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ONTOLOGY REPORT - ANNOTATIONS


Term:superoxide metabolic process
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Accession:GO:0006801 term browser browse the term
Definition:The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
Synonyms:exact_synonym: oxygen free radical metabolic process;   oxygen free radical metabolism;   superoxide free radical metabolic process;   superoxide free radical metabolism;   superoxide metabolism


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superoxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBS cystathionine beta-synthase ISO (MGI:MGI:1888627|PMID:10953023) MGI PMID:10953023 MGI:MGI:1888627 NCBI chr21:29,361,519...29,385,610 JBrowse link
G IMMP2L inner mitochondrial membrane peptidase subunit 2 ISO (MGI:MGI:5299279|PMID:21824519) MGI PMID:21824519 MGI:MGI:5299279 NCBI chr 7:102,647,212...103,536,293 JBrowse link
G LOC100977566 cytochrome b5 reductase 4 ISO (PMID:10611283) UniProtKB PMID:10611283 NCBI chr 6:81,756,292...81,864,365
Ensembl chr 6:85,030,058...85,130,948
JBrowse link
G LOC100982531 cytochrome b-245 heavy chain ISO (MGI:MGI:5568138|PMID:24739962)
(PMID:12042318)
UniProtKB
BHF-UCL
PMID:12042318, PMID:24739962 MGI:MGI:5568138 NCBI chr  X:30,230,394...30,267,379
Ensembl chr  X:37,939,704...37,973,183
JBrowse link
G LOC100986914 cytochrome b-245 light chain ISO (PMID:1763037), (PMID:2243141) BHF-UCL
RGD
PMID:1763037, PMID:2243141, PMID:8798532, PMID:15322091 RGD:1580287, RGD:2317869 NCBI chr16:69,356,396...69,364,225 JBrowse link
G NOS2 nitric oxide synthase 2 ISO (MGI:MGI:2673089|PMID:12933833) MGI PMID:12933833 MGI:MGI:2673089 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
JBrowse link
G NOX4 NADPH oxidase 4 ISO (PMID:18760347) RGD
CACAO
PMID:15322091, PMID:18760347 RGD:1580287 NCBI chr11:84,330,362...84,496,755 JBrowse link
G NOXA1 NADPH oxidase activator 1 ISO (MGI:MGI:2449827|PMID:12473664)
(PMID:20609497)
MGI
UniProtKB
PMID:12473664, PMID:20609497 MGI:MGI:2449827 NCBI chr 9:108,490,455...108,503,555
Ensembl chr 9:137,455,874...137,468,196
JBrowse link
G NOXO1 NADPH oxidase organizer 1 ISO (MGI:MGI:2449827|PMID:12473664) MGI PMID:12473664 MGI:MGI:2449827 NCBI chr16:720,087...725,567 JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ISO RGD PMID:17901563 RGD:5133248 NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731
JBrowse link
G NRROS negative regulator of reactive oxygen species NOT ISO (MGI:MGI:5568138|PMID:24739962)
(MGI:MGI:6192878|PMID:29909984)
UniProtKB
UniProt
PMID:24739962, PMID:29909984 MGI:MGI:5568138, MGI:MGI:6192878 NCBI chr 3:193,984,797...194,007,173
Ensembl chr 3:203,920,334...203,948,506
JBrowse link
G SH3PXD2A SH3 and PX domains 2A ISO (PMID:19755710)
(PMID:20609497)
UniProtKB PMID:19755710, PMID:20609497 NCBI chr10:100,193,961...100,455,200
Ensembl chr10:103,663,163...103,861,437
JBrowse link
G SH3PXD2B SH3 and PX domains 2B ISO (PMID:19755710) UniProtKB PMID:19755710 NCBI chr 5:167,678,633...167,807,960
Ensembl chr 5:174,591,759...174,719,957
JBrowse link
G SOD1 superoxide dismutase 1 ISO (MGI:MGI:2136726|PMID:11404260)
(PMID:12551919)
RGD
MGI
BHF-UCL
PMID:10640619, PMID:11404260, PMID:12514262, PMID:12551919 MGI:MGI:2136726, RGD:1601266, RGD:634854 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SOD2 superoxide dismutase 2 ISO (PMID:12551919), (PMID:14980699)
(MGI:MGI:1332377|PMID:10049502)
(MGI:MGI:3577668|PMID:15637112)
(MGI:MGI:2386432|PMID:12176043)
BHF-UCL
MGI
PMID:10049502, PMID:12176043, PMID:12551919, PMID:14980699, PMID:15637112 MGI:MGI:1332377, MGI:MGI:2386432, MGI:MGI:3577668 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960
JBrowse link
negative regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AATF apoptosis antagonizing transcription factor ISO (PMID:15207272) UniProtKB PMID:15207272 NCBI chr17:20,027,351...20,129,255
