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ONTOLOGY REPORT - ANNOTATIONS

Term:water-soluble vitamin metabolic process
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Accession:GO:0006767 term browser browse the term
Definition:The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water.
Synonyms:exact_synonym: water-soluble vitamin metabolism

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biotin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hlcs holocarboxylase synthetase involved_in ISO (MGI:7260196|PMID:35385533) MGI PMID:35385533 MGI:7260196 NCBI chrNW_004936500:5,827,213...5,976,457
Ensembl chrNW_004936500:5,827,299...5,975,439 		JBrowse link
G LOC101961662 biotinidase acts_upstream_of_or_within
involved_in		 ISO (MGI:4888153|PMID:21051254)
(MGI:5544528|PMID:24075304)		 MGI PMID:21051254 PMID:24075304 MGI:4888153 MGI:5544528 NCBI chrNW_004936473:2,787,386...2,823,014 JBrowse link
G Slc5a6 solute carrier family 5 member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936493:5,338,119...5,349,758
Ensembl chrNW_004936493:5,338,289...5,349,758 		JBrowse link
cobalamin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cubn cubilin ISO RGD PMID:14576052 RGD:8554807 NCBI chrNW_004936520:10,140,784...10,410,082
Ensembl chrNW_004936520:10,140,784...10,409,851 		JBrowse link
cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd4 ATP binding cassette subfamily D member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936488:3,526,875...3,538,851
Ensembl chrNW_004936488:3,523,344...3,538,858 		JBrowse link
G Amn amnion associated transmembrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936835:961,840...970,287
Ensembl chrNW_004936835:961,826...970,234 		JBrowse link
G Cubn cubilin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936520:10,140,784...10,410,082
Ensembl chrNW_004936520:10,140,784...10,409,851 		JBrowse link
G Mmaa metabolism of cobalamin associated A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936535:3,511,389...3,538,038
Ensembl chrNW_004936535:3,511,349...3,525,507 		JBrowse link
G Mmab metabolism of cobalamin associated B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936769:1,261,553...1,274,353
Ensembl chrNW_004936769:1,259,703...1,274,396 		JBrowse link
G Mmachc metabolism of cobalamin associated C involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:26,636,277...26,641,486
Ensembl chrNW_004936474:26,636,245...26,641,486 		JBrowse link
G Mmadhc metabolism of cobalamin associated D involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936469:27,771,741...27,804,324
Ensembl chrNW_004936469:27,771,937...27,787,233 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:16,087,924...16,180,089
Ensembl chrNW_004936484:16,087,923...16,180,148 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (MGI:3710265|PMID:17369066) MGI PMID:17369066 MGI:3710265 NCBI chrNW_004936643:379,790...410,034
Ensembl chrNW_004936643:380,968...409,464 		JBrowse link
folic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfs methenyltetrahydrofolate synthetase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:37,910,856...37,964,655
Ensembl chrNW_004936471:37,902,554...37,964,812 		JBrowse link
folic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 involved_in ISO PMID:1848231 UniProt PMID:1848231 RGD:632027 NCBI chrNW_004936898:456,299...484,681
Ensembl chrNW_004936898:456,521...484,282 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family member L2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:9,605,611...9,657,717
Ensembl chrNW_004936492:9,605,708...9,657,743 		JBrowse link
G Dhfr dihydrofolate reductase involved_in ISO PMID:20424322 BHF-UCL PMID:20424322 RGD:10054082 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Folr1 folate receptor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2669340|PMID:12854656) Ensembl
MGI		 PMID:12854656 GO_REF:0000107 MGI:2669340 NCBI chrNW_004936498:1,489,916...1,497,200
Ensembl chrNW_004936498:1,491,547...1,497,226 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936643:379,790...410,034
Ensembl chrNW_004936643:380,968...409,464 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936741:1,849,239...1,877,724
Ensembl chrNW_004936741:1,849,609...1,877,727 		JBrowse link
L-ascorbic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3588122|PMID:15769935) MGI
Ensembl		 PMID:15769935 GO_REF:0000107 MGI:3588122 NCBI chrNW_004936474:26,680,736...26,696,996
