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ONTOLOGY REPORT - ANNOTATIONS


Term:heme biosynthetic process
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Accession:GO:0006783 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
Synonyms:exact_synonym: haem biosynthesis;   haem biosynthetic process;   heme anabolism;   heme biosynthesis;   heme formation;   heme synthesis
 xref: MetaCyc:HEMESYN2-PWY


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heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb10 ATP binding cassette subfamily B member 10 involved_in ISO (MGI:5648801|PMID:24421385) RGD PMID:24421385 MGI:5648801 NCBI chr19:56,742,809...56,772,904
Ensembl chr19:56,742,835...56,772,904
JBrowse link
G Alad aminolevulinate dehydratase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
ISS
(MGI:53493|PMID:4959158), (MGI:53609|PMID:4981581), (MGI:63121|PMID:14050799)
(PMID:11032836)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:4959158 PMID:4981581 PMID:11032836 PMID:14050799, PMID:1764448, PMID:21873635 GO_REF:0000024 MGI:53493 MGI:53609 MGI:63121, RGD:1599020, RGD:13792537 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:3694153|PMID:9446639)
PMID:21873635
UniProt
RGD
PMID:9446639, PMID:21873635 GO_REF:0000024 MGI:3694153, RGD:13792537 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:5447588|PMID:23135403)
GO_REF:0000024
(PMID:23135403)
RGD
UniProt
PMID:23135403, PMID:21873635 GO_REF:0000024 MGI:5447588, RGD:13792537 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:50,439,778...50,563,920
Ensembl chr10:50,439,782...50,574,539
JBrowse link
G Cpox coproporphyrinogen oxidase acts_upstream_of_or_within IDA
ISO
(MGI:77569|PMID:8407975) RGD PMID:8407975, PMID:3955059 MGI:77569, RGD:1600961 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
MGI:1858114|MGI:2384729 (MGI:1327758|PMID:9989256), (MGI:3620268|PMID:16503645), (MGI:3696634|PMID:15496139), (MGI:3794459|PMID:16306232), (MGI:79136|PMID:8611576)
PMID:21873635
(PMID:27599036)
RGD PMID:8611576 PMID:9989256 PMID:15496139 PMID:16306232 PMID:16503645 PMID:27599036, PMID:3955059, PMID:21873635 MGI:1327758 MGI:3620268 MGI:3696634 MGI:3794459 MGI:79136, RGD:1600961, RGD:13792537 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Fxn frataxin involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834
JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in IBA
ISO
PMID:21873635
(PMID:18936296)
RGD PMID:18936296, PMID:21873635 RGD:13792537 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within ISO MGI:2384429 (MGI:1352605|PMID:10617683) RGD PMID:10617683 MGI:1352605 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 involved_in ISO
ISS
IEA
(PMID:27599036)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:27599036 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882
JBrowse link
G Ppox protoporphyrinogen oxidase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(MGI:3687447|PMID:3346226)
(PMID:7713909)
PMID:21873635
RGD PMID:3346226 PMID:7713909, PMID:3955059, PMID:21873635 MGI:3687447, RGD:1600961, RGD:13792537 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
G Slc11a2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856400 (MGI:3691553|PMID:11739192)
Ensembl
RGD
PMID:11739192 GO_REF:0000107 MGI:3691553 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc25a39 solute carrier family 25, member 39 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:90,351,899...90,356,905
Ensembl chr10:90,351,900...90,356,242
JBrowse link
G Tmem14c transmembrane protein 14C involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:21,571,510...21,577,651
Ensembl chr17:21,571,518...21,577,631
JBrowse link
G Urod uroporphyrinogen decarboxylase acts_upstream_of_or_within
involved_in
NAS
ISO
IBA
IC
MGI:2687172 (MGI:3703836|PMID:17360334)
PMID:21873635
RGD PMID:17360334, PMID:3658690, PMID:21873635, PMID:15736160 MGI:3703836, RGD:70052, RGD:13792537, RGD:2301379 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
G Uros uroporphyrinogen III synthase involved_in ISO
IBA
(PMID:3805019)
PMID:21873635
RGD PMID:3805019, PMID:21873635 RGD:13792537 NCBI chr 1:205,755,766...205,778,170
