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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular iron ion homeostasis
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Accession:GO:0006879 term browser browse the term
Definition:A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.
Synonyms:exact_synonym: cellular iron ion homeostasis
 broad_synonym: iron homeostasis
 xref: Reactome:R-HSA-917937 "Iron uptake and transport"


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intracellular iron ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:64,304,101...64,407,310
Ensembl chr  X:74,418,754...74,521,726 		JBrowse link
G ACO1 aconitase 1 acts_upstream_of_or_within ISO
IEA		 RGD
Ensembl		 PMID:15086359 GO_REF:0000107 RGD:1642737 NCBI chr 9:32,157,763...32,225,116
Ensembl chr 9:32,967,993...33,035,177 		JBrowse link
G ACVR2B activin A receptor type 2B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,350,838...38,389,839
Ensembl chr 3:38,633,093...38,662,063 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:47,219,588...47,241,592
Ensembl chr  X:55,451,794...55,473,680 		JBrowse link
G ATP13A2 ATPase cation transporting 13A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:15,929,613...15,955,631
Ensembl chr 1:16,986,385...17,006,033
Ensembl chr 1:16,986,385...17,006,033 		JBrowse link
G ATP6AP1 ATPase H+ transporting accessory protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:143,870,421...143,878,288
Ensembl chr  X:153,740,751...153,748,621 		JBrowse link
G ATP6V0A2 ATPase H+ transporting V0 subunit a2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:121,297,959...121,343,294
Ensembl chr12:125,522,886...125,569,858 		JBrowse link
G ATP6V0D1 ATPase H+ transporting V0 subunit d1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:47,783,327...47,826,138
Ensembl chr16:67,171,883...67,214,670 		JBrowse link
G ATP6V1A ATPase H+ transporting V1 subunit A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:110,888,504...110,951,750
Ensembl chr 3:117,808,963...117,872,349 		JBrowse link
G ATP6V1G1 ATPase H+ transporting V1 subunit G1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:85,685,910...85,696,255
Ensembl chr 9:114,048,387...114,058,878 		JBrowse link
G B2M beta-2-microglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:23,668,108...23,674,791
Ensembl chr15:41,836,345...41,842,991 		JBrowse link
G BMP6 bone morphogenetic protein 6 acts_upstream_of_or_within
involved_in		 IEA
ISO		 (PMID:19252488) Ensembl
BHF-UCL		 PMID:19252488 GO_REF:0000107 NCBI chr 6:7,564,164...7,720,341
Ensembl chr 6:7,848,249...8,000,649 		JBrowse link
G BOLA2B bolA family member 2B involved_in IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118
G CP ceruloplasmin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:146,180,527...146,239,833
Ensembl chr 3:153,764,830...153,817,544 		JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:206,915,541...206,976,656 JBrowse link
G ERFE erythroferrone involved_in ISO (PMID:24880340) UniProt PMID:24880340 NCBI chr2B:125,390,190...125,401,677 JBrowse link
G FBXL5 F-box and leucine rich repeat protein 5 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 4:10,050,909...10,107,573
Ensembl chr 4:15,348,977...15,430,631 		JBrowse link
G FRRS1 ferric chelate reductase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:102,364,390...102,423,252
Ensembl chr 1:101,083,973...101,124,865 		JBrowse link
G FTH1 ferritin heavy chain 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr11:57,329,163...57,332,248 JBrowse link
G FTHL17 ferritin heavy chain like 17 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr  X:23,680,709...23,681,515
Ensembl chr  X:31,232,234...31,232,785 		JBrowse link
G FTL ferritin light chain involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr19:45,966,431...45,968,015
Ensembl chr19:54,788,854...54,790,465 		JBrowse link
G FTMT ferritin mitochondrial involved_in IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 NCBI chr 5:117,243,371...117,244,872
Ensembl chr 5:123,028,372...123,029,097 		JBrowse link
G FXN frataxin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9405681) Ensembl
TreeGrafter
MGI
InterPro
UniProt		 PMID:9405681 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:55,690,483...55,754,755
Ensembl chr 9:67,800,579...67,866,031 		JBrowse link
G GLRX3 glutaredoxin 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:126,730,314...126,775,918
Ensembl chr10:130,973,022...131,019,742 		JBrowse link
G HAMP hepcidin antimicrobial peptide involved_in ISO
