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ONTOLOGY REPORT - ANNOTATIONS


Term:superoxide metabolic process
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Accession:GO:0006801 term browser browse the term
Definition:The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
Synonyms:exact_synonym: oxygen free radical metabolic process;   oxygen free radical metabolism;   superoxide free radical metabolic process;   superoxide free radical metabolism;   superoxide metabolism


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superoxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta-synthase ISO (MGI:MGI:1888627|PMID:10953023) MGI PMID:10953023 MGI:MGI:1888627 NCBI chrNW_004936500:976,043...1,003,559 JBrowse link
G Immp2l inner mitochondrial membrane peptidase subunit 2 ISO (MGI:MGI:5299279|PMID:21824519) MGI PMID:21824519 MGI:MGI:5299279 NCBI chrNW_004936653:3,268,229...3,543,173 JBrowse link
G LOC101966992 cytochrome b-245 heavy chain ISO (MGI:MGI:5568138|PMID:24739962)
(PMID:12042318)
UniProtKB
BHF-UCL
PMID:12042318, PMID:24739962 MGI:MGI:5568138 NCBI chrNW_004936502:4,631,750...4,676,686 JBrowse link
G LOC101967032 cytochrome b-245 light chain ISO (PMID:1763037), (PMID:2243141) BHF-UCL
RGD
PMID:1763037, PMID:2243141, PMID:8798532, PMID:15322091 RGD:1580287, RGD:2317869 NCBI chrNW_004936641:1,036,967...1,044,954 JBrowse link
G LOC101972377 cytochrome b5 reductase 4 ISO (PMID:10611283) UniProtKB PMID:10611283 NCBI chrNW_004936510:7,018,038...7,104,491 JBrowse link
G Nos2 nitric oxide synthase 2 ISO (MGI:MGI:2673089|PMID:12933833) MGI PMID:12933833 MGI:MGI:2673089 NCBI chrNW_004936538:4,052,277...4,097,051 JBrowse link
G Nox4 NADPH oxidase 4 ISO (PMID:18760347) CACAO
RGD
PMID:15322091, PMID:18760347 RGD:1580287 NCBI chrNW_004936736:230,465...394,859 JBrowse link
G Noxa1 NADPH oxidase activator 1 ISO (PMID:20609497)
(MGI:MGI:2449827|PMID:12473664)
UniProtKB
MGI
PMID:12473664, PMID:20609497 MGI:MGI:2449827 NCBI chrNW_004936669:632,864...641,257 JBrowse link
G Noxo1 NADPH oxidase organizer 1 ISO (MGI:MGI:2449827|PMID:12473664) MGI PMID:12473664 MGI:MGI:2449827 NCBI chrNW_004936694:2,054,429...2,060,098 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 ISO RGD PMID:17901563 RGD:5133248 NCBI chrNW_004936475:19,771,384...19,785,034 JBrowse link
G Nrros negative regulator of reactive oxygen species NOT ISO (MGI:MGI:6192878|PMID:29909984)
(MGI:MGI:5568138|PMID:24739962)
UniProt
UniProtKB
PMID:24739962, PMID:29909984 MGI:MGI:5568138, MGI:MGI:6192878 NCBI chrNW_004936784:1,222,381...1,250,501 JBrowse link
G Sh3pxd2a SH3 and PX domains 2A ISO (PMID:19755710)
(PMID:20609497)
UniProtKB PMID:19755710, PMID:20609497 NCBI chrNW_004936600:2,343,709...2,513,497 JBrowse link
G Sh3pxd2b SH3 and PX domains 2B ISO (PMID:19755710) UniProtKB PMID:19755710 NCBI chrNW_004936609:2,934,814...2,975,111 JBrowse link
G Sod1 superoxide dismutase 1 ISO (MGI:MGI:2136726|PMID:11404260)
(PMID:12551919)
RGD
MGI
BHF-UCL
PMID:10640619, PMID:11404260, PMID:12514262, PMID:12551919 MGI:MGI:2136726, RGD:1601266, RGD:634854 NCBI chrNW_004936500:10,345,154...10,352,873 JBrowse link
G Sod2 superoxide dismutase 2 ISO (PMID:12551919), (PMID:14980699)
(MGI:MGI:2386432|PMID:12176043)
(MGI:MGI:3577668|PMID:15637112)
(MGI:MGI:1332377|PMID:10049502)
BHF-UCL
MGI
PMID:10049502, PMID:12176043, PMID:12551919, PMID:14980699, PMID:15637112 MGI:MGI:1332377, MGI:MGI:2386432, MGI:MGI:3577668 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link
