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ONTOLOGY REPORT - ANNOTATIONS

Term:water-soluble vitamin metabolic process
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Accession:GO:0006767 term browser browse the term
Definition:The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water.
Synonyms:exact_synonym: water-soluble vitamin metabolism


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biotin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btd biotinidase involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:4888510 (MGI:4888153|PMID:21051254)		 RGD PMID:21051254 PMID:21873635 MGI:4888153, RGD:13792537 NCBI chr16:6,863,068...6,894,345
Ensembl chr16:6,862,407...6,940,945 		JBrowse link
cobalamin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cubn cubilin IMP RGD PMID:14576052 RGD:8554807 NCBI chr17:76,385,046...76,593,133
Ensembl chr17:76,385,060...76,593,231 		JBrowse link
cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 involved_in ISO MGI:2155908 (MGI:4436975|PMID:19897579) RGD PMID:19897579 MGI:4436975 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcd4 ATP binding cassette subfamily D member 4 involved_in ISO (PMID:22922874) RGD PMID:22922874 NCBI chr 6:104,246,459...104,260,965
Ensembl chr 6:104,246,468...104,280,276 		JBrowse link
G Amn amnion associated transmembrane protein involved_in ISO (PMID:14576052) RGD PMID:14576052 NCBI chr 6:130,311,372...130,318,815
Ensembl chr 6:130,311,372...130,318,815 		JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase TAS RGD PMID:3994693 RGD:5135263 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889 		JBrowse link
G Cblif cobalamin binding intrinsic factor involved_in IDA
ISO		 MGI:4363945 (MGI:5586607|PMID:24911144) RGD PMID:24911144 PMID:14166172 MGI:5586607, RGD:1624368 NCBI chr 1:208,605,983...208,620,231
Ensembl chr 1:208,605,983...208,620,344 		JBrowse link
G Cd320 CD320 molecule involved_in ISO MGI:3858540 (MGI:5506682|PMID:23430977) RGD PMID:23430977 MGI:5506682 NCBI chr 7:14,626,171...14,631,976
Ensembl chr 7:14,609,146...14,631,976 		JBrowse link
G Cubn cubilin involved_in ISO (PMID:14576052) RGD PMID:14576052 NCBI chr17:76,385,046...76,593,133
Ensembl chr17:76,385,060...76,593,231 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase TAS RGD PMID:3994693 RGD:5135263 NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125 		JBrowse link
G Lmbrd1 LMBR1 domain containing 1 involved_in ISO (PMID:27456980) RGD PMID:27456980 NCBI chr 9:27,096,387...27,178,095
Ensembl chr 9:27,096,297...27,178,090 		JBrowse link
G Mmaa metabolism of cobalamin associated A involved_in ISO (PMID:31056463) RGD PMID:31056463 NCBI chr19:28,619,060...28,649,319
Ensembl chr19:28,619,087...28,649,319 		JBrowse link
G Mmachc metabolism of cobalamin associated C involved_in ISO
IBA		 (PMID:19700356), (PMID:22642810), (PMID:23825108)
PMID:21873635		 RGD PMID:19700356 PMID:22642810 PMID:23825108 PMID:21873635 RGD:13792537 NCBI chr 5:130,166,056...130,172,735
Ensembl chr 5:130,166,451...130,172,601 		JBrowse link
G Mmadhc metabolism of cobalamin associated D involved_in IEA
ISS
ISO		 GO_REF:0000002
GO_REF:0000024
(PMID:24722857)		 InterPro
UniProt
RGD		 PMID:24722857 GO_REF:0000002 GO_REF:0000024 NCBI chr 3:34,708,649...34,726,554
Ensembl chr 3:34,708,649...34,726,771 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in ISO
IEA		 (PMID:23825108)
MGI:2180496 (MGI:1930456|PMID:11158293)
GO_REF:0000107		 RGD
Ensembl		 PMID:11158293 PMID:23825108 GO_REF:0000107 MGI:1930456 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (MGI:3710265|PMID:17369066) RGD PMID:17369066 MGI:3710265 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
folic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO (PMID:12764149) RGD PMID:12764149 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Pm20d2 peptidase M20 domain containing 2 NOT|involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:47,566,059...47,586,334
Ensembl chr 5:47,566,072...47,586,212 		JBrowse link
folic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 involved_in IDA PMID:1848231 UniProt PMID:1848231 RGD:632027 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 involved_in ISO (MGI:6489626|PMID:33168096) RGD PMID:33168096 MGI:6489626 NCBI chr 7:20,254,196...20,305,793
