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ONTOLOGY REPORT - ANNOTATIONS

Term:water-soluble vitamin metabolic process
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Accession:GO:0006767 term browser browse the term
Definition:The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water.
Synonyms:exact_synonym: water-soluble vitamin metabolism

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biotin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btd biotinidase acts_upstream_of_or_within
involved_in		 ISO (MGI:4888153|PMID:21051254)
(MGI:5544528|PMID:24075304)		 MGI PMID:21051254 PMID:24075304 MGI:4888153 MGI:5544528 NCBI chrNW_004955430:7,960,036...7,988,754
Ensembl chrNW_004955430:7,960,039...7,988,754 		JBrowse link
G Hlcs holocarboxylase synthetase involved_in ISO (MGI:7260196|PMID:35385533) MGI PMID:35385533 MGI:7260196 NCBI chrNW_004955407:35,870,820...36,062,066
Ensembl chrNW_004955407:35,873,826...36,074,868 		JBrowse link
cobalamin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cubn cubilin ISO RGD PMID:14576052 RGD:8554807 NCBI chrNW_004955429:10,789,674...11,038,297
Ensembl chrNW_004955429:10,788,959...11,038,845 		JBrowse link
cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd4 ATP binding cassette subfamily D member 4 involved_in ISO (PMID:33845046)
(PMID:22922874)		 MGI
UniProt		 PMID:22922874 PMID:33845046 NCBI chrNW_004955523:1,170,306...1,181,352
Ensembl chrNW_004955523:1,170,303...1,182,467 		JBrowse link
G Amn amnion associated transmembrane protein involved_in ISO (PMID:14576052) MGI PMID:14576052 NCBI chrNW_004955538:2,017,476...2,021,890 JBrowse link
G Cubn cubilin involved_in ISO (PMID:14576052) MGI PMID:14576052 NCBI chrNW_004955429:10,789,674...11,038,297
Ensembl chrNW_004955429:10,788,959...11,038,845 		JBrowse link
G Mmaa metabolism of cobalamin associated A involved_in ISO (PMID:31056463) MGI PMID:31056463 NCBI chrNW_004955428:1,465,118...1,489,332
Ensembl chrNW_004955428:1,473,898...1,489,665 		JBrowse link
G Mmab metabolism of cobalamin associated B involved_in ISO (PMID:12514191) UniProt PMID:12514191 NCBI chrNW_004955455:8,954,099...8,985,170
Ensembl chrNW_004955455:8,954,094...8,965,866 		JBrowse link
G Mmachc metabolism of cobalamin associated C involved_in ISO (PMID:23825108)
(PMID:19700356), (PMID:22642810)		 BHF-UCL
UniProt		 PMID:19700356 PMID:22642810 PMID:23825108 NCBI chrNW_004955464:12,774,018...12,780,612
Ensembl chrNW_004955464:12,772,420...12,780,612 		JBrowse link
G Mmadhc metabolism of cobalamin associated D involved_in ISO (PMID:22156578), (PMID:24722857) MGI PMID:22156578 PMID:24722857 NCBI chrNW_004955440:15,317,877...15,338,139
Ensembl chrNW_004955440:15,316,822...15,337,688 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in ISO (PMID:23825108)
(MGI:1930456|PMID:11158293)		 BHF-UCL
MGI		 PMID:11158293 PMID:23825108 MGI:1930456 NCBI chrNW_004955492:3,372,915...3,474,173
Ensembl chrNW_004955492:3,376,512...3,474,180 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (MGI:3710265|PMID:17369066) MGI PMID:17369066 MGI:3710265 NCBI chrNW_004955504:5,412,290...5,435,409
Ensembl chrNW_004955504:5,413,586...5,435,645 		JBrowse link
folic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO (PMID:12764149) BHF-UCL PMID:12764149 NCBI chrNW_004955533:720,255...756,893