Ensembl chr 1:205,756,640...205,777,167
JBrowse link
heme A biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in
acts_upstream_of_or_within
ISO (PMID:12928484)
(MGI:3604933|PMID:16103131), (MGI:3640032|PMID:16782876)
RGD PMID:12928484 PMID:16103131 PMID:16782876 MGI:3604933 MGI:3640032 NCBI chr10:50,439,778...50,563,920
Ensembl chr10:50,439,782...50,574,539
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 involved_in ISO
IBA
UniProtKB:Q7KZN9-1 (PMID:12474143)
PMID:21873635
RGD PMID:12474143, PMID:21873635 RGD:13792537 NCBI chr 1:263,494,850...263,511,510
Ensembl chr 1:263,494,852...263,511,505
JBrowse link
heme B biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 NOT|involved_in ISO (PMID:22655043) RGD PMID:22655043 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
heme O biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:50,439,778...50,563,920
Ensembl chr10:50,439,782...50,574,539
JBrowse link
positive regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:30765471)
(MGI:6695684|PMID:30765471)
UniProt
Ensembl
RGD
PMID:30765471 GO_REF:0000024 GO_REF:0000107 MGI:6695684 NCBI chr  X:75,150,511...75,291,950
Ensembl chr  X:75,150,608...75,291,938
JBrowse link
G Slc6a9 solute carrier family 6 member 9 involved_in ISO (MGI:6450351|PMID:28495915) RGD PMID:28495915 MGI:6450351 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Cpox coproporphyrinogen oxidase involved_in IDA
IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:3814086, PMID:21873635 GO_REF:0000041, RGD:4145128, RGD:13792537 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Ireb2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2181660 (MGI:3695992|PMID:15831703)
Ensembl
RGD
PMID:15831703 GO_REF:0000107 MGI:3695992 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Ppox protoporphyrinogen oxidase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
G Urod uroporphyrinogen decarboxylase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
G Uros uroporphyrinogen III synthase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:205,755,766...205,778,170
Ensembl chr 1:205,756,640...205,777,167
JBrowse link
regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srrd SRR1 domain containing involved_in ISO (MGI:6282940|PMID:28802827) RGD PMID:28802827 MGI:6282940 NCBI chr12:50,315,876...50,321,488
Ensembl chr12:50,315,933...50,321,144
JBrowse link
G Tmem14c transmembrane protein 14C acts_upstream_of_or_within ISO MGI:4351741 (MGI:5581691|PMID:25157825) RGD PMID:25157825 MGI:5581691 NCBI chr17:21,571,510...21,577,651
Ensembl chr17:21,571,518...21,577,631
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      pigment metabolic process 73
        heme metabolic process 33
          heme biosynthetic process 24
            heme A biosynthetic process 2
            heme B biosynthetic process 1
            heme C biosynthetic process 0
            heme O biosynthetic process 1
            negative regulation of heme biosynthetic process 0
            positive regulation of heme biosynthetic process 2
            protoporphyrinogen IX biosynthetic process + 9
            regulation of heme biosynthetic process + 4
            siroheme biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      cellular metabolic process 10755
        cellular aromatic compound metabolic process 5636
          tetrapyrrole metabolic process 49
            porphyrin-containing compound metabolic process 40
              porphyrin-containing compound biosynthetic process 27
                heme biosynthetic process 24
                  heme A biosynthetic process 2
                  heme B biosynthetic process 1
                  heme C biosynthetic process 0
                  heme O biosynthetic process 1
                  negative regulation of heme biosynthetic process 0
                  positive regulation of heme biosynthetic process 2
                  protoporphyrinogen IX biosynthetic process + 9
                  regulation of heme biosynthetic process + 4
                  siroheme biosynthetic process 0
paths to the root