Ensembl chr17:20,325,282...20,426,359
JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant ISO (MGI:MGI:1930064|PMID:11168643) MGI PMID:11168643 MGI:MGI:1930064 NCBI chr19:11,120,451...11,125,167
Ensembl chr19:11,832,575...11,835,203
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO RGD PMID:24601882 RGD:39128160 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
JBrowse link
G CRP C-reactive protein ISO RGD PMID:9767445 RGD:9586000 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G PON3 paraoxonase 3 ISO (MGI:MGI:5543365|PMID:22441669) CACAO PMID:22441669 MGI:MGI:5543365 NCBI chr 7:87,314,788...87,354,020
Ensembl chr 7:100,902,432...100,941,611
JBrowse link
positive regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:21376054 RGD:5129173 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044
JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:21076237 RGD:5129195 NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380
JBrowse link
G APP amyloid beta precursor protein ISO (PMID:11316806) ARUK-UCL PMID:11316806 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072
JBrowse link
G CD177 CD177 molecule ISO (PMID:21193407) UniProt PMID:21193407 NCBI chr19:40,287,083...40,295,914 JBrowse link
G CLEC7A C-type lectin domain containing 7A ISO (PMID:19358895) ARUK-UCL PMID:19358895 NCBI chr12:10,161,780...10,174,943
Ensembl chr12:10,410,384...10,425,452
JBrowse link
G CRP C-reactive protein ISO (PMID:24141169) AgBase PMID:24141169 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO (MGI:MGI:5586806|PMID:10725737) UniProtKB PMID:10725737 MGI:MGI:5586806 NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474
JBrowse link
G EGFR epidermal growth factor receptor ISO RGD PMID:22966991 RGD:7204494 NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615
JBrowse link
G F2RL1 F2R like trypsin receptor 1 ISO (PMID:11714832) UniProtKB PMID:11714832 NCBI chr 5:38,462,521...38,478,882
Ensembl chr 5:39,006,331...39,024,265
JBrowse link
G FPR2 formyl peptide receptor 2 ISO (MGI:MGI:5905278|PMID:11316806) ARUK-UCL PMID:11316806 MGI:MGI:5905278 NCBI chr19:48,663,622...48,715,535 JBrowse link
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:27912212 RGD:13507308 NCBI chr 3:50,154,731...50,187,948
Ensembl chr 3:51,398,981...51,421,988
JBrowse link
G GNAI3 G protein subunit alpha i3 ISO RGD PMID:27912212 RGD:13507308 NCBI chr 1:111,925,668...111,971,941
Ensembl chr 1:111,154,060...111,198,768
JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO (MGI:MGI:5009187|PMID:11408560) BHF-UCL PMID:11408560 MGI:MGI:5009187 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472
JBrowse link
G HVCN1 hydrogen voltage gated channel 1 ISO RGD PMID:24935944 RGD:14985214 NCBI chr12:108,217,516...108,258,210
Ensembl chr12:111,591,050...111,645,632
JBrowse link
G IL18 interleukin 18 ISO RGD PMID:19497959 RGD:4889403 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
JBrowse link
G ITGAM integrin subunit alpha M ISO (MGI:MGI:3814938|PMID:18981141)
(PMID:21193407)
(MGI:MGI:3812233|PMID:18685038)
ARUK-UCL
UniProt
PMID:18685038, PMID:18981141, PMID:21193407 MGI:MGI:3812233, MGI:MGI:3814938 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406
JBrowse link
G ITGB2 integrin subunit beta 2 ISO (PMID:21193407) UniProt PMID:21193407 NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963
JBrowse link
G LOC100986914 cytochrome b-245 light chain ISO RGD PMID:15036821 RGD:8693734 NCBI chr16:69,356,396...69,364,225 JBrowse link
G MAPT microtubule associated protein tau ISO (PMID:22920254) ParkinsonsUK-UCL PMID:22920254 NCBI chr17:11,373,220...11,506,669
Ensembl chr17:11,458,159...11,523,129
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 ISO (PMID:24141169) AgBase PMID:24141169 NCBI chr12:10,196,712...10,210,432
Ensembl chr12:10,445,202...10,461,071
JBrowse link
G PRKCD protein kinase C delta ISO (PMID:19801500) UniProtKB PMID:19801500 NCBI chr 3:53,104,137...53,135,588
