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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular iron ion homeostasis
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Accession:GO:0006879 term browser browse the term
Definition:A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.
Synonyms:exact_synonym: cellular iron ion homeostasis
 broad_synonym: iron homeostasis
 xref: Reactome:R-HSA-917937 "Iron uptake and transport"


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intracellular iron ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:58,305,804...58,470,827
Ensembl chr  X:58,306,776...58,471,417 		JBrowse link
G ACO1 aconitase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 RGD
Ensembl
GO_Central		 PMID:15086359 GO_REF:0000033 GO_REF:0000107 RGD:1642737 NCBI chr11:49,699,072...49,758,783
Ensembl chr11:49,699,109...49,923,257 		JBrowse link
G ACVR2B activin A receptor type 2B involved_in ISO (PMID:31800957) UniProt PMID:31800957 NCBI chr23:8,211,555...8,225,596
Ensembl chr23:8,192,483...8,218,894 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 acts_upstream_of_or_within ISO (PMID:10562540) MGI PMID:10562540 NCBI chr  X:46,703,477...46,731,767
Ensembl chr  X:46,703,477...46,723,529 		JBrowse link
G ATP13A2 ATPase cation transporting 13A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:81,196,355...81,215,736
Ensembl chr 2:81,196,463...81,215,689 		JBrowse link
G ATP6AP1 ATPase H+ transporting accessory protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:122,133,314...122,140,949
Ensembl chr  X:122,133,325...122,140,447 		JBrowse link
G ATP6V0A2 ATPase H+ transporting V0 subunit a2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:5,911,319...5,952,773
Ensembl chr26:5,912,887...5,952,306 		JBrowse link
G ATP6V0D1 ATPase H+ transporting V0 subunit d1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:81,926,589...81,965,959
Ensembl chr 5:81,926,612...81,965,526 		JBrowse link
G ATP6V1A ATPase H+ transporting V1 subunit A involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:18,038,143...18,103,649
Ensembl chr33:18,038,801...18,101,435 		JBrowse link
G ATP6V1G1 ATPase H+ transporting V1 subunit G1 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chr11:68,755,586...68,760,863 JBrowse link
G B2M beta-2-microglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997 		JBrowse link
G B2M beta-2-microglobulin involved_in IEA Ensembl GO_REF:0000107
G BMP6 bone morphogenetic protein 6 acts_upstream_of_or_within
involved_in		 IEA
ISO		 (PMID:19252488) Ensembl
BHF-UCL		 PMID:19252488 GO_REF:0000107 NCBI chr35:7,780,763...7,833,095
Ensembl chr35:7,804,231...7,831,845 		JBrowse link
G BOLA2B bolA family member 2B involved_in IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 6:18,170,106...18,171,012 JBrowse link
G CCDC115 coiled-coil domain containing 115 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chr25:19,027,014...19,031,467
Ensembl chr25:19,027,342...19,030,887 		JBrowse link
G CISD1 CDGSH iron sulfur domain 1 involved_in IBA GO_Central GO_REF:0000033
G CP ceruloplasmin involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:43,969,297...44,033,226
Ensembl chr23:43,969,435...44,030,369 		JBrowse link
G CYB561 cytochrome b561 involved_in ISO (PMID:14499595) ARUK-UCL PMID:14499595 NCBI chr 9:11,461,738...11,474,413
Ensembl chr 9:11,463,585...11,468,282 		JBrowse link
G CYB561A3 cytochrome b561 family member A3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:55,039,788...55,049,739
Ensembl chr18:55,043,942...55,049,143 		JBrowse link
G CYBRD1 cytochrome b reductase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:15,970,873...16,001,296
Ensembl chr36:15,970,946...15,997,983 		JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:8,053,486...8,110,791
Ensembl chr 4:8,053,837...8,109,325 		JBrowse link
G ERFE erythroferrone involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:48,656,576...48,665,620 JBrowse link
G FBXL5 F-box and leucine rich repeat protein 5 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 3:64,683,770...64,727,161
Ensembl chr 3:64,575,348...64,726,931 		JBrowse link
G FRRS1 ferric chelate reductase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:50,169,518...50,215,170
Ensembl chr 6:50,111,718...50,215,177 		JBrowse link
G FTH1 ferritin heavy chain 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr11:39,037,349...39,038,170
Ensembl chr11:39,037,318...39,038,079 		JBrowse link
G FTH1 ferritin heavy chain 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr18:54,466,167...54,468,733
Ensembl chr18:54,466,023...54,468,732 		JBrowse link
G FTL ferritin light chain involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 1:107,418,457...107,419,923
Ensembl chr 1:107,418,458...107,419,923 		JBrowse link
G FXN frataxin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9405681) UniProt
InterPro
MGI		 PMID:9405681 GO_REF:0000002 GO_REF:0000043 NCBI chr 1:88,288,566...88,311,228
Ensembl chr 1:88,288,566...88,311,228 		JBrowse link
