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ONTOLOGY REPORT - ANNOTATIONS

Term:water-soluble vitamin metabolic process
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Accession:GO:0006767 term browser browse the term
Definition:The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water.
Synonyms:exact_synonym: water-soluble vitamin metabolism


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biotin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTD biotinidase acts_upstream_of_or_within
involved_in		 ISO (MGI:4888153|PMID:21051254)
(MGI:5544528|PMID:24075304)		 MGI PMID:21051254 PMID:24075304 MGI:4888153 MGI:5544528 NCBI chr 3:15,526,339...15,575,475
Ensembl chr 3:15,863,489...15,907,497 		JBrowse link
G HLCS holocarboxylase synthetase involved_in ISO (MGI:7260196|PMID:35385533) MGI PMID:35385533 MGI:7260196 NCBI chr21:23,112,477...23,352,121
Ensembl chr21:36,470,872...36,655,688 		JBrowse link
G SLC5A6 solute carrier family 5 member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:27,199,422...27,213,650
Ensembl chr2A:27,288,726...27,301,896 		JBrowse link
cobalamin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CUBN cubilin ISO RGD PMID:14576052 RGD:8554807 NCBI chr10:17,141,464...17,446,867
Ensembl chr10:17,415,551...17,719,129 		JBrowse link
cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCD4 ATP binding cassette subfamily D member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:54,833,388...54,850,482
Ensembl chr14:73,684,109...73,701,344 		JBrowse link
G AMN amnion associated transmembrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:83,541,891...83,550,346
Ensembl chr14:103,356,773...103,365,352 		JBrowse link
G CUBN cubilin involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:17,141,464...17,446,867
Ensembl chr10:17,415,551...17,719,129 		JBrowse link
G MMAA metabolism of cobalamin associated A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:137,960,877...138,001,384
Ensembl chr 4:149,620,381...149,658,470 		JBrowse link
G MMAB metabolism of cobalamin associated B involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:107,130,410...107,150,274
Ensembl chr12:110,528,043...110,544,871 		JBrowse link
G MMACHC metabolism of cobalamin associated C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:44,802,724...44,811,893
Ensembl chr 1:46,160,364...46,171,662 		JBrowse link
G MMADHC metabolism of cobalamin associated D involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr2B:10,278,656...10,298,700
Ensembl chr2B:153,924,371...153,942,537 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (MGI:3710265|PMID:17369066) MGI PMID:17369066 MGI:3710265 NCBI chr 5:8,195,868...8,228,071
Ensembl chr 5:8,017,403...8,049,322 		JBrowse link
folic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFS methenyltetrahydrofolate synthetase involved_in ISO (PMID:12764149) BHF-UCL PMID:12764149 NCBI chr15:58,810,966...58,864,831
Ensembl chr15:77,770,216...77,822,206 		JBrowse link
folic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 involved_in ISO PMID:1848231 UniProt PMID:1848231 RGD:632027 NCBI chr 3:123,166,630...123,244,257
Ensembl chr 3:130,484,862...130,562,934 		JBrowse link
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:102,596,881...102,661,617
Ensembl chr12:105,997,045...106,056,607 		JBrowse link
G DHFR dihydrofolate reductase involved_in ISO PMID:20424322 BHF-UCL PMID:20424322 RGD:10054082 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003 		JBrowse link
G LOC100994139 folate receptor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2669340|PMID:12854656) Ensembl
MGI		 PMID:12854656 GO_REF:0000107 MGI:2669340 NCBI chr11:67,268,721...67,275,498
Ensembl chr11:70,492,039...70,498,665 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:8,195,868...8,228,071
Ensembl chr 5:8,017,403...8,049,322 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:32,870,949...32,905,690
Ensembl chr17:37,849,206...37,884,220 		JBrowse link
L-ascorbic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3588122|PMID:15769935) MGI
Ensembl		 PMID:15769935 GO_REF:0000107 MGI:3588122 NCBI chr 1:44,853,867...44,871,764
Ensembl chr 1:46,211,859...46,230,072 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B involved_in ISO (MGI:4834110|PMID:20410296) MGI PMID:20410296 MGI:4834110 NCBI chr 7:126,400,861...126,417,756
