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ONTOLOGY REPORT - ANNOTATIONS

Term:water-soluble vitamin metabolic process
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Accession:GO:0006767 term browser browse the term
Definition:The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water.
Synonyms:exact_synonym: water-soluble vitamin metabolism


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biotin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTD biotinidase acts_upstream_of_or_within
involved_in		 ISO (MGI:4888153|PMID:21051254)
(MGI:5544528|PMID:24075304)		 MGI PMID:21051254 PMID:24075304 MGI:4888153 MGI:5544528 NCBI chr23:27,037,640...27,069,544
Ensembl chr23:27,037,921...27,069,456 		JBrowse link
G HLCS holocarboxylase synthetase involved_in ISO (MGI:7260196|PMID:35385533) MGI PMID:35385533 MGI:7260196 NCBI chr31:31,934,796...32,159,866
Ensembl chr31:31,937,087...32,150,861 		JBrowse link
G SLC5A6 solute carrier family 5 member 6 involved_in ISO (MGI:5474531|PMID:23104561) MGI PMID:23104561 MGI:5474531 NCBI chr17:21,181,916...21,194,301
Ensembl chr17:21,031,765...21,193,112 		JBrowse link
cobalamin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CUBN cubilin ISO RGD PMID:14576052 RGD:8554807 NCBI chr 2:19,784,125...20,041,840
Ensembl chr 2:19,784,198...20,041,839 		JBrowse link
cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCD4 ATP binding cassette subfamily D member 4 involved_in ISO (PMID:22922874)
(PMID:33845046)		 UniProt
MGI		 PMID:22922874 PMID:33845046 NCBI chr 8:47,488,414...47,507,041
Ensembl chr 8:47,488,475...47,504,654 		JBrowse link
G AMN amnion associated transmembrane protein involved_in ISO (PMID:14576052) MGI PMID:14576052 NCBI chr 8:70,800,435...70,807,835 JBrowse link
G CUBN cubilin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:19,784,125...20,041,840
Ensembl chr 2:19,784,198...20,041,839 		JBrowse link
G MMAA metabolism of cobalamin associated A involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:44,221,082...44,243,530
Ensembl chr15:44,220,934...44,241,101 		JBrowse link
G MMAB metabolism of cobalamin associated B involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:17,519,158...17,531,200
Ensembl chr26:17,519,199...17,529,514 		JBrowse link
G MMACHC metabolism of cobalamin associated C involved_in ISO (PMID:23825108)
(PMID:19700356), (PMID:22642810)		 BHF-UCL
UniProt		 PMID:19700356 PMID:22642810 PMID:23825108 NCBI chr15:14,857,236...14,863,211
Ensembl chr15:14,857,231...14,863,113 		JBrowse link
G MMADHC metabolism of cobalamin associated D involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr19:51,154,227...51,177,950
Ensembl chr19:51,154,249...51,177,836 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:3,219,851...3,328,000
Ensembl chr 4:3,215,090...3,328,115 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (MGI:3710265|PMID:17369066) MGI PMID:17369066 MGI:3710265 NCBI chr34:6,068,572...6,119,580
Ensembl chr34:6,070,046...6,098,312 		JBrowse link
folic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFS methenyltetrahydrofolate synthetase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:57,480,935...57,514,836 JBrowse link
folic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 involved_in ISO PMID:1848231 UniProt PMID:1848231 RGD:632027 NCBI chr20:52,722...99,180
Ensembl chr20:61,349...99,160 		JBrowse link
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:33,310,523...33,365,677
Ensembl chr10:33,310,558...33,365,228 		JBrowse link
G DHFR dihydrofolate reductase involved_in ISO PMID:20424322 BHF-UCL PMID:20424322 RGD:10054082 NCBI chr 3:26,521,214...26,556,065 JBrowse link
G LOC609612 folate receptor alpha acts_upstream_of_or_within ISO (MGI:2669340|PMID:12854656) MGI PMID:12854656 MGI:2669340 NCBI chr21:25,944,350...25,951,010 JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:6,068,572...6,119,580
Ensembl chr34:6,070,046...6,098,312 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 involved_in ISO (PMID:11278996) UniProt PMID:11278996 NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166 		JBrowse link
L-ascorbic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 acts_upstream_of_or_within
involved_in		 ISO (MGI:3588122|PMID:15769935)
(MGI:4834110|PMID:20410296)
PMID:22820017		 MGI
UniProt		 PMID:15769935 PMID:20410296 PMID:22820017 MGI:3588122 MGI:4834110 RGD:13825440 NCBI chr15:14,792,398...14,808,805