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
G Dhfr dihydrofolate reductase involved_in IBA
IDA		 PMID:21873635
PMID:20424322		 GO_Central
BHF-UCL		 PMID:21873635 PMID:20424322 RGD:13792537, RGD:10054082 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Folr1 folate receptor alpha acts_upstream_of_or_within ISO MGI:2383986 (MGI:2669340|PMID:12854656) RGD PMID:12854656 MGI:2669340 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Gnmt glycine N-methyltransferase TAS RGD PMID:12054489 RGD:728472 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISS
ISO		 GO_REF:0000024
(MGI:5512657|PMID:24074862)
(PMID:11466310)		 UniProt
RGD		 PMID:11466310 PMID:24074862 GO_REF:0000024 MGI:5512657 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in IBA
ISO		 PMID:21873635
(PMID:11278996)		 RGD PMID:11278996 PMID:21873635 RGD:13792537 NCBI chr10:45,468,698...45,497,820
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
L-ascorbic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 involved_in
acts_upstream_of_or_within		 IMP
ISO		 PMID:22820017
(MGI:4834110|PMID:20410296)
(MGI:3588122|PMID:15769935)		 RGD PMID:15769935 PMID:20410296 PMID:22820017 MGI:3588122 MGI:4834110, RGD:13825440 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 IMP RGD PMID:9786866 RGD:70644 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Gulo gulonolactone (L-) oxidase involved_in ISS
IEA		 GO_REF:0000024
GO_REF:0000107
GO_REF:0000041		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr15:40,205,677...40,227,766
Ensembl chr15:40,205,665...40,227,874 		JBrowse link
G Rgn regucalcin involved_in IBA
ISO
ISS		 PMID:21873635
(MGI:5486063|PMID:23349732)
GO_REF:0000024		 RGD
UniProt		 PMID:23349732 PMID:21873635 GO_REF:0000024 MGI:5486063, RGD:13792537 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
L-ascorbic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within ISO MGI:2429419 (MGI:1928560|PMID:11118286) RGD PMID:11118286 MGI:1928560 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:11511179)		 Ensembl
UniProt
RGD		 PMID:11511179 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Gsto2 glutathione S-transferase omega 2 involved_in ISO
IBA
ISS		 (PMID:15970797)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:15970797 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:246,731,314...246,757,592
Ensembl chr 1:246,732,089...246,753,866 		JBrowse link
G Mir125a microRNA 125a IDA RGD PMID:27085842 RGD:26884454 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 involved_in IMP
IBA		 PMID:21873635 RGD
GO_Central		 PMID:10331392 PMID:21873635 RGD:634186, RGD:13792537 NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343 		JBrowse link
nicotinamide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nnmt nicotinamide N-methyltransferase involved_in ISO (PMID:21823666)
(MGI:5708799|PMID:26168293)		 RGD PMID:21823666 PMID:26168293 MGI:5708799 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655 		JBrowse link
pantothenate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vnn1 vanin 1 involved_in ISO
IBA		 (PMID:11491533), (PMID:25478849)
PMID:21873635		 RGD PMID:11491533 PMID:25478849 PMID:21873635 RGD:13792537 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395 		JBrowse link
G Vnn3 vanin 3 involved_in IBA
ISO		 PMID:21873635
(MGI:2149227|PMID:11491533)		 RGD PMID:11491533 PMID:21873635 MGI:2149227, RGD:13792537 NCBI chr 1:21,571,364...21,583,626
Ensembl chr 1:21,571,364...21,583,626 		JBrowse link
positive regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clybl citramalyl-CoA lyase involved_in ISO (MGI:5926841|PMID:29056341) RGD PMID:29056341 MGI:5926841 NCBI chr15:99,283,644...99,505,697
Ensembl chr15:99,283,650...99,505,695 		JBrowse link
pyridoxal 5'-phosphate salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase involved_in IBA
IEA		 PMID:21873635
GO_REF:0000002		 InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr20:10,210,393...10,231,937
Ensembl chr20:10,210,289...10,232,110 		JBrowse link
