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ONTOLOGY REPORT - ANNOTATIONS


Term:superoxide metabolic process
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Accession:GO:0006801 term browser browse the term
Definition:The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
Synonyms:exact_synonym: oxygen free radical metabolic process;   oxygen free radical metabolism;   superoxide free radical metabolic process;   superoxide free radical metabolism;   superoxide metabolism


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superoxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBS cystathionine beta-synthase IEA Ensembl GO_REF:0000107 NCBI chr13:206,205,942...206,231,363 JBrowse link
G CYBA cytochrome b-245 alpha chain ISO (PMID:1763037), (PMID:2243141) RGD
BHF-UCL
PMID:1763037, PMID:2243141, PMID:8798532, PMID:15322091 RGD:1580287, RGD:2317869 NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,154...1,021,418
JBrowse link
G GP91-PHOX NADPH oxidase heavy chain subunit ISS UniProt GO_REF:0000024 NCBI chr  X:33,654,656...33,678,346
Ensembl chr  X:33,642,015...33,680,580
JBrowse link
G IMMP2L inner mitochondrial membrane peptidase subunit 2 IEA Ensembl GO_REF:0000107 NCBI chr18:34,006,841...34,930,252
Ensembl chr18:34,006,688...34,906,268
JBrowse link
G LOC100622980 cytochrome b5 reductase 4 IEA Ensembl GO_REF:0000107 NCBI chr 1:53,092,006...53,191,216
Ensembl chr 1:53,091,419...53,191,212
JBrowse link
G NCF1 neutrophil cytosolic factor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:11,820,367...11,834,394
Ensembl chr 3:11,820,285...11,839,426
JBrowse link
G NCF4 neutrophil cytosolic factor 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:10,876,147...10,994,002
Ensembl chr 5:10,874,953...10,994,015
JBrowse link
G NOS2 nitric oxide synthase 2 IEA Ensembl GO_REF:0000107 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,944...44,327,111
JBrowse link
G NOX4 NADPH oxidase 4 ISO (PMID:18760347) RGD
CACAO
PMID:15322091, PMID:18760347 RGD:1580287 NCBI chr 9:22,622,105...22,776,691
Ensembl chr 9:22,624,195...22,776,554
JBrowse link
G NOXA1 NADPH oxidase activator 1 ISO (PMID:20609497)
(MGI:MGI:2449827|PMID:12473664)
UniProtKB
MGI
PMID:12473664, PMID:20609497 MGI:MGI:2449827
G NOXO1 NADPH oxidase organizer 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:39,987,340...39,989,640
Ensembl chr 3:39,987,384...39,989,624
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ISO RGD PMID:17901563 RGD:5133248 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G NRROS negative regulator of reactive oxygen species NOT IEA
ISO
(MGI:MGI:6192878|PMID:29909984) Ensembl
UniProt
PMID:29909984 GO_REF:0000107, MGI:MGI:6192878 NCBI chr13:133,470,641...133,496,218
Ensembl chr13:133,470,643...133,496,264
JBrowse link
G SH3PXD2A SH3 and PX domains 2A IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:114,515,459...114,777,251
Ensembl chr14:114,519,904...114,777,238
JBrowse link
G SH3PXD2B SH3 and PX domains 2B IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr16:51,733,170...51,858,774
Ensembl chr16:51,733,131...51,858,772
JBrowse link
G SOD1 superoxide dismutase 1 ISO (PMID:12551919)
(MGI:MGI:2136726|PMID:11404260)
BHF-UCL
MGI
RGD
PMID:10640619, PMID:11404260, PMID:12514262, PMID:12551919 MGI:MGI:2136726, RGD:1601266, RGD:634854 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOD2 superoxide dismutase 2 ISO (PMID:12551919), (PMID:14980699)
(MGI:MGI:2386432|PMID:12176043)
(MGI:MGI:3577668|PMID:15637112)
(MGI:MGI:1332377|PMID:10049502)
BHF-UCL
MGI
PMID:10049502, PMID:12176043, PMID:12551919, PMID:14980699, PMID:15637112 MGI:MGI:1332377, MGI:MGI:2386432, MGI:MGI:3577668 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
negative regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AATF apoptosis antagonizing transcription factor IEA Ensembl GO_REF:0000107 NCBI chr12:38,461,809...38,563,537
Ensembl chr12:38,461,797...38,585,132
JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant IEA Ensembl GO_REF:0000107 NCBI chr 2:70,206,159...70,209,855
Ensembl chr 2:70,206,159...70,208,328
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO RGD PMID:24601882 RGD:39128160
G CRP C-reactive protein, pentraxin-related ISO RGD PMID:9767445 RGD:9586000 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,722,352...90,805,236
JBrowse link
G PON3 paraoxonase 3 IEA Ensembl GO_REF:0000107 NCBI chr 9:74,983,040...75,017,947
Ensembl chr 9:74,991,277...75,017,942
JBrowse link
positive regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:21376054 RGD:5129173 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:21076237 RGD:5129195 NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,131