G GLRX3 glutaredoxin 3 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr28:38,724,895...38,755,323
Ensembl chr28:38,724,941...38,755,316 		JBrowse link
G HAMP hepcidin antimicrobial peptide involved_in ISO
IEA
IBA		 RGD
Ensembl
GO_Central
InterPro		 PMID:14592944 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:1304454 NCBI chr 1:117,305,531...117,306,587
Ensembl chr 1:117,305,411...117,306,619 		JBrowse link
G HEPHL1 hephaestin like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:6,720,472...6,813,946
Ensembl chr21:6,716,562...6,814,486 		JBrowse link
G HFE homeostatic iron regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:24,031,479...24,038,922
Ensembl chr35:24,031,387...24,042,413 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692 		JBrowse link
G HJV hemojuvelin BMP co-receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:58,792,647...58,797,504
Ensembl chr17:58,793,247...58,797,373 		JBrowse link
G HMOX1 heme oxygenase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773 		JBrowse link
G HPX hemopexin involved_in IEA InterPro GO_REF:0000002 NCBI chr21:29,749,913...29,759,176
Ensembl chr21:29,719,589...29,759,046 		JBrowse link
G INHCA inhibitor of carbonic anhydrase involved_in IEA InterPro GO_REF:0000002 NCBI chr23:30,578,853...30,634,510
Ensembl chr23:30,595,704...30,683,845 		JBrowse link
G IREB2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr13:38,398,445...38,441,128
Ensembl chr13:38,400,591...38,441,015 		JBrowse link
G ISCU iron-sulfur cluster assembly enzyme involved_in IBA GO_Central GO_REF:0000033 NCBI chr26:18,300,800...18,307,668
Ensembl chr26:18,300,803...18,307,652 		JBrowse link
G LOC100684085 ferritin heavy chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr23:2,687,141...2,688,064 JBrowse link
G LOC100688200 ferritin heavy chain-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr31:220,118...222,732 JBrowse link
G LOC102154317 ferritin light chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 6:10,515,824...10,516,618 JBrowse link
G LOC102154780 CDGSH iron-sulfur domain-containing protein 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:72,536,932...72,546,574 JBrowse link
G LOC102155200 ferritin light chain involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr23:16,294,409...16,295,335 JBrowse link
G LOC119865338 ferritin heavy chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043
G LOC119868188 ferritin heavy chain-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043
G LOC119868273 ferritin heavy chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043
G LOC119868428 ferritin light chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043
G LOC119877428 ferritin heavy chain-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043
G LOC119878170 ferritin heavy chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043
G LOC119878918 ferritin heavy chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043
G LOC477072 serotransferrin involved_in IEA InterPro GO_REF:0000002 NCBI chr23:30,658,250...30,683,816
Ensembl chr23:30,595,704...30,683,845 		JBrowse link
G LOC484507 ferritin light chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 1:113,711,027...113,712,086 JBrowse link
G LOC608550 ferritin heavy chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr11:11,512,268...11,513,672 JBrowse link
G LOC612257 ferritin heavy chain-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr  X:31,868,893...31,869,858 JBrowse link
G MECR mitochondrial trans-2-enoyl-CoA reductase acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 2:71,369,768...71,400,499
Ensembl chr 2:71,369,806...71,400,499 		JBrowse link
G MELTF melanotransferrin NOT|acts_upstream_of_or_within ISO (PMID:16291590) MGI PMID:16291590 NCBI chr33:29,985,007...30,006,437
Ensembl chr33:29,985,206...30,003,742 		JBrowse link
G MON1A MON1 homolog A, secretory trafficking associated acts_upstream_of_or_within ISO (PMID:17632513) MGI PMID:17632513 NCBI chr20:39,368,757...39,383,175
Ensembl chr20:39,378,694...39,383,175 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309 		JBrowse link
G NCOA4 nuclear receptor coactivator 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25327288) InterPro
MGI		 PMID:25327288 GO_REF:0000002 NCBI chr28:1,801,655...1,867,705
Ensembl chr28:1,802,678...1,825,020 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:36,978,148...37,065,247
Ensembl chr 2:36,961,024...37,064,303 		JBrowse link
G NEO1 neogenin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr30:36,387,425...36,622,491
Ensembl chr30:36,387,259...36,622,154 		JBrowse link
G NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:31,900,540...31,922,087
Ensembl chr 6:31,896,596...31,921,989 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:13,437,819...13,540,167
Ensembl chr21:13,437,925...13,539,616 		JBrowse link
G SCARA5 scavenger receptor class A member 5 involved_in IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chr25:29,591,248...29,714,159