Ensembl chrNW_004936474:26,680,676...26,697,214 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B involved_in ISO (MGI:4834110|PMID:20410296) MGI PMID:20410296 MGI:4834110 NCBI chrNW_004936579:1,312,175...1,328,397 JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISO RGD PMID:9786866 RGD:70644 NCBI chrNW_004936600:1,932,152...1,943,342
Ensembl chrNW_004936600:1,930,695...1,943,422 		JBrowse link
G LOC101974420 L-gulonolactone oxidase involved_in IEA Ensembl
UniProt		 GO_REF:0000043 GO_REF:0000107 NCBI chrNW_004936675:471,975...492,986 JBrowse link
G Rgn regucalcin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936502:12,872,938...12,891,270
Ensembl chrNW_004936502:12,872,824...12,891,506 		JBrowse link
L-ascorbic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clstn3 calsyntenin 3 involved_in ISO (PMID:34673103)
(MGI:6728656|PMID:33672967)		 UniProt PMID:33672967 PMID:34673103 MGI:6728656 NCBI chrNW_004936709:641,615...673,309
Ensembl chrNW_004936709:637,641...673,314 		JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1928560|PMID:11118286) MGI
Ensembl		 PMID:11118286 GO_REF:0000107 MGI:1928560 NCBI chrNW_004936476:7,371,270...7,418,756
Ensembl chrNW_004936476:7,371,149...7,418,958 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936600:1,932,152...1,943,342
Ensembl chrNW_004936600:1,930,695...1,943,422 		JBrowse link
G Gsto2 glutathione S-transferase omega 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936600:1,907,396...1,925,256
Ensembl chrNW_004936600:1,907,517...1,925,235 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 ISO RGD PMID:10331392 RGD:634186 NCBI chrNW_004936485:13,885,067...13,976,623
Ensembl chrNW_004936485:13,885,091...13,976,550 		JBrowse link
nicotinamide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nnmt nicotinamide N-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936612:333,421...351,202
Ensembl chrNW_004936612:333,421...351,202 		JBrowse link
pantothenate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101975419 vascular non-inflammatory molecule 2 involved_in ISO (PMID:11491533) BHF-UCL PMID:11491533 NCBI chrNW_004936560:760,550...779,218 JBrowse link
G Vnn1 vanin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936560:701,857...729,516
Ensembl chrNW_004936560:701,892...729,526 		JBrowse link
G Vnn3 vanin 3 involved_in ISO (MGI:2149227|PMID:11491533) BHF-UCL PMID:11491533 MGI:2149227 NCBI chrNW_004936560:734,701...741,248 JBrowse link
positive regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clybl citramalyl-CoA lyase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:10,666,345...10,919,694
Ensembl chrNW_004936472:10,686,927...10,919,702 		JBrowse link
pyridoxal 5'-phosphate salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936500:510,977...539,166
Ensembl chrNW_004936500:509,510...529,455 		JBrowse link
pyridoxal metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:510,977...539,166
Ensembl chrNW_004936500:509,510...529,455 		JBrowse link
pyridoxal phosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase ISO RGD PMID:2988502 RGD:2303018 NCBI chrNW_004936500:510,977...539,166
Ensembl chrNW_004936500:509,510...529,455 		JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,374,925...13,382,037
Ensembl chrNW_004936490:13,374,737...13,382,071 		JBrowse link
pyridoxal phosphate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxp pyridoxal phosphatase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:3,420,590...3,426,764
Ensembl chrNW_004936492:3,421,516...3,426,715 		JBrowse link
pyridoxal phosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:7,209,196...7,229,899
Ensembl chrNW_004936474:7,209,093...7,229,989 		JBrowse link
G Pdxk pyridoxal kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:510,977...539,166
Ensembl chrNW_004936500:509,510...529,455 		JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,374,925...13,382,037
Ensembl chrNW_004936490:13,374,737...13,382,071 		JBrowse link
pyridoxamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:510,977...539,166
Ensembl chrNW_004936500:509,510...529,455 		JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,374,925...13,382,037
Ensembl chrNW_004936490:13,374,737...13,382,071 		JBrowse link
pyridoxine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnpo pyridoxamine 5'-phosphate oxidase involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936490:13,374,925...13,382,037
Ensembl chrNW_004936490:13,374,737...13,382,071 		JBrowse link
regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clybl citramalyl-CoA lyase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:10,666,345...10,919,694
Ensembl chrNW_004936472:10,686,927...10,919,702 		JBrowse link
riboflavin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rfk riboflavin kinase involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936503:11,921,125...11,930,562
Ensembl chrNW_004936503:11,919,982...11,930,622 		JBrowse link
riboflavin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flad1 flavin adenine dinucleotide synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,530,007...4,535,909
Ensembl chrNW_004936580:4,530,006...4,536,730 		JBrowse link
G Rfk riboflavin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:11,921,125...11,930,562
Ensembl chrNW_004936503:11,919,982...11,930,622 		JBrowse link
G Slc52a2 solute carrier family 52 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:7,886,169...7,888,592 JBrowse link
G Slc52a3 solute carrier family 52 member 3 involved_in ISO (MGI:6472232|PMID:33116204) MGI PMID:33116204 MGI:6472232 NCBI chrNW_004936485:17,771,797...17,777,637 JBrowse link
thiamine diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101963615 thiamine transporter 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936525:8,323,550...8,339,686
Ensembl chrNW_004936525:8,322,602...8,340,082 		JBrowse link
G Slc19a2 solute carrier family 19 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:17,197,133...17,225,435
Ensembl chrNW_004936481:17,197,095...17,227,891 		JBrowse link
G Slc25a19 solute carrier family 25 member 19 involved_in ISO (MGI:3691401|PMID:17035501)
(MGI:3691401|PMID:17035501), (MGI:7484782|PMID:8186267)		 MGI PMID:8186267 PMID:17035501 MGI:3691401 MGI:7484782 NCBI chrNW_004936594:557,823...570,599 JBrowse link
G Thtpa thiamine triphosphatase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936722:858,119...904,630
Ensembl chrNW_004936722:855,975...863,098 		JBrowse link
G Tpk1 thiamin pyrophosphokinase 1 involved_in IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936527:1,450,918...1,786,431
Ensembl chrNW_004936527:1,450,430...1,786,521 		JBrowse link
thiamine diphosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thtpa thiamine triphosphatase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936722:858,119...904,630
Ensembl chrNW_004936722:855,975...863,098 		JBrowse link
thiamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 involved_in IEA
ISS		 Ensembl
CAFA		 GO_REF:0000024 GO_REF:0000107 NCBI chrNW_004936529:5,661,772...5,723,108
Ensembl chrNW_004936529:5,661,702...5,725,363 		JBrowse link
G Thtpa thiamine triphosphatase involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936722:858,119...904,630
Ensembl chrNW_004936722:855,975...863,098 		JBrowse link
G Tpk1 thiamin pyrophosphokinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:1350425|PMID:10567383) Ensembl
MGI
InterPro		 PMID:10567383 GO_REF:0000002 GO_REF:0000107 MGI:1350425 NCBI chrNW_004936527:1,450,918...1,786,431
Ensembl chrNW_004936527:1,450,430...1,786,521 		JBrowse link
thiamine-containing compound metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tpk1 thiamin pyrophosphokinase 1 involved_in IEA UniProt GO_REF:0000117 NCBI chrNW_004936527:1,450,918...1,786,431
Ensembl chrNW_004936527:1,450,430...1,786,521 		JBrowse link
vitamin B6 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase involved_in IEA UniProt GO_REF:0000117 NCBI chrNW_004936500:510,977...539,166
Ensembl chrNW_004936500:509,510...529,455 		JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase involved_in IEA UniProt GO_REF:0000117 NCBI chrNW_004936490:13,374,925...13,382,037
Ensembl chrNW_004936490:13,374,737...13,382,071 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15080
    metabolic process 9016
      small molecule metabolic process 1541
        vitamin metabolic process 84
          water-soluble vitamin metabolic process 46
            L-ascorbic acid metabolic process + 9
            biotin metabolic process + 3
            cobalamin metabolic process + 10
            folic acid metabolic process + 7
            nicotinamide metabolic process + 1
            pantothenate metabolic process + 3
            riboflavin metabolic process + 4
            thiamine-containing compound metabolic process + 6
            vitamin B6 metabolic process + 4
            water-soluble vitamin biosynthetic process + 13
            water-soluble vitamin catabolic process + 3
paths to the root