Ensembl chrNW_004955533:720,353...756,893 		JBrowse link
folic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 involved_in ISO PMID:1848231 UniProt PMID:1848231 RGD:632027 NCBI chrNW_004955421:21,420,264...21,506,004
Ensembl chrNW_004955421:21,420,147...21,527,037 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family member L2 involved_in ISO (MGI:6489626|PMID:33168096) UniProt PMID:33168096 MGI:6489626 NCBI chrNW_004955405:39,387,949...39,437,282
Ensembl chrNW_004955405:39,387,527...39,437,322 		JBrowse link
G Dhfr dihydrofolate reductase involved_in ISO PMID:20424322 BHF-UCL PMID:20424322 RGD:10054082 NCBI chrNW_004955418:29,274,170...29,283,028 JBrowse link
G Folr1 folate receptor alpha acts_upstream_of_or_within ISO (MGI:2669340|PMID:12854656) MGI PMID:12854656 MGI:2669340 NCBI chrNW_004955414:19,188,830...19,197,728
Ensembl chrNW_004955414:19,187,388...19,197,728 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (PMID:11466310)
(MGI:5512657|PMID:24074862)		 BHF-UCL
UniProt		 PMID:11466310 PMID:24074862 MGI:5512657 NCBI chrNW_004955504:5,412,290...5,435,409
Ensembl chrNW_004955504:5,413,586...5,435,645 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in ISO (PMID:11278996) UniProt PMID:11278996 NCBI chrNW_004955478:10,972,791...11,001,535
Ensembl chrNW_004955478:10,978,139...11,001,202 		JBrowse link
L-ascorbic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 acts_upstream_of_or_within
involved_in		 ISO (MGI:3588122|PMID:15769935)
(MGI:4834110|PMID:20410296)
PMID:22820017		 MGI
UniProt		 PMID:15769935 PMID:20410296 PMID:22820017 MGI:3588122 MGI:4834110 RGD:13825440 NCBI chrNW_004955464:12,715,238...12,729,034
Ensembl chrNW_004955464:12,714,717...12,729,662 		JBrowse link
G Rgn regucalcin involved_in ISO (MGI:5486063|PMID:23349732)
(MGI:3623658|PMID:16585534)		 UniProt
MGI		 PMID:16585534 PMID:23349732 MGI:3623658 MGI:5486063 NCBI chrNW_004955516:958,416...978,829
Ensembl chrNW_004955516:955,680...978,910 		JBrowse link
L-ascorbic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clstn3 calsyntenin 3 involved_in ISO (PMID:34673103)
(MGI:6728656|PMID:33672967)		 UniProt PMID:33672967 PMID:34673103 MGI:6728656 NCBI chrNW_004955413:4,690,637...4,719,929
Ensembl chrNW_004955413:4,690,637...4,719,929 		JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within ISO (MGI:1928560|PMID:11118286) MGI PMID:11118286 MGI:1928560 NCBI chrNW_004955411:2,593,523...2,617,553
Ensembl chrNW_004955411:2,593,541...2,616,539 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 ISO RGD PMID:10331392 RGD:634186 NCBI chrNW_004955415:15,565,344...15,677,935
Ensembl chrNW_004955415:15,565,249...15,642,153 		JBrowse link
nicotinamide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nnmt nicotinamide N-methyltransferase involved_in ISO (MGI:5708799|PMID:26168293)
(PMID:21823666), (PMID:8182091)		 UniProt PMID:8182091 PMID:21823666 PMID:26168293 MGI:5708799 NCBI chrNW_004955412:15,892,906...15,916,166 JBrowse link
pantothenate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vnn1 vanin 1 involved_in ISO (PMID:11491533), (PMID:25478849) UniProt PMID:11491533 PMID:25478849 NCBI chrNW_004955436:13,238,307...13,266,800
Ensembl chrNW_004955436:13,238,603...13,259,577 		JBrowse link