Ensembl chr25:29,591,294...29,712,173 		JBrowse link
G SCO1 synthesis of cytochrome C oxidase 1 acts_upstream_of_or_within ISO (PMID:36301669) MGI PMID:36301669 NCBI chr 5:34,957,358...34,971,684
Ensembl chr 5:34,957,785...34,971,661 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 acts_upstream_of_or_within
involved_in		 IEA Ensembl GO_REF:0000107 NCBI chr37:25,039,203...25,047,461
Ensembl chr37:25,038,360...25,047,282 		JBrowse link
G SLC40A1 solute carrier family 40 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:308,054...329,037
Ensembl chr37:303,104...368,865 		JBrowse link
G SMAD1 SMAD family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:44,093,491...44,171,177
Ensembl chr15:44,095,497...44,170,098 		JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405 		JBrowse link
G SMAD5 SMAD family member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:24,027,603...24,082,673
Ensembl chr11:24,028,126...24,078,169 		JBrowse link
G SMAD9 SMAD family member 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:3,768,851...3,844,645
Ensembl chr25:3,779,197...3,841,321 		JBrowse link
G SOD1 superoxide dismutase 1 acts_upstream_of_or_within ISO (PMID:16377630) MGI PMID:16377630 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815 		JBrowse link
G TFR2 transferrin receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:9,059,501...9,076,646
Ensembl chr 6:9,060,629...9,076,158 		JBrowse link
G TFRC transferrin receptor involved_in
acts_upstream_of_or_within		 IEA
IBA		 UniProt
Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr33:29,206,024...29,237,221
Ensembl chr33:29,208,609...29,238,242 		JBrowse link
G TMEM199 transmembrane protein 199 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:42,607,688...42,614,776
Ensembl chr 9:42,607,733...42,611,445 		JBrowse link
G TMPRSS6 transmembrane serine protease 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:27,393,650...27,435,893
Ensembl chr10:27,397,123...27,435,908 		JBrowse link
G TTC7A tetratricopeptide repeat domain 7A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:49,102,256...49,246,663
Ensembl chr10:49,129,584...49,314,495 		JBrowse link
cellular response to iron ion starvation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HFE homeostatic iron regulator ISO RGD PMID:16208485 RGD:1582698 NCBI chr35:24,031,479...24,038,922
Ensembl chr35:24,031,387...24,042,413 		JBrowse link
endocytic iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TFR2 transferrin receptor 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:9,059,501...9,076,646
Ensembl chr 6:9,060,629...9,076,158 		JBrowse link
iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC11A2 solute carrier family 11 member 2 acts_upstream_of_or_within
involved_in		 IEA
ISO		 (PMID:17109629) Ensembl
UniProt		 PMID:17109629 GO_REF:0000107 NCBI chr27:3,788,785...3,823,852
Ensembl chr27:3,787,855...3,822,672 		JBrowse link
G SLC39A14 solute carrier family 39 member 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:34,854,371...34,901,030
Ensembl chr25:34,846,653...34,869,695 		JBrowse link
G STEAP3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chr19:30,745,910...30,795,310
Ensembl chr19:30,747,921...30,795,338 		JBrowse link
G STEAP4 STEAP4 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chr14:14,319,895...14,345,719
Ensembl chr14:14,321,757...14,327,720 		JBrowse link
iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC39A8 solute carrier family 39 member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr32:23,727,920...23,801,459
Ensembl chr32:23,729,476...23,800,941 		JBrowse link
G STEAP2 STEAP2 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chr14:16,118,384...16,138,985
Ensembl chr14:16,119,073...16,135,238 		JBrowse link
negative regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ISCU iron-sulfur cluster assembly enzyme involved_in ISO (PMID:20436681) ARUK-UCL PMID:20436681 NCBI chr26:18,300,800...18,307,668
Ensembl chr26:18,300,803...18,307,652 		JBrowse link
positive regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in ISO (PMID:29061364) ARUK-UCL PMID:29061364 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G LCN2 lipocalin 2 ISO RGD PMID:25557118 RGD:126790477 NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22141
    homeostatic process 1990
      chemical homeostasis 1212
        inorganic ion homeostasis 593
          intracellular iron ion homeostasis 86
            cellular response to iron ion starvation + 1
            iron import into cell + 10
Path 2
Term Annotations click to browse term
  biological_process 22141
    homeostatic process 1990
      chemical homeostasis 1212
        monoatomic ion homeostasis 674
          intracellular monoatomic ion homeostasis 584
            intracellular monoatomic cation homeostasis 571
              intracellular iron ion homeostasis 86
                cellular response to iron ion starvation + 1
                iron import into cell + 10
paths to the root