JBrowse link
G APP amyloid beta precursor protein ISO (PMID:11316806) ARUK-UCL PMID:11316806 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,434,869...189,716,057
JBrowse link
G CD177 CD177 molecule ISO (PMID:21193407) UniProt PMID:21193407 NCBI chr 6:50,246,165...50,255,935
Ensembl chr 6:50,246,537...50,255,713
JBrowse link
G CLEC7A C-type lectin domain containing 7A IEA Ensembl GO_REF:0000107 NCBI chr 5:61,832,910...61,846,441
Ensembl chr 5:61,832,944...61,846,438
JBrowse link
G CRP C-reactive protein, pentraxin-related IEA Ensembl GO_REF:0000107 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,722,352...90,805,236
JBrowse link
G CYBA cytochrome b-245 alpha chain ISO RGD PMID:15036821 RGD:8693734 NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,154...1,021,418
JBrowse link
G EGFR epidermal growth factor receptor ISO RGD PMID:22966991 RGD:7204494 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,478,882
JBrowse link
G F2RL1 F2R like trypsin receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858
JBrowse link
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:27912212 RGD:13507308 NCBI chr13:32,705,326...32,733,804
Ensembl chr13:32,705,321...32,733,363
JBrowse link
G GNAI3 G protein subunit alpha i3 ISO RGD PMID:27912212 RGD:13507308 NCBI chr 4:110,527,363...110,579,331
Ensembl chr 4:110,525,547...110,579,020
JBrowse link
G HVCN1 hydrogen voltage gated channel 1 ISO RGD PMID:24935944 RGD:14985214 NCBI chr14:32,006,837...32,044,165
Ensembl chr14:31,989,170...32,043,744
JBrowse link
G IL18 interleukin 18 ISO RGD PMID:19497959 RGD:4889403 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300
JBrowse link
G ITGAM integrin subunit alpha M IEA Ensembl GO_REF:0000107 NCBI chr 3:17,216,719...17,272,134
Ensembl chr 3:17,136,161...17,273,657
JBrowse link
G ITGAX integrin subunit alpha X IEA Ensembl GO_REF:0000107 NCBI chr 3:17,178,725...17,201,388 JBrowse link
G ITGB2 integrin subunit beta 2 IEA Ensembl GO_REF:0000107 NCBI chr13:207,514,281...207,544,108
Ensembl chr13:207,512,954...207,544,108
JBrowse link
G LOC100739163 glutathione S-transferase P-like ISO (MGI:MGI:5009187|PMID:11408560) BHF-UCL PMID:11408560 MGI:MGI:5009187 NCBI chr 2:4,978,761...4,982,233 JBrowse link
G MAPT microtubule associated protein tau IEA Ensembl GO_REF:0000107 NCBI chr12:17,098,259...17,211,483
Ensembl chr12:17,095,587...17,211,368
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 IMP (PMID:24141169) AgBase PMID:24141169 NCBI chr 5:61,799,356...61,809,691
Ensembl chr 5:61,799,286...61,810,624
JBrowse link
G PRKCD protein kinase C delta IEA Ensembl GO_REF:0000107 NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,264...35,323,356
JBrowse link
G SOD1 superoxide dismutase 1 IEA Ensembl GO_REF:0000107 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SYK spleen associated tyrosine kinase IEA Ensembl GO_REF:0000107 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,712...2,161,172
JBrowse link
G TGFB1 transforming growth factor beta 1 ISS UniProt GO_REF:0000024 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP IEA Ensembl GO_REF:0000107 NCBI chr 6:45,309,199...45,312,562
Ensembl chr 6:45,309,197...45,312,537
JBrowse link
regulation of removal of superoxide radicals term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD36 CD36 molecule IEA Ensembl GO_REF:0000107 NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105
JBrowse link
G DHFR dihydrofolate reductase IEA Ensembl GO_REF:0000107 NCBI chr 2:89,230,660...89,255,830 JBrowse link
G FBLN5 fibulin 5 IEA Ensembl GO_REF:0000107 NCBI chr 7:113,423,629...113,526,412
Ensembl chr 7:113,423,629...113,522,069
JBrowse link
G GCH1 GTP cyclohydrolase 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:184,201,232...184,264,060
Ensembl chr 1:184,202,007...184,257,315
JBrowse link
G LOC100511343 platelet glycoprotein 4-like IEA Ensembl GO_REF:0000107 NCBI chr 9:99,601,863...99,670,275
Ensembl chr 9:99,605,181...99,782,105
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 IEA Ensembl GO_REF:0000107 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYK spleen associated tyrosine kinase ISS UniProt GO_REF:0000024 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,712...2,161,172
JBrowse link
regulation of superoxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SHC1 SHC adaptor protein 1 ISO (PMID:24177325) BHF-UCL PMID:24177325 NCBI chr 4:94,818,226...94,831,766
Ensembl chr 4:94,810,875...94,831,765
JBrowse link
removal of superoxide radicals term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA4 apolipoprotein A4 IEA Ensembl GO_REF:0000107 NCBI chr 9:44,201,587...44,204,072