positive regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clybl citramalyl-CoA lyase involved_in ISO (MGI:5926841|PMID:29056341) CACAO PMID:29056341 MGI:5926841 NCBI chrNW_004955404:10,813,161...11,016,687
Ensembl chrNW_004955404:10,814,307...11,034,467 		JBrowse link
pyridoxal metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase involved_in ISO (MGI:6492058|PMID:33318193) MGI PMID:33318193 MGI:6492058 NCBI chrNW_004955407:41,482,216...41,494,174
Ensembl chrNW_004955407:41,482,216...41,494,177 		JBrowse link
pyridoxal phosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase ISO RGD PMID:2988502 RGD:2303018 NCBI chrNW_004955407:41,482,216...41,494,174
Ensembl chrNW_004955407:41,482,216...41,494,177 		JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase involved_in ISO (PMID:12824491) CAFA PMID:12824491 NCBI chrNW_004955451:13,184,861...13,190,933
Ensembl chrNW_004955451:13,183,826...13,191,707 		JBrowse link
pyridoxal phosphate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxp pyridoxal phosphatase involved_in ISO (PMID:14522954), (PMID:8132548)
(MGI:6277432|PMID:30327125)
(MGI:5545856|PMID:24338687), (MGI:5545857|PMID:24338473), (MGI:6695679|PMID:25783190)		 UniProt
MGI		 PMID:8132548 PMID:14522954 PMID:24338473 PMID:24338687 PMID:25783190 More... MGI:5545856 MGI:5545857 MGI:6277432 MGI:6695679 NCBI chrNW_004955413:24,055,900...24,063,902 JBrowse link
pyridoxal phosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated involved_in ISO (MGI:76012|PMID:7550313) UniProt PMID:7550313 MGI:76012 NCBI chrNW_004955452:1,820,212...1,873,877
Ensembl chrNW_004955452:1,820,174...1,874,226 		JBrowse link
G Pdxk pyridoxal kinase involved_in ISO (MGI:6386909|PMID:31935373)
(MGI:6492058|PMID:33318193)		 MGI PMID:31935373 PMID:33318193 MGI:6386909 MGI:6492058 NCBI chrNW_004955407:41,482,216...41,494,174
Ensembl chrNW_004955407:41,482,216...41,494,177 		JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase involved_in ISO (MGI:6386909|PMID:31935373) MGI PMID:31935373 MGI:6386909 NCBI chrNW_004955451:13,184,861...13,190,933
Ensembl chrNW_004955451:13,183,826...13,191,707 		JBrowse link
pyridoxamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase involved_in ISO (MGI:6386909|PMID:31935373) MGI PMID:31935373 MGI:6386909 NCBI chrNW_004955407:41,482,216...41,494,174
Ensembl chrNW_004955407:41,482,216...41,494,177 		JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase involved_in ISO (MGI:6386909|PMID:31935373) MGI PMID:31935373 MGI:6386909 NCBI chrNW_004955451:13,184,861...13,190,933
Ensembl chrNW_004955451:13,183,826...13,191,707 		JBrowse link
regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clybl citramalyl-CoA lyase involved_in ISO (PMID:29056341)
(MGI:5926841|PMID:29056341)		 UniProt PMID:29056341 MGI:5926841 NCBI chrNW_004955404:10,813,161...11,016,687
Ensembl chrNW_004955404:10,814,307...11,034,467 		JBrowse link
riboflavin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flad1 flavin adenine dinucleotide synthetase 1 involved_in ISO (MGI:6103054|PMID:28402850) MGI PMID:28402850 MGI:6103054 NCBI chrNW_004955545:1,487,929...1,495,808
Ensembl chrNW_004955545:1,487,818...1,497,839 		JBrowse link
G Rfk riboflavin kinase involved_in ISO (PMID:19641494)
(MGI:5565643|PMID:24272050)		 UniProt
MGI		 PMID:19641494 PMID:24272050 MGI:5565643 NCBI chrNW_004955512:2,889,265...2,898,195