negative regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor ISO (PMID:15207272) UniProtKB PMID:15207272 NCBI chrNW_004936490:1,209,760...1,320,046 JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant ISO (MGI:MGI:1930064|PMID:11168643) MGI PMID:11168643 MGI:MGI:1930064 NCBI chrNW_004936659:1,598,252...1,642,615 JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:24601882 RGD:39128160 NCBI chrNW_004936621:620,163...639,115 JBrowse link
G Crp C-reactive protein ISO RGD PMID:9767445 RGD:9586000 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Pon3 paraoxonase 3 ISO (MGI:MGI:5543365|PMID:22441669) CACAO PMID:22441669 MGI:MGI:5543365 NCBI chrNW_004936585:4,902,430...4,928,377 JBrowse link
positive regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:21376054 RGD:5129173 NCBI chrNW_004936484:19,713,299...19,721,144 JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:21076237 RGD:5129195 NCBI chrNW_004936519:6,831,096...6,873,977 JBrowse link
G App amyloid beta precursor protein ISO (PMID:11316806) ARUK-UCL PMID:11316806 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Clec7a C-type lectin domain containing 7A ISO (PMID:19358895) ARUK-UCL PMID:19358895 NCBI chrNW_004936902:436,224...446,435 JBrowse link
G Crp C-reactive protein ISO (PMID:24141169) AgBase PMID:24141169 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:22966991 RGD:7204494 NCBI chrNW_004936678:365,005...560,546 JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO (PMID:11714832) UniProtKB PMID:11714832 NCBI chrNW_004936549:142,281...153,575 JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:27912212 RGD:13507308 NCBI chrNW_004936529:1,779,582...1,801,251 JBrowse link
G Gnai3 G protein subunit alpha i3 ISO RGD PMID:27912212 RGD:13507308 NCBI chrNW_004936704:1,031,476...1,075,662 JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO (MGI:MGI:5009187|PMID:11408560) BHF-UCL PMID:11408560 MGI:MGI:5009187 NCBI chrNW_004936599:2,197,681...2,200,642 JBrowse link
G Hvcn1 hydrogen voltage gated channel 1 ISO RGD PMID:24935944 RGD:14985214 NCBI chrNW_004936558:3,581,409...3,609,714 JBrowse link
G Il18 interleukin 18 ISO RGD PMID:19497959 RGD:4889403 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Itgam integrin subunit alpha M ISO (MGI:MGI:3812233|PMID:18685038)
(PMID:21193407)
(MGI:MGI:3814938|PMID:18981141)
ARUK-UCL
UniProt
PMID:18685038, PMID:18981141, PMID:21193407 MGI:MGI:3812233, MGI:MGI:3814938 NCBI chrNW_004936543:8,460,526...8,508,524 JBrowse link
G Itgb2 integrin subunit beta 2 ISO (PMID:21193407) UniProt PMID:21193407 NCBI chrNW_004936778:1,286,475...1,311,184 JBrowse link
G LOC101967032 cytochrome b-245 light chain ISO RGD PMID:15036821 RGD:8693734 NCBI chrNW_004936641:1,036,967...1,044,954 JBrowse link
G Mapt microtubule associated protein tau ISO (PMID:22920254) ParkinsonsUK-UCL PMID:22920254 NCBI chrNW_004936541:2,381,411...2,479,984 JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 ISO (PMID:24141169) AgBase PMID:24141169 NCBI chrNW_004936902:405,536...416,393 JBrowse link
G Prkcd protein kinase C delta ISO (PMID:19801500) UniProtKB PMID:19801500 NCBI chrNW_004936473:3,892,625...3,923,467 JBrowse link
G Sod1 superoxide dismutase 1 ISO (PMID:18219391) UniProtKB PMID:18219391 NCBI chrNW_004936500:10,345,154...10,352,873 JBrowse link