Ensembl chr 9:44,201,508...44,204,206
JBrowse link
G ATP7A ATPase copper transporting alpha ISO (MGI:MGI:3616392|PMID:16371425) MGI PMID:16371425 MGI:MGI:3616392 NCBI chr  X:61,972,544...62,110,058
Ensembl chr  X:61,972,874...62,110,058
JBrowse link
G CCS copper chaperone for superoxide dismutase IEA
IBA
(PMID:21873635) GOC
GO_Central
PMID:21873635 GO_REF:0000108 NCBI chr 2:5,819,471...5,833,263
Ensembl chr 2:5,819,471...5,836,064
JBrowse link
G FANCC FA complementation group C ISO (MGI:MGI:2149223|PMID:11493445) MGI PMID:11493445 MGI:MGI:2149223 NCBI chr10:26,796,546...27,055,271 JBrowse link
G MPO myeloperoxidase IEA Ensembl GO_REF:0000107 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904
JBrowse link
G MT3 metallothionein 3 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,721...18,789,137
JBrowse link
G NOS3 nitric oxide synthase 3 IEA Ensembl GO_REF:0000107 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G PRDX1 peroxiredoxin 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:165,847,390...165,859,918
Ensembl chr 6:165,824,520...165,861,442
JBrowse link
G PRDX2 peroxiredoxin 2 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 2:66,207,829...66,211,474
Ensembl chr 2:66,207,796...66,213,567
JBrowse link
G SOD1 superoxide dismutase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOD2 superoxide dismutase 2 IEA GOC GO_REF:0000108 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
G SOD3 superoxide dismutase 3 IEA
IBA
(PMID:21873635) GOC
GO_Central
PMID:21873635 GO_REF:0000108 NCBI chr 8:18,796,633...18,802,156
Ensembl chr 8:18,796,636...18,802,154
JBrowse link
superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYBA cytochrome b-245 alpha chain IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,154...1,021,418
JBrowse link
G DUOX1 dual oxidase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:126,572,533...126,603,084
Ensembl chr 1:126,572,492...126,620,118
JBrowse link
G DUOX2 dual oxidase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,477...126,641,419
JBrowse link
G DUOXA2 dual oxidase maturation factor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:126,616,631...126,620,359
Ensembl chr 1:126,572,533...126,652,463
JBrowse link
G EDN1 endothelin 1 ISO RGD PMID:16788136 RGD:4892602 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G GP91-PHOX NADPH oxidase heavy chain subunit IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:33,654,656...33,678,346
Ensembl chr  X:33,642,015...33,680,580
JBrowse link
G LOC100625180 proteoglycan 3 ISO (PMID:10318872) UniProtKB PMID:10318872 NCBI chr 2:13,525,472...13,529,620 JBrowse link
G NCF1 neutrophil cytosolic factor 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:11,820,367...11,834,394
Ensembl chr 3:11,820,285...11,839,426
JBrowse link
G NCF2 neutrophil cytosolic factor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:124,776,516...124,813,358
Ensembl chr 9:124,773,498...124,812,928
JBrowse link
G NOX1 NADPH oxidase 1 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr  X:82,540,664...82,575,811
Ensembl chr  X:82,540,666...82,586,532
JBrowse link
G NOX3 NADPH oxidase 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:11,443,681...11,501,140
Ensembl chr 1:11,446,060...11,500,978
JBrowse link
G NOX4 NADPH oxidase 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:22,622,105...22,776,691
Ensembl chr 9:22,624,195...22,776,554
JBrowse link
G NOX5 NADPH oxidase 5 IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr 1:166,866,930...166,907,994
Ensembl chr 1:166,868,087...166,906,218
JBrowse link
G NOXA1 NADPH oxidase activator 1 IBA (PMID:21873635) GO_Central PMID:21873635
G SOD1 superoxide dismutase 1 IEA Ensembl GO_REF:0000107 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOD2 superoxide dismutase 2 ISO (MGI:MGI:3654558|PMID:10212301)
(MGI:MGI:3653322|PMID:16677818)
(MGI:MGI:3625564|PMID:15781740)
MGI PMID:10212301, PMID:15781740, PMID:16677818 MGI:MGI:3625564, MGI:MGI:3653322, MGI:MGI:3654558 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
G TAFA4 TAFA chemokine like family member 4 IEA Ensembl GO_REF:0000107 NCBI chr13:50,142,679...50,353,448
Ensembl chr13:50,142,679...50,353,425
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    cellular process 15777
      cellular metabolic process 9578
        reactive oxygen species metabolic process 299
          superoxide metabolic process 70
            regulation of superoxide metabolic process + 35
            removal of superoxide radicals + 18
            superoxide anion generation + 43
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.