Ensembl chrNW_004955512:2,890,106...2,898,195 		JBrowse link
G Slc52a2 solute carrier family 52 member 2 involved_in ISO (MGI:5766100|PMID:26791833)
(MGI:6709300|PMID:23911957)		 MGI PMID:23911957 PMID:26791833 MGI:5766100 MGI:6709300 NCBI chrNW_004955454:2,944,169...2,982,203
Ensembl chrNW_004955454:2,979,889...2,982,203 		JBrowse link
G Slc52a3 solute carrier family 52 member 3 involved_in ISO (MGI:6472232|PMID:33116204) MGI PMID:33116204 MGI:6472232 NCBI chrNW_004955596:48,463...60,239
Ensembl chrNW_004955596:47,108...60,239 		JBrowse link
thiamine diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc19a2 solute carrier family 19 member 2 involved_in ISO (MGI:7484782|PMID:8186267) MGI PMID:8186267 MGI:7484782 NCBI chrNW_004955462:7,786,920...7,804,828
Ensembl chrNW_004955462:7,786,913...7,805,792 		JBrowse link
G Slc19a3 solute carrier family 19 member 3 involved_in ISO (MGI:5917227|PMID:28665968)
(MGI:7484782|PMID:8186267)		 MGI PMID:8186267 PMID:28665968 MGI:5917227 MGI:7484782 NCBI chrNW_004955453:6,935,372...6,957,808
Ensembl chrNW_004955453:6,935,371...6,958,103 		JBrowse link
G Slc25a19 solute carrier family 25 member 19 involved_in ISO (MGI:3691401|PMID:17035501)
(MGI:3691401|PMID:17035501), (MGI:7484782|PMID:8186267)		 MGI PMID:8186267 PMID:17035501 MGI:3691401 MGI:7484782 NCBI chrNW_004955553:2,134,715...2,160,777 JBrowse link
G Thtpa thiamine triphosphatase involved_in ISO (MGI:3796446|PMID:18276586) MGI PMID:18276586 MGI:3796446 NCBI chrNW_004955409:36,803,721...36,808,094
Ensembl chrNW_004955409:36,804,258...36,808,091 		JBrowse link
G Tpk1 thiamin pyrophosphokinase 1 involved_in ISO (PMID:11342111)
(MGI:1350425|PMID:10567383)		 UniProt
MGI		 PMID:10567383 PMID:11342111 MGI:1350425 NCBI chrNW_004955491:621,941...968,570
Ensembl chrNW_004955491:623,530...968,253 		JBrowse link
thiamine diphosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thtpa thiamine triphosphatase involved_in ISO (MGI:3796446|PMID:18276586) UniProt PMID:18276586 MGI:3796446 NCBI chrNW_004955409:36,803,721...36,808,094
Ensembl chrNW_004955409:36,804,258...36,808,091 		JBrowse link
thiamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 involved_in ISO (MGI:3849266|PMID:18940592) UniProt PMID:18940592 MGI:3849266 NCBI chrNW_004955501:6,168,083...6,218,934
Ensembl chrNW_004955501:6,164,152...6,218,967 		JBrowse link
G Tpk1 thiamin pyrophosphokinase 1 acts_upstream_of_or_within ISO (MGI:1350425|PMID:10567383) MGI PMID:10567383 MGI:1350425 NCBI chrNW_004955491:621,941...968,570
Ensembl chrNW_004955491:623,530...968,253 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12228
    metabolic process 7369
      small molecule metabolic process 1301
        vitamin metabolic process 74
          water-soluble vitamin metabolic process 39
            L-ascorbic acid metabolic process + 5
            biotin metabolic process + 2
            cobalamin metabolic process + 10
            folic acid metabolic process + 7
            nicotinamide metabolic process + 1
            pantothenate metabolic process + 1
            riboflavin metabolic process + 4
            thiamine-containing compound metabolic process + 6
            vitamin B6 metabolic process + 4
            water-soluble vitamin biosynthetic process + 9
            water-soluble vitamin catabolic process + 3
paths to the root