IEA		 RGD
Ensembl
TreeGrafter
InterPro		 PMID:14592944 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1304454 NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861 		JBrowse link
G HEPHL1 hephaestin like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:89,035,265...89,127,508
Ensembl chr11:92,521,421...92,613,455 		JBrowse link
G HFE homeostatic iron regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885 		JBrowse link
G HJV hemojuvelin BMP co-receptor involved_in ISO (PMID:25860887) BHF-UCL PMID:25860887 NCBI chr 1:121,738,465...121,742,743
Ensembl chr 1:113,926,383...113,930,761 		JBrowse link
G HMOX1 heme oxygenase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G HPX hemopexin involved_in IEA InterPro GO_REF:0000002 NCBI chr11:6,558,279...6,572,946
Ensembl chr11:6,246,392...6,256,410 		JBrowse link
G IREB2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within		 IEA Ensembl GO_REF:0000107 NCBI chr15:57,367,314...57,430,322
Ensembl chr15:76,331,610...76,394,476 		JBrowse link
G ISCU iron-sulfur cluster assembly enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:106,132,987...106,140,879
Ensembl chr12:109,529,162...109,537,053 		JBrowse link
G LOC100971948 ferritin light chain involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr11:43,650,332...43,651,204
Ensembl chr19:54,788,854...54,790,465 		JBrowse link
G LOC100972759 plasma membrane ascorbate-dependent reductase CYBRD1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:58,813,554...58,849,162
Ensembl chr2B:176,272,010...176,307,618 		JBrowse link
G LOC100974743 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:56,648,322...56,661,758
Ensembl chr11:60,013,043...60,026,207 		JBrowse link
G LOC100988585 transmembrane protein 220 acts_upstream_of_or_within ISO (PMID:36301669) MGI PMID:36301669 NCBI chr17:40,923,397...40,973,382
Ensembl chr17:45,703,642...45,720,520
Ensembl chr17:45,703,642...45,720,520 		JBrowse link
G LOC100992304 ferritin heavy chain involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr13:3,997,646...3,998,422 JBrowse link
G LOC100993774 transmembrane ascorbate-dependent reductase CYB561 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:57,513,820...57,528,326
Ensembl chr17:62,660,598...62,674,396 		JBrowse link
G LOC134729904 ferritin heavy chain-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043
G LOC134731254 ferritin heavy chain-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043
G MECR mitochondrial trans-2-enoyl-CoA reductase acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 1:28,463,466...28,501,518
Ensembl chr 1:29,490,318...29,527,704 		JBrowse link
G MELTF melanotransferrin NOT|acts_upstream_of_or_within ISO (PMID:16291590) MGI PMID:16291590 NCBI chr 3:194,345,474...194,373,690
Ensembl chr 3:204,262,182...204,310,710 		JBrowse link
G MON1A MON1 homolog A, secretory trafficking associated acts_upstream_of_or_within ISO (PMID:17632513) MGI PMID:17632513 NCBI chr 3:49,840,824...49,862,101
Ensembl chr 3:51,077,398...51,099,498 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863 		JBrowse link
G NCOA4 nuclear receptor coactivator 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25327288) InterPro
MGI		 PMID:25327288 GO_REF:0000002 NCBI chr10:43,159,014...43,184,558
Ensembl chr10:46,420,952...46,443,223 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:137,467,161...137,511,569
Ensembl chr 5:143,600,789...143,622,913 		JBrowse link
G NEO1 neogenin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:51,968,238...52,221,116
Ensembl chr15:70,789,035...70,977,178 		JBrowse link
G NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:9,681,800...9,708,673
Ensembl chr16:10,906,719...10,931,800 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:81,011,324...81,122,352
Ensembl chr11:84,619,241...84,730,684 		JBrowse link
G SCARA5 scavenger receptor class A member 5 involved_in IEA Ensembl
UniProt		 GO_REF:0000104 GO_REF:0000107 NCBI chr 8:27,143,737...27,271,301
Ensembl chr 8:24,345,260...24,469,881 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within		 IEA Ensembl GO_REF:0000107 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941 		JBrowse link
G SLC40A1 solute carrier family 40 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:76,867,908...76,888,403
Ensembl chr2B:194,787,575...194,810,993 		JBrowse link
G SMAD1 SMAD family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:137,822,269...137,899,700
Ensembl chr 4:149,481,836...149,558,135 		JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359 		JBrowse link
