,916,349 		JBrowse link
positive regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in IDA (PMID:29061364) ARUK-UCL PMID:29061364 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Lcn2 lipocalin 2 involved_in ISO RGD
GO_Central		 PMID:25557118 GO_REF:0000096 RGD:126790477 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Mir210 microRNA 210 involved_in ISO (PMID:20436681) ARUK-UCL PMID:20436681 NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28630
    homeostatic process 2068
      chemical homeostasis 1250
        inorganic ion homeostasis 591
          intracellular iron ion homeostasis 74
            cellular response to iron ion starvation + 1
            iron import into cell + 11
Path 2
Term Annotations click to browse term
  biological_process 28630
    homeostatic process 2068
      chemical homeostasis 1250
        monoatomic ion homeostasis 673
          intracellular monoatomic ion homeostasis 583
            intracellular monoatomic cation homeostasis 572
              intracellular iron ion homeostasis 74
                cellular response to iron ion starvation + 1
                iron import into cell + 11
paths to the root