G RGD1566085 similar to pyridoxal (pyridoxine, vitamin B6) kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:10,162,934...10,192,610 JBrowse link
pyridoxal phosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase IDA RGD PMID:2988502 RGD:2303018 NCBI chr20:10,210,393...10,231,937
Ensembl chr20:10,210,289...10,232,110 		JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase involved_in IBA
ISO		 PMID:21873635
(PMID:12824491)		 RGD PMID:12824491 PMID:21873635 RGD:13792537 NCBI chr10:81,924,584...81,930,844
Ensembl chr10:81,924,569...81,930,871 		JBrowse link
pyridoxal phosphate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxp pyridoxal phosphatase involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5545856|PMID:24338687), (MGI:5545857|PMID:24338473), (MGI:6695679|PMID:25783190)
(PMID:14522954), (PMID:8132548)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:8132548 PMID:14522954 PMID:24338473 PMID:24338687 PMID:25783190 GO_REF:0000024 GO_REF:0000107 MGI:5545856 MGI:5545857 MGI:6695679 NCBI chr 7:110,472,515...110,477,963
Ensembl chr 7:110,472,515...110,477,963 		JBrowse link
pyridoxal phosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated involved_in ISO (MGI:76012|PMID:7550313) RGD PMID:7550313 MGI:76012 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
pyridoxine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnpo pyridoxamine 5'-phosphate oxidase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:81,924,584...81,930,844
Ensembl chr10:81,924,569...81,930,871 		JBrowse link
regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clybl citramalyl-CoA lyase involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:29056341)
PMID:21873635
(MGI:5926841|PMID:29056341)		 UniProt
RGD		 PMID:29056341 PMID:21873635 GO_REF:0000024 MGI:5926841, RGD:13792537 NCBI chr15:99,283,644...99,505,697
Ensembl chr15:99,283,650...99,505,695 		JBrowse link
riboflavin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rfk riboflavin kinase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438 		JBrowse link
riboflavin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rfk riboflavin kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438 		JBrowse link
thiamine diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tpk1 thiamin pyrophosphokinase 1 involved_in IEA
IBA		 GO_REF:0000041
PMID:21873635		 UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 4:72,170,134...72,557,707
Ensembl chr 4:72,170,134...72,557,694 		JBrowse link
thiamine diphosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thtpa thiamine triphosphatase involved_in IEA
ISO
IBA
ISS		 GO_REF:0000107
(MGI:3796446|PMID:18276586)
PMID:21873635
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:18276586 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:3796446, RGD:13792537 NCBI chr15:28,567,619...28,571,580
Ensembl chr15:28,567,323...28,571,580 		JBrowse link
thiamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3849266|PMID:18940592)		 Ensembl
RGD		 PMID:18940592 GO_REF:0000107 MGI:3849266 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236 		JBrowse link
G Thtpa thiamine triphosphatase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:28,567,619...28,571,580
Ensembl chr15:28,567,323...28,571,580 		JBrowse link
G Tpk1 thiamin pyrophosphokinase 1 acts_upstream_of_or_within ISO (MGI:1350425|PMID:10567383) RGD PMID:10567383 MGI:1350425 NCBI chr 4:72,170,134...72,557,707
Ensembl chr 4:72,170,134...72,557,694 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    metabolic process 11824
      small molecule metabolic process 1804
        vitamin metabolic process 92
          water-soluble vitamin metabolic process 45
            L-ascorbic acid metabolic process + 8
            biotin metabolic process + 1
            cobalamin metabolic process + 15
            folic acid metabolic process + 10
            nicotinamide metabolic process + 1
            pantothenate metabolic process + 2
            riboflavin metabolic process + 1
            thiamine-containing compound metabolic process + 3
            vitamin B6 metabolic process + 5
            water-soluble vitamin biosynthetic process + 9
            water-soluble vitamin catabolic process + 4
paths to the root