G SMAD5 SMAD family member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:131,524,229...131,574,119
Ensembl chr 5:137,664,067...137,712,635 		JBrowse link
G SMAD9 SMAD family member 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:18,055,427...18,130,571
Ensembl chr13:36,486,597...36,521,646 		JBrowse link
G SOD1 superoxide dismutase 1 acts_upstream_of_or_within ISO (PMID:16377630) MGI PMID:16377630 NCBI chr21:18,029,831...18,037,526 JBrowse link
G TF transferrin involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 3:130,799,063...130,830,227
Ensembl chr 3:138,274,159...138,305,476 		JBrowse link
G TFR2 transferrin receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:92,647,431...92,669,889
Ensembl chr 7:106,048,935...106,069,238 		JBrowse link
G TFRC transferrin receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10192390) UniProt
TreeGrafter
MGI		 PMID:10192390 GO_REF:0000104 GO_REF:0000118 NCBI chr 3:193,384,817...193,417,532
Ensembl chr 3:203,333,953...203,373,998 		JBrowse link
G TMPRSS6 transmembrane serine protease 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:17,979,094...18,032,590
Ensembl chr22:35,815,051...35,859,940 		JBrowse link
G TTC7A tetratricopeptide repeat domain 7A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2A:47,031,859...47,190,995
Ensembl chr2A:47,963,094...48,121,083 		JBrowse link
G VMA12 vacuolar ATPase assembly factor VMA12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:28,412,229...28,416,840
Ensembl chr17:28,914,604...28,919,194 		JBrowse link
G VMA22 vacuolar ATPase assembly factor VMA22 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chr2B:28,624,800...28,629,543 JBrowse link
cellular response to iron ion starvation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HFE homeostatic iron regulator ISO RGD PMID:16208485 RGD:1582698 NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591 		JBrowse link
endocytic iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TFR2 transferrin receptor 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:92,647,431...92,669,889
Ensembl chr 7:106,048,935...106,069,238 		JBrowse link
iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC11A2 solute carrier family 11 member 2 acts_upstream_of_or_within
involved_in		 IEA
ISO		 (PMID:17109629) Ensembl
UniProt		 PMID:17109629 GO_REF:0000107 NCBI chr12:37,726,158...37,774,554
Ensembl chr12:38,629,686...38,677,377 		JBrowse link
G SLC39A14 solute carrier family 39 member 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:21,617,529...21,672,726
Ensembl chr 8:18,555,895...18,621,510 		JBrowse link
G STEAP3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chr2B:6,166,296...6,208,338
Ensembl chr2B:119,752,363...119,787,051 		JBrowse link
G STEAP4 STEAP4 metalloreductase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:80,263,528...80,299,470
Ensembl chr 7:93,918,327...93,948,754 		JBrowse link
iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC39A8 solute carrier family 39 member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:94,675,458...94,770,380
Ensembl chr 4:105,339,488...105,433,568 		JBrowse link
G STEAP2 STEAP2 metalloreductase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:82,220,814...82,246,718
Ensembl chr 7:95,823,012...95,849,354 		JBrowse link
negative regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ISCU iron-sulfur cluster assembly enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:106,132,987...106,140,879
Ensembl chr12:109,529,162...109,537,053 		JBrowse link
positive regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in ISO (PMID:29061364) ARUK-UCL PMID:29061364 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G LCN2 lipocalin 2 ISO RGD PMID:25557118 RGD:126790477 NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    homeostatic process 1924
      chemical homeostasis 1175
        inorganic ion homeostasis 574
          intracellular iron ion homeostasis 73
            cellular response to iron ion starvation + 1
            iron import into cell + 10
Path 2
Term Annotations click to browse term
  biological_process 19315
    homeostatic process 1924
      chemical homeostasis 1175
        monoatomic ion homeostasis 657
          intracellular monoatomic ion homeostasis 571
            intracellular monoatomic cation homeostasis 559
              intracellular iron ion homeostasis 73
                cellular response to iron ion starvation + 1
                iron import into cell + 10
paths to the root