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ONTOLOGY REPORT - ANNOTATIONS

Term:fat-soluble vitamin metabolic process
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Accession:GO:0006775 term browser browse the term
Definition:The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water.
Synonyms:exact_synonym: fat-soluble vitamin metabolism


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calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
(PMID:15465040)		 Ensembl
RGD		 PMID:15465040 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in ISO
IEA
IBA		 (PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)
GO_REF:0000107
(MGI:3590419|PMID:15972816)
PMID:21873635		 RGD
Ensembl		 PMID:9415400 PMID:15795327 PMID:15972816 PMID:16549446 PMID:17023519 More... GO_REF:0000107 MGI:3590419, RGD:13792537 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:15465040), (PMID:18511070)
(MGI:2677973|PMID:12867411)		 RGD PMID:12867411 PMID:15465040 PMID:18511070 MGI:2677973 NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in ISO
IEA		 (PMID:16549446)
GO_REF:0000107		 RGD
Ensembl		 PMID:16549446 GO_REF:0000107 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor involved_in ISO (PMID:15947108) RGD PMID:15947108 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO (PMID:15243130) RGD PMID:15243130 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snai1 snail family transcriptional repressor 1 involved_in ISO (PMID:19502595) RGD PMID:19502595 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:18485278), (PMID:19502595) RGD PMID:18485278 PMID:19502595 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
phylloquinone catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbr1l1 carbonyl reductase 1 like 1 IDA menadione catabolism RGD PMID:16359670 RGD:2316273 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,857,991...32,895,275
Ensembl chr11:32,857,991...32,895,275 		JBrowse link
G Cbr3 carbonyl reductase 3 IDA menadione catabolism RGD PMID:18983987 RGD:2316293 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875 		JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940 		JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506 		JBrowse link
G Cyp4f40 cytochrome P450, family 4, subfamily f, polypeptide 40 involved_in IBA
ISO		 PMID:21873635
(PMID:24138531)		 RGD PMID:24138531 PMID:21873635 RGD:13792537 NCBI chr 7:11,691,648...11,707,437
Ensembl chr 7:11,692,086...11,706,229 		JBrowse link
positive regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:9282826) RGD PMID:9282826 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:1690216) RGD PMID:1690216 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
regulation of vitamin A metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgat1 diacylglycerol O-acyltransferase 1 IMP RGD PMID:18000880 RGD:10400849 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299 		JBrowse link
G Isx intestine-specific homeobox acts_upstream_of_or_within ISO MGI:3775943 (MGI:3775349|PMID:18093975) RGD PMID:18093975 MGI:3775349 NCBI chr19:13,218,552...13,239,754
Ensembl chr19:13,218,552...13,239,760 		JBrowse link
retinoic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 involved_in ISO (PMID:10823918)
(MGI:894533|PMID:9250660)		 RGD PMID:9250660 PMID:10823918 MGI:894533 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 involved_in IMP
ISO		 (PMID:10823918) RGD PMID:10823918 PMID:21138835 RGD:6771354 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628 		JBrowse link
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 involved_in ISO (PMID:14532297) RGD PMID:14532297 NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842 		JBrowse link
G Cyp2w1 cytochrome P450, family 2, subfamily w, polypeptide 1 involved_in ISO (PMID:26936974) RGD PMID:26936974 NCBI chr12:15,291,552...15,296,421
Ensembl chr12:15,291,704...15,296,421 		JBrowse link
vitamin A metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipa lipase A, lysosomal acid type acts_upstream_of_or_within ISO MGI:2451080 (MGI:5805310|PMID:27354281) RGD PMID:27354281 MGI:5805310 NCBI chr 1:232,024,351...232,167,329
Ensembl chr 1:232,024,356...232,057,633 		JBrowse link
G Lrat lecithin retinol acyltransferase involved_in
acts_upstream_of_or_within		 IDA
IBA
ISO		 PMID:21873635
(MGI:6414681|PMID:28758396)
(MGI:1928450|PMID:11108736)		 RGD PMID:11108736 PMID:28758396 PMID:2253789 PMID:21873635 PMID:9244401 More... MGI:1928450 MGI:6414681, RGD:1599829, RGD:13792537, RGD:1599832, RGD:1599831 NCBI chr 2:168,264,093...168,273,155
Ensembl chr 2:168,266,877...168,273,619 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta IMP RGD PMID:12576510 RGD:1625187 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Rbp1 retinol binding protein 1 involved_in ISO
ISS		 (PMID:15632377)
GO_REF:0000024		 RGD
UniProt		 PMID:15632377 GO_REF:0000024 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743 		JBrowse link
vitamin D catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 involved_in TAS
IBA
IDA
ISO		 PMID:21873635
PMID:16617161
(PMID:16617161), (PMID:24893882), (PMID:29461981), (PMID:8506296), (PMID:8679605)
PMID:10231362		 RGD PMID:8506296 PMID:8679605 PMID:16617161 PMID:24893882 PMID:29461981 More... RGD:625496, RGD:13792537, RGD:14995311, RGD:14995316 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in IBA
IDA
IEA
ISO		 PMID:21873635
PMID:9333115
GO_REF:0000107
(MGI:1097206|PMID:9295274)		 Ensembl
RGD		 PMID:9295274 PMID:21873635 PMID:9333115 GO_REF:0000107 MGI:1097206, RGD:13792537, RGD:69373 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 involved_in ISO (PMID:29461981) RGD PMID:29461981 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fgf23 fibroblast growth factor 23 involved_in ISO (PMID:15040831) RGD PMID:15040831 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
vitamin D metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calb1 calbindin 1 TAS RGD PMID:2792772 RGD:68751 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 acts_upstream_of_or_within IDA
