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ONTOLOGY REPORT - ANNOTATIONS


Term:folic acid-containing compound metabolic process
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Accession:GO:0006760 term browser browse the term
Definition:The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.
Synonyms:exact_synonym: folate and derivative metabolic process;   folate and derivative metabolism;   folate-containing compound metabolic process;   folate-containing compound metabolism;   folic acid and derivative metabolic process;   folic acid and derivative metabolism;   folic acid-containing compound metabolism;   vitamin B9 and derivative metabolic process;   vitamin B9 and derivative metabolism;   vitamin M and derivative metabolic process;   vitamin M and derivative metabolism


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folic acid-containing compound metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fpgs folylpolyglutamate synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:15,453,010...15,466,591 JBrowse link
G LOC101964348 glutamate carboxypeptidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936736:32,617...79,968 JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IEA UniProt GO_REF:0000117 NCBI chrNW_004936495:8,100,977...8,170,244 JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936489:3,877,423...4,060,129 JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase involved_in IEA UniProt GO_REF:0000117 NCBI chrNW_004936556:462,998...475,092 JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like involved_in IEA UniProt GO_REF:0000117 NCBI chrNW_004936598:1,401,392...1,514,314 JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:8,100,977...8,170,244 JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936489:3,877,423...4,060,129 JBrowse link
10-formyltetrahydrofolate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aasdhppt aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase acts_upstream_of_positive_effect ISO (PMID:19933275), (PMID:21238436) UniProt PMID:19933275 PMID:21238436 NCBI chrNW_004936551:2,312,510...2,335,810 JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936898:456,299...484,681 JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family member L2 involved_in IEA Ensembl
InterPro
UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936492:9,605,611...9,657,717 JBrowse link
10-formyltetrahydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like ISO RGD PMID:21163947 RGD:7244288 NCBI chrNW_004936598:1,401,392...1,514,314 JBrowse link
dihydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO RGD PMID:8948466 RGD:5144056 NCBI chrNW_004936586:1,782,581...1,809,458 JBrowse link
G Dhfr dihydrofolate reductase involved_in ISO (PMID:2303423), (PMID:23707606) RGD
BHF-UCL
PMID:2303423 PMID:3970530 PMID:11502523 PMID:23707606 RGD:1298877 RGD:2300196 NCBI chrNW_004936469:67,962...83,116 JBrowse link
folic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO (PMID:12764149) BHF-UCL PMID:12764149 NCBI chrNW_004936471:37,910,856...37,964,655 JBrowse link
folic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 involved_in ISO PMID:1848231 UniProt PMID:1848231 RGD:632027 NCBI chrNW_004936898:456,299...484,681 JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family member L2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:9,605,611...9,657,717 JBrowse link
G Dhfr dihydrofolate reductase involved_in ISO PMID:20424322 BHF-UCL PMID:20424322 RGD:10054082 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Folr1 folate receptor alpha acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2669340|PMID:12854656) MGI
Ensembl
PMID:12854656 GO_REF:0000107 MGI:2669340 NCBI chrNW_004936498:1,489,916...1,497,200 JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936643:379,790...410,034 JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936741:1,849,239...1,877,724 JBrowse link
folic acid-containing compound biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fpgs folylpolyglutamate synthase involved_in IEA InterPro
UniProt
GO_REF:0000002 GO_REF:0000117 NCBI chrNW_004936487:15,453,010...15,466,591 JBrowse link
tetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO RGD PMID:7057182 RGD:2301991 NCBI chrNW_004936586:1,782,581...1,809,458 JBrowse link
G Dhfr dihydrofolate reductase involved_in ISO
IEA
RGD
UniProt
InterPro
PMID:11502523 GO_REF:0000002 GO_REF:0000041 RGD:1298877 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:4078017 RGD:2301990 NCBI chrNW_004936500:8,750,928...8,782,303 JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936697:232,048...275,420 JBrowse link
tetrahydrofolate interconversion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Dmgdh dimethylglycine dehydrogenase ISO RGD PMID:6163778 RGD:7245485 NCBI chrNW_004936549:6,838,773...6,899,961 JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase involved_in IEA UniProt GO_REF:0000041 NCBI chrNW_004936778:375,800...390,764 JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IEA Ensembl
UniProt
GO_REF:0000041 GO_REF:0000107 NCBI chrNW_004936495:8,100,977...8,170,244 JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like involved_in IEA UniProt GO_REF:0000041 NCBI chrNW_004936489:3,877,423...4,060,129 JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like involved_in ISO PMID:24733394 RGD
UniProt
PMID:21163947 PMID:24733394 RGD:150521648 RGD:7244288 NCBI chrNW_004936598:1,401,392...1,514,314 JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in IEA Ensembl
UniProt
GO_REF:0000041 GO_REF:0000107 NCBI chrNW_004936474:623,438...637,849 JBrowse link
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO (PMID:12764149) BHF-UCL PMID:12764149 NCBI chrNW_004936471:37,910,856...37,964,655 JBrowse link
G Sardh sarcosine dehydrogenase ISO RGD PMID:6163778 RGD:7245485 NCBI chrNW_004936669:3,244,302...3,297,906 JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in IEA InterPro
UniProt
Ensembl
GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 NCBI chrNW_004936741:1,849,239...1,877,724 JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 involved_in IEA InterPro
Ensembl
UniProt
GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 NCBI chrNW_004936646:1,422,844...1,427,929 JBrowse link
G Tyms thymidylate synthetase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:33,797...42,233 JBrowse link
tetrahydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in ISO (PMID:12096917), (PMID:21876184) UniProt PMID:12096917 PMID:21876184 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936556:462,998...475,092 JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:11730351 RGD:1601423 NCBI chrNW_004936474:623,438...637,849 JBrowse link
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO (PMID:19738041), (PMID:7766710) BHF-UCL PMID:7766710 PMID:19738041 NCBI chrNW_004936471:37,910,856...37,964,655 JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:11730351 PMID:21121936 RGD:1601423 RGD:7207080 NCBI chrNW_004936484:16,087,924...16,180,089 JBrowse link
G Pipox pipecolic acid and sarcosine oxidase involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936538:5,218,097...5,252,579 JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936741:1,849,239...1,877,724 JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936646:1,422,844...1,427,929 JBrowse link
G Tyms thymidylate synthetase ISO 5-formyltetrahydrofolate RGD PMID:7503782 RGD:5133451 NCBI chrNW_004936550:33,797...42,233 JBrowse link
tetrahydrofolylpolyglutamate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fpgs folylpolyglutamate synthase involved_in IEA UniProt
Ensembl
GO_REF:0000041 GO_REF:0000107 NCBI chrNW_004936487:15,453,010...15,466,591 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14953
    cellular process 14088
      cellular metabolic process 8560
        cellular modified amino acid metabolic process 182
          folic acid-containing compound metabolic process 25
            dihydrofolate metabolic process + 2
            folic acid metabolic process + 7
            folic acid-containing compound biosynthetic process + 7
            folic acid-containing compound catabolic process + 4
            tetrahydrofolate metabolic process + 21
            tetrahydrofolylpolyglutamate metabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 14953
    cellular process 14088
      cellular metabolic process 8560
        cellular aromatic compound metabolic process 4569
          pteridine-containing compound metabolic process 31
            folic acid-containing compound metabolic process 25
              dihydrofolate metabolic process + 2
              folic acid metabolic process + 7
              folic acid-containing compound biosynthetic process + 7
              folic acid-containing compound catabolic process + 4
              tetrahydrofolate metabolic process + 21
              tetrahydrofolylpolyglutamate metabolic process + 1
paths to the root