Ensembl chr 3:54,330,328...54,357,910
JBrowse link
G SOD1 superoxide dismutase 1 ISO (PMID:18219391) UniProtKB PMID:18219391 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SYK spleen associated tyrosine kinase ISO (PMID:19358895) ARUK-UCL PMID:19358895 NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101
JBrowse link
G TGFB1 transforming growth factor beta 1 ISO (PMID:22073128) BHF-UCL PMID:22073128 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP ISO (MGI:MGI:3812233|PMID:18685038) ARUK-UCL PMID:18685038 MGI:MGI:3812233 NCBI chr19:32,821,279...32,825,488
Ensembl chr19:41,570,683...41,575,226
JBrowse link
regulation of removal of superoxide radicals term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD36 CD36 molecule ISO (MGI:MGI:4850200|PMID:20978343) BHF-UCL PMID:20978343 MGI:MGI:4850200 NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865
JBrowse link
G DHFR dihydrofolate reductase ISO (MGI:MGI:5645206|PMID:19666465) BHF-UCL PMID:19666465 MGI:MGI:5645206 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003
JBrowse link
G FBLN5 fibulin 5 ISO (MGI:MGI:3610795|PMID:15528465) BHF-UCL PMID:15528465 MGI:MGI:3610795 NCBI chr14:72,504,240...72,583,160
Ensembl chr14:91,848,430...91,927,304
JBrowse link
G GCH1 GTP cyclohydrolase 1 ISO (PMID:19666465) BHF-UCL PMID:19666465 NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 ISO (MGI:MGI:4850200|PMID:20978343) BHF-UCL PMID:20978343 MGI:MGI:4850200 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085
JBrowse link
regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYK spleen associated tyrosine kinase ISO (MGI:MGI:4414596|PMID:19797524) UniProtKB PMID:19797524 MGI:MGI:4414596 NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101
JBrowse link
regulation of superoxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SHC1 SHC adaptor protein 1 ISO (PMID:24177325) BHF-UCL PMID:24177325 NCBI chr 1:130,310,778...130,323,001
Ensembl chr 1:133,920,532...133,929,008
JBrowse link
removal of superoxide radicals term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA4 apolipoprotein A4 ISO (PMID:16945374) HGNC PMID:16945374 NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382
JBrowse link
G ATP7A ATPase copper transporting alpha ISO (MGI:MGI:3616392|PMID:16371425) MGI PMID:16371425 MGI:MGI:3616392 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756
JBrowse link
G FANCC FA complementation group C ISO (MGI:MGI:2149223|PMID:11493445) MGI PMID:11493445 MGI:MGI:2149223 NCBI chr 9:66,201,581...66,418,229
Ensembl chr 9:94,329,971...94,477,198
JBrowse link
G MPO myeloperoxidase ISO (MGI:MGI:1333719|PMID:10085024) MGI PMID:10085024 MGI:MGI:1333719 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111
JBrowse link
G MT3 metallothionein 3 ISO (PMID:12383939) UniProtKB PMID:12383939 NCBI chr16:36,875,919...36,877,558 JBrowse link
G NOS3 nitric oxide synthase 3 ISO (PMID:19666465) BHF-UCL PMID:19666465 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233
JBrowse link
G PRDX1 peroxiredoxin 1 ISO (MGI:MGI:3695235|PMID:16880205)
(MGI:MGI:3611115|PMID:16170382)
MGI PMID:16170382, PMID:16880205 MGI:MGI:3611115, MGI:MGI:3695235 NCBI chr 1:44,813,508...44,824,430
Ensembl chr 1:46,171,453...46,182,018
JBrowse link
G PRDX2 peroxiredoxin 2 ISO (MGI:MGI:4850200|PMID:20978343)
(PMID:20978343)
BHF-UCL PMID:20978343 MGI:MGI:4850200 NCBI chr19:12,359,084...12,363,552
Ensembl chr19:13,103,422...13,107,369
JBrowse link
G SOD1 superoxide dismutase 1 ISO (MGI:MGI:1353351|PMID:10679476)
(MGI:MGI:1342989|PMID:10436316), (MGI:MGI:1351737|PMID:10471451), (MGI:MGI:2149223|PMID:11493445), (MGI:MGI:80951|PMID:8673102)
(MGI:MGI:3625573|PMID:12433839), (MGI:MGI:3710732|PMID:17448893)
(MGI:MGI:1201750|PMID:9516486), (MGI:MGI:1314762|PMID:9788901)
(MGI:MGI:2149223|PMID:11493445)
RGD
MGI