Ensembl chr 7:138,912,953...138,924,095 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 ISO RGD PMID:9786866 RGD:70644 NCBI chr10:100,853,682...100,866,892
Ensembl chr10:104,313,024...104,325,733 		JBrowse link
G RGN regucalcin involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:39,513,135...39,530,188
Ensembl chr  X:47,371,226...47,388,881 		JBrowse link
L-ascorbic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLSTN3 calsyntenin 3 involved_in ISO (PMID:34673103)
(MGI:6728656|PMID:33672967)		 UniProt PMID:33672967 PMID:34673103 MGI:6728656 NCBI chr12:7,260,361...7,288,903
Ensembl chr12:7,175,951...7,204,526 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1928560|PMID:11118286) MGI
Ensembl		 PMID:11118286 GO_REF:0000107 MGI:1928560 NCBI chr 6:53,052,145...53,102,794
Ensembl chr 6:54,687,315...54,734,994 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:100,853,682...100,866,892
Ensembl chr10:104,313,024...104,325,733 		JBrowse link
G GSTO2 glutathione S-transferase omega 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:100,868,109...100,901,013
Ensembl chr10:104,326,175...104,357,604 		JBrowse link
G SLC23A2 solute carrier family 23 member 2 ISO RGD PMID:10331392 RGD:634186 NCBI chr20:4,874,185...5,024,750
Ensembl chr20:4,670,294...4,790,800 		JBrowse link
nicotinamide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NNMT nicotinamide N-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:109,174,490...109,186,758
Ensembl chr11:113,016,613...113,029,581 		JBrowse link
pantothenate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100978332 pantetheinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:130,459,268...130,491,167
Ensembl chr 6:134,566,117...134,598,784 		JBrowse link
G LOC100979321 pantetheine hydrolase VNN2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:130,521,698...130,535,944
Ensembl chr 6:134,629,464...134,643,934 		JBrowse link
G VNN3P vascular non-inflammatory molecule 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:130,499,664...130,511,900 JBrowse link
positive regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLYBL citramalyl-CoA lyase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:80,774,572...81,066,375
Ensembl chr13:99,912,773...100,195,417 		JBrowse link
pyridoxal 5'-phosphate salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDXK pyridoxal kinase involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr21:29,977,286...30,021,266
Ensembl chr21:43,273,237...43,313,637 		JBrowse link
pyridoxal metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDXK pyridoxal kinase involved_in ISO (MGI:6492058|PMID:33318193) MGI PMID:33318193 MGI:6492058 NCBI chr21:29,977,286...30,021,266
Ensembl chr21:43,273,237...43,313,637 		JBrowse link
pyridoxal phosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDXK pyridoxal kinase ISO RGD PMID:2988502 RGD:2303018 NCBI chr21:29,977,286...30,021,266
Ensembl chr21:43,273,237...43,313,637 		JBrowse link
G PNPO pyridoxamine 5'-phosphate oxidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:7489789|PMID:9601034) Ensembl
GOC
GOC		 PMID:9601034 GO_REF:0000107 GO_REF:0000108 MGI:7489789 NCBI chr17:9,589,253...9,596,973
Ensembl chr17:9,773,052...9,778,922 		JBrowse link
pyridoxal phosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPL alkaline phosphatase, biomineralization associated involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:20,702,509...20,772,301
Ensembl chr 1:21,667,732...21,736,688 		JBrowse link
G PDXK pyridoxal kinase involved_in ISO (MGI:6386909|PMID:31935373)
(MGI:6492058|PMID:33318193)		 MGI PMID:31935373 PMID:33318193 MGI:6386909 MGI:6492058 NCBI chr21:29,977,286...30,021,266
Ensembl chr21:43,273,237...43,313,637 		JBrowse link
G PNPO pyridoxamine 5'-phosphate oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:9,589,253...9,596,973
Ensembl chr17:9,773,052...9,778,922 		JBrowse link
pyridoxamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDXK pyridoxal kinase involved_in ISO (MGI:6386909|PMID:31935373) MGI PMID:31935373 MGI:6386909 NCBI chr21:29,977,286...30,021,266
Ensembl chr21:43,273,237...43,313,637 		JBrowse link
G PNPO pyridoxamine 5'-phosphate oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:9,589,253...9,596,973
Ensembl chr17:9,773,052...9,778,922 		JBrowse link
pyridoxine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNPO pyridoxamine 5'-phosphate oxidase involved_in IEA InterPro GO_REF:0000002 NCBI chr17:9,589,253...9,596,973
Ensembl chr17:9,773,052...9,778,922 		JBrowse link
regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLYBL citramalyl-CoA lyase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:80,774,572...81,066,375
Ensembl chr13:99,912,773...100,195,417 		JBrowse link
riboflavin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFK riboflavin kinase involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:48,447,295...48,456,262
Ensembl chr 9:75,245,636...75,254,350 		JBrowse link
riboflavin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLAD1 flavin adenine dinucleotide synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:130,331,795...130,341,279
Ensembl chr 1:133,941,665...133,950,399 		JBrowse link
G RFK riboflavin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:48,447,295...48,456,262
Ensembl chr 9:75,245,636...75,254,350 		JBrowse link
G SLC52A2 solute carrier family 52 member 2 involved_in ISO (MGI:5766100|PMID:26791833)
(MGI:6709300|PMID:23911957)		 MGI PMID:23911957 PMID:26791833 MGI:5766100 MGI:6709300 NCBI chr 8:141,122,292...141,124,985
Ensembl chr 8:144,112,498...144,114,319 		JBrowse link
G SLC52A3 solute carrier family 52 member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:970,380...986,368
Ensembl chr20:739,556...755,486 		JBrowse link
thiamine diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100974683 thiamine transporter 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:114,925,990...114,957,841
Ensembl chr2B:233,736,050...233,764,514 		JBrowse link
G SLC19A2 solute carrier family 19 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:144,946,248...144,968,736
Ensembl chr 1:148,668,687...148,690,713 		JBrowse link
G SLC25A19 solute carrier family 25 member 19 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:69,220,073...69,237,067
Ensembl chr17:74,773,341...74,789,699 		JBrowse link
G THTPA thiamine triphosphatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:4,374,439...4,378,028
Ensembl chr14:22,467,506...22,471,356 		JBrowse link
G TPK1 thiamin pyrophosphokinase 1 involved_in IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 NCBI chr 7:136,165,941...136,549,606
Ensembl chr 7:148,654,445...149,036,342 		JBrowse link
thiamine diphosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G THTPA thiamine triphosphatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:4,374,439...4,378,028
Ensembl chr14:22,467,506...22,471,356 		JBrowse link
thiamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP3 acid phosphatase 3 involved_in ISS CAFA GO_REF:0000024 NCBI chr 3:129,392,396...129,465,962
Ensembl chr 3:136,713,816...136,764,655 		JBrowse link
G THTPA thiamine triphosphatase involved_in IEA InterPro GO_REF:0000002 NCBI chr14:4,374,439...4,378,028
Ensembl chr14:22,467,506...22,471,356 		JBrowse link
G TPK1 thiamin pyrophosphokinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:1350425|PMID:10567383) InterPro
MGI
Ensembl		 PMID:10567383 GO_REF:0000002 GO_REF:0000107 MGI:1350425 NCBI chr 7:136,165,941...136,549,606
Ensembl chr 7:148,654,445...149,036,342 		JBrowse link
thiamine-containing compound metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPK1 thiamin pyrophosphokinase 1 involved_in IEA UniProt GO_REF:0000117 NCBI chr 7:136,165,941...136,549,606
Ensembl chr 7:148,654,445...149,036,342 		JBrowse link
vitamin B6 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDXK pyridoxal kinase involved_in IEA UniProt GO_REF:0000117 NCBI chr21:29,977,286...30,021,266
Ensembl chr21:43,273,237...43,313,637 		JBrowse link
G PNPO pyridoxamine 5'-phosphate oxidase involved_in IEA UniProt GO_REF:0000117 NCBI chr17:9,589,253...9,596,973
Ensembl chr17:9,773,052...9,778,922 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15635
    metabolic process 9767
      small molecule metabolic process 1631
        vitamin metabolic process 87
          water-soluble vitamin metabolic process 44
            L-ascorbic acid metabolic process + 8
            biotin metabolic process + 3
            cobalamin metabolic process + 10
            folic acid metabolic process + 7
            nicotinamide metabolic process + 1
            pantothenate metabolic process + 3
            riboflavin metabolic process + 4
            thiamine-containing compound metabolic process + 6
            vitamin B6 metabolic process + 3
            water-soluble vitamin biosynthetic process + 12
            water-soluble vitamin catabolic process + 2
paths to the root