Ensembl chr15:14,742,012...14,808,592 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B involved_in ISO (MGI:4834110|PMID:20410296) MGI PMID:20410296 MGI:4834110 NCBI chr14:2,991,888...3,006,941
Ensembl chr14:2,991,888...3,006,940 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 ISO RGD PMID:9786866 RGD:70644 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880 		JBrowse link
G GULO gulonolactone (L-) oxidase involved_in IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr25:30,007,888...30,039,996 JBrowse link
G RGN regucalcin involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:40,697,292...40,715,491
Ensembl chr  X:40,698,768...40,715,490 		JBrowse link
L-ascorbic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLSTN3 calsyntenin 3 involved_in ISO (PMID:34673103)
(MGI:6728656|PMID:33672967)		 UniProt PMID:33672967 PMID:34673103 MGI:6728656 NCBI chr27:37,879,047...37,913,317
Ensembl chr27:37,879,269...37,913,281 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1928560|PMID:11118286) MGI
Ensembl		 PMID:11118286 GO_REF:0000107 MGI:1928560 NCBI chr12:20,999,815...21,047,779
Ensembl chr12:21,000,792...21,047,779 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 involved_in ISO (PMID:11511179) UniProt PMID:11511179 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880 		JBrowse link
G GSTO2 glutathione S-transferase omega 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:16,580,250...16,604,977
Ensembl chr28:16,586,777...16,604,976 		JBrowse link
G MIR125A microRNA mir-125a ISO RGD PMID:27085842 RGD:26884454 NCBI chr 1:105,400,273...105,400,332
Ensembl chr 1:105,400,270...105,400,337 		JBrowse link
G SLC23A2 solute carrier family 23 member 2 ISO RGD PMID:10331392 RGD:634186 NCBI chr24:16,573,616...16,709,296
Ensembl chr24:16,574,168...16,709,296 		JBrowse link
nicotinamide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NNMT nicotinamide N-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:19,026,514...19,044,154
Ensembl chr 5:19,026,556...19,044,016 		JBrowse link
pantothenate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VNN1 vanin 1 involved_in IBA
ISS		 (PMID:21873635) GO_Central
UniProt		 PMID:21873635 GO_REF:0000024 NCBI chr 1:25,678,039...25,704,579
Ensembl chr 1:25,678,042...25,696,807 		JBrowse link
G VNN3 vanin 3 involved_in ISO (MGI:2149227|PMID:11491533) BHF-UCL PMID:11491533 MGI:2149227
positive regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLYBL citramalyl-CoA lyase involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:49,608,997...49,893,766
Ensembl chr22:49,608,358...49,871,572 		JBrowse link
pyridoxal 5'-phosphate salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDXK pyridoxal kinase involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr31:37,686,002...37,710,059
Ensembl chr31:37,685,492...37,707,767 		JBrowse link
pyridoxal phosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNPO pyridoxamine 5'-phosphate oxidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:7489789|PMID:9601034) Ensembl
GOC
GOC		 PMID:9601034 GO_REF:0000107 GO_REF:0000108 MGI:7489789 NCBI chr 9:24,252,895...24,258,523
Ensembl chr 9:24,252,964...24,258,106 		JBrowse link
pyridoxal phosphate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDXP pyridoxal phosphatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:26,945,751...26,952,234
Ensembl chr10:26,946,838...26,952,217 		JBrowse link
pyridoxal phosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPL alkaline phosphatase, biomineralization associated involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:77,559,791...77,614,102
Ensembl chr 2:77,559,791...77,614,820 		JBrowse link
G PNPO pyridoxamine 5'-phosphate oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:24,252,895...24,258,523
Ensembl chr 9:24,252,964...24,258,106 		JBrowse link
pyridoxamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNPO pyridoxamine 5'-phosphate oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:24,252,895...24,258,523
Ensembl chr 9:24,252,964...24,258,106 		JBrowse link
pyridoxine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNPO pyridoxamine 5'-phosphate oxidase involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:24,252,895...24,258,523
Ensembl chr 9:24,252,964...24,258,106 		JBrowse link
regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLYBL citramalyl-CoA lyase involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:49,608,997...49,893,766
Ensembl chr22:49,608,358...49,871,572 		JBrowse link
riboflavin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFK riboflavin kinase involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:82,062,290...82,071,033
Ensembl chr 1:82,059,631...82,069,257 		JBrowse link
riboflavin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLAD1 flavin adenine dinucleotide synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,489,045...42,494,524
Ensembl chr 7:42,489,061...42,494,471 		JBrowse link
G RFK riboflavin kinase involved_in ISO (PMID:19641494)
(MGI:5565643|PMID:24272050)		 UniProt
MGI		 PMID:19641494 PMID:24272050 MGI:5565643 NCBI chr 1:82,062,290...82,071,033
Ensembl chr 1:82,059,631...82,069,257 		JBrowse link
G SLC52A2 solute carrier family 52 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:37,779,896...37,786,653
Ensembl chr13:37,783,562...37,786,621 		JBrowse link
G SLC52A3 solute carrier family 52 member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:20,127,527...20,141,070
Ensembl chr24:20,127,520...20,156,003 		JBrowse link
thiamine diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC486151 thiamine transporter 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:40,411,489...40,442,183
Ensembl chr25:40,412,427...40,438,042 		JBrowse link
G SLC19A2 solute carrier family 19 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:29,094,341...29,114,319
Ensembl chr 7:29,094,101...29,113,249 		JBrowse link
G SLC25A19 solute carrier family 25 member 19 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:5,208,982...5,226,925
Ensembl chr 9:5,209,059...5,226,569 		JBrowse link
G THTPA thiamine triphosphatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:3,781,931...3,785,093
Ensembl chr 8:3,782,163...3,785,394 		JBrowse link
G TPK1 thiamin pyrophosphokinase 1 involved_in IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 NCBI chr16:5,257,749...5,588,179
Ensembl chr16:5,257,205...5,636,153 		JBrowse link
thiamine diphosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G THTPA thiamine triphosphatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:3,781,931...3,785,093
Ensembl chr 8:3,782,163...3,785,394 		JBrowse link
thiamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP3 acid phosphatase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:29,294,641...29,353,970
Ensembl chr23:29,294,843...29,343,499 		JBrowse link
G THTPA thiamine triphosphatase involved_in IEA InterPro GO_REF:0000002 NCBI chr 8:3,781,931...3,785,093
Ensembl chr 8:3,782,163...3,785,394 		JBrowse link
G TPK1 thiamin pyrophosphokinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:1350425|PMID:10567383) InterPro
MGI
Ensembl		 PMID:10567383 GO_REF:0000002 GO_REF:0000107 MGI:1350425 NCBI chr16:5,257,749...5,588,179
Ensembl chr16:5,257,205...5,636,153 		JBrowse link
thiamine-containing compound metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPK1 thiamin pyrophosphokinase 1 involved_in IEA UniProt GO_REF:0000117 NCBI chr16:5,257,749...5,588,179
Ensembl chr16:5,257,205...5,636,153 		JBrowse link
vitamin B6 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDXK pyridoxal kinase involved_in IEA UniProt GO_REF:0000117 NCBI chr31:37,686,002...37,710,059
Ensembl chr31:37,685,492...37,707,767 		JBrowse link
G PNPO pyridoxamine 5'-phosphate oxidase involved_in IEA UniProt GO_REF:0000117 NCBI chr 9:24,252,895...24,258,523
Ensembl chr 9:24,252,964...24,258,106 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16569
    metabolic process 10155
      small molecule metabolic process 1693
        vitamin metabolic process 88
          water-soluble vitamin metabolic process 46
            L-ascorbic acid metabolic process + 10
            biotin metabolic process + 3
            cobalamin metabolic process + 10
            folic acid metabolic process + 7
            nicotinamide metabolic process + 1
            pantothenate metabolic process + 2
            riboflavin metabolic process + 4
            thiamine-containing compound metabolic process + 6
            vitamin B6 metabolic process + 4
            water-soluble vitamin biosynthetic process + 13
            water-soluble vitamin catabolic process + 3
paths to the root