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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione biosynthetic process
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Accession:GO:0006750 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Synonyms:exact_synonym: glutathione anabolism;   glutathione biosynthesis;   glutathione formation;   glutathione synthesis
 xref: MetaCyc:GLUTATHIONESYN-PWY



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glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLC glutamate-cysteine ligase catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3607629|PMID:16081425)
(MGI:1858542|PMID:10805773)
UniProt
MGI
RGD
PMID:10805773 PMID:16081425 PMID:16183645 GO_REF:0000041 MGI:1858542 MGI:3607629 RGD:1582661 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
(PMID:21873635)
(MGI:3607629|PMID:16081425)
GO_Central
MGI
RGD
UniProt
PMID:16081425 PMID:16183645 PMID:21873635 GO_REF:0000041 MGI:3607629 RGD:1582661 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,135
JBrowse link
G GGT1 gamma-glutamyltransferase 1 involved_in IEA UniProt
Ensembl
GO_REF:0000043 GO_REF:0000107 NCBI chr14:49,618,737...49,638,054 JBrowse link
G GSS glutathione synthetase involved_in IEA
ISO
InterPro
RGD
UniProt
PMID:10964706 GO_REF:0000002 GO_REF:0000041 RGD:1599340 NCBI chr17:38,316,199...38,342,253
Ensembl chr17:38,312,720...38,342,304
JBrowse link
G HAGH hydroxyacylglutathione hydrolase involved_in ISO (PMID:8550579) UniProt PMID:8550579 NCBI chr 3:40,139,099...40,162,921 JBrowse link
G MGST2 microsomal glutathione S-transferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:87,318,180...87,394,563
Ensembl chr 8:87,319,533...87,390,520
JBrowse link
G SLC1A1 solute carrier family 1 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:217,366,493...217,441,643
Ensembl chr 1:217,366,499...217,441,674
JBrowse link
G SLC1A2 solute carrier family 1 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:25,603,892...25,771,840
Ensembl chr 2:25,604,950...25,848,276
JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:5616326 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,875...57,506,247
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC7A11 solute carrier family 7 member 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3588610|PMID:16037214) Ensembl
MGI
PMID:16037214 GO_REF:0000107 MGI:3588610 NCBI chr 8:88,608,083...88,690,589
Ensembl chr 8:88,607,884...88,940,100
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16581
    cellular process 15867
      cellular metabolic process 9471
        cellular modified amino acid metabolic process 178
          glutathione metabolic process 61
            glutathione biosynthetic process 11
              negative regulation of glutathione biosynthetic process 0
              positive regulation of glutathione biosynthetic process 2
              regulation of glutathione biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 16581
    metabolic process 10424
      cellular metabolic process 9471
        cellular biosynthetic process 5143
          cellular nitrogen compound biosynthetic process 4197
            amide biosynthetic process 780
              peptide biosynthetic process 662
                nonribosomal peptide biosynthetic process 13
                  glutathione biosynthetic process 11
                    negative regulation of glutathione biosynthetic process 0
                    positive regulation of glutathione biosynthetic process 2
                    regulation of glutathione biosynthetic process + 3
paths to the root