PMID:8673102, PMID:9516486, PMID:9788901, PMID:10436316, PMID:10471451, PMID:10640619, PMID:10679476, PMID:11493445, PMID:12433839, PMID:12514262, PMID:17448893, PMID:21757500 MGI:MGI:1201750, MGI:MGI:1314762, MGI:MGI:1342989, MGI:MGI:1351737, MGI:MGI:1353351, MGI:MGI:2149223, MGI:MGI:3625573, MGI:MGI:3710732, MGI:MGI:80951, RGD:1601266, RGD:634854, RGD:8655968 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SOD2 superoxide dismutase 2 ISO (MGI:MGI:3765405|PMID:16873728)
(PMID:16179351)
RGD
MGI
BHF-UCL
PMID:12107766, PMID:15642720, PMID:16179351, PMID:16873728, PMID:19439219 MGI:MGI:3765405, RGD:2291939, RGD:2291946, RGD:2317387 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960
JBrowse link
superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOX2 dual oxidase 2 ISO (PMID:22814254) UniProt PMID:22814254 NCBI chr15:24,040,513...24,061,758
Ensembl chr15:42,395,135...42,414,281
JBrowse link
G EDN1 endothelin 1 ISO RGD PMID:16788136 RGD:4892602 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
JBrowse link
G LOC100982531 cytochrome b-245 heavy chain ISO (PMID:12042318) BHF-UCL PMID:12042318 NCBI chr  X:30,230,394...30,267,379
Ensembl chr  X:37,939,704...37,973,183
JBrowse link
G LOC100986914 cytochrome b-245 light chain ISO (PMID:2243141)
PMID:8798532
BHF-UCL PMID:2243141, PMID:8798532 RGD:2317869 NCBI chr16:69,356,396...69,364,225 JBrowse link
G NCF1 neutrophil cytosolic factor 1 ISO (PMID:2547247)
(MGI:MGI:1354608|PMID:10725280), (MGI:MGI:1930845|PMID:11156938)
UniProtKB
MGI
PMID:2547247, PMID:10725280, PMID:11156938 MGI:MGI:1354608, MGI:MGI:1930845 Ensembl chr 7:81,917,167...81,932,589 JBrowse link
G NCF2 neutrophil cytosolic factor 2 ISO (MGI:MGI:1196082|PMID:9490028) MGI PMID:9490028 MGI:MGI:1196082 NCBI chr 1:159,085,923...159,121,259
Ensembl chr 1:163,243,636...163,278,420
JBrowse link
G NOX1 NADPH oxidase 1 ISO (PMID:18023288)
(MGI:MGI:3796728|PMID:18397177)
(PMID:10485709)
(MGI:MGI:2449827|PMID:12473664)
BHF-UCL
MGI
PMID:10485709, PMID:12473664, PMID:18023288, PMID:18397177 MGI:MGI:2449827, MGI:MGI:3796728, RGD:633401 NCBI chr  X:90,046,023...90,076,968
Ensembl chr  X:100,182,398...100,215,192
JBrowse link
G NOX3 NADPH oxidase 3 ISO (MGI:MGI:3512869|PMID:15326186) MGI PMID:15326186 MGI:MGI:3512869 NCBI chr 6:153,210,190...153,270,955
Ensembl chr 6:159,174,261...159,234,642
JBrowse link
G NOX4 NADPH oxidase 4 ISO (MGI:MGI:3694159|PMID:10869423) UniProtKB PMID:10869423 MGI:MGI:3694159 NCBI chr11:84,330,362...84,496,755 JBrowse link
G NOX5 NADPH oxidase 5 ISO (PMID:11483596) UniProtKB PMID:11483596 NCBI chr15:47,961,085...48,003,529
Ensembl chr15:66,734,521...66,777,037
JBrowse link
G PRG3 proteoglycan 3, pro eosinophil major basic protein 2 ISO (PMID:10318872) UniProtKB PMID:10318872 NCBI chr11:52,617,688...52,622,058
Ensembl chr 3:160,108,051...160,112,421
JBrowse link
G SOD1 superoxide dismutase 1 ISO (MGI:MGI:3522379|PMID:15317809) MGI PMID:15317809 MGI:MGI:3522379 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SOD2 superoxide dismutase 2 ISO (MGI:MGI:3653322|PMID:16677818)
(MGI:MGI:3625564|PMID:15781740)
(MGI:MGI:3654558|PMID:10212301)
MGI PMID:10212301, PMID:15781740, PMID:16677818 MGI:MGI:3625564, MGI:MGI:3653322, MGI:MGI:3654558 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960
JBrowse link
G TAFA4 TAFA chemokine like family member 4 ISO (MGI:MGI:6282963|PMID:25109685) UniProt PMID:25109685 MGI:MGI:6282963 NCBI chr 3:68,666,666...68,867,917
Ensembl chr 3:70,035,940...70,186,928
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12564
    cellular process 11665
      cellular metabolic process 7331
        reactive oxygen species metabolic process 282
          superoxide metabolic process 65
            regulation of superoxide metabolic process + 35
            removal of superoxide radicals + 15
            superoxide anion generation + 41
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.