G Syk spleen associated tyrosine kinase ISO (PMID:19358895) ARUK-UCL PMID:19358895 NCBI chrNW_004936780:1,553,605...1,601,036 JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO (PMID:22073128) BHF-UCL PMID:22073128 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP ISO (MGI:MGI:3812233|PMID:18685038) ARUK-UCL PMID:18685038 MGI:MGI:3812233 NCBI chrNW_004936570:457,993...460,735 JBrowse link
regulation of removal of superoxide radicals term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule ISO (MGI:MGI:4850200|PMID:20978343) BHF-UCL PMID:20978343 MGI:MGI:4850200 NCBI chrNW_004936810:791,823...838,303 JBrowse link
G Dhfr dihydrofolate reductase ISO (MGI:MGI:5645206|PMID:19666465) BHF-UCL PMID:19666465 MGI:MGI:5645206 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Fbln5 fibulin 5 ISO (MGI:MGI:3610795|PMID:15528465) BHF-UCL PMID:15528465 MGI:MGI:3610795 NCBI chrNW_004936733:136,374...200,106 JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO (PMID:19666465) BHF-UCL PMID:19666465 NCBI chrNW_004936697:232,048...275,420 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2 like 2 ISO (MGI:MGI:4850200|PMID:20978343) BHF-UCL PMID:20978343 MGI:MGI:4850200 NCBI chrNW_004936509:6,589,967...6,621,171 JBrowse link
regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syk spleen associated tyrosine kinase ISO (MGI:MGI:4414596|PMID:19797524) UniProtKB PMID:19797524 MGI:MGI:4414596 NCBI chrNW_004936780:1,553,605...1,601,036 JBrowse link
regulation of superoxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shc1 SHC adaptor protein 1 ISO (PMID:24177325) BHF-UCL PMID:24177325 NCBI chrNW_004936580:4,511,560...4,522,003 JBrowse link
removal of superoxide radicals term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa4 apolipoprotein A4 ISO (PMID:16945374) HGNC PMID:16945374 NCBI chrNW_004936542:2,098,683...2,101,127 JBrowse link
G Atp7a ATPase copper transporting alpha ISO (MGI:MGI:3616392|PMID:16371425) MGI PMID:16371425 MGI:MGI:3616392 NCBI chrNW_004936683:2,874,022...2,936,214 JBrowse link
G Fancc FA complementation group C ISO (MGI:MGI:2149223|PMID:11493445) MGI PMID:11493445 MGI:MGI:2149223 NCBI chrNW_004936626:3,980,311...4,147,042 JBrowse link
G Mpo myeloperoxidase ISO (MGI:MGI:1333719|PMID:10085024) MGI PMID:10085024 MGI:MGI:1333719 NCBI chrNW_004936490:4,809,773...4,819,070 JBrowse link
G Mt3 metallothionein 3 ISO (PMID:12383939) UniProtKB PMID:12383939 NCBI chrNW_004936475:8,864,512...8,866,516 JBrowse link
G Nos3 nitric oxide synthase 3 ISO (PMID:19666465) BHF-UCL PMID:19666465 NCBI chrNW_004936527:6,427,147...6,445,770 JBrowse link
G Prdx1 peroxiredoxin 1 ISO (MGI:MGI:3695235|PMID:16880205)
(MGI:MGI:3611115|PMID:16170382)
MGI PMID:16170382, PMID:16880205 MGI:MGI:3611115, MGI:MGI:3695235 NCBI chrNW_004936474:26,641,776...26,653,291 JBrowse link
G Prdx2 peroxiredoxin 2 ISO (MGI:MGI:4850200|PMID:20978343)
(PMID:20978343)
BHF-UCL PMID:20978343 MGI:MGI:4850200 NCBI chrNW_004936659:1,894,423...1,897,690 JBrowse link
G Sod1 superoxide dismutase 1 ISO (MGI:MGI:1201750|PMID:9516486), (MGI:MGI:1314762|PMID:9788901)
(MGI:MGI:3625573|PMID:12433839), (MGI:MGI:3710732|PMID:17448893)
(MGI:MGI:1342989|PMID:10436316), (MGI:MGI:1351737|PMID:10471451), (MGI:MGI:2149223|PMID:11493445), (MGI:MGI:80951|PMID:8673102)
(MGI:MGI:1353351|PMID:10679476)
(MGI:MGI:2149223|PMID:11493445)
RGD
MGI