ISO
TAS		 MGI:2182338 (MGI:3046628|PMID:15225763) RGD PMID:15225763 PMID:1991512 PMID:12372434 MGI:3046628, RGD:1298844, RGD:734870 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in TAS
ISO
IDA		 (PMID:9415400) RGD PMID:9415400 PMID:11316734 PMID:9371776 RGD:68680, RGD:69372 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 acts_upstream_of_or_within ISO (MGI:2677973|PMID:12867411) RGD PMID:12867411 MGI:2677973 NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759 		JBrowse link
G Fgf23 fibroblast growth factor 23 IEP RGD PMID:15531762 RGD:1598934 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Gc GC, vitamin D binding protein acts_upstream_of_or_within ISO (MGI:3046628|PMID:15225763) RGD PMID:15225763 MGI:3046628 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567 		JBrowse link
G Lrp2 LDL receptor related protein 2 acts_upstream_of_or_within ISO (MGI:1331347|PMID:10052453) RGD PMID:10052453 MGI:1331347 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708 		JBrowse link
vitamin D3 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO MGI:1857079 (MGI:6282476|PMID:28798354) RGD PMID:28798354 MGI:6282476 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO MGI:95525 (MGI:5548021|PMID:24259513) RGD PMID:24259513 MGI:5548021 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 acts_upstream_of_or_within ISO MGI:95522 (MGI:5548021|PMID:24259513) RGD PMID:24259513 MGI:5548021 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 involved_in ISO (PMID:23756265) RGD PMID:23756265 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 involved_in ISO (PMID:18177842), (PMID:24641623) RGD PMID:18177842 PMID:24641623 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
vitamin E biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pltp phospholipid transfer protein acts_upstream_of_or_within ISO MGI:2176342 (MGI:3622506|PMID:16467369) RGD PMID:16467369 MGI:3622506 NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647 		JBrowse link
vitamin E metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 involved_in ISO (PMID:28315682) RGD PMID:28315682 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:9271353)		 UniProt
RGD		 PMID:9271353 GO_REF:0000024 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ttpa alpha tocopherol transfer protein involved_in
acts_upstream_of_or_within		 IDA
ISO
IBA		 (MGI:4461120|PMID:19923370)
MGI:1932559|MGI:2386172 (MGI:1928440|PMID:11095717), (MGI:1929784|PMID:11076932), (MGI:3691723|PMID:16014812)
PMID:21873635		 RGD PMID:11076932 PMID:11095717 PMID:16014812 PMID:19923370 PMID:9356467 More... MGI:1928440 MGI:1929784 MGI:3691723 MGI:4461120, RGD:1600435, RGD:13792537 NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073 		JBrowse link
vitamin K biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ubiad1 UbiA prenyltransferase domain containing 1 involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(PMID:20953171), (PMID:23169578)		 UniProt
RGD		 PMID:20953171 PMID:23169578 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:158,856,582...158,880,490
Ensembl chr 5:158,868,672...158,880,271 		JBrowse link
vitamin K catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp4f40 cytochrome P450, family 4, subfamily f, polypeptide 40 involved_in ISO (PMID:24138531) RGD PMID:24138531 NCBI chr 7:11,691,648...11,707,437
Ensembl chr 7:11,692,086...11,706,229 		JBrowse link
vitamin K metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07039936.1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr  X:82,134,804...82,146,443 JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 involved_in ISO (PMID:35922516) RGD PMID:35922516 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236 		JBrowse link
G Cbr1 carbonyl reductase 1 involved_in ISO (PMID:18449627) RGD PMID:18449627 NCBI chr11:32,876,563...32,884,234 JBrowse link
G Cbr1l1 carbonyl reductase 1 like 1 involved_in ISO
ISS		 (PMID:18449627)
GO_REF:0000024		 RGD
UniProt		 PMID:18449627 GO_REF:0000024 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,857,991...32,895,275
Ensembl chr11:32,857,991...32,895,275 		JBrowse link
G Cbr1l2 carbonyl reductase 1 like 2 involved_in ISO (PMID:18449627) RGD PMID:18449627 NCBI chr11:32,892,640...32,895,277
Ensembl chr11:32,857,991...32,895,275 		JBrowse link
G Crcp CGRP receptor component involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:26,623,968...26,659,756
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
G ENSRNOG00000070855 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr17:34,016,445...34,017,156 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 involved_in IDA
ISO		 PMID:8999809
(MGI:85821|PMID:8999809)
(PMID:8999809)		 RGD PMID:8999809 PMID:8999809 MGI:85821, RGD:151356617 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:16270630), (PMID:33154105)
GO_REF:0000002
(MGI:3604816|PMID:15879509)
(MGI:5559848|PMID:19492146)
PMID:21873635		 UniProt
RGD
InterPro		 PMID:15879509 PMID:16270630 PMID:19492146 PMID:33154105 PMID:21873635 GO_REF:0000002 GO_REF:0000024 MGI:3604816 MGI:5559848, RGD:13792537 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 involved_in ISO
IEA
IDA
IBA		 (PMID:21367861)
GO_REF:0000002
(MGI:5559651|PMID:23928358)
PMID:21873635		 RGD
InterPro		 PMID:21367861 PMID:23928358 PMID:23928358 PMID:21873635 GO_REF:0000002 MGI:5559651, RGD:8553362, RGD:13792537 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19898
    metabolic process 12211
      small molecule metabolic process 1914
        vitamin metabolic process 103
          fat-soluble vitamin metabolic process 50
            fat-soluble vitamin biosynthetic process + 12
            fat-soluble vitamin catabolic process + 14
            vitamin A metabolic process + 6
            vitamin D metabolic process + 21
            vitamin E metabolic process + 4
            vitamin K metabolic process + 16
paths to the root