PMID:8673102, PMID:9516486, PMID:9788901, PMID:10436316, PMID:10471451, PMID:10640619, PMID:10679476, PMID:11493445, PMID:12433839, PMID:12514262, PMID:17448893, PMID:21757500 MGI:MGI:1201750, MGI:MGI:1314762, MGI:MGI:1342989, MGI:MGI:1351737, MGI:MGI:1353351, MGI:MGI:2149223, MGI:MGI:3625573, MGI:MGI:3710732, MGI:MGI:80951, RGD:1601266, RGD:634854, RGD:8655968 NCBI chrNW_004936500:10,345,154...10,352,873 JBrowse link
G Sod2 superoxide dismutase 2 ISO (PMID:16179351)
(MGI:MGI:3765405|PMID:16873728)
BHF-UCL
MGI
RGD
PMID:12107766, PMID:15642720, PMID:16179351, PMID:16873728, PMID:19439219 MGI:MGI:3765405, RGD:2291939, RGD:2291946, RGD:2317387 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link
superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duox2 dual oxidase 2 ISO (PMID:22814254) UniProt PMID:22814254 NCBI chrNW_004936471:7,812,163...7,831,258 JBrowse link
G Edn1 endothelin 1 ISO RGD PMID:16788136 RGD:4892602 NCBI chrNW_004936534:885,489...892,292 JBrowse link
G LOC101966992 cytochrome b-245 heavy chain ISO (PMID:12042318) BHF-UCL PMID:12042318 NCBI chrNW_004936502:4,631,750...4,676,686 JBrowse link
G LOC101967032 cytochrome b-245 light chain ISO PMID:8798532
(PMID:2243141)
BHF-UCL PMID:2243141, PMID:8798532 RGD:2317869 NCBI chrNW_004936641:1,036,967...1,044,954 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO (PMID:2547247)
(MGI:MGI:1354608|PMID:10725280), (MGI:MGI:1930845|PMID:11156938)
UniProtKB
MGI
PMID:2547247, PMID:10725280, PMID:11156938 MGI:MGI:1354608, MGI:MGI:1930845 NCBI chrNW_004936543:3,617,369...3,630,990 JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO (MGI:MGI:1196082|PMID:9490028) MGI PMID:9490028 MGI:MGI:1196082 NCBI chrNW_004936481:6,300,894...6,325,878 JBrowse link
G Nox1 NADPH oxidase 1 ISO PMID:10485709
(MGI:MGI:3796728|PMID:18397177)
(PMID:10485709)
(MGI:MGI:2449827|PMID:12473664)
(PMID:18023288)
BHF-UCL
MGI
PMID:10485709, PMID:12473664, PMID:18023288, PMID:18397177 MGI:MGI:2449827, MGI:MGI:3796728, RGD:633401 NCBI chrNW_004936584:6,023,960...6,040,041 JBrowse link
G Nox3 NADPH oxidase 3 ISO (MGI:MGI:3512869|PMID:15326186) MGI PMID:15326186 MGI:MGI:3512869 NCBI chrNW_004936489:7,568,162...7,623,370 JBrowse link
G Nox4 NADPH oxidase 4 ISO (MGI:MGI:3694159|PMID:10869423) UniProtKB PMID:10869423 MGI:MGI:3694159 NCBI chrNW_004936736:230,465...394,859 JBrowse link
G Nox5 NADPH oxidase 5 ISO (PMID:11483596) UniProtKB PMID:11483596 NCBI chrNW_004936471:28,777,926...28,838,700 JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 ISO (PMID:10318872) UniProtKB PMID:10318872 NCBI chrNW_004936581:5,109,165...5,113,617 JBrowse link
G Sod1 superoxide dismutase 1 ISO (MGI:MGI:3522379|PMID:15317809) MGI PMID:15317809 MGI:MGI:3522379 NCBI chrNW_004936500:10,345,154...10,352,873 JBrowse link
G Sod2 superoxide dismutase 2 ISO (MGI:MGI:3654558|PMID:10212301)
(MGI:MGI:3625564|PMID:15781740)
(MGI:MGI:3653322|PMID:16677818)
MGI PMID:10212301, PMID:15781740, PMID:16677818 MGI:MGI:3625564, MGI:MGI:3653322, MGI:MGI:3654558 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12001
    cellular process 11174
      cellular metabolic process 7071
        reactive oxygen species metabolic process 271
          superoxide metabolic process 61
            regulation of superoxide metabolic process + 32
            removal of superoxide radicals + 15
            superoxide anion generation + 37
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.